Menée en Suède auprès de 471 patients atteints d'un cancer de stade avancé, cette étude analyse les facteurs associés à une perte de la masse musculaire en fin de vie

Loss of muscle mass in the end of life in patients with advanced cancer

Wallengren, Ola ; Iresjö, Britt-Marie ; Lundholm, Kent ; Bosaeus, Ingvar

Purpose : Muscle mass depletion is associated with adverse outcomes in cancer patients. There is limited information on the impact of age, sex, tumor type, and inflammation on muscle loss in the end of life of cancer patients. Methods : Muscle depletion and loss of muscle in the last 2 years of life was estimated in 471 cancer patients from 779 dual-energy X-ray absorptiometry scans. A linear mixed model was used to estimate the impact of age, sex, tumor type, and inflammation. Results : [...]

A partir des données des registres américains des cancers portant sur des patients âgés de plus de 65 ans et atteints d'un cancer diagnostiqué entre 2005 et 2007, cette étude rétrospective analyse l'association entre une utilisation à long terme d'un cathéter veineux central et le risque d'infections

Long-Term Central Venous Catheter Use and Risk of Infection in Older Adults With Cancer

Lipitz-Snyderman, Allison ; Sepkowitz, Kent A. ; Elkin, Elena B. ; Pinheiro, Laura C. ; Sima, Camelia S. ; Son, Crystal H. ; Atoria, Coral L. ; Bach, Peter B.

Purpose : Long-term central venous catheters (CVCs) are often used in patients with cancer to facilitate venous access to administer intravenous fluids and chemotherapy. CVCs can also be a source of bloodstream infections, although this risk is not well understood. We examined the impact of long-term CVC use on infection risk, independent of other risk factors such as chemotherapy, in a population-based cohort of patients with cancer. Patients and Methods : We conducted a retrospective analysis [...]

Menée aux Etats-Unis, cette étude analyse les facteurs cognitifs et psychologiques associés à l'adhésion aux stratégies de prévention du lymphœdème chez des patientes atteintes d'un cancer du sein

Factors predicting adherence to risk management behaviors of women at increased risk for developing lymphedema

Sherman, KerryA ; Miller, SuzanneM ; Roussi, Pagona ; Taylor, Alan

Purpose : Lymphedema affects 20–30 % of women following breast cancer treatment. However, even when women are informed, they do not necessarily adhere to recommended lymphedema self-management regimens. Utilizing the Cognitive-Social Health Information Processing framework, we assessed the cognitive and emotional factors influencing adherence to lymphedema risk management. Methods : Women with breast cancer who had undergone breast and lymph node surgery were recruited through the Fox Chase [...]

Menée en Belgique par entretiens auprès de 41 professionnels de santé, cette étude analyse l'intérêt et l'efficacité d'interventions d'ergothérapie dans le contexte d'une reprise du travail, pour des patientes atteintes d'un cancer du sein

What is the value of occupational therapy in return to work for breast cancer patients? A qualitative inquiry among experts

Désiron, H. A. M. ; Donceel, P. ; Godderis, L. ; Van Hoof, E. ; de Rijk, A.

An increasing number of patients are confronted with breast cancer (BC) and functional limitations after treatment. Occupational therapy (OT) is successful in return to work (RTW), but not yet available for BC patients. This paper explores experts' opinions on OT interventions for RTW in BC patients in the Belgian context. Primary data were topic-interviews with all heads of OT departments in Flemish University Hospitals (n = 5). Secondary data were four focus group interviews with care [...]

A partir d'une revue systématique de la littérature, cette étude analyse, dans la population des patients infectés par le VIH, l'incidence des cancers non spécifiques du sida, en particulier le cancer de l'anus, le lymphome hodgkinien, le carcinome hépatocellulaire et le cancer du poumon

The Evolving Scenario of Non-AIDS-Defining Cancers: Challenges and Opportunities of Care

Vaccher, Emanuela ; Serraino, Diego ; Carbone, Antonino ; De Paoli, Paolo

Background : The impact of highly active antiretroviral therapies (HAART) on the risk of non-AIDS-defining cancers (NADCs) and the role of biological and clinical factors in their pathogenesis are debated issues. The purpose of this review is to examine the epidemiology, etiology, and not-yet-defined pathogenic characteristics of NADCs and discuss topics such as treatment strategies, comorbidity, and multidrug interactions. Four types of NADCs that deserve special attention are examined: anal [...]

Menée aux Etats-Unis auprès de patients atteints d'un cancer (3 045 VIH+ et 1 087 648 VIH-), cette étude analyse les disparités dans les traitements anti-cancéreux administrés et la survie

Cancer Treatment Disparities in HIV-Infected Individuals in the United States

Suneja, Gita ; Shiels, Meredith S. ; Angulo, Rory ; Copeland, Glenn E. ; Gonsalves, Lou ; Hakenewerth, Anne M. ; Macomber, Kathryn E. ; Melville, Sharon K. ; Engels, Eric A.

