Menée aux Etats-Unis par enquête auprès de 1 122 patients atteints de cancer (âge médian : 58 ans) et 800 professionnels de santé, cette étude analyse les disparités de perceptions dans la prévalence et l'intensité de la douleur ou de la fatigue liée à la maladie

Disparities found in perception of symptoms between patients and oncology team

Barton, Mary Kay

Key Points •The prevalence and importance of pain and fatigue in patients with cancer continue to be underestimated by oncology physicians and nurses. •Clinicians need to assess symptoms of fatigue and pain carefully at each encounter. •An increased awareness of patient-reported outcomes and education for HCPs is needed to improve patients' QOL. A recent study has demonstrated that oncology physicians and nurses underestimate the prevalence and impact of fatigue and pain in their patients with [...]

Cette étude présente les recommandations actualisées de deux sociétés savantes relatives à la prévention des nausées et vomissements induits par la chimiothérapie chez l'enfant de moins de 18 ans

2016 updated MASCC/ESMO consensus recommendations: Prevention of acute chemotherapy-induced nausea and vomiting in children

Dupuis, L. Lee ; Sung, Lillian ; Molassiotis, Alexander ; Orsey, Andrea D. ; Tissing, Wim ; van de Wetering, Marianne

Purpose : To update the 2009 recommendations for the prevention of acute chemotherapy-induced emesis in children. Methods : We updated the original systematic literature search. Randomized studies were included in the evidence to support this guideline if they were primary studies fully published in full text in English or French; included only children less than 18 years old or, for mixed studies of adults and children, reported the pediatric results separately or the median or mean age was no [...]

Mené aux Etats-Unis auprès de 44 patients atteints d'un cancer ou ayant survécu à un cancer (âge moyen : 61 ans), cet essai randomisé évalue l'efficacité de 4 sessions d'une psychothérapie comportementale pour prendre en charge leurs douleurs, leur fatigue et leurs troubles du sommeil

Randomized controlled trial of the Valencia model of waking hypnosis plus CBT for pain, fatigue, and sleep management in patients with cancer and cancer survivors

Mendoza, M. E. ; Capafons, A. ; Gralow, J. R. ; Syrjala, K. L. ; Suárez-Rodríguez, J. M. ; Fann, J. R. ; Jensen, M. P.

Background: This study evaluated the efficacy of an intervention combining the Valencia model of waking hypnosis with cognitive-behavioral therapy (VMWH-CBT) in managing cancer-related pain, fatigue, and sleep problems in individuals with active cancer or who were post-treatment survivors. We hypothesized that four sessions of VMWH-CBT would result in greater improvement in participants' symptoms than four sessions of an education control intervention. Additionally, we examined the effects on [...]

Menée en Inde auprès de 100 patients atteints de cancer, cette étude randomisée évalue l'efficacité de l'olanzapine pour prévenir et réduire les nausées et vomissements induits par une chimiothérapie à base de sels de platine (cisplatine, carboplatine, oxaliplatine)

Role of olanzapine in chemotherapy-induced nausea and vomiting on platinum-based chemotherapy patients: a randomized controlled study

Mukhopadhyay, Sandip ; Kwatra, Gagandeep ; Alice K, Pamela ; Badyal, Dinesh

Purpose : Even with the use of modern antiemetic drugs, chemotherapy-induced nausea and vomiting (CINV) is still a cause of great distress to the patients. Olanzapine, primarily marketed as an antipsychotic, was found to reduce nausea and vomiting in some chemotherapy patients. But it was never tested in Indian population with a diverse genetic background. The present study aims to evaluate the role of olanzapine in CINV in patients receiving platinum-based chemotherapy. Methods :The study was [...]

Menée en Australie par enquête auprès de 441 patientes ayant survécu à une greffe de moelle osseuse allogénique, cette étude analyse leurs difficultés nutritionnelles, leurs symptômes gastro-intestinaux, leur poids et leurs perceptions liées à leur image corporelle

Nutritional issues and body weight in long-term survivors of allogeneic blood and marrow transplant (BMT) in NSW Australia

Smith, Jennifer ; Poon, Christine ; Gilroy, Nicole ; Kabir, Masura ; Brice, Lisa ; Dyer, Gemma ; Hogg, Megan ; Greenwood, Matthew ; Moore, John ; Hertzberg, Mark ; Brown, Louisa ; Tan, Jeff ; Huang, Gillian ; Kwan, John ; Larsen, Stephen ; Ward, Christopher ; Kerridge, Ian

Purpose : The aims of this study were to describe the long-term nutrition, body weight and body image issues facing survivors of Allogeneic Blood and Marrow Transplant (BMT) and their impact on quality of life. It also describes survivors’ perception of enteral feeding during BMT. Methods : Four hundred and forty-one survivors who had undergone a BMT in NSW, Australia between 2000 and 2012 (n = 441/583) completed the Sydney Post BMT Study Survey (SPBS). Results : Forty-five percent of survivors [...]

