Immune Therapy in GI Malignancies: A Review

Ces 14 articles passent en revue les études concernant le dépistage et la prise en charge thérapeutique des cancers gastro-intestinaux de stade avancé ainsi que des cancers du pancréas et des voies biliaires

Résumé en anglais

The balance between tumor-promoting and tumor-suppressing immune responses and the difference between them ultimately determine whether a cancer escapes immune recognition mechanisms. Defining the complex relationships between the tumor itself, the tumor environment, and the immune system has been critical in facilitating the development of successful immunotherapies. This review explores the role of oncogenes in inducing cancer-associated inflammation, the local and systemic factors that lead to immune suppression, and immunotherapy approaches to overcome immune privilege.