Cet article passe en revue les progrès récents concernant la prévention, le diagnostic et la prise en charge thérapeutique d'un lymphœdème lié aux traitements d'un cancer

Recent progress in the treatment and prevention of cancer-related lymphedema

Shaitelman, Simona F. ; Cromwell, Kate D. ; Rasmussen, John C. ; Stout, Nicole L. ; Armer, Jane M. ; Lasinski, Bonnie B. ; Cormier, Janice N.

This article provides an overview of the recent developments in the diagnosis, treatment, and prevention of cancer-related lymphedema. Lymphedema incidence by tumor site is evaluated. Measurement techniques and trends in patient education and treatment are also summarized to include current trends in therapeutic and surgical treatment options as well as longer-term management. Finally, an overview of the policies related to insurance coverage and reimbursement will give the clinician an [...]

Menée en Chine par questionnaire auprès de 229 patients atteints de cancer, cette étude analyse l'efficacité de l'olanzapine pour prévenir les nausées et vomissements induits par la chimiothérapie en comparaison avec un médicament antagoniste de la sérotonine

QoL evaluation of olanzapine for chemotherapy-induced nausea and vomiting comparing with 5-HT3 receptor antagonist

Liu, J. ; Tan, L. ; Zhang, H. ; Li, H. ; Liu, X. ; Yan, Z. ; Chen, J. ; Yang, H. ; Zhang, D.

This study evaluated the efficacy of olanzapine in preventing chemotherapy-induced nausea and vomiting (CINV) and improving the quality of life (QoL) of patients with cancer during chemotherapy. Two hundred twenty-nine patients with cancer who received chemotherapy from January 2008 to August 2008 were enrolled, and they were randomised to receive olanzapine or a 5-HT3 receptor antagonist. The patients completed a CINV questionnaire once daily on days 1–5 and a QoL questionnaire on days 0 and [...]

Mené sur 1 901 patients présentant des métastases osseuses ayant pour origine un cancer de la prostate résistant à la castration, cet essai de phase III évalue, par rapport à l'acide zolédronique, l'efficacité du denosumab pour prévenir le risque de complications osseuses symptomatiques ou non

Denosumab for the Prevention of Skeletal Complications in Metastatic Castration-Resistant Prostate Cancer: Comparison of Skeletal-Related Events and Symptomatic Skeletal Events

Smith, M. R. ; Coleman, R. E. ; Klotz, L. ; Pittman, K. ; Milecki, P. ; Ng, S. ; Chi, K. N. ; Balakumaran, A. ; Wei, R. ; Wang, H. ; Braun, A. ; Fizazi, K.

Background : In a phase 3 trial in patients with castration-resistant prostate cancer (CRPC) and bone metastases, denosumab was superior to zoledronic acid in reducing skeletal-related events (SREs; radiation to bone, pathologic fracture, surgery to bone, or spinal cord compression). This study reassessed the efficacy of denosumab using symptomatic skeletal events (SSEs) as a prespecified exploratory endpoint. Patients and Methods : Patients with CRPC, no previous bisphosphonate exposure, and [...]

Menée au Japon auprès de 144 patients atteints d'un cancer colorectal métastatique, cette étude identifie les facteurs associés à l'évolution d'une neutropénie de grade 2 vers le grade 3 durant une chimiothérapie

Can grade 2 neutropenia predict the risk of grade 3 neutropenia in metastatic colorectal cancer patients treated with chemotherapy?

Yoshida, Yoichiro ; Hoshino, Seiichiro ; Aisu, Naoya ; Mogi, Ai ; Yamada, Teppei ; Kojima, Daibo ; Tanimura, Syu ; Hirata, Keiji ; Yamashita, Yuichi

Purpose : Neutropenia is a major factor affecting continuation of chemotherapy for colorectal cancer. In many clinical trials, a neutrophil count of >1500 is targeted for continuation; for a count of <1500, medication is commonly discontinued. However, there is no definitive evidence supporting the need for a neutrophil count of 1500 for continuation of chemotherapy. In the clinical trials that we conducted, we discontinued chemotherapy when the neutrophil count was <1000 (grade 3); for a count [...]

