A partir d'une revue systématique de la littérature (8 études, 1 389 cas, 569 620 témoins), cette méta-analyse fait le point sur l'association entre l'utilisation de biphosphonates et le risque d'ostéonécrose de la mâchoire chez les patients atteints de cancer

Use of bisphosphonates and the risk of osteonecrosis among cancer patients: a systemic review and meta-analysis of the observational studies

Lee, Si-Huei ; Chan, Rai-Chi ; Chang, Shy-Shin ; Tan, Yin-Ling ; Chang, Kai-Hsiang ; Lee, MatthewC ; Chang, Huai-En ; Lee, Chien-Chang

Purpose : This study aims to systematically review observational studies evaluating the use of bisphosphonates (BPs) and risk of osteonecrosis of the jaw (ONJ) among cancer patients. Methods : PubMed, Embase, and Cochrane Library were screened from database inception to Aug 2012. Two reviewers independently identified cohort and case–control studies evaluating the use of oral or intravenous (IV) BPs and the risk of ONJ and extracted the characteristics of the studies and risk estimates. Pooled [...]

Mené en Corée auprès de 1 311 patients atteints de cancer, cet essai prospectif multicentrique analyse l'efficacité de gélules d'hydromorphone à libération prolongée pour traiter la douleur non soulagée par d'autres types d'analgésiques

A prospective, open-label, multicenter study of the clinical efficacy of extended-release hydromorphone in treating cancer pain inadequately controlled by other analgesics

Han, Hye-Suk ; Lee, KiHyeong ; Lee, KyungHee ; Ryu, JeongSeon ; Kim, YoungChul ; Park, SeungWoo ; Oh, Ho-Suk ; Park, KyungTae ; Kwon, JungHye ; Lee, PyungBok ; Lee, WonSik ; Kim, YangSoo ; Ahn, JoongBae ; Jeon, SeongWoo ; Lee, SungYong ; Seol, YoungMi ; Kang, JungHun ; Yuh, YoungJin ; Oh, SoYeon ; Kim, SukRan ; Ahn, JinSeok

Purpose : The objective of this study was to evaluate whether extended-release hydromorphone (osmotic-controlled release oral delivery system [OROS] hydromorphone) treatment provided pain relief in cancer patients whose pain was inadequately controlled by other analgesics. Methods : In this prospective, open-label, multicenter trial, patients who have sustained cancer pain with other analgesics were enrolled. After the baseline evaluation (visit 1), OROS hydromorphone was administered. Two [...]

A partir d'une revue systématique de la littérature publiée de 2000 à 2012, cette étude fait le point sur les déficiences cognitives associées à la chimiothérapie et propose des axes de réflexion afin d'élaborer des statégies de prévention et de traitement de ces déficiences dans le cadre de l'oncologie gynécologique

Cognitive impairment in gynecologic cancers: a systematic review of current approaches to diagnosis and treatment

Craig, ChristineD ; Monk, BradleyJ ; Farley, JohnH ; Chase, DanaM

Purpose : To review the etiology and assessment of chemotherapy-related cognitive impairment (CRCI). To explore current treatment and prevention strategies for CRCI and propose future research goals in the field of gynecologic oncology. Methods : Computerized searches in PubMed of cognitive impairment in cancer between 2000 and 2012 were conducted. The inclusion criteria were randomized control trials evaluating treatment of CRCI and search terms 'cognitive function, cognitive impairment, [...]

Menée au Canada auprès de 64 jeunes adultes atteints de cancer (âge moyen : 28,8 ans), cette étude analyse l'association entre le stress, une activité physique et l'existence de ressources d'aide et de soutien sociaux

Stress and physical activity in young adults treated for cancer: the moderating role of social support

Brunet, Jennifer ; Love, Caitlin ; Ramphal, Raveena ; Sabiston, CatherineM

Purpose : The first objective of the current investigation was to explore the relationships between adolescents and young adults’ (AYA) experiences of stress and social support resources (i.e., perceived social support and support group involvement) following treatment for cancer. The second objective was to examine the relationship between stress and physical activity behavior, and test if social support resources are moderators of this relationship. Methods : AYAs (N=64; mean age=28.8 years, [...]

A partir d'une revue systématique de la littérature (8 études), cette étude fait le point sur l'utilisation de la radiothérapie pour traiter la douleur des patients atteints d'un mésothéliome pleural malin

Radiotherapy for the Treatment of Pain in Malignant Pleural Mesothelioma: A Systematic Review

MacLeod, N. ; Price, A. ; O’Rourke, N. ; Fallon, M. ; Laird, B.

