Couplée à la cohorte française E3N-EPIC et menée auprès de 328 cas et 619 témoins, cette étude évalue l'association entre le niveau de concentrations d'acides gras alimentaires ou d'acides gras du métabolisme et le risque d'adénome colorectal

Erythrocyte membrane phospholipid fatty acid concentrations and risk of colorectal adenomas : a case-control nested in the French E3N-EPIC cohort study

Cottet, Vanessa ; Collin, Melanie ; Gross, Anne-Sophie ; Boutron-Ruault, Marie Christine ; Morois, Sophie ; Clavel-Chapelon, Françoise ; Chajès, Veronique

Background: Although dietary fatty acids may influence colorectal carcinogenesis, few studies have examined the association with adenoma risk. We assessed the association between biomarkers of dietary fatty acids or metabolism of fatty acids, and the risk of colorectal adenomas in a nested case-control study from the French E3N-EPIC cohort. Methods: Among 13,106 women without prevalent cancer who completed the diet history questionnaire and provided blood samples, 328 cases of adenomatous polyp [...]

Menée en Espagne, cette étude de cohorte rétrospective évalue l'association entre la distance séparant le lieu d'habitation d'une usine d'amiante, les conditions météorologiques (principalement le vent) et le risque de mésothéliome pleural

Pleural mesothelioma in relation to meteorological conditions and residential distance from an industrial source of asbestos

Tarrés, Josep ; Albertí, Constança ; Martínez-Artés, Xavier ; Abós-Herràndiz, Rafael ; Rosell-Murphy, Magdalena ; García-Allas, Isabel ; Krier, Ilona ; Cantarell, Gloria ; Gallego, Miguel ; Canela-Soler, Jaume ; Orriols, Ramon

Objectives Few studies have focused on pleural mesothelioma and environmental exposure in individuals residing around an industrial source of asbestos. The aim of this study is to determine whether residential distance and wind conditions are related to the risk of developing pleural mesothelioma. Methods In this retrospective cohort study carried out in an area of Barcelona province (Catalonia, Spain), 24 environmental pleural mesothelioma cases were diagnosed between 2000 and 2009. We [...]

Menée dans la région du Lac Victoria en Tanzanie auprès de 185 participants, cette étude rétrospective évalue l'association entre une schistosomiase, une maladie parasitaire due à un ver hématophage, et le cancer de la vessie

Schistosomiasis and urinary bladder cancer in North Western Tanzania: a retrospective review of 185 patients

Rambau, Peter ; Chalya, Philipo ; Jackson, Kahima

INTRODUCTION:Worldwide, cancers of the urinary bladder are well known to be associated with environmental chemical carcinogens such as smoking and occupational exposure to polycyclic aromatic hydrocarbons. These cancers are typically transitional cell carcinoma (urothelial carcinoma). In areas where schistosomiasis is endemic there is a high incidence of squamous cell carcinoma of the urinary bladder. Schistosomiasis causes chronic granulomatous cystitis leading to squamous metaplasia of [...]

Menée en Australie à partir des données de 11 millions d'individus nés entre 1985 et 2005, cette étude de cohorte évalue l'association entre une exposition à des rayonnements ionisants médicaux lors d'examens de diagnostic et le risque de cancer chez l'enfant et l'adolescent

Cancer risk in 680 000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians

John D Mathews ; Anna V Forsythe ; Zoe Brady ; Martin W Butler ; Stacy K Goergen ; Graham B Byrnes ; Graham G Giles ; Anthony B Wallace ; Philip R Anderson ; Tenniel A Guiver ; Paul McGale ; Timothy M Cain ; James G Dowty ; Adrian C Bickerstaffe ; Sarah C Darby

Objective To assess the cancer risk in children and adolescents following exposure to low dose ionising radiation from diagnostic computed tomography (CT) scans. Design Population based, cohort, data linkage study in Australia. Cohort members 10.9 million people identified from Australian Medicare records, aged 0-19 years on 1 January 1985 or born between 1 January 1985 and 31 December 2005; all exposures to CT scans funded by Medicare during 1985-2005 were identified for this cohort. Cancers [...]

