Menée à partir de données portant sur 232 882 femmes ayant subi une hystérectomie mini-invasive entre 2006 et 2012, cette étude évalue l'association entre une hystérectomie réalisée par morcellation (36 470 cas) et le risque de pathologies ou de cancers utérins

Uterine pathology in women undergoing minimally invasive hysterectomy using morcellation

Wright, J. D. ; Tergas, A. I. ; Burke, W. M. ; et al.,

Even though minimally invasive surgery has improved outcomes for hysterectomy, the procedure requires removal of the uterus through small incisions. Morcellation, or fragmentation of the uterus into smaller pieces, is one method to remove the uterus. Recently, concern has been raised that morcellation may result in the spread of undetected malignancies. Despite the commercial availability of electric power morcellators for 2 decades, accurate estimates of the prevalence of malignancy at the [...]

Menée à partir des données des registres américains du cancer portant sur 56 681 patientes atteintes d'un cancer utérin diagnostiqué entre 1980 et 2005 (durée médiane de suivi : 15 ans), cette étude évalue l'effet d'une radiothérapie sur le risque de cancer de la vessie et la mortalité des patientes

Bladder cancer incidence and mortality in patients treated with radiation for uterine cancer

Baack Kukreja, Janet E. ; Scosyrev, Emil ; Brasacchio, Ralph A. ; Toy, Eugene P. ; Messing, Edward M. ; Wu, Guan

Objective : To estimate the effect of radiation therapy (RT) administered for uterine cancer (UtC) on bladder cancer (BC) incidence, tumour characteristics at presentation, and mortality. Patients and Methods : In this retrospective cohort study, records of 56 681 patients diagnosed with UtC as their first primary malignancy during 1980–2005 were obtained from the Surveillance, Epidemiology and End-Results (SEER) database. Follow-up for incident BC ended on 31 December 2008. Occurrences of BC [...]

Menée sur 518 patients atteints d'un cancer sporadique de la prostate, 433 témoins et 154 hommes dont l'autopsie a révélé un cancer latent de la prostate, cette étude japonaise met en évidence une association entre un polymorphisme du gène TMPRSS2 et le risque de cancer sporadique de la prostate

TMPRSS2 Met160Val polymorphism: Significant association with sporadic prostate cancer, but not with latent prostate cancer in Japanese men

Maekawa, S. ; Suzuki, M. ; Arai, T. ; Kato, M. ; Morikawa, T. ; Kasuya, Y. ; Kume, H. ; Kitamura, T. ; Homma, Y.

OBJECTIVES : To investigate the association between the TMPRSS2 Met160Val polymorphism and the risk of prostate cancer in Japanese men. METHODS : Genomic DNA samples from 518 Japanese sporadic prostate cancer patients, 433 controls and 154 Japanese men who were diagnosed as having latent prostate cancer based on autopsy results were genotyped for the TMPRSS2 Met160Val polymorphism using a TaqMan assay. Logistic regression analyses were carried out to estimate the odds ratios and 95% confidence [...]

Menée à partir des données d'une étude internationale d'association sur le génome entier (3 593 cas et 2 328 témoins), cette étude identifie, sur la région chromosomique 4q32.2, un nouveau locus de susceptibilité au cancer colorectal

A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study

Stenzel, Stephanie L. ; Schumacher, Fredrick R. ; Edlund, Christopher K. ; Conti, David V. ; Raskin, Leon ; Lejbkowicz, Flavio ; Pinchev, Mila ; Rennert, Hedy S. ; Jenkins, Mark A. ; Hopper, John L. ; Buchanan, Daniel D. ; Lindor, Noralane M. ; Le Marchand, Loic ; Gallinger, steven ; Haile, Robert W. ; Newcomb, Polly A. ; Huang, Shu-Chen ; Rennert, Gad ; Casey, Graham ; Gruber, Stephen B.

Only a fraction of colorectal cancer heritability is explained by known risk-conferring genetic variation. This study was designed to identify novel risk alleles in Europeans. We conducted a genome-wide association study (GWAS) meta-analysis of colorectal cancer in participants from a population-based case control study in Israel (n = 1,616 cases, 1,329 controls) and a consortium study from the Colon Cancer Family Registry (n=1,977 cases, 999 controls). We used a two-stage [...]

