Menée aux Etats-Unis auprès de 158 patients et 153 témoins, cette étude analyse les comportements d'activité physique, notamment la marche et les déplacements à vélo, chez des adultes ayant survécu à un cancer de l'enfance

Active transportation in adult survivors of childhood cancer and neighborhood controls

Slater, MeganE ; Kelly, AaronS ; Sadak, KarimT ; Ross, JulieA

Purpose : Childhood cancer survivors (CCS) are at high risk of treatment-related late effects, including cardiovascular disease and diabetes, which can be exacerbated by inadequate physical activity (PA). Previous PA interventions targeting CCS have focused on the domain of leisure-time/recreational PA. Active transportation, another domain of PA, has not been described in CCS. Therefore, this study aimed to identify active transportation behaviors, barriers, and correlates in adult CCS. [...]

Menée aux Etats-Unis par questionnaire auprès de 277 patients atteints de mélanome, cette étude évalue les effets d'un lymphœdème sur leur qualité de vie, leur capacité à accomplir leurs activités quotidiennes et à faire face à la maladie

Is surviving enough? Coping and impact on activities of daily living among melanoma patients with lymphoedema

Cromwell, K. D. ; Chiang, Y. J. ; Armer, J. ; Heppner, P. P. ; Mungovan, K. ; Ross, M. I. ; Gershenwald, J. E. ; Lee, J. E. ; Royal, R. E. ; Lucci, A. ; Cormier, J. N.

We assessed the impact of lymphoedema (defined as ≥10% limb volume change) on quality of life (QOL), ability to perform activities of daily living (ADLs) and coping in 277 melanoma patients. Limb volume was measured prospectively, pre-operatively and every 3–6 months for 18 months post-operatively using a perometer. Three questionnaires were administered to measure QOL, coping and impact on ADLs. Statistical analyses were conducted using longitudinal logistic regression models. At 18 months, [...]

Menée aux Etats-Unis auprès de 87 patients atteints d'un cancer de la prostate et de 172 témoins, cette étude analyse les effets à long terme (36 mois) d'une hormonothérapie anti-androgénique sur leurs fonctions physiques et leur qualité de vie

Long-term impact of androgen-deprivation therapy on physical function and quality of life

Alibhai, Shabbir M. H. ; Breunis, Henriette ; Timilshina, Narhari ; Naglie, Gary ; Tannock, Ian ; Krahn, Murray ; Warde, Padraig ; Fleshner, Neil E. ; Canning, Sarah Duff ; Tomlinson, George

BACKGROUND This study examined the impact of androgen-deprivation therapy (ADT) on physical function and quality of life (QOL) over 36 months. METHODS Eighty-seven men with nonmetastatic prostate cancer (PC) who were starting continuous ADT and 2 control groups (86 PC controls without ADT and 86 healthy controls), matched by age and education, were enrolled. Physical function was assessed with the 6-minute walk test (6MWT), grip strength, and Timed Up and Go (TUG) test. QOL was measured with [...]

Menée aux Etats-Unis à partir des données médicales de 385 patientes atteintes d'un cancer du sein de stade avancé, incluses dans un essai randomisé et en cours de traitement, cette étude analyse l'association entre la sévérité des symptômes et les interruptions dans la chimiothérapie

Chemotherapy interruptions in relation to symptom severity in advanced breast cancer

Wyatt, Gwen ; Sikorskii, Alla ; Tesnjak, Irena ; Victorson, David ; Srkalovic, Gordan

Purpose : Interruptions in medical treatment such as dose delays, reductions, or stoppages can lead to suboptimal treatment of cancer. Knowing how and for whom symptom severity and symptom interference with activities of daily living (ADL) are associated with treatment interruptions can guide behavioral interventions for supportive care. The purpose of this analysis is to inform research and clinical practice by bringing attention to specific patient symptoms that may hinder dose completion. [...]

