Menée en Espagne auprès de 78 survivants de cancer âgés de 12 à 20 ans, cette étude analyse leur qualité de vie, en fonction du sexe, du type de la tumeur et du temps écoulé depuis le diagnostic de la maladie

Type of tumour, gender and time since diagnosis affect differently health-related quality of life in adolescent survivors

Pérez-Campdepadrós, M. ; Castellano-Tejedor, C. ; Sábado-Álvarez, C. ; Gros-Subías, L. ; Capdevila, L. ; Blasco-Blasco, T.

Research findings about health-related quality of life (HRQoL) of childhood cancer survivors are mixed and the features which could modulate these results have not been investigated rigorously. This research aims to improve the knowledge on these topics. Thus, HRQoL between central nervous system (CNST) and non-central nervous system (non-CNST) adolescent cancer survivors was compared. The influence of selected factors (gender and years since diagnosis) on HRQoL was also analysed. In a [...]

Mené en Norvège auprès de 592 participants, cet essai randomisé analyse l'efficacité de la méthylprednisolone, un corticoïde synthétique, pour soulager les symptômes de douleur, de fatigue et de perte d'appétit chez des patients atteints d'un cancer de stade avancé et recevant des opioïdes

Efficacy of Methylprednisolone on Pain, Fatigue, and Appetite Loss in Patients With Advanced Cancer Using Opioids: A Randomized, Placebo-Controlled, Double-Blind Trial

Paulsen, Ørnulf ; Klepstad, Pål ; Rosland, Jan Henrik ; Aass, Nina ; Albert, Eva ; Fayers, Peter ; Kaasa, Stein

Purpose : Corticosteroids are frequently used in cancer pain management despite limited evidence. This study compares the analgesic efficacy of corticosteroid therapy with placebo. Patients and Methods : Adult patients with cancer receiving opioids with average pain intensity ≥ 4 (numeric rating scale [NRS], 0 to 10) in the last 24 hours were eligible. Patients were randomly assigned to methylprednisolone (MP) 16 mg twice daily or placebo (PL) for 7 days. Primary outcome was average pain [...]

Menée par enquête en ligne auprès de 737 participants vivant en Europe et aux Etats-Unis, cette étude analyse les disparités, selon les pays, dans la prévention et la prise en charge des toxicités dermatologiques aiguës induites par la radiothérapie

Prophylaxis and management of acute radiation-induced skin toxicity: a survey of practice across Europe and the USA

O'Donovan, A. ; Coleman, M. ; Harris, R. ; Herst, P.

Radiation-induced toxicity is a common adverse side effect of radiation therapy. Previous studies have demonstrated a lack of evidence to support common skincare advice for radiotherapy patients. The aim of the current study was to investigate the management of radiation-induced skin toxicity across Europe and the USA. Where previous surveys have focused on national practice or treatment of specific sites, the current study aimed to gain a broader representation of skincare practice. An [...]

Mené au Canada auprès de 90 patients atteints de cancer et ayant une insuffisance cardiaque médicalement stable, cet essai analyse l'efficacité et la sécurité d'un programme de gymnastique tonique pour améliorer leur qualité de vie

Safety and Efficacy of Aerobic Training in Patients With Cancer Who Have Heart Failure: An Analysis of the HF-ACTION Randomized Trial

Jones, Lee W. ; Douglas, Pamela S. ; Khouri, Michel G. ; Mackey, John R. ; Wojdyla, Daniel ; Kraus, William E. ; Whellan, David J. ; O’Connor, Christopher M.

Purpose : To investigate the efficacy and safety of aerobic training (AT) in patients with cancer with medically stable heart failure (HF). Patients and Methods : A retrospective analysis of 90 patients with cancer who have HF and who were randomly assigned to AT (n = 47) or guideline-based usual care (UC; n = 43) was performed. AT consisted of three supervised sessions per week at 20 to 45 minutes per session at 60% to 70% of heart rate reserve for 12 weeks followed by home-based sessions for [...]

