A partir des données du registre bavarois des cancers, cette étude allemande évalue le risque d'un second cancer primaire lié au tabac chez des personnes ayant déjà eu un premier cancer lié au tabac

Risk of tobacco-related multiple primary cancers in Bavaria, Germany

Braisch, Ulrike ; Meyer, Martin ; Radespiel-Troger, Martin

BACKGROUND:With the prospect of increasing prevalence of cancer, the issue of multiple primary cancers becomes more relevant. The aim of this study was to estimate the risk of developing a tobacco-related subsequent primary cancer (TRSPC) in persons with a tobacco-related first primary cancer (TRFPC) compared with the general population in Bavaria, Germany.METHODS:Using data from the Population-Based Cancer Registry Bavaria, we analyzed TRFPC and TRSPC diagnosed in Bavaria between 2002 and 2008 [...]

Cette étude de cohorte américaine incluant 152 958 participants évalue l'association entre le tabagisme et le risque de lymphome non hodgkinien

The association between cigarette smoking and non-Hodgkin lymphoid neoplasms in a large US cohort study

Diver, W. ; Patel, Alpa ; Thun, Michael ; Teras, Lauren ; Gapstur, Susan

Purpose Results from studies of smoking and non-Hodgkin lymphoid neoplasms (NHL) are inconsistent. This study assessed whether this inconsistency might be due to the heterogeneous nature of the disease, to different relationships in subpopulations such as gender, or to chance. Methods We examined cigarette smoking status, initiation, intensity, and duration in relation to the risk of NHL, and subtypes of NHL in men and women from the American Cancer Society Cancer Prevention Study II Nutrition [...]

Menée aux Etats-Unis, cette étude (173 cas et 300 témoins) évalue l'association entre une infection cutanée par le papillomavirus humain et le risque de carcinome épidermoïde de la peau

Case-control study of cutaneous human papillomaviruses in squamous cell carcinomas of the skin

Iannacone, Michelle R. ; Gheit, Tarik ; Waterboer, Tim ; Giuliano, Anna R. ; Messina, Jane L. ; Fenske, Neil A. ; Cherpelis, Basil S. ; Sondak, Vernon K. ; Roetzheim, Richard G. ; Michael, Kristina M. ; Tommasino, Massimo ; Pawlita, Michael ; Rollison, Dana E.

Background: Cutaneous human papillomavirus (HPV) infection may be a risk factor for squamous cell carcinoma of the skin (SCC). Methods: To investigate the association between cutaneous HPV and SCC, a case-control study was conducted, including 173 SCC cases from a university dermatology clinic and 300 controls that screened negative for skin cancer. Serum antibodies against cutaneous HPV types in genera alpha, beta, gamma, mu, and nu were measured. Tumor tissue from 159 SCC cases was tested for [...]

Cette étude américaine (902 cas et 1 802 témoins) évalue l'association entre la prise de traitements médicamenteux de la stérilité et le risque de cancer de l'ovaire

Use of fertility drugs and risk of ovarian cancer: results from a US-based case-control study

Kurta, Michelle L. ; Moysich, Kirsten B. ; Weissfeld, Joel L. ; Youk, Ada O. ; Bunker, Clareann ; Edwards, Robert P. ; Modugno, Francesmary ; Ness, Roberta B. ; Diergaarde, Brenda

Background: Previous studies examining associations between use of fertility drugs and ovarian cancer risk have provided conflicting results. We used data from a large case-control study to determine whether fertility drug use significantly impacts ovarian cancer risk when taking into account parity, gravidity, and cause of infertility. Methods: Data from the Hormones and Ovarian Cancer Prediction (HOPE) study were used (902 cases, 1802 controls). Medical and reproductive histories were [...]

Menée en population française sur la période 2005-2008, cette étude (1 232 cas et 1 317 témoins) évalue l'association entre le travail de nuit et le risque de cancer du sein

Night work and breast cancer: A population-based case-control study in France (the CECILE study)

Menegaux, Florence ; Truong, Thérèse ; Anger, Antoinette ; Cordina-Duverger, Emilie ; Lamkarkach, Farida ; Arveux, Patrick ; Kerbrat, Pierre ; Févotte, Joëlle ; Guénel, Pascal

Night work involving disruption of circadian rhythm was suggested as a possible cause of breast cancer. We examined the role of night work in a large population-based case-control study carried out in France between 2005 and 2008. Lifetime occupational history including work schedules of each night work period was elicited in 1232 cases of breast cancer and 1317 population controls. Thirteen percent of the cases and eleven percent of the controls had ever worked on night shifts (OR = 1.27 [95% [...]

