Menée à l'aide d'une matrice emploi-exposition et de données d'une étude espagnole portant sur 216 témoins et 174 patientes atteintes d'un cancer de l'endomètre, cette étude évalue l'association entre une exposition professionnelle aux pesticides et le risque de développer la maladie

Occupational exposure to pesticides and endometrial cancer in the Screenwide case-control study

Peñalver-Piñol, Arnau ; Benavente, Yolanda ; Frias-Gomez, Jon ; Alguacil, Juan ; Santibáñez, Miguel ; Contreras-Llanes, Manuel ; Peremiquel-Trillas, Paula ; López-Querol, Marta ; Paytubi, Sonia ; Pelegrina, Beatriz ; Onieva, Irene ; Martínez, José Manuel ; Fernandez-Gonzalez, Sergi ; Francisco, Javier de ; Caño, Victor ; Brunet, Joan ; Pineda, Marta ; Ponce, Jordi ; Matias-Guiu, Xavier ; Bosch, Francesc Xavier ; Sanjosé, Silvia de ; Alemany, Laia ; Costas, Laura

Background: Endometrial cancer is the most common gynaecological tumour in developed countries and disease burden is expected to increase over the years. Identifying modifiable risk factors may help developing strategies to reduce the expected increasing incidence of these neoplasms. Objective: This study evaluates the association between occupational exposure to pesticides and endometrial cancer using data from a recent case-control study in Spain. Methods: The analyses included data from 174 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2023 (6 articles), cette étude analyse l'association entre une exposition aux résidus de pesticides dans l'alimentation et le risque de cancer chez des adultes non exposés professionnellement

Dietary pesticide exposure and non-communicable diseases and mortality: a systematic review of prospective studies among adults

Baudry, Julia ; Rebouillat, Pauline ; Samieri, Cécilia ; Berlivet, Justine ; Kesse-Guyot, Emmanuelle

Background: Research on the effect of pesticide exposure on health has been largely focused on occupational settings. Few reviews have synthesized the associations between dietary pesticide exposure and health outcomes in non-occupationally exposed adults. Objective: We aim to summarize the evidence regarding dietary pesticide exposure and non-communicable diseases (NCD) in adults, using a systematic review of prospective studies. Methods: Electronic and manual searches were performed until [...]

Menée à partir de 15 ans de données sur la mortalité par cancer, cette étude analyse l'association entre l'intensification de la production de soja au Brésil, l'exposition de la population aux pesticides et l'incidence des cancers pédiatriques, notamment la leucémie lymphoblastique aiguë

Agricultural intensification and childhood cancer in Brazil

Skidmore, Marin Elisabeth ; Sims, Kaitlyn M. ; Gibbs, Holly K.

Over the last several decades, Brazil has become both the world’s leading soy producer and the world’s leading consumer of hazardous pesticides. Despite identified links between pesticide exposure and carcinogenesis, there has been little population-level research on the effects of pesticide intensification on broader human health in Brazil. We estimate the relationship between expanded soy production—and related community exposure to pesticides—on childhood cancer incidence using 15 y of data [...]

Menée en Finlande auprès de 400 témoins et 400 patientes atteintes d'un cancer papillaire de la thyroïde, cette étude analyse l'association entre les niveaux sériques de 19 substances per- et polyfluoroalkyles au moment de la première grossesse et le risque de développer la maladie

Prediagnostic serum concentrations of per- and polyfluoroalkyl substances and risk of papillary thyroid cancer in the Finnish Maternity Cohort

Madrigal, Jessica M. ; Troisi, Rebecca ; Surcel, Helja-Marja ; Öhman, Hanna ; Kivelä, Juha ; Kiviranta, Hannu ; Rantakokko, Panu ; Koponen, Jani ; Medgyesi, Danielle N. ; Kitahara, Cari M. ; McGlynn, Katherine A. ; Sampson, Joshua ; Albert, Paul S. ; Ward, Mary H. ; Jones, Rena R.

Human exposure to per- and polyfluoroalkyl substances (PFAS) occurs globally through contaminated food, dust, and drinking water. Studies of PFAS and thyroid cancer have been limited. We conducted a nested case-control study of prediagnostic serum levels of 19 PFAS and papillary thyroid cancer (400 cases, 400 controls) in the Finnish Maternity Cohort (pregnancies 1986-2010; follow-up through 2016), individually matched on sample year and age. We used conditional logistic regression to estimate [...]

Menée à partir de données suédoises portant sur 13 992 témoins et 1 452 patients atteints d'un lymphome à cellules du manteau dignostiqué sur la période 2000-2017 (durée moyenne de suivi : 6,6 ans), cette étude analyse le risque de second cancer lié au traitement (230 cas)

Secondary malignancies among mantle cell lymphoma patients

Abalo, Kossi D. ; Smedby, Karin E. ; Ekberg, Sara ; Eloranta, Sandra ; Pahnke, Simon ; Albertsson-Lindblad, Alexandra ; Jerkeman, Mats ; Glimelius, Ingrid

Purpose: With modern treatments, mantle cell lymphoma (MCL) patients more frequently experience long-lasting remission resulting in a growing population of long-term survivors. Follow-up care includes identification and management of treatment-related late-effects, such as secondary malignancies (SM). We conducted a population-based study to describe the burden of SM in MCL patients. Methods: All patients with a primary diagnosis of MCL, aged ≥18 years and diagnosed between 2000-2017 in Sweden [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données pangénomiques, cette étude analyse l'association entre 23 caractéristiques hématologiques et le risque de cancer du poumon par sous-type histologique

Investigating Causal Effects of Hematological Traits on Lung Cancer: A Mendelian Randomization Study

Yang, Zhanghuan ; He, Hao ; He, Guangxu ; Zeng, Chudai ; Hu, Qian

Background: Observational studies have suggested blood cell counts may act as predictors of cancer. It is not known whether these hematological traits are causally associated with lung cancer. Methods: Two-sample bi-directional univariable Mendelian Randomization (MR) and multivariable MR were performed to investigate the causal association between hematological traits and the overall risk of lung cancer and three histological subtypes [lung adenocarcinoma, squamous cell lung cancer (SqCLC), [...]

Menée en Chine à l'aide du séquençage ADN de 419 témoins, 177 femmes présentant des lésions cervicales intraépithéliales et 227 patientes atteintes d'un cancer du col de l'utérus, cette étude analyse l'association entre les polymorphismes rs10754558 et rs10733113 du gène NLRP3, l'infection par le papillomavirus humain (HPV) et le risque de cancer du col de l'utérus

Impact of NLRP3 gene polymorphisms (rs10754558 and rs10733113) on HPV infection and cervical cancer in southern Chinese population

Lu, Qingchun ; Lao, Xiaoxia ; Gan, Jinghua ; Du, Ping ; Zhou, Yingpei ; Nong, Wenzheng ; Yang, Zhige

Objective: Mutations in the NLRP3gene have previously been linked to certain forms of cancer, but there have not been any specific studies examining the association between NLRP3 polymorphisms and cervical cancer (CC). This study was therefore designed to investigate the effect of NLRP3 gene polymorphisms on HPV infection and cervical cancer in southern Chinese population. Methods: Multiplex PCR and next-generation sequencing approaches were used to assess the NLRP3 rs10754558 and rs10733113 [...]