Menée aux Etats-Unis auprès de 400 patientes atteintes d'un cancer du sein de stade I à III (âge moyen : 51 ans), cette étude analyse l'intérêt d'un outil permettant d'évaluer leurs besoins en soins de support après un premier traitement

Identifying the unmet needs of breast cancer patients post-primary treatment: the Cancer Survivor Profile (CSPro)

Todd, BrianaL ; Feuerstein, Michael ; Gehrke, Amanda ; Hydeman, Jennifer ; Beaupin, Lynda

Purpose : The purpose of this study is to develop a brief measure of problem areas experienced by patients following primary treatment for breast cancer. Method : Systematic reviews of the quantitative and qualitative literature were used to inform selection of scale items using (1) valid and reliable items from a national item bank (patient reported outcomes measurement information system [PROMIS]), (2) existing scales from prior breast cancer survivorship research, or (3) items developed by [...]

Menée en Allemagne auprès de 1 119 patients atteints d'un carcinome hépatocellulaire associé à une stéatose hépatique non alcoolique, cette étude analyse l'association entre les caractéristiques de la tumeur, les modalités de traitement et la survie

Treatment and survival of non-alcoholic steatohepatitis associated hepatocellular carcinoma

Arndt Weinmann ; Yvonne Alt ; Sandra KochCarina Nelles ; Christoph Düber ; Hauke Lang ; Gerd Otto ; Tim Zimmermann ; Jens U Marquardt ; Peter R Galle ; Marcus A Wörns ; Jörn M Schattenberg

Background The incidence of non-alcoholic steatohepatitis (NASH) is increasing worldwide and a poorly defined subset of patients develops end-stage liver disease and hepatocellular carcinoma (HCC). Differences in the biological behaviour, tumour characteristics, associated risk factors, treatment outcomes and overall survival of patients with NASH-HCC remain poorly defined. The aim of this study was to determine and analyze these differences in a large clinical cohort to guide treatment [...]

Menée en Australie auprès de 571 patients immigrés (145 patients arabes, 248 patients chinois, 178 patients grecs) et 274 témoins (patients anglo-australiens), cette étude analyse les disparités, selon le pays d'origine, dans la qualité de vie et dans les morbidités psychologiques, chez des patients atteints de cancer

Migrant Health in Cancer: Outcome Disparities and the Determinant Role of Migrant-Specific Variables

Sze, Ming ; Butow, Phyllis ; Bell, Melanie ; Vaccaro, Lisa ; Dong, Skye ; Eisenbruch, Maurice ; Jefford, Michael ; Girgis, Afaf ; King, Madeleine ; McGrane, Joshua ; Ng, Weng ; Asghari, Ray ; Parente, Phillip ; Liauw, Winston ; Goldstein, David ; on behalf of the Psycho-oncology Co-operative Research Group Culturally ; Linguistically Diverse TEAM

Background : Multiethnic societies face challenges in delivering evidence-based culturally competent health care. This study compared health-related quality of life and psychological morbidity in a hospital-based sample of first-generation migrants and Australian-born Anglo cancer patients, controlling for potential confounders related to migrant status. Further, it explored the relative contribution of ethnicity versus migrant-related variables. Methods : Eligible participants, recruited via [...]

Menée au Canada auprès de 6 271 patients, cette étude analyse les disparités selon le lieu de résidence, urbain ou rural, dans l'incidence des tumeurs neuroendocrines et dans la survie

Rural-urban disparities in incidence and outcomes of neuroendocrine tumors: A population-based analysis of 6271 cases

Hallet, Julie ; Law, Calvin H. L. ; Karanicolas, Paul J. ; Saskin, Refik ; Liu, Ning ; Singh, Simron

BACKGROUND Despite their rising incidence, neuroendocrine tumors (NETs) remain a poorly understood disease. Living in a rural area (RA) affects the incidence and outcomes of other types of cancer. This study compared the incidence and outcomes of NETs for patients in RAs and patients in urban areas (UAs). METHODS A population-based cohort study of patients with NETs in Ontario, Canada from 1994 to 2011 was conducted. An RA was defined as any community with a population < 10,000 and outside the [...]