Menée aux Etats-Unis auprès de 431 cas et 361 témoins, cette étude analyse les facteurs associés à l'adhésion à des recommandations relatives à la nutrition et à l'activité physique chez des survivants d'un cancer de l'enfance

Childhood cancer survivors and adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity

Berdan, ChloeA ; Tangney, ChristyC ; Scala, Celina ; Stolley, Melinda

Purpose : The objective of this study was to assess adherence of childhood cancer survivors in comparison to cancer-free adults of comparable age and sex (or “controls”) to the 2012 American Cancer Society (ACS) Guidelines on Nutrition and Physical Activity. Methods : As part of the Chicago Healthy Living Study, 431 childhood cancer survivors (18.5 ± 8.1 years from diagnosis) and 361 controls completed a structured, health-focused interview including the Block Brief Food Frequency Questionnaire [...]

Menée en Allemagne auprès de 110 patientes atteintes de tumeurs "borderline" de l'ovaire, cette étude prospective analyse leur activité sexuelle et leur qualité de vie

Quality of life and sexual function in patients with borderline tumors of the ovary. A substudy of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) study group ROBOT study

Farthmann, Juliane ; Hasenburg, Annette ; Weil, Meike ; Fotopoulou, Christina ; Ewald-Riegler, Nina ; du Bois, Oya ; Trillsch, Fabian ; Mahner, Sven ; Strauss, Hans-Georg ; Wimberger, Pauline ; Reuss, Alexander ; du Bois, Andreas

Purpose : Borderline tumors of the ovary (BOT) represent an entity of ovarian neoplasms with low malignant potential and excellent prognosis. Mainstay of therapy is surgery including adequate staging and complete tumor resection, possibly inducing long-term side effects, especially in premenopausal women. The aim of this study was to evaluate quality of life (QoL) and sexual function in patients treated for BOT, also with respect to treatment modalities. Methods : This prospective study was [...]

Menée aux Etats-Unis auprès de 4 334 patients atteints d'un cancer du poumon, cette étude analyse les disparités dans leurs perceptions relatives aux besoins en soins de support non statisfaits

Disparities in perceived unmet need for supportive services among patients with lung cancer in the Cancer Care Outcomes Research and Surveillance Consortium

John, Dolly A. ; Kawachi, Ichiro ; Lathan, Christopher S. ; Ayanian, John Z.

BACKGROUND The authors investigated the prevalence, determinants of, and disparities in any perceived unmet need for 8 supportive services (home nurse, support group, psychological services, social worker, physical/occupational rehabilitation, pain management, spiritual counseling, and smoking cessation) by race/ethnicity and nativity and how it is associated with perceived quality of care among US patients with lung cancer. METHODS Data from a multiregional, multihealth system representative [...]

Menée en Allemagne auprès de 64 patients atteints d'un cancer hématologique, cette étude analyse l'efficacité d'un outil destiné à mesurer les symptômes et événements indésirables induits par la chimiothérapie

Quantitative tool to evaluate the somatic burden due to chemotherapy-induced adverse events: the somatic burden score

Koehler, Michael ; Fischer, Thomas ; Kropf, Siegfried ; Frommer, Joerg

Purpose : Although there are several established methods like the Common Terminology Criteria for Adverse Events (CTCAE), heretofore, no objective, quantitative measurement exists for the somatic burden due to chemotherapy-induced adverse events (SB-CHINAE). We developed the Somatic Burden Score (SBS-AE) that combines the severity grade and duration of an AE. This paper describes the development and validation of the SBS-AE. Methods : SBS-AE’s calculation was based on the number of days of [...]

Menée en Australie auprès de 71 cas et 71 témoins, cette étude analyse le niveau d'activité physique et de pratique de la gymnastique chez des patientes atteintes d'un cancer du sein métastatique

Physical activity and fitness in women with metastatic breast cancer

Yee, Jasmine ; Davis, GlenM ; Beith, JaneM ; Wilcken, Nicholas ; Currow, David ; Emery, Jon ; Phillips, Jane ; Martin, Andrew ; Hui, Rina ; Harrison, Michelle ; Segelov, Eva ; Kilbreath, SharonL

Purpose : This study aimed to explore differences in physical activity and fitness between women with metastatic breast cancer compared to healthy controls and factors associated with their physical activity levels. Methods : Seventy-one women with metastatic breast cancer, aged (mean (SD)) 57.7 (9.5) and 2.9 (3.1) years after the onset of metastatic disease, and 71 healthy controls aged 55.0 (9.4) years participated. Of those with metastatic disease, 27 % had bone-only metastases, 35 % [...]