Menée aux Etats-Unis auprès de 921 patientes atteintes d'un cancer du sein et à faibles revenus, cette étude analyse les facteurs associés à leur qualité de vie, cinq ans après le diagnostic, notamment la communication avec le médecin en fonction de l'appartenance ethnique

Quality of life over 5 years after a breast cancer diagnosis among low-income women: Effects of race/ethnicity and patient-physician communication

Maly, Rose C. ; Liu, Yihang ; Liang, Li-Jung ; Ganz, Patricia A.

BACKGROUND The current study was performed to identify risk factors for a lower quality of life (QOL) among low-income women with breast cancer (BC), with an emphasis on the impact of patient-physician communication. In addition, ethnic/racial group differences in QOL changes over time were examined. METHODS A longitudinal study was conducted among 921 low-income women with BC. Patients were interviewed at 6 months, 18 months, 36 months, and 60 months after their diagnosis of BC. Mixed-effect [...]

Mené au Canada auprès de 6 professionnels de santé, cette étude analyse l'efficacité d'un outil permettant de mesurer la qualité de vie à long terme de survivantes d'un cancer du sein

Validation of the long-term quality of life breast cancer scale (LTQOL-BC) by health care professionals

Ecclestone, Christine ; Verma, Sunil ; Leahey, Angela ; Bedard, Gillian ; Hamer, Julia ; Rakovitch, Eileen ; Pulenzas, Natalie ; Bhatia, Anchal ; DeAngelis, Carlo ; Ellis, Janet ; Chow, Edward

Introduction : Quality of life has become an important measure of treatment success and is currently being explored not only for patients on active treatment, but also for long-term breast cancer survivors. The long-term quality of life breast cancer scale (LTQOL-BC) is a tool to assess QOL in breast cancer survivors. This study aimed to validate the tool with health care professionals (HCPs). Methods : Six HCPs with extensive experience working with breast cancer survivors were selected. HCPs [...]

Menée aux Etats-Unis auprès de 23 patients atteints d'un cancer en phase terminale, cette étude observationnelle analyse l'impact d'une hypothyroxinémie induite médicalement sur la durée de la vie

Medically Induced Euthyroid Hypothyroxinemia May Extend Survival in Compassionate Need Cancer Patients: An Observational Study

Hercbergs, Aleck ; Johnson, Rebecca E. ; Ashur-Fabian, Osnat ; Garfield, David H. ; Davis, Paul J.

Background : Clinical studies have shown that interventional lowering of serum free thyroxine (FT4) may be associated with extended survival in patients with some terminal cancers. The report of success with this approach in glioblastoma multiforme caused involvement of the author (A.H.) in the prospective consultative management of 23 end-stage solid tumor patients in whom hypothyroxinemia was induced to prolong life. Patients and Methods : Patients were self-referred or recommended by [...]

A partir des données du registre sud africain des cancers, cette étude analyse l'évolution de l'incidence des cancers de l'enfance, en fonction de l'origine ethnique, du sexe et de l'âge, sur la période 2000-2006

Childhood cancer incidence patterns by race, sex and age for 2000–2006: A report from the South African National Cancer Registry

Erdmann, Friederike ; Kielkowski, Danuta ; Schonfeld, Sara J. ; Kellett, Patricia ; Stanulla, Martin ; Dickens, Caroline ; Kaatsch, Peter ; Singh, Elvira ; Schüz, Joachim

Higher childhood cancer incidence rates are generally reported for high income countries although high quality information on descriptive patterns of childhood cancer incidence for low or middle income countries is limited, particularly in Sub-Saharan Africa. There is a need to quantify global differences by cancer types, and to investigate whether they reflect true incidence differences or can be attributed to under-diagnosis or under-reporting. For the first time, we describe childhood cancer [...]

