A partir d'une revue systématique de la littérature publiée jusqu'en 2014 (32 études), cette méta-analyse évalue l'association entre une ingestion d'acrylamide d'origine alimentaire et le risque de cancer

Dietary acrylamide and cancer risk: An updated meta-analysis

Pelucchi, Claudio ; Bosetti, Cristina ; Galeone, Carlotta ; La Vecchia, Carlo

The debate on the potential carcinogenic effect of dietary acrylamide is open. In consideration of the recent findings from large prospective investigations, we conducted an updated meta-analysis on acrylamide intake and the risk of cancer at several sites. Up to July 2014, we identified 32 publications. We performed meta-analyses to calculate the summary relative risk (RR) of each cancer site for the highest versus lowest level of intake and for an increment of 10 µg/day of dietary acrylamide, [...]

Menée en Chine auprès de 1 709 cas et 4 780 témoins dans l'industrie textile, cette étude de cohorte évalue l'association entre le travail posté et le risque de cancer du sein

Shift work and breast cancer among women textile workers in Shanghai, China

Li, Wenjin ; Ray, RobertaM ; Thomas, DavidB ; Davis, Scott ; Yost, Michael ; Breslow, Norman ; Gao, DaoLi ; Fitzgibbons, E. Dawn ; Camp, JaniceE ; Wong, Eva ; Wernli, KarenJ ; Checkoway, Harvey

Purpose : Although night-shift work has been associated with elevated risk of breast cancer in numerous epidemiologic studies, evidence is not consistent. We conducted a nested case–cohort study to investigate a possible association between shift work including a night shift and risk of breast cancer within a large cohort of women textile workers in Shanghai, China. Methods : The study included 1,709 incident breast cancer cases and 4,780 non-cases. Data on historical shift work schedules were [...]

Menée en Australie auprès de participants âgés de 18 à 79 ans, cette étude évalue l'association entre une exposition solaire répétée ayant entrainé une élastose solaire et le risque de mélanome cutané, notamment du tronc ou de la tête et du cou

Solar elastosis and cutaneous melanoma: A site-specific analysis

Kvaskoff, Marina ; Pandeya, Nirmala ; Green, Adèle C. ; Perry, Susan ; Baxter, Catherine ; Davis, Marcia B. ; Mortimore, Rohan ; Westacott, Lorraine ; Wood, Dominic ; Triscott, Joe ; Williamson, Richard ; Whiteman, David C.

Cutaneous melanomas are postulated to arise through at least two causal pathways, namely the “chronic sun exposure” and “nevus” pathways. While chronic sun exposure probably causes many head/neck melanomas, its role at other sites is unclear. In a population-based, case-case comparison study conducted in Brisbane, Australia, we determined the prevalence and epidemiologic correlates of chronic solar damage in skin adjacent to invasive, incident melanomas on the trunk (n = 418) or head/neck [...]

Menée en Suède partir de 91 échantillons tumoraux cutanés, cette étude analyse la prévalence d'une infection par le papillomavirus humain de type 197

Human papillomavirus type 197 is commonly present in skin tumors

Arroyo Mühr, L. Sara ; Hultin, Emilie ; Bzhalava, Davit ; Eklund, Carina ; Lagheden, Camilla ; Ekström, Johanna ; Johansson, Hanna ; Forslund, Ola ; Dillner, Joakim

Non-melanoma skin cancers commonly contain Human Papillomavirus (HPV), but the types found have varied depending on the polymerase chain reaction (PCR) primer systems used. Whole genome amplified DNA (not amplified by any specific PCR primers) from 91 skin lesions [41 squamous cell skin carcinomas (SCCs), 8 keratoacanthomas, 22 actinic keratoses, 3 basal cell carcinomas and 17 SCCs in situ] were sequenced. All samples were sequenced both at 160 Mb and 1.8 Gb sequencing depth per sample. The [...]

A partir des données d'une étude internationale portant sur 1 809 cas et 4 370 témoins, cette étude évalue l'association entre des infections urinaires répétées et le risque de cancer de la vessie

Recurrent urinary tract infection and risk of bladder cancer in the Nijmegen bladder cancer study

Vermeulen, S. H. ; Hanum, N. ; Grotenhuis, A. J. ; Castano-Vinyals, G. ; van der Heijden, A. G. ; Aben, K. K. ; Mysorekar, I. U. ; Kiemeney, L. A.

Background:Controversy exists on whether urinary tract infection (UTI) is a risk factor for urinary bladder cancer (UBC). Here, the association is investigated using data from one of the largest bladder cancer case–control studies worldwide. Methods : Information on (i) history and age at onset of regular cystitis (‘regular low-UTI’) and (ii) number and age at onset of UTI treated with antibiotics (‘UTI-ab’) from 1809 UBC patients and 4370 controls was analysed. Odds ratios (ORs) and 95% [...]

Menée en Espagne à partir d'échantillons tumoraux inclus en paraffine (124 patients), cette étude analyse la prévalence d'une infection par le papillomavirus humain dans des cas de cancer du larynx (62 cas) et de l'hypopharynx (62 cas)

Prevalence of human papillomavirus in laryngeal and hypopharyngeal squamous cell carcinomas in northern Spain

Rodrigo, Juan P. ; Hermsen, Mario A. ; Fresno, Manuel F. ; Brakenhoff, Ruud H. ; García-Velasco, Fabian ; Snijders, Peter J. F. ; Heideman, Daniëlle A. M. ; García-Pedrero, Juana M.

