Menée sur 853 échantillons tumoraux prélevés sur des patients atteints d'un cancer du poumon, cette étude identifie des gènes dont l'expression est associée au tabagisme des patients

Molecular Signature of Smoking in Human Lung Tissues

Bosse, Yohan ; Postma, Dirkje S. ; Sin, Don D ; Lamontagne, Maxime ; Couture, Christian ; Gaudreault, Nathalie ; Joubert, Philippe ; Wong, Vivien ; Elliott, Mark ; van den Berge, Maarten ; Brandsma, Corry A ; Tribouley, Catherine ; Malkov, Vladislav ; Tsou, Jeffrey A ; Opiteck, Gregory J ; Hogg, James C ; Sandford, Andrew J ; Timens, Wim ; Pare, Peter D ; Laviolette, Michel

Cigarette smoking is the leading risk factor for lung cancer. To identify genes deregulated by smoking and to distinguish gene expression changes that are reversible and persistent following smoking cessation, we performed genome-wide gene expression profiling on non-tumor lung tissue from 853 patients with lung cancer. Gene expression levels were compared between never- and current-smokers, and time-dependent changes in gene expression were studied in former-smokers. A total of 3,223 [...]

Menée à Shanghaï, cette étude de cohorte incluant 73 317 femmes âgées de 40 à 70 ans évalue l'association entre une consommation alimentaire de nitrates et de nitrites et le risque de cancer de la thyroïde

Thyroid cancer risk and dietary nitrate and nitrite intake in the Shanghai Women's Health Study

Aschebrook-Kilfoy, Briseis ; Shu, Xiao-Ou ; Gao, Yu-Tang ; Ji, Bu-Tian ; Yang, Gong ; Li, Hong Lan ; Rothman, Nathaniel ; Chow, Wong-Ho ; Zheng, Wei ; Ward, Mary H.

Nitrate and nitrite are precursors in the endogenous formation of N-nitroso compounds and nitrate can disrupt thyroid homeostasis by inhibiting iodide uptake. We evaluated nitrate and nitrite intake and risk of thyroid cancer in the Shanghai Women's Health Study that included 73,317 women, aged 40–70 years enrolled in 1996-2000. Dietary intake was assessed at baseline using a food frequency questionnaire. During approximately 11 years of follow-up, 164 incident thyroid cancer cases with [...]

Cette étude de cohorte suédoise (18 113 hommes et 2 292 femmes) évalue l'association entre une exposition professionnelle à des sulfates et des sulfites dans l'industrie papetière et le risque de cancer

Cancer incidence among Swedish pulp and paper mill workers: a cohort study of sulphate and sulphite mills

Andersson, Eva ; Westberg, Håkan ; Bryngelsson, Ing-Liss ; Magnuson, Anders ; Persson, Bodil

Purpose Associations between various malignancies and work in the pulp and paper industry have been reported but mostly in analyses of mortality rather than incidence. We aimed to study cancer incidence by main mill pulping process, department and gender in a Swedish cohort of pulp and paper mill workers. Methods The cohort (18,113 males and 2,292 females, enrolled from 1939 to 1999 with >1 year of employment) was followed up for cancer incidence from 1958 to 2001. Information on the [...]

Menée auprès de 34 028 femmes chinoises vivant à Singapour, cette étude de cohorte évalue l'association entre la durée du sommeil, le niveau urinaire de 6-sulfatoxymélatonine et le risque de cancer du sein (durée de suivi : 14 ans)

Sleep duration, spot urinary 6-Sulfatoxymelatonin levels and risk of breast cancer among Chinese women in Singapore

Wu, Anna H. ; Stanczyk, Frank Z. ; Wang, Renwei ; Koh, Woon-Puay ; Yuan, Jian-Min ; Yu, Mimi C.

We previously reported an inverse association between sleep duration and breast cancer risk in the prospective, population-based Singapore Chinese Health Study (SCHS) cohort1. Sleep duration was significantly, positively associated with 6-Sulfatoxymelatonin (aMT6s) levels determined in a spot urine, but aMT6s levels in breast cancer cases were lacking1. We updated the sleep duration-breast cancer association with 14 years of follow-up of 34,028 women in the SCHS. In a nested case-control study [...]

Couplée à une cohorte d'employées de l'armée danoise (18 551 participantes), cette étude (218 cas et 899 témoins) évalue l'association entre le travail posté de nuit et le risque de cancer du sein

Nested case–control study of night shift work and breast cancer risk among women in the Danish military

Hansen, Johnni ; Lassen, Christina F

Objectives Growing but limited evidence suggests that night shift work is associated with breast cancer. The authors conducted a nationwide case–control study nested within a cohort of 18 551 female military employees born in 1929–1968 to investigate the risk for breast cancer after night shift work and to explore the role of leisure time sun exposure and diurnal preference.Methods The authors documented 218 cases of breast cancer (1990–2003) and selected 899 age-matched controls from the [...]