Cette étude marocaine (94 cas et 220 témoins) évalue l'association entre des polymorphismes des gènes EP300 et PCAF et le risque de carcinome hépatocellulaire

Associations of genetic variants in the transcriptional coactivators EP300 and PCAF with hepatocellular carcinoma

Akil, Abdellah ; Ezzikouri, Sayeh ; El Feydi, Abdellah Essaid ; Benazzouz, Mustapha ; Afifi, Rajaa ; Diagne, Ama Gassama ; Benjouad, Aziz ; Dejean, Anne ; Pineau, Pascal ; Benjelloun, Soumaya

Background and aims: Hepatocellular carcinoma (HCC) is a common cause of death by cancer worldwide. In Morocco, HCC is characterized by few mutations and a mild chromosome instability suggesting that epigenetic changes may represent the driving force of tumorigenesis in the region. Recently, three studies looked for an association between EP300 or PCAF polymorphisms and cancer but there is a conspicuous lack of data regarding these histone acetyltransferase (HAT) variants and HCC development. [...]

Menée sur 572 participants ayant subi un test génétique de susceptibilité à l'athérosclérose, cette étude de séquençage des exons met en évidence le taux de variants secondaires, ou fortuits, associés à une susceptibilité au cancer

Secondary Variants in Individuals Undergoing Exome Sequencing: Screening of 572 Individuals Identifies High-Penetrance Mutations in Cancer-Susceptibility Genes

Johnston, Jennifer J. ; Rubinstein, Wendy S. ; Facio, Flavia M. ; Ng, David ; Singh, Larry N ; Teer, Jamie K ; Mullikin, James C ; Biesecker, Leslie G

Genome- and exome-sequencing costs are continuing to fall, and many individuals are undergoing these assessments as research participants and patients. The issue of secondary (so-called incidental) findings in exome analysis is controversial, and data are needed on methods of detection and their frequency. We piloted secondary variant detection by analyzing exomes for mutations in cancer-susceptibility syndromes in subjects ascertained for atherosclerosis phenotypes. We performed exome [...]

A partir d'une revue systématique de la littérature (12 études de cohorte), cette méta-analyse évalue l'association entre la taille de l'individu et le risque de cancer du pancréas

Height and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies

Aune, Dagfinn ; Vieira, Ana ; Chan, Doris ; Navarro Rosenblatt, Deborah ; Vieira, Rui ; Greenwood, Darren ; Cade, Janet ; Burley, Victoria ; Norat, Teresa

Background Greater height has been associated with increased risk of several cancers, but epidemiological data on height and pancreatic cancer are inconclusive. We conducted a systematic review and meta-analysis of prospective studies to clarify these results. Methods PubMed and several other databases were searched up to September 2011. Prospective studies of height and pancreatic cancer were included. Summary relative risks were estimated by the use of a random effects model. Results We [...]

A partir des données de la cohorte "Cancer Prevention Study II Nutrition" incluant 14 241 hommes sains, cette étude évalue l'association entre le niveau sanguin de cholestérol et le risque d'un cancer agressif de la prostate

Plasma total, LDL, and HDL cholesterol and risk of aggressive prostate cancer in the Cancer Prevention Study II Nutrition Cohort

Jacobs, Eric ; Stevens, Victoria ; Newton, Christina ; Gapstur, Susan

Purpose Some recent studies have suggested that higher total cholesterol levels are positively associated with risk of aggressive prostate cancer. However, evidence about this association is limited and few studies examined cholesterol subfractions. We therefore examined associations of total, LDL, and HDL cholesterol concentrations with subsequent risk of aggressive prostate cancer within the Cancer Prevention Study II Nutrition Cohort. Methods A total of 14,241 men with no history of cancer [...]

Cet article présente un nouveau modèle d'interaction gènes-environnement dans lequel une exposition environnementale durant le développement induit, par reprogrammation épigénétique, une susceptibilité accrue au cancer à l'âge adulte

Developmental reprogramming of cancer susceptibility

Walker, Cheryl Lyn ; Ho, Shuk-mei

Gene–environment interactions have been traditionally understood to promote the acquisition of mutations that drive multistage carcinogenesis, and, in the case of inherited defects in tumour suppressor genes, additional mutations are required for cancer development. However, the developmental origins of health and disease (DOHAD) hypothesis provides an alternative model whereby environmental exposures during development increase susceptibility to cancer in adulthood, not by inducing genetic [...]

A partir des données de l'étude "Netherlands Cohort Study" (58 279 hommes âgés de 55 à 69 ans), cette étude analyse et compare l'efficacité d'une évaluation par des experts au cas par cas et d'une matrice emploi-exposition pour estimer l'exposition professionnelle à des agents cancérogènes

Comparison of expert and job-exposure matrix-based retrospective exposure assessment of occupational carcinogens in the Netherlands Cohort Study

Offermans, Nadine S M ; Vermeulen, Roel ; Burdorf, Alex ; Peters, Susan ; Goldbohm, R Alexandra ; Koeman, Tom ; van Tongeren, Martie ; Kauppinen, T ; Kant, Ijmert ; Kromhout, Hans ; van den Brandt, Piet A

Objectives Reliable retrospective exposure assessment continues to be a challenge in most population-based studies. Several methodologies exist for estimating exposures retrospectively, of which case-by-case expert assessment and job-exposure matrices (JEMs) are commonly used. This study evaluated the reliability of exposure estimates for selected carcinogens obtained through three JEMs by comparing the estimates with case-by-case expert assessment within the Netherlands Cohort Study [...]