Menée à partir des données de 20 études prospectives américaines, suédoises ou australiennes incluant au total plus de 300 000 participants (âge : 19 à 83 ans), cette étude évalue, en fonction du sexe, l'association entre une obésité de classe III (IMC de 40–59 kg/m2) et la mortalité, notamment la mortalité par cancer

Association between Class III Obesity (BMI of 40–59 kg/m2) and Mortality: A Pooled Analysis of 20 Prospective Studies

Kitahara, Cari M. ; Flint, Alan J. ; Berrington de Gonzalez, Amy ; Bernstein, Leslie ; Brotzman, Michelle ; MacInnis, Robert J. ; Moore, Steven C. ; Robien, Kim ; Rosenberg, Philip S. ; Singh, Pramil N. ; Weiderpass, Elisabete ; Adami, Hans Olov ; Anton-Culver, Hoda ; Ballard-Barbash, Rachel ; Buring, Julie E. ; Freedman, D. Michal ; Fraser, Gary E. ; Beane Freeman, Laura E. ; Gapstur, Susan M. ; Gaziano, John Michael ; Giles, Graham G. ; Håkansson, Niclas ; Hoppin, Jane A. ; Hu, Frank B. ; Koenig, Karen ; Linet, Martha S. ; Park, Yikyung ; Patel, Alpa V. ; Purdue, Mark P. ; Schairer, Catherine ; Sesso, Howard D. ; Visvanathan, Kala ; White, Emily ; Wolk, Alicja ; Zeleniuch-Jacquotte, Anne ; Hartge, Patricia

Background : The prevalence of class III obesity (body mass index [BMI]≥40 kg/m2) has increased dramatically in several countries and currently affects 6% of adults in the US, with uncertain impact on the risks of illness and death. Using data from a large pooled study, we evaluated the risk of death, overall and due to a wide range of causes, and years of life expectancy lost associated with class III obesity. Methods and Findings : In a pooled analysis of 20 prospective studies from the [...]

Menée en Norvège à partir de données portant sur la période 1997-2012, cette étude met en évidence l'intérêt de l'indicateur "nombre d'années de vies perdues" pour mesurer l'impact de la maladie sur la société

Years of life lost as a measure of cancer burden on a national level

Brustugun, O. T. ; Moller, B. ; Helland, A.

Background: The severity of cancers is often measured in number of deaths. However, number of years of life lost (YLL) may be a more appropriate indicator of impact on society. Here we have calculated the YLL of adult cancers in Norway for the year 2012, as well as for the previous 15-year period. Methods: Data on age composition, expected remaining years of life, total numbers of deaths and deaths due to cancer were retrieved from the National Census Agency Statistics Norway. YLL were [...]

A partir des données du registre suédois des lymphomes portant sur 755 patients atteints d'un lymphome T périphérique, cette étude de cohorte évalue les facteurs pronostiques, les traitements et la survie des patients sur une période de 10 ans

Real world data on prognostic factors and treatment in peripheral T-cell lymphomas: a study from the Swedish Lymphoma Registry

Fredrik Ellin ; Jenny Landström ; Mats Jerkeman ; Thomas Relander

Peripheral T-cell Lymphomas (PTCLs) are rare lymphomas with mostly poor outcome with current treatment. Addition of etoposide to CHOP and up-front consolidation with autologous stem cell transplantation (autoSCT) have shown promising results, but have never been tested in randomized trials. As a complement to retrospective analyses of clinical trials, we aimed at analyzing prognostic factors and outcome in an unselected, population-based cohort. Through the Swedish Lymphoma Registry we [...]