A partir des données de la cohorte "Women’s Health Initiative" incluant 145 765 femmes âgées de 50 à 79 ans, cette étude évalue l'association entre un diabète et le risque de cancer gastrointestinal

Diabetes mellitus as a risk factor for gastrointestinal cancers among postmenopausal women

Luo, Juhua ; Chlebowski, Rowan ; Liu, Simin ; McGlynn, Katherine ; Parekh, Niyati ; White, Donna ; Margolis, Karen

Objectives While diabetes has been linked to several cancers in the gastrointestinal (GI) tract, findings have been mixed for sites other than colorectal and liver cancer. We used the Women’s Health Initiative (WHI) data and conducted a comprehensive assessment of associations between diabetes and GI malignancy (esophagus, stomach, liver, biliary, pancreas, colon, and rectal). Methods A total of 145,765 postmenopausal women aged 50–79 enrolled in the WHI were followed for a mean 10.3 years. Cox [...]

Menée à Mexico auprès de 103 participantes, cette étude cas-témoins évalue l'association entre des polymorphismes du gène DHFR chez la mère, la supplémentation en acide folique pendant la grossesse et le risque de rétinoblastome chez l'enfant

Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake

Orjuela, Manuela A. ; Cabrera-Muñoz, Lourdes ; Paul, Ligi ; Ramirez-Ortiz, Marco A. ; Liu, Xinhua ; Chen, Jia ; Mejia-Rodriguez, Fabiola ; Medina-Sanson, Aurora ; Diaz-Carreño, Silvia ; Suen, Ida H. ; Selhub, Jacob ; Ponce-Castañeda, M. Veronica

BACKGROUND: The incidence of unilateral retinoblastoma varies globally, suggesting possible environmental contributors to disease incidence. Maternal intake of naturally occurring folate from vegetables during pregnancy is associated inversely with the risk of retinoblastoma in offspring. METHODS: The authors used a case-control study design to examine the association between retinoblastoma risk and maternal variations in the folate-metabolizing genes methylenetetrahydrofolate reductase (MTHFR) [...]

A partir des données des registres américains du cancer, cette étude (1,2 million de cas et 100 000 témoins) évalue l'association entre le syndrome de fatigue chronique et le risque de cancer chez des personnées âgées de 66 à 99 ans

Chronic fatigue syndrome and subsequent risk of cancer among elderly US adults

Chang, Cindy M. ; Warren, Joan L. ; Engels, Eric A.

BACKGROUND: The cause of chronic fatigue syndrome (CFS) is unknown but is thought to be associated with immune abnormalities or infection. Because cancer can arise from similar conditions, associations between CFS and cancer were examined in a population-based case-control study among the US elderly. METHODS: Using linked Surveillance, Epidemiology, and End Results (SEER)-Medicare registry data, approximately 1.2 million cancer cases and 100,000 controls (age range, 66-99 years; 1992-2005) were [...]

A partir de l'analyse des données de 19 études menées dans 10 pays et incluant 16 895 femmes de type caucasien, cette étude identifie des variants des gènes LSP1 et RAD51L1, en association avec la densité mammaire et le risque de cancer du sein

Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk

Vachon, Celine M. ; Scott, Christopher G. ; Fasching, Peter A. ; Hall, Per ; Tamimi, Rulla M. ; Li, Jingmei ; Stone, Jennifer ; Apicella, Carmel ; Odefrey, Fabrice ; Gierach, Gretchen L. ; Jud, Sebastian M. ; Heusinger, Katharina ; Beckmann, Matthias W. ; Pollan, Marina ; Fernandez-Navarro, Pablo ; Gonzalez-Neira, Anna ; Benítez, Javier ; van Gils, Carla H. ; Lokate, Mariëtte ; Onland-Moret, N. Charlotte ; Peeters, Petra H.M. ; Brown, Judith ; Leyland, Jean ; Varghese, Jajini S. ; Easton, Douglas F. ; Thompson, Deborah J. ; Luben, Robert N. ; Warren, Ruth M.L. ; Wareham, Nicholas J. ; Loos, Ruth J.F. ; Khaw, Kay-Tee ; Ursin, Giske ; Lee, Eunjung ; Gayther, Simon A. ; Ramus, Susan J. ; Eeles, Rosalind A. ; Leach, Martin O. ; Kwan-Lim, Gek ; Couch, Fergus J. ; Giles, Graham G. ; Baglietto, Laura ; Krishnan, Kavitha ; Southey, Melissa C. ; Le Marchand, Loic ; Kolonel, Laurence N. ; Woolcott, Christy ; Maskarinec, Gertraud ; Haiman, Christopher A. ; Walker, Kate ; Johnson, Nichola ; McCormack, Valeria A. ; Biong, Margarethe ; Alnaes, Grethe I.G. ; Gram, Inger Torhild ; Kristensen, Vessela N. ; Børresen-Dale, Anne-Lise ; Lindström, Sara ; Hankinson, Susan E. ; Hunter, David J. ; Andrulis, Irene L. ; Knight, Julia A. ; Boyd, Norman F. ; Figuero, Jonine D. ; Lissowska, Jolanta ; Wesolowska, Ewa ; Peplonska, Beata ; Bukowska, Agnieszka ; Reszka, Edyta ; Liu, Jianjun ; Eriksson, Louise ; Czene, Kamila ; Audley, Tina ; Wu, Anna H. ; Pankratz, V. Shane ; Hopper, John L. ; dos-Santos-Silva, Isabel

Background: Mammographic density adjusted for age and body mass index (BMI) is a heritable marker of breast cancer susceptibility. Little is known about the biologic mechanisms underlying the association between mammographic density and breast cancer risk. We examined whether common low-penetrance breast cancer susceptibility variants contribute to interindividual differences in mammographic density measures.Methods: We established an international consortium (DENSNP) of 19 studies from 10 [...]