Menée auprès de 2 768 cas et 22 127 témoins , cette étude américaine évalue l'association entre une utilisation de médicaments antidépresseurs tricycliques et le risque de lymphome non-hodgkinien

Risk of non-Hodgkin lymphoma in relation to tricyclic antidepressant use

Lowry, Sarah J. ; Chubak, Jessica ; Press, Oliver W. ; McKnight, Barbara ; Weiss, Noel S.

We investigated the relationship between use of tricyclic antidepressants (TCAs) and risk of non-Hodgkin lymphoma (NHL). Previous studies provided some evidence of an association, but did not assess risk of NHL subtypes. Cases and controls were members of Group Health, an integrated healthcare delivery system. Cases were persons diagnosed with NHL between 1980 and 2011 at age 25 years or older; eight control subjects were matched to each case on age, sex, and length of enrollment. Information [...]

Menée auprès de 397 292 participants de la cohorte suédoise "AMORIS", cette étude évalue l'association entre le niveau sérique de phosphates inorganiques (calcium, phosphatase alcaline, glucose et créatinine) et le risque de cancer

Inorganic phosphate and the risk of cancer in the Swedish AMORIS study

Wulaningsih, Wahyu ; Michaelsson, Karl ; Garmo, Hans ; Hammar, Niklas ; Jungner, Ingmar ; Walldius, Goran ; Holmberg, Lars ; Van Hemelrijck, Mieke

BACKGROUND:Both dietary and serum levels of inorganic phosphate (Pi) have been linked to development of cancer in experimental studies. This is the first population-based study investigating the relation between serum Pi and risk of cancer in humans. METHODS:From the Swedish Apolipoprotein Mortality Risk (AMORIS) study, we selected all participants (> 20 years old) with baseline measurements of serum Pi, calcium, alkaline phosphatase, glucose, and creatinine (n = 397,292). Multivariable Cox [...]

Menée à Taïwan sur la période 2000-2010 auprès de 10 215 participants, cette étude de cohorte évalue l'association entre des mesures anthropométriques corporelles et le risque de cancer des organes internes

Waist-to-thigh ratio is a predictor of internal organ cancers in humans: findings from a cohort study

Kuang-Hung Hsu, ; Chia-Pang Shih, ; Pei-Ju Liao

Objective : Studies have shown that some specific body measures are associated with the occurrence of cancers. Few studies have demonstrated the relationship with more comprehensive approaches. This study aims to explore body measures and the combinations associated with internal organ cancers. Methods : Three-dimensional anthropometric body surface scanning data collected 10,215 participants from the health examination department in a medical center of Taiwan during 2000–2010. Follow-up was [...]

Menée en population mexicaine auprès de 97 cas et de 222 témoins, cette étude évalue l'association entre des allergies, le risque de leucémie aiguë ou de leucémie lymphoblastique aiguë chez des patients pédiatriques atteints d'une trisomie 21

Allergy and acute leukaemia in children with Down syndrome: a population study. Report from the Mexican inter-institutional group for the identification of the causes of childhood leukaemia

Nunez-Enriquez, J. C. ; Fajardo-Gutierrez, A. ; Buchan-Duran, E. P. ; Bernaldez-Rios, R. ; Medina-Sanson, A. ; Jimenez-Hernandez, E. ; Amador-Sanchez, R. ; Penaloza-Gonzalez, J. G. ; Paredes-Aguilera, R. ; Alvarez-Rodriguez, F. J. ; Bolea-Murga, V. ; de Diego Flores-Chapa, J. ; Flores-Lujano, J. ; Bekker-Mendez, V. C. ; Rivera-Luna, R. ; del Carmen Rodriguez-Zepeda, M. ; Rangel-Lopez, A. ; Dorantes-Acosta, E. M. ; Nunez-Villegas, N. ; Velazquez-Avina, M. M. ; Torres-Nava, J. R. ; Reyes-Zepeda, N. C. ; Cardenas-Cardos, R. ; Flores-Villegas, L. V. ; Martinez-Avalos, A. ; Salamanca-Gomez, F. ; Gorodezky, C. ; Arellano-Galindo, J. ; Mejia-Arangure, J. M.