Abstract : Radiotherapy is commonly used to treat pain in malignant pleural mesothelioma (MPM). The purpose of this systematic review is to examine the evidence for this practice. Medline (1946-2013), Embase (1974-2013) and Central (The Cochrane Library Issue 9, 2012) databases were searched. Eligible studies met the following criteria: MPM (histological or radiological diagnosis), radiotherapy given with the intent of improving pain, response rates to radiotherapy reported, dose and [...]

A partir d'une revue systématique de la littérature (26 études), cette étude fait le point sur les expériences, les besoins et la qualité de vie de femmes américaines d'origine asiatique survivantes d'un cancer du sein

Breast cancer experience and survivorship among Asian Americans: a systematic review

Wen, Kuang-Yi ; Fang, CarolynY ; Ma, GraceX

Introduction : Breast cancer is the most common cancer in Asian American women, and the number of Asian American breast cancer survivors is rapidly increasing. Although Asian Americans are one of the fastest growing and most heterogeneous ethnic groups in the United States, limited data exist in regard to their breast cancer experience and survivorship. Methods : A systematic review of the breast cancer experience literature was conducted and included studies of Asian Americans or their [...]

Menée en Australie auprès de 112 patients atteints de glioblastome, cette étude prospective analyse le pourcentage de survivants pouvant reprendre leur emploi après une chimioradiothérapie et évalue leur qualité de vie

Employment following chemoradiotherapy in glioblastoma: a prospective case series

Gzell, Cecelia ; Wheeler, H. ; Guo, L. ; Kastelan, M. ; Back, M.

Purpose: Radiotherapy (RT) and temozolomide (TMZ) for glioblastoma (GBM) has resulted in longer survival. Uncertainties exist regarding quality of survival. This study aims to determine the rate of patients returning to previous employment (EM) following treatment. Methods : Eligible patients were diagnosed with GBM, aged 18–70 years, and treated with intensity-modulated radiotherapy to 60 Gray and TMZ (EORTC Protocol) between July 2007 and July 2011. EM was defined as paid work. Exclusion [...]

Mené au Canada auprès de 106 patients atteints d'un cancer de la tête et du cou, cet essai randomisé analyse l'efficacité du miel de manuka pour prévenir et traiter une mucite buccale causée par la radiothérapie

A randomized placebo-controlled trial of manuka honey for radiation-induced oral mucositis

Hawley, Philippa ; Hovan, Allan ; McGahan, ColleenE ; Saunders, Deborah

Background : Few treatments have the potential to reduce the severity of radiation-induced mucositis in head and neck cancer patients. Some small studies have suggested that organic honey may be a useful preventive treatment. Methods : This investigator-initiated double-blind randomized placebo-controlled trial investigated whether honey reduced the severity of radiation-induced oral mucositis (ROM). One hundred six head and neck cancer patients from the Vancouver and Sudbury Cancer Centers in [...]

Cette étude canadienne ré-évalue la mortalité par cancer, sur la période 1956–1994, dans une cohorte de salariés travaillant dans trois centrales nucléaires, en recalculant les données d'exposition et en prenant en compte les données relatives au statut socioéconomique des participants

A reanalysis of cancer mortality in Canadian nuclear workers (1956-1994) based on revised exposure and cohort data

Zablotska, L. B. ; Lane, R. S. D. ; Thompson, P. A.

Background: A 15-country study of nuclear workers reported significantly increased radiation-related risks of all cancers excluding leukaemia, with Canadian data a major factor behind the pooled results. We analysed mortality (1956–1994) in the updated Canadian cohort and provided revised risk estimates. Methods: Employment records were searched to verify and revise exposure data and to restore missing socioeconomic status. Excess relative risks per sievert (ERR/Sv) of recorded radiation dose [...]

Menée auprès de 1 922 survivants d'un cancer de l'enfance et de 341 participants sans histoire de cancer, cette étude de cohorte analyse la prévalence de symptômes de fragilité physiologique et leur association avec des morbidités ainsi qu'avec la mortalité

Physiologic Frailty As a Sign of Accelerated Aging Among Adult Survivors of Childhood Cancer: A Report From the St Jude Lifetime Cohort Study

Ness, Kirsten K. ; Krull, Kevin R. ; Jones, Kendra E. ; Mulrooney, Daniel A. ; Armstrong, Gregory T. ; Green, Daniel M. ; Chemaitilly, Wassim ; Smith, Webb A. ; Wilson, Carmen L. ; Sklar, Charles A. ; Shelton, Kyla ; Srivastava, Deo Kumar ; Ali, Sabeen ; Robison, Leslie L. ; Hudson, Melissa M.