Menée en Grande-Bretagne à partir de données portant sur 34 489 patients ayant survécu 5 ans à un cancer pédiatrique diagnostiqué entre 1940 et 2006, cette étude de cohorte analyse l'évolution de la mortalité, en lien avec les changements de traitements et de prise en charge de leurs effets secondaires (4 475 décès)

Long term cause specific mortality among 34 489 five year survivors of childhood cancer in Great Britain: population based cohort study

Miranda M Fidler ; Raoul C Reulen ; David L Winter ; Julie Kelly ; Helen C Jenkinson ; Rod Skinner ; Clare Frobisher ; Michael M Hawkins

Objective : To determine whether modern treatments for cancer are associated with a net increased or decreased risk of death from neoplastic and non-neoplastic causes among survivors of childhood cancer. Design : Population based cohort study. Setting : British Childhood Cancer Survivor Study. Participants : Nationwide population based cohort of 34 489 five year survivors of childhood cancer with a diagnosis from 1940 to 2006 and followed up until 28 February 2014. Main outcome measures : Cause [...]

A partir des données de l'Organisation Mondiale de la Santé, cette étude met à jour les données relatives à la mortalité par cancer de l'ovaire jusqu'en 2012 et présente des projections jusqu'en 2020

Global trends and predictions in ovarian cancer mortality

Malvezzi, M. ; Carioli, G. ; Rodriguez, T. ; Negri, E. ; La Vecchia, C.

Background : Over the last two decades, ovarian cancer mortality rates have levelled or declined. There are, however, persisting and substantial differences in ovarian cancer patterns and trends. Patients and methods : We updated global trends in ovarian cancer mortality to 2012, and predicted trends in rates to 2020 using data from the World Health Organization database. Results : In the EU, age-adjusted ovarian cancer mortality rates decreased 10% between 2002 and 2012, to 5.2/100 000. The [...]

A partir des données de trois essais européens incluant 1 105 patients atteints d'un cancer du pancréas ayant subi une résection et ayant reçu une chimiothérapie adjuvante, cette étude évalue l'effet d'un diabète sur la survie

The impact of diabetes mellitus on survival following resection and adjuvant chemotherapy for pancreatic cancer

Kleeff, Jorg ; Costello, Eithne ; Jackson, Richard ; Halloran, Chris ; Greenhalf, William ; Ghaneh, Paula ; Lamb, Richard F. ; Lerch, Markus M. ; Mayerle, Julia ; Palmer, Daniel ; Cox, Trevor ; Rawcliffe, Charlotte L. ; Strobel, Oliver ; Büchler, Markus W. ; Neoptolemos, John P.

Background: Diabetes mellitus is frequently observed in pancreatic cancer patients and is both a risk factor and an early manifestation of the disease. Methods: We analysed the prognostic impact of diabetes on the outcome of pancreatic cancer following resection and adjuvant chemotherapy using individual patient data from three European Study Group for Pancreatic Cancer randomised controlled trials. Analyses were carried out to assess the association between clinical characteristics and the [...]

Menée aux Etats-Unis à partir de données portant sur 2 446 patients atteints d'un cancer colorectal de stade I à III, cette étude évalue l'association entre une obésité, un syndrome métabolique et la survie

Metabolic Dysfunction, Obesity, and Survival Among Patients With Early-Stage Colorectal Cancer

Cespedes Feliciano, Elizabeth M. ; Kroenke, Candyce H. ; Meyerhardt, Jeffrey A. ; Prado, Carla M. ; Bradshaw, Patrick T. ; Dannenberg, Andrew J. ; Kwan, Marilyn L. ; Xiao, Jingjie ; Quesenberry, Charles ; Weltzien, Erin K. ; Castillo, Adrienne L. ; Caan, Bette J.

Purpose : The effects of obesity and metabolic dysregulation on cancer survival are inconsistent. To identify high-risk subgroups of obese patients and to examine the joint association of metabolic syndrome (MetSyn) in combination with obesity, we categorized patients with early-stage (I to III) colorectal cancer (CRC) into four metabolic categories defined by the presence of MetSyn and/or obesity and examined associations with survival. Methods : We studied 2,446 patients diagnosed from 2006 [...]

Menée en France à partir de données portant sur 600 patientes atteintes d'un cancer du sein, cette étude de cohorte rétrospective évalue les facteurs associés à l'abandon d'une hormonothérapie initiée entre 2006 et 2007 (durée de suivi : 5 ans)

Persistence to 5-year hormonal breast cancer therapy: a French national population-based study

Bosco-Levy, Pauline ; Jove, Jeremy ; Robinson, Philip ; Moore, Nicholas ; Fourrier-Reglat, Annie ; Bezin, Julien

Background: Non-persistence to oral hormonal therapy (HT) in breast cancer (BC) is an emerging health issue, and estimations vary according to the population selected and/or the statistical method applied. This study aimed to estimate non-persistence over 5 years to HT in an unselected sample of women with BC using a French national population-based database and accounting for competing risks. Methods: A retrospective cohort of 600 women initiating a HT between 2006 and 2007 was constituted [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2015 (35 études) et de données d'autopsies, cette méta-analyse décrit l'évolution de la prévalence d'un cancer différencié de la thyroïde sur la période 1949-2007

Prevalence of Differentiated Thyroid Cancer in Autopsy Studies Over Six Decades: A Meta-Analysis

Furuya-Kanamori, Luis ; Bell, Katy J.L. ; Clark, Justin ; Glasziou, Paul ; Doi, Suhail A.R.