Background: Allergies have been described as protective factors against the development of childhood acute leukaemia (AL). Our objective was to investigate the associations between allergy history and the development of AL and acute lymphoblastic leukaemia (ALL) in children with Down syndrome (DS). Methods: A case–control study was performed in Mexico City. The cases (n=97) were diagnosed at nine public hospitals, and the controls (n=222) were recruited at institutions for children with DS. [...]

A partir d'une revue de la littérature publiée de 1999 à 2011 (26 études), cette méta-analyse évalue l'association entre deux polymorphismes à simple nucléotide du gène CYP1A1 et le risque de leucémie

Novel Insights Into Etiologies of Leukemia: A HuGE Review and Meta-Analysis of CYP1A1 Polymorphisms and Leukemia Risk

Han, Fujun ; Tan, Yehui ; Cui, Weijiu ; Dong, Lihua ; Li, Wei

We conducted a meta-analysis to investigate the association of 2 single nucleotide polymorphisms in the cytochrome P450, family 1, subfamily 1A1 gene (CYP1A1), CYP1A1*2A and CYP1A1*2C, with the risk of developing different subtypes of leukemia in adults and children. A total of 26 studies published between 1999 and 2011 were identified by searching the PubMed, EMBASE, Medline, and Web of Science databases. The odds ratios for the CYP1A1 polymorphisms and leukemia risk were calculated. The [...]

Couplée à la cohorte européenne EPIC et portant sur 533 cas et 1 367 témoins de 49 à 69 ans, cette étude menée aux Pays-Bas analyse l'association entre l'âge, la densité mammaire et le risque de cancer du sein

Age-related Changes in Mammographic Density and Breast Cancer Risk

Lokate, Mariëtte ; Stellato, Rebecca K. ; Veldhuis, Wouter B. ; Peeters, Petra H. M. ; van Gils, Carla H.

High mammographic density is a strong breast cancer risk factor. Density normally declines with aging. We investigated whether the level of decline in mammographic density is related to breast cancer risk using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Prospect cohort. This cohort was recruited among participants of a population-based breast cancer screening program in the Netherlands between 1993 and 1997. We examined whether [...]

Cette étude évalue la relation entre des polymorphismes à simple nucléotide de six gènes de cytokines et le risque de glioblastome parmi la population chinoise Han

Genetic association between selected cytokine genes and glioblastoma in the Han Chinese population

Jin, Tianbo ; Li, Xiaolan ; Zhang, Jiayi ; Wang, Hong ; Geng, Tingting ; Li, Gang ; Gao, Guodong ; Chen, Chao

BACKGROUND:Glioblastoma (GBM) is the most malignant brain tumor. Many abnormal secretion and expression of cytokines have been found in GBM, initially speculated that the occurrence of GBM may be involved in these abnormal secretion of cytokines. This study aims to detect the association of cytokine genes with GBM. METHODS:We selected seven tag single nucleotide polymorphisms (tSNPs) in six cytokine genes, which previously reported to be associated with brain tumors, and analyzed their [...]

Menée aux Etats-Unis auprès de 631 cas et de 1 234 témoins, cette étude analyse l'association entre un reflux gastrique, des antécédents de brûlures d'estomac et le risque de carcinome épidermoïde du laryngopharynx

Gastric Reflux Is an Independent Risk Factor for Laryngopharyngeal Carcinoma

Langevin, Scott M. ; Michaud, Dominique S. ; Marsit, Carmen J. ; Nelson, Heather H. ; Birnbaum, Ariel E. ; Eliot, Melissa ; Christensen, Brock C. ; McClean, Michael D. ; Kelsey, Karl T.

Background: Gastric reflux can reach into the upper airway, inducing cellular damage in the epithelial lining. This condition is believed to be a risk factor for development of laryngopharyngeal squamous cell carcinoma (LPSCC), although the literature is conflicting. Methods: To better clarify this relationship, we assessed the association of self-reported heartburn history and medication use among 631 patients with LPSCCs and 1234 control subjects (frequency-matched on age, gender, and town of [...]