A partir des données du registre français des tumeurs hématologiques pédiatriques, cette étude évalue l'association entre une exposition, sur le lieu de résidence, aux rayonnements UV d'origine solaire et le risque de cancers hématologiques chez l'enfant (9 082 cas de leucémie aiguë et 3 563 cas de lymphome diagnostiqués avant l'âge de 15 ans, entre 1990 et 2009)

Residential exposure to solar ultraviolet radiation and incidence of childhood hematological malignancies in France

Coste, Astrid ; Goujon, Stéphanie ; Boniol, Mathieu ; Marquant, Fabienne ; Faure, Laure ; Doré, Jean-François ; Hémon, Denis ; Clavel, Jacqueline

Purpose : Few studies have investigated the relationship between solar ultraviolet radiation (UV) and childhood hematological malignancies (CHM). This study addresses the associations between residential UV exposure at diagnosis and the incidence of types and subtypes of CHM, by age and gender, in France, over a long period, on the fine scale of the 36,326 Communes that constitute mainland France. Methods : The 9,082 cases of acute leukemia and 3,563 cases of lymphoma diagnosed before the age [...]

A partir des données d'un registre canadien des cancers portant sur 7 920 patients pédiatriques atteints de cancer (âgés de moins de 15 ans lors du diagnostic initial), cette étude évalue le risque de second cancer, notamment dans les 5 années suivant le diagnostic (durée moyenne de suivi : 10,7 ans)

Subsequent malignant neoplasms in a population-based cohort of pediatric cancer patients: A focus on the first 5 years

Pole, Jason D ; Gu, Lan Ying ; Kirsh, Victoria ; Greenberg, Mark L ; Nathan, Paul C.

Background: The purpose was to describe the development of subsequent malignant neoplasms (SMNs) among a population-based cohort of pediatric cancer patients with a focus on SMN that occurred within the first 5 years from diagnosis. Methods: The cohort was identified from POGONIS, an active provincial registry. Cohort members were Ontario residents ages 0-14.9 years at primary diagnosis between January 1985 and December 2008. SMNs that developed < 18 years were captured by POGONIS while SMNs [...]

A partir de données de la cohorte européenne EPIC portant sur 456 cas de cancer de l'estomac et 900 témoins, cette étude évalue l'association entre divers indicateurs liés au niveau de fer dans l'organisme et le risque de la maladie

Body iron status and gastric cancer risk in the EURGAST study

Fonseca-Nunes, Ana ; Agudo, Antonio ; Aranda, Núria ; Arija, Victoria ; Cross, Amanda J. ; Molina, Esther ; Sánchez, María José ; Bueno-de-Mesquita, Bas ; Siersema, Peter ; Weiderpass, Elisabete ; Krogh, Vittorio ; Mattiello, Amalia ; Tumino, Rosario ; Saieva, Calogero ; Naccarati, Alessio ; Ohlsson, Bodil ; Sjöberg, Klas ; Boutron-Ruault, Marie-Christine ; Cadeau, Claire ; Fagherazzi, Guy ; Boeing, Heiner ; Steffen, Annika ; Kühn, Tilman ; Katzke, Verena ; Tjønneland, Anne ; Olsen, Anja ; Khaw, Kay-Tee ; Wareham, Nick ; Key, Tim ; Lu, Yunxia ; Riboli, Elio ; Peeters, Petra H. ; Gavrila, Diana ; Dorronsoro, Miren ; Quirós, Jose Ramón ; Barricarte, Aurelio ; Jenab, Mazda ; Zamora-Ros, Raul ; Freisling, Heinz ; Trichopoulou, Antonia ; Lagiou, Pagona ; Bamia, Christina ; Jakszyn, Paula

Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case–control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an [...]

Couplée aux données de la cohorte "Health Professionals Follow-up Study" et portant sur 1 169 cas de cancer de la prostate et 1 233 témoins, cette étude évalue l'association entre des variants du gène ApoE et le risque de développer la maladie

No Association of ApoE Genotype with Risk of Prostate Cancer: A Nested Case-Control Study

Liu, Hui ; Shui, Irene M. ; Platz, Elizabeth A. ; Mucci, Lorelei A. ; Giovannucci, Edward L

Background: Previous studies found low total cholesterol level was associated with a lower risk of high-grade prostate cancer. Apolipoprotein E (ApoE) isoform is associated with total cholesterol level. The aim of this study was to explore associations of ApoE isoforms with prostate cancer risk. Methods: We assessed ApoE genotypes and risk of prostate cancer in a prospective case-control study nested among men who provided a blood sample in 1993-95 within Health Professionals Follow-up Study. [...]

Menée aux Etats-Unis à partir des données de la cohorte "Sister Study" incluant 50 884 participantes âgées de 35 à 74 ans, cette étude prospective évalue l'association entre divers indicateurs de l'adiposité et le risque de cancer du sein

Overall and central adiposity and breast cancer risk in the sister study

White, Alexandra J. ; Nichols, Hazel B. ; Bradshaw, Patrick T. ; Sandler, Dale P.

BACKGROUND : Greater body mass index (BMI), a measure of overall adiposity, is associated with a higher risk of postmenopausal breast cancer. The role of central adiposity, often measured by waist circumference, is less well understood, especially among premenopausal women. The objective of the current study was to examine multiple measures of adiposity in relation to breast cancer in a prospective cohort study. METHODS : A total of 50,884 Sister Study cohort participants aged 35 to 74 years [...]