Purpose : Frailty, a phenotype reported among 9.9% of individuals 65 years old and older (9.6% of women; 5.2% of men), has not been assessed among adult childhood cancer survivors (CCS). We estimated the prevalence of frailty and examined associations with morbidity and mortality. Methods : Participants included 1,922 CCS at least 10 years from original cancer diagnosis (men, 50.3%; mean age, 33.6 ± 8.1 years) and a comparison population of 341 participants without cancer histories. Prefrailty [...]

Menée auprès d'une cohorte de patients atteints de cancer et ayant reçu une chimiothérapie sur la période 2005-2008, cette étude américaine analyse l'incidence des maladies thromboemboliques veineuses

Venous Thromboembolism Risk in Patients With Cancer Receiving Chemotherapy: A Real-World Analysis

Lyman, Gary H. ; Eckert, Laurent ; Wang, Yanxin ; Wang, Hongwei ; Cohen, Alexander

Introduction. The occurrence of malignant disease increases the risk for venous thromboembolism (VTE). Here we evaluate the risk for VTE in a large unselected cohort of patients with cancer receiving chemotherapy. Methods. The United States IMPACT health care claims database was retrospectively analyzed to identify patients with a range of solid tumors who started chemotherapy from January 2005 through December 2008. International Classification of Diseases, 9th revision, Clinical Modification [...]

A partir de données portant sur 2 031 patients chinois atteints d'un cancer de l'œsophage et ayant subi une œsophagectomie, cette méta-analyse évalue l'association entre l'indice de masse corporelle et les complications post-opératoires, ainsi que la survie

The impact of body mass index on complication and survival in resected oesophageal cancer: a clinical-based cohort and meta-analysis

Zhang, S. S. ; Yang, H. ; Luo, K. J. ; Huang, Q. Y. ; Chen, J. Y. ; Yang, F. ; Cai, X. L. ; Xie, X. ; Liu, Q. W. ; Bella, A. E. ; Hu, R. G. ; Wen, J. ; Hu, Y. ; Fu, J. H.

Background: Body mass index (BMI) has been associated with the risk of oesophageal cancer. But the influence of BMI on postoperative complication and prognosis has always been controversial. Methods: In total, 2031 consecutive patients who underwent oesophagectomy between 1998 and 2008 were classified according to Asian-specific BMI (kg m−2) cutoff values. The impact of BMI on overall survival (OS) was estimated using the Kaplan–Meier method and Cox proportional hazard models. We performed a [...]

Cette étude analyse l'évolution de la mortalité par cancer de la plèvre et présente des projections sur la période 2011-2020 en Espagne

Pleural cancer mortality in Spain: time-trends and updating of predictions up to 2020

López-Abente, Gonzalo ; Garcia-Gomez, Montserrat ; Menendez-Navarro, Alfredo ; Fernandez-Navarro, Pablo ; Ramis, Rebeca ; Garcia-Perez, Javier ; Cervantes, Marta ; Ferreras, Eva ; Jimenez-Munoz, Maria ; Pastor-Barriuso, Roberto

BACKGROUND:A total of 2,514,346 metric tons (Mt) of asbestos were imported into Spain from 1906 until the ban on asbestos in 2002. Our objective was to study pleural cancer mortality trends as an indicator of mesothelioma mortality and update mortality predictions for the periods 2011-2015 and 2016-2020 in Spain. METHODS:Log-linear Poisson models were fitted to study the effect of age, period of death and birth cohort (APC) on mortality trends. Change points in cohort- and period-effect [...]

A partir des données d'un registre américain des cancers portant sur 193 survivants d'un cancer du poumon (âge moyen : 63,1 ans), cette étude analyse les disparités dans leur santé psychique (symptômes d'anxiété, de dépression) associées à un lieu de résidence urbain ou rural

Disparities in mental health outcomes among lung cancer survivors associated with ruralness of residence

Andrykowski, Michael A. ; Steffens, Rachel F. ; Bush, Heather M. ; Tucker, Thomas C.