Menée en Espagne auprès de 225 patients atteints de cancer, cette étude rétrospective analyse les facteurs associés au risque d'infection par la bactérie Clostridium difficile chez des patients recevant une chimiothérapie

Risk factors associated with Clostridium difficile infection in adult oncology patients

Rodríguez Garzotto, Analia ; Mérida García, Antonio ; Muñoz Unceta, Nerea ; Galera Lopez, M. Mar ; Orellana-Miguel, M. Ángeles ; Díaz-García, C. Vanesa ; Cortijo-Cascajares, Susana ; Cortes-Funes, Hernán ; Agulló-Ortuño, M. Teresa

Purpose : Clostridium difficile infection (CDI) prevention is particularly important for cancer patients, because diarrhea often results in dose reductions or delays of chemotherapy or radiotherapy. We conducted this study to better ascertain the incidence, susceptibility, and risk factors for CDI in cancer patients receiving chemotherapy at our hospital. Methods : We performed a retrospective study among adult cancer patients admitted at “12 de Octubre” University Hospital between January 2009 [...]

A partir de données publiées, cette étude analyse le nombre de décès causés par des cancers liés à une infection par le virus d'Epstein-Barr (lymphomes de Burkitt, lymphomes hodgkiniens, carcinomes nasopharyngés ou gastriques, maladies lymphoprolifératives) dans 21 régions du monde, sur la période 1990-2010

Global burden of deaths from Epstein-Barr virus attributable malignancies 1990-2010

Khan, Gulfaraz ; Hashim, Muhammad

BACKGROUND:Epstein-Barr virus (EBV) is an oncogenic virus implicated in the pathogenesis of a number of human malignancies of both lymphoid and epithelial origin. Thus, a comprehensive and up-to-date analysis focused on the global burden of EBV-attributable malignancies is of significant interest. METHODS:Based on published studies, we estimated the proportion of Burkitt's lymphoma (BL), Hodgkin's lymphoma (HL), nasopharyngeal carcinoma NPC), gastric carcinoma (GC) and post-transplant [...]

A partir d'une revue systématique de la littérature (11 études, 4 055 participants), cette méta-analyse évalue l'impact, sur la survie et la récidive, de diverses stratégies de suivi des patients atteints d'un cancer colorectal non métastatique après une traitement chirurgical curatif

Intensive follow-up strategies improve outcomes in non-metastatic colorectal cancer patients after curative surgery. A systematic review and meta-analysis

Pita-Fernández, S. ; Alhayek-Aí, M. ; González-Martín, C. ; López-Calviño, B. ; Seoane-Pillado, T. ; Pértega-Díaz, S.

Background : A wide variety of follow-up strategies are used for patients with colorectal cancer (CRC) after curative surgery. The aim of this study is to review the evidence of the impact of different follow-up strategies in patients with non-metastatic colorectal cancer after curative surgery, in relation to overall survival and other outcomes. Patients and methods : A systematic search of PubMed, EMBASE, SCOPUS and ISI Web of Knowledge up to June 2014 was carried out. Eligible studies were [...]

A partir des données du registre suédois des cancers portant sur des femmes nées en Suède entre 1940 et 1957, cette étude évalue l'association entre le niveau d'éducation et le risque de cancer du sein

Does Women's Education Affect Breast Cancer Risk and Survival? Evidence from a Population Based Social Experiment in Education

Palme, Mårten ; Simeonova, Emilia

Breast cancer is a notable exception to the well documented positive education gradient in health. A number of studies have found that highly educated women are more likely to be diagnosed with the disease. Breast cancer is therefore often labeled as a “welfare disease”. However, it has not been established whether the strong positive correlation holds up when education is exogenously determined. We estimate the causal effect of education on the probability of being diagnosed with breast cancer [...]

Menée sur deux cohortes incluant au total 7 178 patientes atteintes d'un cancer du sein de stade I ou III diagnostiqué entre 1986 et 1992 ou entre 2004 et 2008, cette étude analyse l'évolution du taux de récidive en fonction du sous-type moléculaire de la tumeur

Comparison of Breast Cancer Recurrence and Outcome Patterns Between Patients Treated From 1986 to 1992 and From 2004 to 2008

Cossetti, Rachel J.D. ; Tyldesley, Scott K. ; Speers, Caroline H. ; Zheng, Yvonne ; Gelmon, Karen A.