Menée au Japon auprès de 37 participants, cette étude analyse les facteurs associés au risque de neutropénie fébrile chez des patients atteints d'un cancer de la prostate résistant à la castration et recevant une chimiothérapie à base de docétaxel

Risk factors for febrile neutropenia in patients receiving docetaxel chemotherapy for castration-resistant prostate cancer

Shiota, Masaki ; Yokomizo, Akira ; Takeuchi, Ario ; Kiyoshima, Keijiro ; Inokuchi, Junichi ; Tatsugami, Katsunori ; Naito, Seiji

Purpose : Docetaxel is a standard therapy for patients with castration-resistant prostate cancer (CRPC). However, docetaxel-associated adverse events (AEs) such as febrile neutropenia (FN) can impair quality of life and may become life-threatening. In this study, we clarified the AEs and risk factors associated with FN in clinical settings. Methods : This study included 37 Japanese patients with CRPC who were treated with 70–75 mg/m2 docetaxel and 10 mg prednisone every 3 or 4 weeks between [...]

Menée au Royaume-Uni auprès de 1 598 patients atteints d'un cancer colorectal de stade de I à III, cette étude prospective évalue l'impact du niveau plasmatique de vitamine D sur leur survie

Plasma Vitamin D Concentration Influences Survival Outcome After a Diagnosis of Colorectal Cancer

Zgaga, Lina ; Theodoratou, Evropi ; Farrington, Susan M. ; Din, Farhat V.N. ; Ooi, Li Yin ; Glodzik, Dominik ; Johnston, Susan ; Tenesa, Albert ; Campbell, Harry ; Dunlop, Malcolm G.

Purpose : We investigated whether the plasma level of 25-hydroxyvitamin D (25-OHD) after a diagnosis of colorectal cancer (CRC) influences survival outcome. Patients and Methods : We prospectively studied 1,598 patients with stage I to III CRC. We sought association between plasma 25-OHD and stage-specific survival and tested for interaction between 25-OHD level and variation at the vitamin D receptor (VDR) gene locus. Blood was sampled postoperatively, and plasma was assayed for 25-OHD by [...]

Menée à partir des données de 24 essais cliniques évaluant des traitements de première ligne et incluant au total 20 023 patients atteints d'un cancer colorectal métastatique, cette étude évalue l'association entre l'âge des patients au diagnostic et la survie sans progression ou la survie globale

Association of Age With Survival in Patients With Metastatic Colorectal Cancer: Analysis From the ARCAD Clinical Trials Program

Lieu, Christopher H. ; Renfro, Lindsay A. ; de Gramont, Aimery ; Meyers, Jeffrey P. ; Maughan, Timothy S. ; Seymour, Matthew T. ; Saltz, Leonard ; Goldberg, Richard M. ; Sargent, Daniel J. ; Eckhardt, S. Gail ; Eng, Cathy

Purpose : This study addressed whether age is prognostic for overall survival (OS) or progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC). Patients and Methods : A total of 20,023 patients from 24 first-line clinical trials in the ARCAD (Aide et Recherche en Cancérologie Digestive) database were analyzed. Primary age effects and interactions with age, sex, performance status (PS), and metastatic site were modeled using Cox proportional hazards stratified by [...]

Menée aux Etats-Unis auprès de 2 342 patientes atteintes d'un cancer du sein, cette étude analyse les disparités ethniques dans l'association entre des facteurs liés au mode de vie et à l'alimentation, l'expression des gènes MAPK et la survie des patientes

Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study

Slattery, MarthaL ; Hines, LisaH ; Lundgreen, Abbie ; Baumgartner, KathyB ; Wolff, RogerK ; Stern, MarianaC ; John, EstherM

Introduction : MAPK genes are activated by a variety of factors related to growth factors, hormones, and environmental stress. Methods : We evaluated associations between 13 MAPK genes and survival among 1,187 nonHispanic White and 1,155 Hispanic/Native American (NA) women diagnosed with breast cancer. We assessed the influence of diet, lifestyle, and genetic ancestry on these associations. Percent NA ancestry was determined from 104 Ancestry Informative Markers. Adaptive rank truncation [...]