Objective : Healthy People 2020 identifies elimination of health disparities as a key aim. Rural residence is associated with disparities in cancer screening, physical morbidity, and survival. The present study aimed to identify potential disparities in mental health (MH) outcomes (e.g., anxiety and depression symptoms, distress) in lung cancer (LC) survivors associated with ruralness of residence. Methods : Lung cancer survivors (LC group; n = 193; mean age = 63.1 years; mean time since [...]

A partir des données des registres américains des cancers portant sur 11 216 patients, cette étude analyse les disparités ethniques dans les consultations auprès d'un spécialiste, dans les traitements reçus, et évalue l'impact des ces disparités sur la survie des patients atteints d'un cancer colorectal métastatique

Racial Disparity in Consultation, Treatment, and the Impact on Survival in Metastatic Colorectal Cancer

Simpson, Daniel R. ; Martínez, María Elena ; Gupta, Samir ; Hattangadi-Gluth, Jona ; Mell, Loren K. ; Heestand, Gregory ; Fanta, Paul ; Ramamoorthy, Sonia ; Le, Quynh-Thu ; Murphy, James D.

Background : Black patients with metastatic colorectal cancer have inferior survival compared to white patients. The purpose of this study was to examine disparity in specialist consultation and multimodality treatment and the impact that treatment inequality has on survival. Methods : We identified 9935 non-Hispanic white and 1281 black patients with stage IV colorectal cancer aged 66 years and older from the Surveillance, Epidemiology, and End Results (SEER)–Medicare linked database. Logistic [...]

A partir de données portant sur 26 200 patients, cette étude de cohorte danoise analyse l'incidence de métastases pulmonaires synchrones chez des patients atteints de cancer colorectal, ainsi que leur survie

Occurrence and survival of synchronous pulmonary metastases in colorectal cancer: A nationwide cohort study

Nordholm-Carstensen, Andreas ; Krarup, Peter-Martin ; Jorgensen, Lars N. ; Wille-Jørgensen, Peer A. ; Harling, Henrik

To investigate the occurrence of synchronous colorectal cancer metastases (SCCM) confined to the lungs, risk factors for these metastases and their impact on survival. In a nationwide cohort study of 26,200patients data were prospectively entered into the Danish Colorectal Cancer Group’s (DCCG’s) database between May 2001 and December 2011. The recorded data were merged with data from the Danish Pathology Registry and the National Patient Registry. Multivariable logistic- and extended Cox [...]

Menée aux Etats-Unis auprès de 585 patientes atteintes d'un cancer du sein nouvellement diagnostiqué et âgées de moins de 40 ans, cette étude de cohorte prospective multicentrique analyse les délais entre l'apparition des premiers symptômes de la maladie et le diagnostic de cancer

Breast cancer presentation and diagnostic delays in young women

Ruddy, Kathryn J. ; Gelber, Shari ; Tamimi, Rulla M. ; Schapira, Lidia ; Come, Steven E. ; Meyer, Meghan E. ; Winer, Eric P. ; Partridge, Ann H.

BACKGROUND Young women may experience delays in diagnosis of breast cancer, and these delays may contribute to poorer outcomes. METHODS In a prospective, multicenter cohort study, women recently diagnosed with breast cancer at age ≤40 years were surveyed regarding their initial signs or symptoms of cancer and delays in diagnosis. Self delay was defined as ≥90 days between the first sign or symptom and a patient's first visit to consult a health care provider. Care delay was defined as ≥90 days [...]

Menée à partir des données du registre néerlandais des cancers portant sur 205 827 patientes âgées de 15 à 89 ans atteintes d'un cancer du sein diagnostiqué entre 1989 et 2008, cette étude analyse la survie à cinq ans

Small but significant excess mortality compared with the general population for long-term survivors of breast cancer in the Netherlands

Janssen-Heijnen, M. L. G. ; van Steenbergen, L. N. ; Voogd, A. C. ; Tjan-Heijnen, V. C. G. ; Nijhuis, P. H. ; Poortmans, P. M. ; Coebergh, J. W. W. ; van Spronsen, D. J.

Background : Coinciding with the relatively good and improving prognosis for patients with stage I–III breast cancer, late recurrences, new primary tumours and late side-effects of treatment may occur. We gained insight into prognosis for long-term breast cancer survivors. Patients and methods : Data on all 205 827 females aged 15–89 diagnosed with stage I–III breast cancer during 1989–2008 were derived from the Netherlands Cancer Registry. Conditional 5-year relative survival was calculated [...]