Purpose : To determine whether the patterns of relapse according to estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) status changed in the contemporary era. Patients and Methods : Female patients referred to the British Columbia Cancer Agency with biopsy-proven stage I to III breast cancer (BC), diagnosed between 1986 and 1992 (cohort 1 [C1]) and between mid-2004 and 2008 (cohort 2 [C2]), and with known ER and HER2 status were eligible. Data were prospectively [...]

Menée aux Etats-Unis auprès de 464 patients atteints d'un cancer de la vessie, cette étude évalue l'association entre des symptômes dépressifs, la longueur des télomères et la mortalité

Depressive Symptoms and Short Telomere Length Are Associated with Increased Mortality in Bladder Cancer Patients

Lin, Jie ; Blalock, Janice A. ; Chen, Meng ; Ye, Yuanqing ; Gu, Jian ; Cohen, Lorenzo ; Cinciripini, Paul M. ; Wu, Xifeng

Background: Depression is associated with an increased risk of mortality in cancer patients; it has been hypothesized that depression-associated alterations in cell aging mechanisms in particular, the telomere/telomerase maintenance system, may underlie this increased risk. We evaluated the association of depressive symptoms and telomere length to mortality and recurrence/progression in 464 bladder cancer patients. Methods: We used the CES-D and SCID to assess current depressive symptoms and [...]

A partir des données du registre taïwanais des cancers, cette étude analyse l'évolution de l'incidence des cancers de la tête et du cou liés à une infection par le papillomavirus humain, sur la période 1995-2009

Incidence trends of human papillomavirus-related head and neck cancer in Taiwan, 1995–2009

Hwang, Tzer-Zen ; Hsiao, Jenn-Ren ; Tsai, Chia-Rung ; Chang, Jeffrey S.

Recent studies suggested that human papillomavirus (HPV) is an emerging risk factor of head and neck cancer (HNC), particularly for oropharyngeal cancer. Studies from the West showed a rising trend of HPV-related HNC despite a decrease of the overall HNC incidence. In contrast, the overall HNC incidence in Taiwan has continued to rise. It is not clear whether the incidence trends of HPV-related HNC in Taiwan have a similar pattern to those from countries with an overall decreasing incidence of [...]

Menée au Canada auprès de sept survivants d'un cancer âgés de 18 à 35 ans, cette étude qualitative analyse l'efficacité d'une thérapie créative dans les arts visuels pour améliorer leur qualité de vie psychologique

The lived experience of visual creative expression for young adult cancer survivors

Green, A. R. ; Young, R. A.

Engaging in visual creative expression individually and in a therapeutic setting can be a beneficial experience for cancer survivors; however, most research in this field has been conducted with older adults. The current study aimed to address this gap by utilising van Manen's hermeneutic phenomenology to answer the following question: ‘What is the lived experience and meaning of visual creative expression for young adult cancer survivors?’ Seven young adults, diagnosed with cancer between the [...]

Menée en Allemagne auprès de 2 059 patients atteints de cancer, cette étude évalue l'efficacité d'un questionnaire pour analyser la peur de la progression de la maladie, six mois après leur participation à un programme de réadaptation

Fear of progression in patients 6 months after cancer rehabilitation—a validation study of the fear of progression questionnaire FoP-Q-12

Hinz, Andreas ; Mehnert, Anja ; Ernst, Jochen ; Herschbach, Peter ; Schulte, Thomas

Purpose : Many cancer patients experience fear of progression (FoP). The purpose of this study was to test psychometric properties of the questionnaire FoP-Q-12, to examine age and gender differences of FoP, and to explore prognostic factors of FoP. Methods : A sample of 2059 patients with a cancer diagnosis who had participated in a cancer rehabilitation program was examined 6 months after discharge from the rehabilitation clinic. Participants filled in the Fear of Progression questionnaire [...]

Menée à partir des données 2000-2007 des registres américains des cancers et de la base Medicare portant sur 31 191 colectomies, 2 670 cystectomies, 1 514 pancréatectomies, 2 607 protectomies, 12 228 prostatectomies et 10 151 lobectomies pulmonaires (âge des patients : plus de 65 ans), cette étude analyse la relation entre le volume hospitalier d'actes chirurgicaux, les taux de complication post-opératoire et le coût du traitement chirurgical des cancers

Hospital Volume, Complications, and Cost of Cancer Surgery in the Elderly

Nathan, Hari ; Atoria, Coral L. ; Bach, Peter B. ; Elkin, Elena B.