Menée au Canada auprès de 520 participantes, cette étude rétrospective analyse les facteurs associés au risque de neutropénie fébrile chez des patientes atteintes d'un cancer du sein de stade précoce et recevant un traitement adjuvant à base de fluorouracile, épirubicine, cyclophosphamide puis docétaxel (FEC-D)

Incidence of febrile neutropenia in early stage breast cancer patients receiving adjuvant FEC-D treatment

Assi, Hazem ; Murray, Joshua ; Boyle, Laura ; Rayson, Daniel

Purpose : The purpose of this study is to determine the incidence of febrile neutropenia (FN) among women receiving FEC-D (flurouracil 500 mg/m2, epirubicin 100 mg/m2, and cyclophosphamide 500 mg/m2 every 3 weeks for three cycles followed by docetaxel 100 mg/m2 every 3 weeks for three cycles) chemotherapy for early stage breast cancer (ESBC) and the impact of primary granulocyte colony-stimulating factor (G-CSF) prophylaxis in a non-clinical trial setting. Patients and methods : A retrospective [...]

A partir des données des registres américains des cancers portant sur la période 1998-2007, cette étude analyse l'évolution des dispartités ethniques et géographiques dans l'incidence et les traitements du cancer de l'endomètre

Ethnic and geographic variations in corpus uteri cancer burden: evidence based on data from 29 states and the District of Columbia. CI5 IX, X and SEER data (1998–2010)

Sighoko, Dominique

Purpose : To assess the pattern of corpus uteri cancer (CUC) in individual states of the USA according to ethnicity. Methods : Population-based cancer registries from 29 states and the District of Columbia with information on ethnicity for African-American women (AA) and Caucasian-American women (CA) were extracted from the Cancer Incidence in Five Continents (1998–2002, 2003–2007) and the Surveillance, Epidemiology, and End Results Program (SEER; 2008–2010) databases. Rate ratios (RRs) were [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2013 (39 études), cette méta-synthèse fait le point sur les expériences de survivants d'un cancer relatives à la reprise du travail ainsi que sur les stratégies mises en place pour faciliter le retour à l'emploi

Qualitative meta-synthesis of survivors’ work experiences and the development of strategies to facilitate return to work

Stergiou-Kita, Mary ; Grigorovich, Alisa ; Tseung, Victrine ; Milosevic, Elizabeth ; Hebert, Debbie ; Phan, Stephanie ; Jones, Jennifer

Purpose : To review the empirical qualitative literature on cancer survivors’ experiences of the return to work process in order to develop strategies for health and vocational professionals to facilitate return to work. Methods : A rigorous systematic search of five databases was completed to identify relevant qualitative studies published between Jan 2000 and July 2013. All potentially relevant titles and abstracts were reviewed by two reviewers. For studies that met eligibility, the [...]

Menée aux Etats-Unis auprès de 129 participantes, cette étude transversale analyse les facteurs démographiques, médicaux et psychologiques associés à la malnutrition et à la dépression chez des patientes atteintes d'un cancer gynécologique

Depression and appetite: predictors of malnutrition in gynecologic cancer

Nho, Ju-Hee ; Kim, SungReul ; Kwon, YongSoon

Purpose : The reported prevalence of malnutrition and related factors in gynecologic cancer varies. We aimed to describe nutritional status and to identify demographic, clinical, psychological, and nutritional factors contributing to malnutrition in gynecologic cancer patients. Methods : We used a descriptive cross-sectional design. A total of 129 subjects were enrolled. Subjects agreed to undergo a face-to-face interview, including measurement of body mass index (BMI) and administration of [...]

Mené en Australie, cet essai randomisé évalue l'efficacité d'une intervention de nature psychosociale destinée à réduire la détresse d'aidants familiaux de patients atteints de cancer et recevant des soins palliatifs à domicile

Reducing the psychological distress of family caregivers of home based palliative care patients: longer term effects from a randomised controlled trial

Hudson, Peter ; Trauer, Tom ; Kelly, Brian ; O'Connor, Moira ; Thomas, Kristina ; Zordan, Rachel ; Summers, Michael

Background: Palliative care incorporates comprehensive support of family caregivers because many of them experience burden and distress. However, evidence-based support initiatives are few. Purpose: We evaluated a one-to-one psychoeducational intervention aimed at mitigating the distress of caregivers of patients with advanced cancer receiving home-based palliative care. We hypothesised that caregivers would report decreased distress as assessed by the General Health Questionnaire (GHQ). [...]