Menée à partir d'échantillons plasmatiques prélevés sur 727 patients atteints d'un cancer colorectal diagnostiqué entre 1992 et 2003 et sur 727 témoins, cette étude évalue l'association entre des variants du gène CRP, la concentration de la protéine C-réactive et le risque de développer la maladie

Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk

Nimptsch, K. ; Aleksandrova, K. ; Boeing, H. ; Janke, J. ; Lee, Y. A. ; Jenab, M. ; Bueno-De-Mesquita, B. H. ; Jansen, E. H. ; Tsilidis, K. K. ; Trichopoulou, A. ; Weiderpass, E. ; Wu, C. ; Overvad, K. ; Tj Nneland, A. ; Boutron-Ruault, M. C. ; Dossus, L. ; Racine, A. ; Kaaks, R. ; Canzian, F. ; Lagiou, P. ; Trichopoulos, D. ; Palli, D. ; Agnoli, C. ; Tumino, R. ; Vineis, P. ; Panico, S. ; Johansson, A. ; VanGuelpen, B. ; Khaw, K. T. ; Wareham, N. ; Peeters, P. H. ; Quiros, J. R. ; Garcia, A. V. ; Molina-Montes, E. ; Dorronsoro, M. ; Chirlaque, M. D. ; Gurrea, A. B. ; Key, T. J. ; Duarte-Salles, T. ; Stepien, M. ; Gunter, M. J. ; Riboli, E. ; Pischon, T.

High blood concentrations of C-reactive protein (CRP) have been associated with elevated risk of colorectal cancer in several prospective studies including the European Prospective Investigation into Cancer and Nutrition (EPIC), but it is unknown whether these observations reflect a causal relationship. We aimed to investigate whether CRP genetic variants associated with lifelong higher CRP concentrations translate into higher colorectal cancer risk. We conducted a prospective nested [...]

Menée à partir de données médicales portant sur 487 patients atteints d'un carcinome à cellules rénales, cette étude chinoise met en évidence une association entre l'accumulation de graisse viscérale et différents sous-types de la maladie

Visceral fat accumulation is associated with different pathological subtypes of renal cell carcinoma (RCC): a multicentre study in China

Wang, Hong-Kai ; Song, Xi-Shuang ; Cheng, Yue ; Qu, Yuan-Yuan ; Zhang, Shi-Lin ; Dai, Bo ; Zhang, Hai-Liang ; Shen, Yi-Jun ; Zhu, Yi-Ping ; Shi, Guo-Hai ; Qin, Xiao-Jian ; Ma, Chun-Guang ; Lin, Guo-Wen ; Xiao, Wen-Jun ; Zhu, Yao ; Ye, Ding-Wei

Objective : To investigate whether visceral obesity is associated with certain histological subtypes of renal cell carcinoma (RCC) in a multicentre Chinese cohort. Patients and Methods : A kidney tumour database was created using three tertiary centres in China; 487 patients were enrolled presenting with localised RCC and complete computer tomography (CT)/magnetic resonance imaging (MRI) information. A single-slice CT image was used to measure the area of visceral and subcutaneous adipose [...]

Cet article fait le point sur l'étiologie de la "léiomyomatose familiale et cancer du rein", la surveillance des patients et leur prise en charge thérapeutique

Hereditary leiomyomatosis and renal cell cancer (HLRCC) : renal cancer risk, surveillance and treatment

Menko, FredH ; Maher, EamonnR ; Schmidt, LauraS ; Middelton, LindsayA ; Aittomaki, Kristiina ; Tomlinson, Ian ; Richard, Stéphane ; Linehan, W. Marston

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant condition in which susceptible individuals are at risk for the development of cutaneous leiomyomas, early onset multiple uterine leiomyomas and an aggressive form of type 2 papillary renal cell cancer. HLRCC is caused by germline mutations in the fumarate hydratase (FH) gene which inactivate the enzyme and alters the function of the tricarboxylic acid (Krebs) cycle. Issues surrounding surveillance and treatment for [...]