A partir de données suédoises portant sur 20 543 cas et 204 163 témoins, cette étude analyse la mortalité après un diagnostic de tumeurs cérébrales chez des patients atteints de sclérose en plaques

Mortality following a brain tumour diagnosis in patients with multiple sclerosis

Montgomery, Scott ; Hassan, Ahmad ; Bahmanyar, Shahram ; Brus, Ole ; Hussein, Oula ; Hiyoshi, Ayako ; Hillert, Jan ; Olsson, Tomas ; Fall, Katja

Objectives : As brain tumours and their treatment may theoretically have a poorer prognosis in inflammatory central nervous system diseases such as multiple sclerosis (MS), all-cause mortality following a brain tumour diagnosis was compared between patients with and without MS. The potential role of age at tumour diagnosis was also examined.Setting Hospital inpatients in Sweden with assessment of mortality in hospital or following discharge. Participants : Swedish national registers identified [...]

Cette étude analyse l'évolution de l'incidence des cancers de la cavité buccale et des cancers oropharyngés dans les cinq continents, sur la période 1983-2002

Worldwide Trends in Incidence Rates for Oral Cavity and Oropharyngeal Cancers

Chaturvedi, Anil K. ; Anderson, William F. ; Lortet-Tieulent, Joannie ; Curado, Maria Paula ; Ferlay, Jacques ; Franceschi, Silvia ; Rosenberg, Philip S. ; Bray, Freddie ; Gillison, Maura L.

Purpose : Human papillomavirus (HPV) has been identified as the cause of the increasing oropharyngeal cancer (OPC) incidence in some countries. To investigate whether this represents a global phenomenon, we evaluated incidence trends for OPCs and oral cavity cancers (OCCs) in 23 countries across four continents. Methods : We used data from the Cancer Incidence in Five Continents database Volumes VI to IX (years 1983 to 2002). Using age-period-cohort modeling, incidence trends for OPCs were [...]

Menée par entretiens auprès de 30 survivants adultes d'un cancer de l'enfance, cette étude canadienne analyse les problématiques associées à leur santé physique et psychologique les ayant conduits à un isolement social progressif

Trajectories of social isolation in adult survivors of childhood cancer

Howard, A. Fuchsia ; Tan de Bibiana, Jason ; Smillie, Kirsten ; Goddard, Karen ; Pritchard, Sheila ; Olson, Rob ; Kazanjian, Arminee

Purpose : Long-term childhood cancer survivors may be at increased risk for poor social outcomes as a result of their cancer treatment, as well as physical and psychological health problems. Yet, important challenges, namely social isolation, are not well understood. Moreover, survivors' perspectives of social isolation as well as the ways in which this might evolve through young adulthood have yet to be investigated. The purpose of this research was to describe the trajectories of social [...]

Menée en Espagne par entretiens auprès de 23 infirmières aidant des patients atteints de cancer dans les six derniers mois de leur vie, cette étude qualitative analyse le rôle de la foi religieuse dans les soins dispensés aux patients en phase terminale

Religious faith in coping with terminal cancer: what is the nursing experience?

Granero-Molina, J. ; Díaz Cortés, M. M. ; Márquez Membrive, J. ; Castro-Sánchez, A. M. ; López Entrambasaguas, O. M. ; Fernández-Sola, C.

This qualitative study describes nurses’ reports on the role played by religious faith in the care of patients with terminal cancer. Using Gadamer's philosophical hermeneutics and C. Roy's adaptation model as a base, in-depth interviews were carried out with 23 nurses who had cared for patients with terminal cancer for at least 6 months. Three main themes emerged when a Gadamerian-based hermeneutic research method was applied: faith facilitates the coping process in cases of terminal cancer, [...]

Menée par entretiens auprès de 25 survivants d'un cancer, cette étude américaine qualitative analyse leurs expériences et leur utilisation de programmes en ligne pour gérer la détresse liée à la maladie

Internet-based interventions for cancer-related distress: exploring the experiences of those whose needs are not met

Gorlick, Amanda ; Bantum, Erin O'Carroll ; Owen, Jason E.