A partir des données des registres français des cancers, cette étude présente les estimations de prévalence partielle et totale pour 24 localisations de cancers en 2008

Total and partial cancer prevalence in the adult French population in 2008

Marc Colonna ; Nicolas Mitton ; Nadine Bossard ; Aurelien Belot ; Pascale Grosclaude ; and the French Network of Cancer Registries (FRANCIM)

Background : To provide estimations of partial and total prevalence of 24 cancer sites in France in 2008. The estimations of partial prevalence were compared with the previous estimations for 2002. Methods : Nationwide estimations of incidence and survival data from cancer registries were used for partial prevalence. Nationwide incidence and mortality data were used to estimate total prevalence. Results : At the end of 2008, in France, nearly 3 million people still alive had received a [...]

Menée au Royaume-Uni à partir de données portant sur 5 796 patients atteints de lymphome, cette étude de cohorte analyse l'évolution, sur la période 2004-2014, de l'incidence et de la prévalence des lymphomes par sous-types, ainsi que la survie des patients

Lymphoma incidence, survival and prevalence 2004-2014: sub-type analyses from the UK's Haematological Malignancy Research Network

Smith, A. ; Crouch, S. ; Lax, S. ; Li, J. ; Painter, D. ; Howell, D. ; Patmore, R. ; Jack, A. ; Roman, E.

Background: Population-based information about cancer occurrence and survival are required to inform clinical practice and research; but for most lymphomas data are lacking. Methods: Set within a socio-demographically representative UK population of nearly 4 million, lymphoma data (N=5796) are from an established patient cohort. Results: Incidence, survival (overall and relative) and prevalence estimates for >20 subtypes are presented. With few exceptions, males tended to be diagnosed at [...]

Menée à partir de données portant au total sur 423 patients atteints d'un lymphome folliculaire et inclus dans des essais évaluant différents protocoles de chimiothérapie, cette étude met en évidence une association entre de faibles niveaux sériques de vitamine D avant traitement et des taux de survie moins élevés

Low Serum Vitamin D Levels Are Associated With Inferior Survival in Follicular Lymphoma: A Prospective Evaluation in SWOG and LYSA Studies

Kelly, Jennifer L. ; Salles, Gilles ; Goldman, Bryan ; Fisher, Richard I. ; Brice, Pauline ; Press, Oliver ; Casasnovas, Olivier ; Maloney, David G. ; Soubeyran, Pierre ; Rimsza, Lisa ; Haioun, Corinne ; Xerri, Luc ; LeBlanc, Michael ; Tilly, Herve ; Friedberg, Jonathan W.

Purpose : Recent literature reports a potential association between high vitamin D and improved lymphoma prognosis. We evaluated the impact of pretreatment vitamin D on follicular lymphoma (FL) outcome. Patients and Methods : SWOG participants were previously untreated patients with FL enrolled onto SWOG clinical trials (S9800, S9911, or S0016) involving CHOP chemotherapy plus an anti-CD20 antibody (rituximab or iodine-131 tositumomab) between 1998 and 2008. Participants included in our second [...]

Menée en Italie auprès de 40 patientes atteintes d'un cancer de l'ovaire récidivant entre 2008 et 2014, cette étude analyse les procédures thérapeutiques utilisées pour prendre en charge une occlusion intestinale d'origine maligne, en fonction du statut nutritionnel et d'une cachéxie de la patiente

Palliative care in patients with ovarian cancer and bowel obstruction

Daniele, Alberto ; Ferrero, A. ; Fuso, L. ; Mineccia, M. ; Porcellana, V. ; Vassallo, D. ; Biglia, N. ; Menato, G.