Purpose : Differentiated thyroid cancer (DTC) incidence has been reported to have increased three- to 15-fold in the past few decades. It is unclear whether this represents overdiagnosis or a true increase in incidence. Therefore, the current study aimed to estimate the prevalence of incidental DTC in published autopsy series and determine whether this prevalence has been increasing over time. Materials and Methods : PubMed, Embase, and Web of Science were searched from inception to December [...]

Menée en Afrique auprès de 348 patientes atteintes d'un cancer du col de l'utérus sur la période 2010-2015, cette étude analyse l'effet d'une infection par le HIV sur la survie

HIV Infection and Survival Among Women With Cervical Cancer

Dryden-Peterson, Scott ; Bvochora-Nsingo, Memory ; Suneja, Gita ; Efstathiou, Jason A. ; Grover, Surbhi ; Chiyapo, Sebathu ; Ramogola-Masire, Doreen ; Kebabonye-Pusoentsi, Malebogo ; Clayman, Rebecca ; Mapes, Abigail C. ; Tapela, Neo ; Asmelash, Aida ; Medhin, Heluf ; Viswanathan, Akila N. ; Russell, Anthony H. ; Lin, Lilie L. ; Kayembe, Mukendi K.A. ; Mmalane, Mompati ; Randall, Thomas C. ; Chabner, Bruce ; Lockman, Shahin

Purpose : Cervical cancer is the leading cause of cancer death among the 20 million women with HIV worldwide. We sought to determine whether HIV infection affected survival in women with invasive cervical cancer. Patients and Methods : We enrolled sequential patients with cervical cancer in Botswana from 2010 to 2015. Standard treatment included external beam radiation and brachytherapy with concurrent cisplatin chemotherapy. The effect of HIV on survival was estimated by using an inverse [...]

Menée aux Etats-Unis par enquête auprès de 689 patients atteints d'un cancer du poumon ou du côlon-rectum, cette étude évalue l'association entre le bien-être de l'aidant et sa perception de la qualité des soins reçus par le patient

How Does Caregiver Well-Being Relate to Perceived Quality of Care in Patients With Cancer? Exploring Associations and Pathways

Litzelman, Kristin ; Kent, Erin E. ; Mollica, Michelle ; Rowland, Julia H.

Purpose : Perceived quality of care (QOC) is an increasingly important metric of care quality and can be affected by such factors among patients with cancer as quality of life and physician trust. This study sought to evaluate whether informal caregiver well-being was also associated with perceived QOC among patients with cancer and assessed potential pathways that link these factors. Methods : This study used data from the Cancer Care Outcomes Research and Surveillance (CanCORS) consortium. [...]

Menée en France auprès de 402 médecins généralistes, cette étude analyse les facteurs, financiers ou autres, associés à leur degré d'implication dans les activités de dépistage des cancers du sein, du col utérin et du côlon-rectum

What are GPs' preferences for financial and non-financial incentives in cancer screening? Evidence for breast, cervical, and colorectal cancers

Sicsic, Jonathan ; Krucien, Nicolas ; Franc, Carine

General practitioners (GPs) play a key role in the delivery of preventive and screening services for breast, cervical, and colorectal cancers. In practice, GPs' involvement varies considerably across types of cancer and among GPs, raising important questions about the determinants of GPs' implication in screening activities: what is the relative impact of financial and non-financial incentives? Are GPs' preferences for financial and non-financial incentives cancer-specific? Is there preference [...]

Menée en Nouvelle-Zélande, cette étude analyse le rapport coût-efficacité et l'intérêt de la mise en place d'un coordinateur de parcours de soins, en fonction du pronostic de la maladie, pour aider les patientes atteintes d'un cancer du sein à suivre leur traitement par tamoxifène durant 5 années

Cancer Care Coordinators to Improve Tamoxifen Persistence in Breast Cancer: How Heterogeneity in Baseline Prognosis Impacts on Cost-Effectiveness

Nair, Nisha ; Kvizhinadze, Giorgi ; Blakely, Tony

Objectives : To assess the cost-effectiveness of a cancer care coordinator (CCC) in helping women with estrogen receptor positive (ER+) early breast cancer persist with tamoxifen for 5 years. Methods : We investigated the cost-effectiveness of a CCC across eight breast cancer subtypes, defined by progesterone receptor (PR) status, human epidermal growth factor receptor 2 (HER2) status, and local/regional spread. These subtypes range from excellent to poorer prognoses. The CCC helped in [...]