Objective : Low levels of engagement in Internet-based interventions are common. Understanding users' experiences with these interventions is a key to improving efficacy. Although qualitative methods are well-suited for this purpose, few qualitative studies have been conducted in this area. In the present study, we assessed experiences with an Internet-based intervention among cancer survivors who made minimal use of the intervention. Methods : Semi-structured interviews were conducted with 25 [...]

Cette étude fait le point sur l'utilisation internationale d'un outil permettant de dépister et de mesurer la détresse psychologique des patients atteints de cancer, avec des cultures et des langues différentes

Validation of the Distress Thermometer worldwide: state of the science

Donovan, Kristine A. ; Grassi, Luigi ; McGinty, Heather L. ; Jacobsen, Paul B.

Background : The Distress Thermometer (DT) has been used in psycho-oncology research across the globe and has been recommended as a clinical tool to be used routinely in cancer settings to detect clinically significant distress. We sought to characterize the translation and validation of the DT in cancer patients in different countries and cultures and summarize how the translated versions function to detect clinically significant distress. Methods : An electronic mail survey was sent to the [...]

A partir d'une revue systématique de la littérature (27 études), cette étude analyse les caractéristiques personnelles du médecin ayant un impact sur la qualité de la communication avec son patient atteint de cancer, ainsi que sur la survie

Clinician characteristics, communication, and patient outcome in oncology: a systematic review

De Vries, A. M. M. ; de Roten, Y. ; Meystre, C. ; Passchier, J. ; Despland, J. N. ; Stiefel, F.

Objective The aim of this study was to review the literature on clinician characteristics influencing patient–clinician communication or patient outcome in oncology. Methods Studies investigating the association of clinician characteristics with quality of communication and with outcome for adult cancer patients were systematically searched in MEDLINE, PSYINFO, PUBMED, EMBASE, CINHAL, Web of Science and The Cochrane Library up to November 2012. We used the preferred reporting items for [...]

Menée auprès de 2 260 participants (âge moyen : 59 ans), cette étude américaine analyse leur anxiété et leur détresse psychologique après un résultat positif au test de recherche de sang occulte dans les selles

Psychological Distress after a Positive Fecal Occult Blood Test Result among Members of an Integrated Healthcare Delivery System

Laing, Sharon S. ; Bogart, Andy ; Chubak, Jessica ; Fuller, Sharon ; Green, Beverly B.

Background: Colorectal cancer screening (CRCS) reduces morbidity and mortality; however, the positive benefits might be partially offset by long-term distress following positive screening results. We examined relationships among CRC-specific worry and situational anxiety after positive fecal occult blood tests [FOBT (+)] compared to receipt of negative results. Methods: 2,260 eligible members of Group Health, an integrated healthcare delivery system, completed baseline surveys and received FOBT [...]

Menée aux Pays-Bas auprès de 27 survivantes d'un cancer du sein, cette étude qualitative analyse leurs façons de faire face à la peur d'une récidive de la maladie

How breast cancer survivors cope with fear of recurrence: a focus group study

Vries, Jolanda ; Oudsten, BrendaL ; Jacobs, PattyM E. P. ; Roukema, JanA

Purpose : The aim of this qualitative study was to examine the ways in which breast cancer survivors cope with fear of recurrence. Methods : Three focus groups were held with breast cancer survivors. Focus group interviews were recorded, transcribed verbatim, and analyzed using qualitative techniques. Coding was done on two levels: styles and strategies. Results : Twenty-seven women participated. The majority of the women (74 %) were a little anxious, and some patients (11 %) were somewhat [...]

A partir des données d'un registre américain des cancers portant sur la période 2005-2007, cette étude prospective multiethnique analyse l'évolution dans le temps du bien-être psychique et émotionnel de survivantes d'un cancer du sein

Emotional well-being years post-treatment for breast cancer: prospective, multi-ethnic, and population-based analysis

Janz, NancyK ; Friese, ChristopherR ; Li, Yun ; Graff, JohnJ ; Hamilton, AnnS ; Hawley, SarahT

Purpose : This study investigated factors associated with declines in emotional well-being (EWB) over time in breast cancer survivors. Methods : Women with breast cancer (Stages I–III) residing in Los Angeles, CA, or Detroit, MI, and reported to the Surveillance, Epidemiology, and End Results registries between June 2005 and February 2007 completed surveys at 9 months and 4 years after diagnosis. EWB was measured by the Functional Assessment of Cancer Treatment-Breast. Using a stress coping [...]