A partir des données des registres américains des cancers portant sur 41 275 patients atteints d'un cancer localisé de la prostate diagnostiqué entre 2004 et 2007, cette étude évalue les effets d'une dépression sur les traitements du cancer et la survie des patients

Effect of Depression on Diagnosis, Treatment, and Mortality of Men With Clinically Localized Prostate Cancer

Prasad, Sandip M. ; Eggener, Scott E. ; Lipsitz, Stuart R. ; Irwin, Michael R. ; Ganz, Patricia A. ; Hu, Jim C.

Purpose : Although demographic, clinicopathologic, and socioeconomic differences may affect treatment and outcomes of prostate cancer, the effect of mental health disorders remains unclear. We assessed the effect of previously diagnosed depression on outcomes of men with newly diagnosed prostate cancer. Patients and Methods : We performed a population-based observational cohort study using Surveillance, Epidemiology, and End Results-Medicare linked data of 41,275 men diagnosed with clinically [...]

Menée en Australie par questionnaire auprès de 301 participants âgés de 50 à 76 ans, cette étude analyse l'impact d'une participation au dépistage du cancer colorectal et d'un résultat positif sur l'évolution de leur état psychologique pendant un an

The psychological impact of participating in colorectal cancer screening by faecal immuno-chemical testing - the Australian experience

Bobridge, A. ; Bampton, P. ; Cole, S. ; Lewis, H. ; Young, G.

Background: Occult blood-based colorectal cancer (CRC) screening may result in adverse psychological outcomes for participants. The aims of this study were to measure the psychological consequences of participating in screening at key points along the screening and diagnostic pathway, and examine variation over time within or between test outcome groups. Methods: A total of 301 people (positives=165, negatives=136) aged 50–76 years were surveyed via validated psychological questionnaires after [...]

Menée aux Etats-Unis par enquête auprès de 357 participantes, cette étude transversale analyse l'association entre les capacités cognitives de survivantes d'un cancer du sein, un traitement hormonal et des symptômes de dépression

Cognition in breast cancer survivors: hormones versus depression

Seliktar, Naomi ; Polek, Carolee ; Brooks, Ari ; Hardie, Thomas

Objective : Breast cancer survivors receiving hormone treatment and/or endorsing histories of receiving chemotherapy report changes in their cognitive capacity, which is often not supported by formal testing. To address these conflicting reports, this study examined survivors' applied cognitive capacity and its association with hormone treatment, depression, and selected demographics. Methods : A descriptive, correlational, cross-sectional survey design was employed. There were 357 women who [...]

Menée aux Etats-Unis auprès de 64 survivantes d'un cancer du sein se plaignant de troubles de la mémoire, cette étude de cohorte analyse leurs capacités d'attention et d'apprentissage à la suite des traitements anti-cancéreux

Learning and memory performance in a cohort of clinically referred breast cancer survivors: the role of attention versus forgetting in patient-reported memory complaints

Root, James C. ; Ryan, Elizabeth ; Barnett, Gregory ; Andreotti, Charissa ; Bolutayo, Kemi ; Ahles, Tim

Objective : While forgetfulness is widely reported by breast cancer survivors, studies documenting objective memory performance yield mixed, largely inconsistent, results. Failure to find consistent, objective memory issues may be due to the possibility that cancer survivors misattribute their experience of forgetfulness to primary memory issues rather than to difficulties in attention at the time of learning. Methods : To clarify potential attention issues, factor scores for Attention Span, [...]

Menée aux Pays-Bas auprès de 96 participantes, cette étude analyse leur rôle dans la prise de décision lors de consultations d'oncogénétique initiales et de suivi, leurs perceptions des risques de cancer et de leur sentiment d'auto-efficacité

Counselee participation in follow-up breast cancer genetic counselling visits and associations with achievement of the preferred role, cognitive outcomes, risk perception alignment and perceived personal control

Albada, Akke ; Ausems, Margreet G. E. M. ; van Dulmen, Sandra

The purpose of the study was to assess the counselee participation in the follow-up visits, compared to the first visits, for breast cancer genetic counselling and to explore associations with counselees’ achievement of their preferred role in decision making, information recall, knowledge, risk perception alignment and perceived personal control. First and follow-up visits for breast cancer genetic counseling of 96 counselees of a Dutch genetics center were videotaped (2008-2010). Counselees [...]