Purpose : Hospital surgical volume has been shown to correlate with short-term outcomes after cancer surgery, but the relationship between volume and cost of care is unclear. We sought to characterize variation in payments for cancer surgery and assess the relationship between hospital volume and payments. Methods : Using 2000 to 2007 Surveillance, Epidemiology, and End Results–Medicare data, we assessed risk-adjusted 30-day episode Medicare payments for elderly patients undergoing one of six [...]

Menée aux Etats-Unis à partir de données portant sur 28 692 patients atteints d'un cancer colorectal métastatique, cette étude analyse les coûts associés à l'utilisation d'un test de détection des mutations du gène RAS en plus du test standard sur l'exon 2

Cost Estimates and Economic Implications of Expanded RAS Testing in Metastatic Colorectal Cancer

Kircher, Sheetal M. ; Mohindra, Nisha ; Nimeiri, Halla

Background : In colorectal cancer (CRC), evidence shows that expanding RAS testing to analyze more mutations may better predict benefit from anti-EGFR therapy. The economic implications of expanding RAS testing for metastatic CRC were analyzed. Materials and Methods : Estimates of standard KRAS exon 2 testing were based on the Centers for Medicare and Medicaid Services (CMS) 2014 Diagnostic Laboratory Fee Schedule, and expanded RAS testing was estimated using a sensitivity analysis done with [...]

Menée à partir des données portant sur 132 patientes, cette étude observationnelle analyse les coûts associés aux traitements du cancer du sein métastatique HER2+ en Belgique et aux Pays-Bas

Real world cost of human epidermal receptor 2-positive metastatic breast cancer patients: a longitudinal incidence-based observational costing study in the Netherlands and Belgium

Frederix, G. W. J. ; Severens, J. L. ; Hövels, A. M. ; van Hasselt, J. G. C. ; Hooiveld, M. J. J. ; Neven, P. ; Raaijmakers, J. A. M. ; Schellens, J. H. M.

Currently, no country-specific metastatic breast cancer (MBC) observational costing data are available for the Netherlands and Belgium. Our aim is to describe country-specific resource use and costs of human epidermal receptor 2 (HER-2)-positive MBC in the Netherlands and Belgium, making use of real-world data. The eligibility period for patient selection was from April 2004 to April 2010. Inclusion and retrospective data collection begins at the time of first diagnosis of HER-2-positive MBC [...]

Menée à partir des dossiers informatisés de 63 patients atteints d'un cancer de stade avancé, cette étude analyse l'efficacité de procédures palliatives peu invasives ayant été discutées lors d'une réunion de concertation pluridisciplinaire bimensuelle mise en oeuvre par une agence canadienne

Minimally invasive palliative procedures in oncology: a review of a multidisciplinary collaboration

Chu, Lucy ; Hawley, Pippa ; Munk, Peter ; Mallinson, Paul ; Clarkson, Paul

Introduction : Minimally invasive palliative procedures (MIPPs) are sometimes considered step 4 of the World Health Organization’s three-step ladder. A case conference has been created at the BC Cancer Agency to facilitate access to MIPPs for advanced cancer patients with severe pain not responding to conventional analgesics. The twice monthly conference discusses referrals for pain control procedures and reviews imaging, with palliative care, musculoskeletal interventional radiology, radiation [...]

Cette étude analyse la qualité, la complétude et la validité des données du registre suédois du cancer de la prostate

Evaluation of data quality in the National Prostate Cancer Register of Sweden

Tomic, Katarina ; Sandin, Fredrik ; Wigertz, Annette ; Robinson, David ; Lambe, Mats ; Stattin, Pär

Background : Data in cancer quality registers are increasingly used for quality assurance, benchmarking, and research. Materials and methods : Data in the National Prostate Cancer Register (NPCR) of Sweden were evaluated for completeness, timeliness, comparability and validity. Completeness and timeliness were assessed by cross-linkage to the Swedish Cancer Register, comparability was examined by comparing registration routines in NPCR with national and international guidelines, and validity [...]