Objective : Malignant bowel obstruction (MBO) is usually a pre-terminal event in patients with ovarian cancer. However, because of the lack of data in literature, decisions around surgical intervention, non-resectional procedures, or medical treatment of MBO in patients with ovarian cancer cannot be lightly undertaken. We analyzed medical and surgical procedures, performance status, nutritional status, cachexia, and their prognostic value in this group of patients. Methods : We retrospectively [...]

Cette étude présente le rapport annuel des principaux organismes américains de lutte contre le cancer, les données statistiques sur la période 1975-2011, avec un dossier consacré aux disparités géographiques, ethniques et socioéconomiques dans l'incidence du cancer du sein

Annual Report to the Nation on the Status of Cancer, 1975-2011, Featuring Incidence of Breast Cancer Subtypes by Race/Ethnicity, Poverty, and State

Kohler, Betsy A. ; Sherman, Recinda L. ; Howlader, Nadia ; Jemal, Ahmedin ; Ryerson, A. Blythe ; Henry, Kevin A. ; Boscoe, Francis P. ; Cronin, Kathleen A. ; Lake, Andrew ; Noone, Anne-Michelle ; Henley, S. Jane ; Eheman, Christie R. ; Anderson, Robert N. ; Penberthy, Lynne

Background: The American Cancer Society (ACS), Centers for Disease Control and Prevention (CDC), National Cancer Institute (NCI), and North American Association of Central Cancer Registries (NAACCR) collaborate annually to produce updated, national cancer statistics. This Annual Report includes a focus on breast cancer incidence by subtype using new, national-level data. Methods: Population-based cancer trends and breast cancer incidence by molecular subtype were calculated. Breast cancer [...]

A partir des données d'un registre français des cancers (registre de la Côte d'or) portant sur 4 364 patientes atteintes d'un cancer primitif et invasif du sein diagnostiqué entre 1998 et 2009, cette étude analyse les disparités géographiques et socio-économiques dans le stade de la maladie au diagnostic

Age-related socio-economic and geographic disparities in breast cancer stage at diagnosis: a population-based study

Pegdwende O. Dialla ; Patrick Arveux ; Samiratou Ouedraogo ; Carole Pornet ; Aurélie Bertaut ; Patrick Roignot ; Philippe Janoray ; Marie-Laure Poillot ; Valérie Quipourt ; Tienhan S. Dabakuyo-Yonli

Background: This study aimed to determine the impact of socio-economic and geographic disparities on disease stage at diagnosis according to age in breast cancer (BC) patients. Secondary purpose was to describe survival. Methods: All women with primary invasive BC, diagnosed from 1998 to 2009 in the department of Côte d’Or were retrospectively selected using data from the Côte d’Or BC registry. European transnational ecological deprivation index (French European Deprivation Index) was used to [...]

Menée au Royaume-Uni par entretiens auprès de 13 professionnelles de santé ayant survécu à un cancer, cette étude qualitative analyse leurs expériences lors de leur reprise du travail après les traitements

Both sides of the couch: a qualitative exploration of the experiences of female healthcare professionals returning to work after treatment for cancer

Mitchell, T.

The aim was to explore the experiences of healthcare professionals (HCPs) who had treatment for cancer and then returned to work. The intention was to identify how HCPs' experiences differed to those of the general public with cancer, and also to explore how HCPs were reintegrated into the workplace following treatment. An interpretive phenomenological approach was employed and conversational interviews were undertaken with 13 women volunteers from a variety of healthcare disciplines including [...]

Menée en Australie par enquête auprès de 145 patients atteints d'un cancer traité par radiothérapie, cette étude transversale analyse leurs difficultés à parler de leurs symptômes d'anxiété et de dépression avec des professionnels de santé

A cross-sectional study of radiation oncology outpatients' concern about, preferences for, and perceived barriers to discussing anxiety and depression

Mackenzie, Lisa J. ; Carey, Mariko ; Sanson-Fisher, Rob ; D'Este, Catherine ; Yoong, Sze Lin

Objective : Although elevated psychological distress is commonly reported among cancer patients, our understanding of patients' preferences for, and perceived barriers to, accessing psychological support from key cancer care providers is limited. The aim of this study was to assess cancer patients' level of concern about, and willingness to discuss, their anxiety and depression. Methods : Radiation oncology outpatients completed a touchscreen computer survey with questions assessing their [...]