Menée en population d'Asie orientale sur 22 780 cas de cancer du sein et 24 181 témoins, cette étude identifie, dans les régions chromosomiques 1q32.1, 5q14.3 et 15q26.1, trois nouveaux loci de susceptibilité au cancer du sein

Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

Cai, Qiuyin ; Zhang, Ben ; Sung, Hyuna ; Low, Siew-Kee ; Kweon, Sun-Seog ; Lu, Wei ; Shi, Jiajun ; Long, Jirong ; Wen, Wanqing ; Choi, Ji-Yeob ; Noh, Dong-Young ; Shen, Chen-Yang ; Matsuo, Keitaro ; Teo, Soo-Hwang ; Kim, Mi Kyung ; Khoo, Ui Soon ; Iwasaki, Motoki ; Hartman, Mikael ; Takahashi, Atsushi ; Ashikawa, Kyota ; Matsuda, Koichi ; Shin, Min-Ho ; Park, Min Ho ; Zheng, Ying ; Xiang, Yong-Bing ; Ji, Bu-Tian ; Park, Sue K. ; Wu, Pei-Ei ; Hsiung, Chia-Ni ; Ito, Hidemi ; Kasuga, Yoshio ; Kang, Peter ; Mariapun, Shivaani ; Ahn, Sei Hyun ; Kang, Han Sung ; Chan, Kelvin Y. K. ; Man, Ellen P. S. ; Iwata, Hiroji ; Tsugane, Shoichiro ; Miao, Hui ; Liao, Jiemin ; Nakamura, Yusuke ; Kubo, Michiaki ; Drive Game-On Consortium ; Delahanty, Ryan J. ; Zhang, Yanfeng ; Li, Bingshan ; Li, Chun ; Gao, Yu-Tang ; Shu, Xiao-Ou ; Kang, Daehee ; Zheng, Wei

In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P = 8.82 × 10−9), rs10474352 at 5q14.3 (near the ARRDC3 gene; P = 1.67 × 10−9) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P = 4.25 × 10−8). We replicated these associations in 16,003 cases and 41,335 controls of European ancestry (P = [...]

A partir d'une revue de la littérature (8 études), cette méta-analyse évalue l'association entre le polymorphisme +331G/A du gène du récepteur de la progestérone et le risque de cancer de l'endomètre chez les femmes de type caucasien (3 790 cas et 6 458 témoins)

Association of the +331G/A progesterone receptor gene (PgR) polymorphism with risk of endometrial cancer in Caucasian women: a meta-analysis

Pabalan, N. ; Pineda, M. R. ; Jarjanazi, H. ; Christofolini, D. M. ; Barbosa, C. P. ; Bianco, B.

PURPOSE : The +331G/A progesterone receptor (PgR) gene polymorphism may influence risk of endometrial cancer. However, data from published studies have been controversial. To evaluate whether combined evidence shows an association between this polymorphism and endometrial cancer, we considered all available studies in a meta-analysis. METHODS : We searched PubMed and EMBASE and identified eight studies representing data for 3,790 cases and 6,458 controls. We estimated risk [odds ratio (OR) and [...]

Menée sur 88 107 femmes ménopausées âgées de 50 à 79 ans (durée moyenne de suivi : 11 ans), cette étude évalue l'association entre la présence d'un diabète, les traitements du diabète et le risque de cancer de l'endomètre

Association between diabetes, diabetes treatment and risk of developing endometrial cancer

Luo, J. ; Beresford, S. ; Chen, C. ; Chlebowski, R. ; Garcia, L. ; Kuller, L. ; Regier, M. ; Wactawski-Wende, J. ; Margolis, K. L.

Background : A growing body of evidence suggests that diabetes is a risk factor for endometrial cancer incidence. However, most of these studies used case-control study designs and did not adjust for obesity, an established risk factor for endometrial cancer. In addition, few epidemiological studies have examined the association between diabetes treatment and endometrial cancer risk. The objective of this study was to assess the relationships among diabetes, diabetes treatment and endometrial [...]

A partir de bases de données portant sur des patients atteints d'un cancer du poumon, fumeurs et non fumeurs, cette étude met en évidence la complexité et l'hétérogénéité du paysage des anomalies du nombre de copies de gènes et des profils transcriptionnels en fonction du statut tabagique

Genomic and transcriptional alterations in lung adenocarcinoma in relation to smoking history

Karlsson, Anna ; Ringner, Markus ; Lauss, Martin ; Botling, Johan ; Micke, Patrick ; Planck, Maria ; Staaf, Johan

Purpose : Cigarette smoking is the major pathogenic factor for lung cancer. The precise mechanisms of tobacco-related carcinogenesis, and its effect on the genomic and transcriptional landscape in lung cancer are not fully understood. Experimental Design : 1398 (277 never-smokers, 1121 smokers) genomic and 1449 (370 never-smokers, 1079 smokers) transcriptional profiles were assembled from public lung adenocarcinoma cohorts, including matched next-generation DNA-sequencing data (n=423). [...]