Background : Recent studies support a role for human papillomavirus (HPV) in oropharyngeal squamous cell carcinomas (SCCs); however, the significance of HPV in non-oropharyngeal head and neck cancers is uncertain. The aim of this study was to determine the prevalence of HPV in a large cohort of laryngeal and hypopharyngeal SCCs in northern Spain. Materials and methods : Clinical records and paraffin-embedded tumor specimens of 124 consecutive patients surgically treated for laryngeal (62 cases) [...]

Menée aux Pays-Bas auprès de 12 589 participantes ayant eu recours à une fécondation in vitro, cette étude évalue l'association entre le nombre d'embryons implantés, des naissances multiples et le risque de cancer du sein

Increased breast cancer risk in in vitro fertilisation treated women with a multiple pregnancy: A new hypothesis based on historical in vitro fertilisation treatment data

Krul, I. M. ; Groeneveld, E. ; Spaan, M. ; van den Belt-Dusebout, A. W. ; Mooij, T. M. ; Hauptmann, M. ; Twisk, J. W. R. ; Lambers, M. J. ; Hompes, P. G. A. ; Burger, C. W. ; Lambalk, C. B. ; van Leeuwen, F. E.

Background : Breast cancer risk is temporarily increased after a full-term pregnancy and declines thereafter, possibly due to increased levels of gonadal and placental hormones during pregnancy. Inconsistent results, however, have been reported after twin pregnancies with higher hormone levels. Among women treated with in vitro fertilisation (IVF), for whom the number of embryos available for implantation is known, we recently observed that a multiple birth after implantation of all transferred [...]

Menée à Taïwan auprès de 51 705 patients atteints d'un diabète de type 2 et âgés de plus de 30 ans, cette étude de cohorte évalue l'association entre une hyperglycémie, des maladies chroniques du foie et le risque de carcinome hépatocellulaire

Hyperglycemia and chronic liver diseases on risk of hepatocellular carcinoma in Chinese patients with type 2 diabetes––National cohort of Taiwan Diabetes Study

Li, Chia-Ing ; Chen, Hsuan-Ju ; Lai, Hsueh-Chou ; Liu, Chiu-Shong ; Lin, Wen-Yuan ; Li, Tsai-Chung ; Lin, Cheng-Chieh

This study examined whether glycated hemoglobin A1C (HbA1C) and chronic liver diseases are associated with hepatocellular carcinoma (HCC) risk in Type 2 diabetic patients. A retrospective cohort study consisting of 51,705 patients with Type 2 diabetes aged 30 and over enrolled in the National Diabetes Care Management Program before 2004 was used in Cox proportional hazards models. HbA1C was independently associated with HCC incidence, and multivariate-adjusted hazard ratio (HR) of HCC was 1.20 [...]

A partir des données de la cohorte "Women’s Health Initiative" incluant 143 901 femmes ménopausées, cette étude américiane évalue l'association entre des mesures anthropométriques liées à l'adiposité (adiposité abdominale, tour de taille, indice de masse corporelle, taille) et le risque de cancer du sein, de l'endomètre, du côlon-rectum ou du rein

Risk of breast, endometrial, colorectal, and renal cancers in postmenopausal women in association with a body shape index and other anthropometric measures

Kabat, GeoffreyC ; Xue, Xiaonan ; Kamensky, Victor ; Lane, Dorothy ; Bea, JenniferW ; Chen, Chu ; Qi, Lihong ; Stefanick, MarciaL ; Chlebowski, RowanT ; Wactawski-Wende, Jean ; Wassertheil-Smoller, Sylvia ; Rohan, ThomasE

Purpose : A body shape index (ABSI) has been proposed as a possible improvement over waist circumference (WC) as a marker of abdominal adiposity because it removes the correlation of WC with body mass index (BMI) and with height. We assessed the association of ABSI with four obesity-related cancers compared to that of other anthropometric measures of adiposity. Methods : We used data from the Women’s Health Initiative, a large cohort of postmenopausal women, recruited between 1993 and 1998 and [...]

Menée aux Etats-Unis auprès de 967 cas et 993 témoins, cette étude évalue l'association entre 25 polymorphismes de gènes associés à la vitamine D (gènes VDR,

Vitamin D-related gene polymorphisms, plasma 25-hydroxyvitamin D, and breast cancer risk

Reimers, LauraL ; Crew, KatherineD ; Bradshaw, PatrickT ; Santella, ReginaM ; Steck, SusanE ; Sirosh, Iryna ; Terry, MaryBeth ; Hershman, DawnL ; Shane, Elizabeth ; Cremers, Serge ; Dworakowski, Elzbieta ; Teitelbaum, SusanL ; Neugut, AlfredI ; Gammon, MarilieD

Purpose : Studies of vitamin D-pathway genetic variants in relation to cancer risk have been inconsistent. We examined the associations between vitamin D-related genetic polymorphisms, plasma 25-hydroxyvitamin D [25(OH)D], and breast cancer risk. Methods : In a population-based case–control study of 967 incident breast cancer cases and 993 controls, we genotyped 25 polymorphisms encoding the vitamin D receptor (VDR) gene, 1  [...]