Menée aux Etats-Unis auprès de 110 patients adolescents et jeunes adultes atteints de cancer (âge : 12-24 ans ; 52 % d'hommes), cette étude analyse leurs perceptions relatives à la maladie et à la sévérité des symptômes, puis les compare avec les perceptions de leurs soignants

The shared experience of adolescent and young adult cancer patients and their caregivers

Juth, Vanessa ; Silver, Roxane Cohen ; Sender, Leonard

Objective : We examined the interdependent, dyadic, mental health of adolescent and young adult (AYA) cancer patients and their caregivers. Our aims were as follows: (1) to investigate the degree to which patients' and caregivers' subjective perceptions of illness severity are congruent with objective severity (i.e., medical indicators), (2) to compare patients' and caregivers' subjective perceptions of illness severity and cancer-related posttraumatic stress symptoms (PTSS), and (3) to [...]

Menée en Australie par enquête en ligne auprès de 107 professionnels de santé en oncologie pédiatrique, cette étude analyse leurs symptômes de stress lié au travail au sein d'une équipe pluridisciplinaire

Work-related stress and reward: an Australian study of multidisciplinary pediatric oncology healthcare providers

Bowden, M. J. ; Mukherjee, S. ; Williams, L.   K. ; DeGraves, S. ; Jackson, M. ; McCarthy, M.   C.

Objective : Managing staff stress and preventing long-term burnout in oncology staff are highly important for both staff and patient well-being. Research addressing work-related stress in adult oncology is well documented; however, less is known about this topic in the pediatric context. This study examined sources of work-related stress and reward specific to multidisciplinary staff working in pediatric oncology in Australia. Method : Participants were 107 pediatric oncology clinicians, [...]

Menée aux Etats-Unis à partir de données portant sur 976 178 patientes atteintes d'un cancer du sein, cette étude rétrospective analyse l'impact du statut socio-économique et de la couverture médicale des patientes sur la survie

Effects of payer status on breast cancer survival: a retrospective study

Runhua Shi ; Hannah Taylor ; Jerry McLarty ; Lihong Liu ; Glenn Mills ; Gary Burton

Background : Breast cancer outcomes are influenced by multiple factors including access to care, and payer status is a recognized barrier to treatment access. To further define the influence of payer status on outcome, the National Cancer Data Base data from 1998–2006 was analyzed. Method : Data was analyzed from 976,178 female patients diagnosed with breast cancer registered in the National Cancer Data Base. Overall survival was the primary outcome variable while payer status was the primary [...]

Menée en France par entretiens auprès de 400 médecins généralistes, cette étude prospective multicentrique évalue l'efficacité, dans le cadre de leur pratique clinique et de la communication avec leurs patients, de fiches explicatives décrivant les effets indésirables des traitements anti-cancéreux pour les cancers digestifs et gynécologiques

Guideline sheets on the side effects of anticancer drugs are useful for general practitioners

Rouge-Bugat, Marie-Eve ; Lassoued, Donia ; Bacrie, Joy ; Boussier, Nathalie ; Delord, Jean-Pierre ; Oustric, Stéphane ; Bauvin, Eric ; Lapeyre-Mestre, Maryse ; Bertucci, François ; Grosclaude, Pascale

Purpose : General practitioners (GPs) are more and more involved in the treatment of cancer patients but feel not informed enough about anticancer treatments and associated side effects. Better communication with treatment centers is needed. We hypothesized that information sheets could improve communication. Methods : This prospective, multicentric, and interventionist study aimed at implementing and assessing therapeutic sheets describing the side effects of anticancer drugs used for [...]