Purpose : HIV-infected individuals with cancer have worse survival rates compared with their HIV-uninfected counterparts. One explanation may be differing cancer treatment; however, few studies have examined this. Patients and Methods : We used HIV and cancer registry data from Connecticut, Michigan, and Texas to study adults diagnosed with non-Hodgkin’s lymphoma, Hodgkin’s lymphoma, or cervical, lung, anal, prostate, colorectal, or breast cancers from 1996 to 2010. We used logistic regression [...]

Menée aux Etats-Unis auprès de 75 patients ayant reçu des transfusions de globules rouges pour traiter un cancer dans l'enfance, cette étude analyse la quantité de fer déposé dans divers organes en fonction des volumes transfusés et de l'âge à la transfusion

Characterization of Transfusion-Derived Iron Deposition in Childhood Cancer Survivors

Ruccione, Kathleen S. ; Wood, John C. ; Sposto, Richard ; Malvar, Jemily ; Chen, Cheng ; Freyer, David R.

Background: Childhood cancer survivors (CCS) receiving packed red blood cell (PRBC) transfusions may have increased risk for vital organ iron deposition causing serious late effects. Methods: This cross-sectional cohort study of a CCS cohort quantified organ iron content by magnetic resonance imaging. Iron status by serum markers and hemochromatosis gene mutation status were assessed. Results: Seventy-five patients who had received a range (0-392 mL/kg) of cumulative PRBC transfusion volumes [...]

A partir des données des registres américains des cancers portant sur 445 patients atteints d'une leucémie primitive à plasmocytes entre 1973 et 2009, cette étude analyse l'évolution de la survie

Trends in survival of patients with primary plasma cell leukemia: a population based analysis

Wilson I. Gonsalves, ; Vincent Rajkumar, ; Ronald S. Go, Angela Dispenzieri, ; Vinay Gupta, ; Preet P. Singh

Primary plasma cell leukemia (pPCL) is a rare malignancy with a very aggressive course and poor outcome. There has been significant improvement in the survival of multiple myeloma (MM) patients over the past decade as a result of the incorporation of autologous stem cell transplantation (ASCT) and novel agents in their treatment regimens. However, it is unknown whether these therapies have had a similar impact on the survival of patients with pPCL. We conducted an analysis of the Surveillance, [...]

A partir d'une analyse géographique de l'incidence du mélanome de l'uvée aux Etats-Unis, cette étude suggère que la fluoration de l'eau réduit le risque de la maladie

Eye Cancer Incidence in U.S. States and Access to Fluoridated Water

Schwartz, Gary G.

Environmental risk factors for uveal melanomas (cancer of the iris, ciliary body and choroid) have not been identified. In order to search for these, we examined the correlation of age-adjusted eye cancer incidence rates, a surrogate for uveal melanoma rates, in U.S. states with group level geographic and demographic factors using multivariate linear regression. Incidence rates for eye cancer were inversely correlated with the percent of the population receiving fluoridated water; i.e., higher [...]

Cet article passe en revue les travaux récents mettant en évidence un mécanisme biologique susceptible de rendre compte de l'association entre activité physique et survie des patients atteints d'un cancer colorectal

The insulin-like growth factor axis: A biological mechanism linking physical activity to colorectal cancer survival

Sax, Andrew T. ; Jenkins, David G. ; Devin, James L. ; Hughes, Gareth I. ; Bolam, Kate A. ; Skinner, Tina L.

Physical activity (PA) is related to colorectal cancer (CRC) mortality, with approximately 15% of CRC deaths worldwide attributable to physical inactivity. Moreover, higher levels of PA in CRC survivors have been associated with a reduced risk of the disease recurring. Despite the recognised nexus between PA and the risk of CRC, the physiological mechanisms underlying the inverse relationship between PA and mortality following CRC diagnosis are less apparent, with evidence primarily drawn from [...]

A partir des données des registres néerlandais des cancers, cette étude analyse l'évolution de l'incidence du cancer du sein ainsi que de la mortalité de 1990 à 2010

Breast cancer diagnosis and death in the Netherlands: a changing burden

van der Waal, Daniëlle ; Verbeek, André LM ; den Heeten, Gerard J ; Ripping, Theodora M ; Tjan-Heijnen, Vivianne CG ; Broeders, Mireille JM

Background: Lifetime risks are often used in communications on cancer to the general public. The most-cited estimate for breast cancer risk (1 in 8 women), however, appears to be outdated. Here we describe the breast cancer burden in the Netherlands over time by means of lifetime and age-conditional risks. The aim is to identify changes in absolute risk of primary breast cancer diagnosis and death. Methods: Data on breast cancer incidence, mortality and size of the female population were [...]

