Menée aux Pays-Bas par questionnaire auprès de 120 852 participants, cette étude de cohorte évalue l'association entre la consommation alimentaire de folates, méthionine ou riboflavine et le risque de néoplasies myéloïdes ou lymphoïdes

Dietary one-carbon nutrient intake and risk of lymphoid and myeloid neoplasms: results of the Netherlands Cohort Study

Heinen, Mirjam M. ; van den Brandt, Piet A. ; Schouten, Leo J. ; Goldbohm, R. Alexandra ; Schouten, Harry C. ; Verhage, Bas A.J.

Background: Previous epidemiologic research suggests a protective role of one-carbon nutrients in carcinogenesis. Folate, however, may play a dual role in neoplasms development: protect early in carcinogenesis, promote carcinogenesis at a later stage. We prospectively examined associations between intake of total folate, methionine, riboflavin, vitamin B6 and risk of lymphoid and myeloid neoplasms (including subtypes) and investigated whether alcohol modified the effects of folate. Methods: The [...]

A partir des données de la cohorte "NHANES" portant sur 12 759 participants entre 2003 et 2010, cette étude américaine évalue l'association entre une infection par le papillomavirus humain (4 types différents) et un cancer (8 localisations différentes)

Associations between human papillomavirus and history of cancer among U.S. adults in the National Health and Nutrition Examination Survey (2003-2010)

Liu, B. ; Taioli, E.

Background: Human papillomavirus (HPV) is an infectious agent that has been associated with human cancer. We have updated the U.S. population sero-prevalence using a large National Health and Nutrition Examination Survey (NHANES) sample of adults from 2003 to 2010, and have analysed the associations between HPV seropositivity and self-reported history of cancer. Methods: Four cross-sectional cycles (2003–2004, 2005–2006, 2007–2008, and 2009–2010) were used, for a total of 12 759 participants [...]

Couplée à une cohorte de 19 882 survivants d'un lymphome hodgkinien diagnostiqué entre 1953 et 2003 et portant sur 36 cas et 70 témoins, cette étude évalue l'association entre les traitements du lymphome et le risque de développer un cancer du pancréas

Pancreatic cancer risk after treatment for Hodgkin lymphoma

Dores, G. M. ; Curtis, R. E. ; van Leeuwen, F. E. ; Stovall, M. ; Hall, P. ; Lynch, C. F. ; Smith, S. A. ; Weathers, R. E. ; Storm, H. H. ; Hodgson, D. C. ; Kleinerman, R. A. ; Joensuu, H. ; Johannesen, T. B. ; Andersson, M. ; Holowaty, E. J. ; Kaijser, M. ; Pukkala, E. ; Vaalavirta, L. ; Fossa, S. D. ; Langmark, F. ; Travis, L. B. ; Fraumeni, J. F. ; Aleman, B. M. ; Morton, L. M. ; Gilbert, E. S.

Background : Although elevated risks of pancreatic cancer have been observed in long-term survivors of Hodgkin lymphoma (HL), no prior study has assessed the risk of second pancreatic cancer in relation to radiation dose and specific chemotherapeutic agents. Patients and Methods : We conducted an international case-control study within a cohort of 19,882 HL survivors diagnosed from 1953 to 2003 including 36 cases and 70 matched controls. Results : Median ages at HL and pancreatic cancer [...]

A partir des données de 15 études incluant 8 305 cas et 13 987 témoins, cette étude évalue l'association entre un diabète, l'utilisation de médicaments antidiabétiques et le risque de cancer du pancréas, en fonction de la durée d'exposition aux médicaments

Diabetes, antidiabetic medications and pancreatic cancer risk: an analysis from the international pancreatic cancer case-control consortium

Bosetti, C. ; Rosato, V. ; Li, D. ; Silverman, D. ; Petersen, G. M. ; Bracci, P. M. ; Neale, R. E. ; Muscat, J. ; Anderson, K. ; Gallinger, S. ; Olson, S. H. ; Miller, A. B. ; Bueno-de-Mesquita, H. Bas ; Scelo, G. ; Janout, V. ; Holcatova, I. ; Lagiou, P. ; Serraino, D. ; Lucenteforte, E. ; Fabianova, E. ; Ghadirian, P. ; Baghurst, P. A. ; Zatonski, W. ; Foretova, L. ; Fontham, E. ; Bamlet, W.R. ; Holly, E. A. ; Negri, E. ; Hassan, M. ; Prizment, A. ; Cotterchio, M. ; Cleary, S. ; Kurtz, R.C. ; Maisonneuve, P. ; Trichopoulos, D. ; Polesel, J. ; Duell, E. J. ; Boffetta, P. ; Vecchia, C. La