Menée aux Etats-Unis dans 18 centres de lutte contre le cancer et portant sur 25 589 patients atteints d'un cancer du sein, du côlon-rectum, du poumon ou d'un lymphome hodgkinien, cette étude de cohorte observationnelle analyse les disparités, selon les établissements, dans les décisions thérapeutiques et dans la prise en charge des patients

Interinstitutional Variation in Management Decisions for Treatment of 4 Common Types of Cancer: A Multi-institutional Cohort Study

Weeks, Jane C. ; Uno, Hajime ; Taback, Nathan ; Ting, Gladys ; Cronin, Angel ; D'Amico, Thomas A. ; Friedberg, Jonathan W. ; Schrag, Deborah

Background: When clinical practice is governed by evidence-based guidelines and there is consensus about their validity, practice variation should be minimal. For areas in which evidence gaps exist, greater variation is expected. Objective: To systematically assess interinstitutional variation in management decisions for 4 common types of cancer. Design: Multi-institutional, observational cohort study of patients with cancer diagnosed between July 2006 through May 2011 and observed through 31 [...]

A partir des données du registre écossais des cancers portant sur 958 patients atteints d'un cancer colorectal, cette étude analyse l'impact, sur le stade de la maladie et sur la survie, des délais entre la première présentation chez le médecin généraliste pour des symptômes de cancer et l'accès aux traitements

Time from first presentation in primary care to treatment of symptomatic colorectal cancer: effect on disease stage and survival

Murchie, P. ; Raja, E. A. ; Brewster, D. H. ; Campbell, N. C. ; Ritchie, L. D. ; Robertson, R. ; Samuel, L. ; Gray, N. ; Lee, A. J.

Background: British 5-year survival from colorectal cancer (CRC) is below the European average, but the reasons are unclear. This study explored if longer provider delays (time from presentation to treatment) were associated with more advanced stage disease at diagnosis and poorer survival. Methods: Data on 958 people with CRC were linked with the Scottish Cancer Registry, the Scottish Death Registry and the acute hospital discharge (SMR01) dataset. Time from first presentation in primary care [...]

Menée à Londres par entretiens auprès de 9 113 participants de faible statut socioéconomique et issus de diverses communautés ethniques et religieuses, cette étude analyse l'efficacité d'une intervention destinée à améliorer leurs connaissances relatives au dépistage du cancer colorectal

Evaluation of a service intervention to improve awareness and uptake of bowel cancer screening in ethnically-diverse areas

Shankleman, J. ; Massat, N. J. ; Khagram, L. ; Ariyanayagam, S. ; Garner, A. ; Khatoon, S. ; Rainbow, S. ; Rangrez, S. ; Colorado, Z. ; Hu, W. ; Parmar, D. ; Duffy, S. W.

Background: Uptake of bowel cancer screening is lowest in London, in populations of lower socio-economic status, and in particular ethnic or religious groups. Methods: We report on the evaluation of two interventions to improve uptake in an area including populations of low socio-economic status and considerable ethnic diversity. The interventions were face-to-face health promotion on bowel cancer screening at invitees’ general practice and health promotion delivered by telephone only. Nine [...]

Menée à Hong Kong auprès de 156 patients âgés de plus de 60 ans atteints d'une leucémie myéloïde aiguë, cette étude analyse les caractéristiques des soins de fin de vie et de l'utilisation des soins palliatifs, ainsi que les causes et lieux de décès

End-of-life characteristics and palliative care provision for elderly patients suffering from acute myeloid leukemia

Cheng, Hon-WaiBenjamin ; Li, Cho-Wing ; Chan, Kwok-Ying ; Au, Ho-Yan ; Chan, Pan-Fong ; Sin, Yim-Ching ; Szeto, Yan ; Sham, Mau-Kwong

Purpose : End-of-life care characteristics and palliative care (PC) utilization of elderly acute myeloid leukemia (AML) patients have rarely been reported. The aim of this study was to evaluate the cause of death, place of death and PC utilization of older adults (age 60 years or above) suffering from AML. Methods : Patients were recruited retrospectively from two hematology units in Hong Kong, which consisted of one university department with Bone Marrow Transplant service, and one regional [...]