Cette étude américaine analyse le rapport coût-efficacité d'une thérapie par inhibiteurs de tyrosine kinase combinée avec une chirurgie pour traiter les patients atteints de tumeurs stromales gastrointestinales de stade avancé

The economic impact of cytoreductive surgery and tyrosine kinase inhibitor therapy in the treatment of advanced gastrointestinal stromal tumours: A Markov chain decision analysis

Look Hong, Nicole J. ; Chang, Steven L. ; Raut, Chandrajit P.

The current first-line treatment for patients with recurrent or metastatic gastrointestinal stromal tumours (GIST) is management with tyrosine kinase inhibition (TKI). There is an undefined role for surgery in the management of these patients. This study uses a cost analysis to examine the economic impact of treating patients with TKI in combination with surgery at different time-points in their treatment trajectories. A Markov chain decision analysis was modelled over a 2-year time horizon to [...]

Menée au Danemark par questionnaire, cette étude de cohorte analyse la concordance entre les informations rapportées par le patient et celles rapportées par le médecin généraliste relatives à l'intervalle de temps entre l'apparition des premiers symptômes liés au cancer et la première consultation médicale pour établir le diagnostic de la maladie

Agreement between patient-reported and doctor-reported patient intervals and date of first symptom presentation in cancer diagnosis – A population-based questionnaire study

Larsen, Mette Bach ; Hansen, Rikke Pilegaard ; Sokolowski, Ineta ; Vedsted, Peter

Danemark Background: The concept of delay in cancer diagnosis has been a scientific issue for decades, and there is still no standardised and validated way to measure the time intervals. One of the intervals that are difficult to measure is the patient interval (i.e. the period from the patient's first symptom until the first presentation to the health care system) because dates of symptom onset and first presentation are difficult to establish precisely. Further, since patients may have [...]

A partir des données de l'essai de phase III MAX, cette étude australienne analyse le rapport coût-efficacité d'un ajout de bévacizumab à la capécitabine en traitement de première ligne pour des patients atteints d'un cancer colorectal métastatique

The cost effectiveness of bevacizumab when added to capecitabine, with or without mitomycin-C, in first line treatment of metastatic colorectal cancer: Results from the Australasian phase III MAX study

Carter, Hannah E. ; Zannino, Diana ; John Simes, R. ; Schofield, Deborah J. ; Howard, Kirsten ; Zalcberg, John R. ; Price, Timothy J. ; Tebbutt, Niall C.

Based on the clinical data, bevacizumab has been approved in Australia and globally for the treatment of advanced colorectal cancer. However, limited evidence exists for its cost-effectiveness. The purpose of this study was to evaluate the cost effectiveness of adding bevacizumab to capecitabine monotherapy in patients with metastatic colorectal cancer, using data from the prospective economic evaluation conducted alongside the MAX trial. Individual patient level data on resource use and [...]

Menée en France auprès de 120 femmes atteintes d'un cancer du sein de stade I ou II (âge moyen : 55 ans), cette étude longitudinale analyse l'impact de leur communication avec le médecin sur leur qualité de vie

Perceived communication between physicians and breast cancer patients as a predicting factor of patients' health-related quality of life: a longitudinal analysis

Trudel, Julie G. ; Leduc, Nicole ; Dumont, Serge

Objective : Communication between cancer patients and healthcare providers is recognized as an important aspect of these patients' health-related quality of life (HRQOL). Nevertheless, no study has examined whether perceived communication between physicians and breast cancer patients is a determining factor in their HRQOL along the disease's trajectory. This longitudinal study aimed to ascertain whether such communication influenced the HRQOL of such women at three points in time. Methods : The [...]

Menée par enquête auprès de 81 patientes atteintes d'un cancer du sein, cette étude canadienne analyse leur utilisation d'internet pour trouver de l'information sur la maladie et ses traitements

Tangled in the Breast Cancer Web: an Evaluation of the Usage of Web-Based Information Resources by Breast Cancer Patients

Nguyen, SoniaKimAnh ; Ingledew, Paris-Ann

Canada - This study describes Internet use by breast cancer patients highlighting search patterns and examining the impact of web-based information on the clinical encounter. From September 2011 to January 2012, breast cancer patients at a cancer center completed a survey. Answers were closed and open-ended. Eighty-one patients were approached and 56 completed the survey. Forty-five (80 %) respondents used the Internet and 32 (71 %) searched for breast cancer information. All used Google as [...]