Background : Type 2 diabetes mellitus has been associated with an excess risk of pancreatic cancer, but the magnitude of the risk and the time-risk relationship are unclear, and there is limited information on the role of antidiabetic medications. Patients and Methods : We analyzed individual-level data from 15 case-control studies within the Pancreatic Cancer Case-Control Consortium, including 8305 cases and 13,987 controls. Pooled odds ratios (ORs) were estimated from multiple logistic [...]

Menée au Royaume-Uni à partir des données hospitalières et de mortalité sur la période 1999-2011, cette étude analyse le risque de cancer par localisation chez des patients atteints de la maladie de Parkinson

Differential risks of cancer types in people with Parkinson’s disease: A national record-linkage study

Hui Ong, Eugene Liat ; Goldacre, Raph ; Goldacre, Michael

Background : There is evidence that people with Parkinson’s disease (PD) have a decreased risk of developing cancer. PD has also variably been shown to be associated with an increased risk of cancers like melanoma and breast. We investigated this relationship in a very large cohort of PD patients. Methods : We constructed two cohorts of people from an all-England record-linked hospital and mortality dataset spanning 1999–2011. One cohort comprised people with a record of PD; the other comprised [...]

A partir d'une revue de la littérature (77 études), cette méta-analyse évalue l'association entre le polymorphisme Folk du récepteur de la vitamine D et le risque de cancer

Vitamin D receptor polymorphism FokI and cancer risk: A comprehensive meta-analysis

Gnagnarella, Patrizia ; Pasquali, Elena ; Serrano, Davide ; Raimondi, Sara ; Disalvatore, Davide ; Gandini, Sara

Numerous studies investigated the associations of VDR polymorphisms with various types of cancer, suggesting an influence on cancer risk. FokI is one of the most frequently analysed polymorphisms but the results from single studies are contradictory. We performed a meta-analysis looking at the association between the FokI and all cancer sites and investigating sources of heterogeneity.We identified 77 independent studies up to April 2014. We presented the summary odds ratios (SORs) by cancer [...]

A partir d'une revue systématique de la littérature (20 articles identifiés), cette méta-analyse évalue l'association entre des polymorphismes du gène MTHFR et le risque de leucémie myéloïde aiguë ou de leucémie myéloïde chronique

Methylenetetrahydrofolate reductase gene polymorphisms contribute to acute myeloid leukemia and chronic myeloid leukemia susceptibilities: Evidence from meta-analyses

He, Hairong ; He, Gonghao ; Wang, Taotao ; Cai, Jiangxia ; Wang, Yan ; Zheng, Xiaowei ; Dong, Yalin ; Lu, Jun

Purpose : The expression of methylenetetrahydrofolate reductase (MTHFR) is associated with acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). Most studies have linked the common functional C677T and A1298C polymorphisms of the MTHFR gene and susceptibility to AML and CML, but the results were not consistent. The aim of the present study was to derive a more precise estimation of the relationship. Methods : Meta-analyses assessing the association of MTHFR C677T and A1298C [...]

Menée en Lituanie auprès de 6 729 participants suivis sur la période 1978-2008, cette étude de cohorte évalue l'association entre l'indice de masse corporelle, le niveau sérique de cholestérol et le risque de cancer du poumon

Body Mass Index, Cholesterol Level and Risk of Lung Cancer in Lithuanian Men

Everatt, Ruta ; Virviciute, Dalia ; Kuzmickiene, Irena ; Tamosiunas, Abdonas

Objective : Our objective was to investigate the association between body mass index (BMI), total serum cholesterol (TSC) level and risk of lung cancer in a Lithuanian population-based cohort study. Materials and Methods : The study included 6,729 men initially free from cancer. During the follow-up (1978–2008), 358 lung cancer cases were identified. Cox proportional hazards models were used to estimate hazard ratios (HR) and corresponding 95% confidence intervals (95% CI). Results : Following [...]