Menée aux Etats-Unis auprès de 3 682 participantes travaillant au Département de la Défense, cette étude analyse les disparités ethniques dans le recours à la reconstruction mammaire après une mastectomie

Breast reconstruction after mastectomy among Department of Defense beneficiaries by race

Enewold, Lindsey R. ; McGlynn, Katherine A. ; Zahm, Shelia H. ; Poudrier, Jill ; Anderson, William F. ; Shriver, Craig D. ; Zhu, Kangmin

BACKGROUND Postmastectomy breast reconstruction increased approximately 20% between 1998 and 2008 in the United States and has been found to improve body image, self-esteem, and quality of life. These procedures, however, tend to be less common among minority women, which may be due to variations in health care access. The Department of Defense provides equal health care access, thereby affording an exceptional environment in which to assess whether racial variations persist when access to care [...]

Cet article passe en revue les travaux récents sur la caractérisation des sous-types rares de cancer du sein

Rare Breast Cancer Subtypes: Histological, Molecular, and Clinical Peculiarities

Dieci, Maria Vittoria ; Orvieto, Enrico ; Dominici, Massimo ; Conte, PierFranco ; Guarneri, Valentina

Breast cancer encompasses a collection of different diseases characterized by different biological and pathological features, clinical presentation, response to treatments, clinical behavior, and outcome. On the basis of cell morphology, growth, and architecture patterns, breast cancer can be classified in up to 21 distinct histological types. Breast cancer special types, including the classic lobular invasive carcinoma, represent 25% of all breast cancers. The histological diversity of breast [...]

Menée aux Etats-Unis auprès de 402 parents et de 324 enfants (âgés de 11 à 21 ans), cette étude analyse les facteurs associés aux difficultés psychologiques et comportementales chez les enfants dont les parents sont atteints de cancer

Children of cancer patients: Prevalence and predictors of emotional and behavioral problems

Möller, Birgit ; Barkmann, Claus ; Krattenmacher, Thomas ; Kühne, Franziska ; Bergelt, Corinna ; Beierlein, Volker ; Ernst, Johanna ; Brähler, Elmar ; Flechtner, Hans-Henning ; Herzog, Wolfgang ; von Klitzing, Kai ; Führer, Daniel ; Resch, Franz ; Romer, Georg

BACKGROUND Children of patients with cancer are at increased risk for developing emotional and behavioral problems. This study explored the prevalence and predictors of emotional and behavioral problems in Children of cancer patients in a multisite research project. METHODS A cross-sectional sample of N=235 families was recruited simultaneously in 5 university medical centers. The participants, including parents (N=402) and children (N=324; ages 11-21 years) completed standardized [...]

Menée aux Etats-Unis auprès de 693 survivants d'un cancer de la prostate, cette étude analyse les facteurs associés à des idées suicidaires induites par les traitements et leur état de santé

Suicidal ideation in prostate cancer survivors: Understanding the role of physical and psychological health outcomes

Recklitis, Christopher J. ; Zhou, Eric S. ; Zwemer, Eric K. ; Hu, Jim C. ; Kantoff, Philip W.

BACKGROUND : Epidemiological studies have shown prostate cancer (PC) survivors are at an increased risk of suicide compared with the general population, but to the authors' knowledge very little is known regarding what factors are associated with this increased risk. The current study examined the prevalence of suicidal ideation (SI) and its association with cancer treatment and posttreatment physical and emotional health in a cohort of long-term PC survivors. METHODS : A total of 693 PC [...]

Menée aux Etats-Unis auprès de 6 607 participants, cette étude analyse les effets d'une couverture Medicare spécifique sur les coûts restant à charge des patients en matière de prescriptions médicamenteuses et d'utilisation des services de santé

Impact of Medicare Part D on out-of-pocket drug costs and medical use for patients with cancer

Kircher, Sheetal M. ; Johansen, Michael E. ; Nimeiri, Halla S. ; Richardson, Caroline R. ; Davis, Matthew M.

BACKGROUND Medicare Part D was designed to reduce out-of-pocket (OOP) costs for Medicare beneficiaries, but to the authors' knowledge the extent to which this occurred for patients with cancer has not been measured to date. The objective of the current study was to examine the impact of Medicare Part D eligibility on OOP cost for prescription drugs and use of medical services among patients with cancer. METHODS Using the Medical Expenditure Panel Survey (MEPS) for the years 2002 through 2010, a [...]

Cette étude passe en revue divers systèmes de soins (Danemark, Norvège, Suède, Angleterre, Pays-de-Galles, Irlande du Nord et dans trois provinces canadiennes) et analyse l'impact de l'organisation de ces différents systèmes sur la rapidité du diagnostic d'un cancer et sur la survie des patients

How might healthcare systems influence speed of cancer diagnosis: a narrative review

Brown, Sally ; Castelli, Michele ; Hunter, David J. ; Erskine, Jonathan ; Vedsted, Peter ; Foot, Catherine ; Rubin, Greg

Abstract : Striking differences exist in outcomes for cancer between developed countries with comparable healthcare systems. We compare the healthcare systems of 3 countries (Denmark, Norway, Sweden), 3 UK jurisdictions (England, Wales and Northern Ireland), 3 Canadian provinces (British Columbia, Manitoba, Ontario) and 2 Australian states (New South Wales, Victoria) using a framework which assesses the possible contribution of primary care systems to a range of health outcomes, drawing on key [...]