Menée sur des cellules épithéliales prostatiques primaires, cette étude identifie, dans le cadre de la prévention de la carcinogenèse, les protéines dont l'expression est affectée par le lycopène, un caroténoïde présent dans les fruits rouges

Is Lycopene an Effective Agent for Preventing Prostate Cancer?

Sporn, Michael B. ; Liby, Karen T.

The role of lycopene, an open-chain carotenoid found in tomatoes and devoid of retinoid activity, as an anticarcinogenic, chemopreventive agent, especially for use in prostate cancer, is still under active investigation. In this issue, Qui and colleagues show that lycopene induces responses in human prostate epithelial cells that are antiproliferative, antioxidative, and anti-inflammatory, as well as downregulating targets in the androgen receptor signaling pathway. In this perspective, we [...]

Menée sur des cellules épithéliales prostatiques primaires, cette étude identifie, dans le cadre de la prévention de la carcinogenèse, les protéines dont l'expression est affectée par le lycopène, un caroténoïde présent dans les fruits rouges

Effects of Lycopene on Protein Expression in Human Primary Prostatic Epithelial Cells

Qiu, Xi ; Yuan, Yang ; Vaishnav, Avani ; Tessel, Michael A. ; Nonn, Larisa ; van Breemen, Richard B.

Clinical trials and animal studies have suggested that lycopene, the red carotenoid found in tomatoes, might be useful for the prevention of prostate cancer in the diet or as a dietary supplement through a variety of chemoprevention mechanisms. As most mechanism of action studies have used prostate cancer cells or males with existing prostate cancer, we investigated the effects of lycopene on protein expression in human primary prostatic epithelial cells. After treatment with lycopene at a [...]

A partir des données de l'assurance maladie taïwanaise portant sur 260 864 patients infectés par le virus de l'hépatite C, cette étude analyse l'association entre l'utilisation de statines et le risque de carcinome hépatocellulaire (1 378 cas parmi les 35 023 utilisateurs de statines ; 26 505 cas parmi les 225 841 témoins)

Statins and the Risk of Hepatocellular Carcinoma in Patients With Hepatitis C Virus Infection

Tsan, Yu-Tse ; Lee, Chang-Hsing ; Ho, Wen-Chao ; Lin, Meng-Hung ; Wang, Jung-Der ; Chen, Pau-Chung

Purpose Statins may have protective effects against cancer, but no studies have focused on their effects in patients with chronic hepatitis C virus (HCV) infection. The purpose of this study was to investigate the association between use of statins and risk of hepatocellular carcinoma (HCC) in HCV-infected patients.Patients and Methods Ours was a population-based cohort study of 260,864 HCV-infected patients enrolled in the Taiwan National Health Insurance Research Database since January 1, [...]

A partir des données de l'assurance maladie taïwanaise portant sur 260 864 patients infectés par le virus de l'hépatite C, cette étude analyse l'association entre l'utilisation de statines et le risque de carcinome hépatocellulaire (1 378 cas parmi les 35 023 utilisateurs de statines ; 26 505 cas parmi les 225 841 témoins)

An Ounce of Prevention Is Better Than a Pound of Cure: A Patient-Centered Approach to Hepatocellular Carcinoma

Siegel, Abby B.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths worldwide. Though it is less commonly seen in the United States, age-adjusted incidence rates have tripled here over the last three decades, and overall survival remains poor for those with advanced disease. Host factors, including viral hepatitis, metabolic syndrome, alcohol use, and genetic disorders, contribute to HCC pathogenesis, both singly and in combination. HCC is notable for [...]

Menée sur 124 000 jeunes filles et femmes incluses dans une cohorte incluant plus de 2 millions de participantes vivant en Suède entre 2006 et 2010 (âge : 10 à 44 ans), cette étude évalue, du point de vue de l'incidence des verrues génitales et en fonction de l'âge à la vaccination, l'efficacité d'un vaccin quadrivalent contre une infection par le papillomavirus humain

Real World Effectiveness of Population-Based Roll Out of Human Papillomavirus Vaccination Against Rates of Genital Warts

Smith, Jennifer S. ; Weiderpass, Elisabete

Dr Leval and colleagues present novel data on the real-world effectiveness of population-based roll-out of human papillomavirus (HPV) vaccination against rates of genital warts among more than 2 million female residents of Sweden aged 10 to 44 years (1). The ability of the Swedish public health system to link unique personal identification numbers of residents to multiple registries allows an exceptional opportunity to examine impact of quadrivalent HPV vaccination on a representative sample of [...]

Menée sur 124 000 jeunes filles et femmes incluses dans une cohorte incluant plus de 2 millions de participantes vivant en Suède entre 2006 et 2010 (âge : 10 à 44 ans), cette étude évalue, du point de vue de l'incidence des verrues génitales et en fonction de l'âge à la vaccination, l'efficacité d'un vaccin quadrivalent contre une infection par le papillomavirus humain

Quadrivalent Human Papillomavirus Vaccine Effectiveness: A Swedish National Cohort Study

Leval, Amy ; Herweijer, Eva ; Ploner, Alexander ; Eloranta, Sandra ; Fridman Simard, Julia ; Dillner, Joakim ; Young, Cecilia ; Netterlid, Eva ; Sparén, Pär ; Arnheim-Dahlström, Lisen

Background Incidence of condyloma, or genital warts (GW), is the earliest possible disease outcome to measure when assessing the effectiveness of human papillomavirus (HPV) vaccination strategies. Efficacy trials that follow prespecified inclusion and exclusion criteria may not be fully generalizable to real-life HPV vaccination programs, which target a broader segment of the population. We assessed GW incidence after on-demand vaccination with quadrivalent HPV vaccine using individual-level [...]

Menée sur 124 000 jeunes filles et femmes incluses dans une cohorte incluant plus de 2 millions de participantes vivant en Suède entre 2006 et 2010 (âge : 10 à 44 ans), cette étude évalue, du point de vue de l'incidence des verrues génitales et en fonction de l'âge à la vaccination, l'efficacité d'un vaccin quadrivalent contre une infection par le papillomavirus humain

Implementing HPV Vaccinations At A Young Age is Significant For Vaccine Effectiveness

Initial vaccinations for human papillomavirus (HPV) at a young age is important for maximizing quadrivalent HPV vaccine effectiveness according to a Swedish study published March 13 in the Journal of the National Cancer Institute. HPV vaccination programs have been launched around the world in hopes of preventing cervical cancer and other HPV-related cancers. While incidence of genital warts is the earliest possible disease outcome to measure the efficacy of the HPV vaccine, the results of such [...]