Menée sur 43 patients appartenant à 29 familles affectées par un cancer colorectal sans cause génétique connue, cette étude identifie un ensemble de variants dans les gènes CDKN1B, XRCC4, EPHX1, NFKBIZ, SMARCA4 et BARD1 en association avec la susceptibilité à la maladie

Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer

Esteban-Jurado, Clara ; Vila-Casadesus, Maria ; Garre, Pilar ; Lozano, Juan Jose ; Pristoupilova, Anna ; Beltran, Sergi ; Munoz, Jenifer ; Ocana, Teresa ; Balaguer, Francesc ; López-Cerón, María ; Cuatrecasas, Miriam ; Franch-Exposito, Sebastia ; Pique, Josep M. ; Castells, Antoni ; Carracedo, Angel ; Ruiz-Ponte, Clara ; Abuli, Anna ; Bessa, Xavier ; Andreu, Montserrat ; Bujanda, Luis ; Caldes, Trinidad ; Castellvi-Bel, Sergi

Purpose: Colorectal cancer is an important cause of mortality in the developed world. Hereditary forms are due to germ-line mutations in APC, MUTYH, and the mismatch repair genes, but many cases present familial aggregation but an unknown inherited cause. The hypothesis of rare high-penetrance mutations in new genes is a likely explanation for the underlying predisposition in some of these familial cases. Methods: Exome sequencing was performed in 43 patients with colorectal cancer from 29 [...]

Couplée aux données de la cohorte européenne EPIC et portant sur 966 cas et 966 témoins, cette étude évalue l'association entre les niveaux sériques du sélénium ou de la sélénoprotéine P et le risque de cancer colorectal

Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort

Hughes, David J. ; Fedirko, Veronika ; Jenab, Mazda ; Schomburg, Lutz ; Méplan, Catherine ; Freisling, Heinz ; Bueno-de-Mesquita, H. B. ; Hybsier, Sandra ; Becker, Niels-Peter ; Czuban, Magdalena ; Tjønneland, Anne ; Outzen, Malene ; Boutron-Ruault, Marie-Christine ; Racine, Antoine ; Bastide, Nadia ; Kühn, Tilman ; Kaaks, Rudolf ; Trichopoulos, Dimitrios ; Trichopoulou, Antonia ; Lagiou, Pagona ; Panico, Salvatore ; Peeters, Petra H. ; Weiderpass, Elisabete ; Skeie, Guri ; Dagrun, Engeset ; Chirlaque, María-Dolores ; Sánchez, María-José ; Ardanaz, Eva ; Ljuslinder, Ingrid ; Wennberg, Maria ; Bradbury, Kathryn E. ; Vineis, Paolo ; Naccarati, Alessio ; Palli, Domenico ; Boeing, Heiner ; Overvad, Kim ; Dorronsoro, Miren ; Jakszyn, Paula ; Cross, Amanda J. ; Quirós, Jose Ramón ; Stepien, Magdalena ; Kong, So Yeon ; Duarte-Salles, Talita ; Riboli, Elio ; Hesketh, John E.

Suboptimal intakes of the micronutrient selenium (Se) are found in many parts of Europe. Low Se status may contribute to colorectal cancer (CRC) development. We assessed Se status by measuring serum levels of Se and Selenoprotein P (SePP) and examined the association with CRC risk in a nested case–control design (966 CRC cases; 966 matched controls) within the European Prospective Investigation into Cancer and Nutrition. Se was measured by total reflection X-ray fluorescence and SePP by [...]

Couplée aux données de la cohorte européenne EPIC et portant sur 727 cas et 727 témoins, cette étude allemande évalue l'association entre des variants du gène de la protéine C-réactive et le risque de cancer colorectal

Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk

Nimptsch, Katharina ; Aleksandrova, Krasimira ; Boeing, Heiner ; Janke, Jürgen ; Lee, Young-Ae ; Jenab, Mazda ; Bueno-de-Mesquita, Bas H. ; Jansen, Eugene H. J. M. ; Tsilidis, Konstantinos K. ; Trichopoulou, Antonia ; Weiderpass, Elisabete ; Wu, Chunsen ; Overvad, Kim ; Tjønneland, Anne ; Boutron-Ruault, Marie-Christine ; Dossus, Laure ; Racine, Antoine ; Kaaks, Rudolf ; Canzian, Federico ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Palli, Domenico ; Agnoli, Claudia ; Tumino, Rosario ; Vineis, Paolo ; Panico, Salvatore ; Johansson, Anders ; Van Guelpen, Bethany ; Khaw, Kay-Tee ; Wareham, Nick ; Peeters, Petra H. ; Quirós, J. Ramón ; Venceslá García, Adoración ; Molina-Montes, Esther ; Dorronsoro, Miren ; Chirlaque, María-Dolores ; Barricarte Gurrea, Aurelio ; Key, Timothy J. ; Duarte-Salles, Talita ; Stepien, Magdalena ; Gunter, Marc J. ; Riboli, Elio ; Pischon, Tobias

High blood concentrations of C-reactive protein (CRP) have been associated with elevated risk of colorectal cancer in several prospective studies including the European Prospective Investigation into Cancer and Nutrition (EPIC), but it is unknown whether these observations reflect a causal relationship. We aimed to investigate whether CRP genetic variants associated with lifelong higher CRP concentrations translate into higher colorectal cancer risk. We conducted a prospective nested [...]

Cet article passe en revue les travaux récents sur l'association entre l'obésité, le métabolisme de l'enzyme responsable de la production de cholestérol et le risque de développer un cancer du sein

Obesity, Cholesterol Metabolism and Breast Cancer Pathogenesis

McDonnell, Donald P ; Park, Sunghee ; Goulet, Matthew T ; Jasper, Jeff ; Wardell, Suzanne E ; Chang, Ching-Yi ; Norris, John D ; Guyton, John R ; Nelson, Erik

Obesity and altered lipid metabolism are risk factors for breast cancer in pre- and post-menopausal women. These pathologic relationships have been attributed in part to the impact of cholesterol on the biophysical properties of cell membranes and to the influence of these changes on signaling events initiated at the membrane. However, more recent studies have indicated that the oxysterol 27-hydroxycholesterol (27HC), and not cholesterol per se, may be the primary biochemical link between lipid [...]

A partir des données de la cohorte européenne EPIC portant sur 345 157 femmes (âge moyen : 51 ans), cette étude évalue l'association entre des facteurs reproductifs et le risque de carcinome différencié de la thyroïde

Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: The EPIC study

Zamora-Ros, Raul ; Rinaldi, Sabina ; Biessy, Carine ; Tjønneland, Anne ; Halkjær, Jytte ; Fournier, Agnès ; Boutron-Ruault, Marie-Christine ; Mesrine, Sylvie ; Tikk, Kaja ; Fortner, Renée T. ; Boeing, Heiner ; Förster, Jana ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Papatesta, Eleni-Maria ; Masala, Giovanna ; Tagliabue, Giovanna ; Panico, Salvatore ; Tumino, Rosario ; Polidoro, Silvia ; Peeters, Petra H. M. ; Bueno-de-Mesquita, H. Bas ; Weiderpass, Elisabete ; Lund, Eiliv ; Argüelles, Marcial ; Agudo, Antonio ; Molina-Montes, Esther ; Navarro, Carmen ; Barricarte, Aurelio ; Larranaga, Nerea ; Manjer, Jonas ; Almquist, Martin ; Sandström, Maria ; Hennings, Joakim ; Tsilidis, Konstantinos K. ; Schmidt, Julie A. ; Khaw, Kay-Thee ; Wareham, Nicholas J. ; Romieu, Isabelle ; Byrnes, Graham ; Gunter, Marc J. ; Riboli, Elio ; Franceschi, Silvia

Differentiated thyroid carcinoma (TC) is threefold more common in women than in men and, therefore, a role of female hormones in the etiology of differentiated TC has been suggested. We assessed these hypotheses in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 345,157 women (mean age 51) followed for an average of 11 years, 508 differentiated TC cases were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox [...]

A partir des données du registre des cancers de l'Ontario et portant sur 1 776 cas et 1 839 témoins, cette étude évalue l'association entre le tabagisme, des variants de gènes d'enzymes impliqués dans le métabolisme des cancérigènes et le risque de cancer du sein

Active Cigarette Smoking, Variants in Carcinogen Metabolism Genes and Breast Cancer Risk among Pre- and Postmenopausal Women in Ontario, Canada

Cotterchio, Michelle ; Mirea, Lucia ; Ozcelik, Hilmi ; Kreiger, Nancy

Cigarette smoking is strongly associated with various diseases including many cancers; however, evidence regarding breast cancer risk remains inconclusive with some studies reporting no association, and others an increased risk with long duration and early initiation of smoking. Genetic variation in carcinogen-metabolizing enzymes may modify these associations. Breast cancer cases were identified from the Ontario Cancer Registry (OCR) during 2003–2004 and population controls through random [...]