Menée en Corée à partir de données portant sur 3 805 patients atteints d'un cancer, sur 109 patients ayant survécu à la maladie et sur 3 609 témoins en population générale, cette étude analyse l'association entre la qualité de vie et la situation professionnelle

Health-related quality of life among cancer patients and survivors and its relationship with current employment status

Kim, Woorim ; Han, Kyu-Tae ; Kim, Seungju

Introduction : Health-related quality of life (HRQoL) is an important end point to measure in cancer patients and survivors. This study investigated whether differences in HRQOL exist between cancer patients, cancer survivors, and the general population, in addition to how employment status interplays in this relationship. Methods : Data were from the 2019 Korea National Health & Nutrition Examination. HRQoL was measured using the HRQoL Instrument with 8 Items (HINT-8) index, which encompasses [...]

Menée en Australie auprès de 142 patients atteints d'un cancer de la prostate, cette étude de cohorte analyse l'intérêt d'un programme en ligne dédié à l'après-cancer et comportant différents types de soins de support pour les patients et leurs aidants

Evaluating a multicomponent survivorship programme for men with prostate cancer in Australia: a single cohort study

Yates, Patsy ; Carter, Rob ; Cockerell, Robyn ; Cowan, Donna ; Dixon, Cyril ; Lal, Anita ; Newton, Robert U ; Hart, Nicolas ; Galvão, Daniel A ; Baguley, Brenton ; Denniston, Nicholas ; Skinner, Tina ; Couper, Jeremy ; Emery, Jon ; Frydenberg, Mark ; Liu, Wei-Hong

Objective :To evaluate the implementation of a multicomponent survivorship programme for men with prostate cancer and their carers. Design A single cohort study, guided by the RE-AIM framework. Setting: Multiple health services in Australia. Participants:Men with prostate cancer and their carers, and health professionals. Intervention : A 12-month telehealth programme that provided centralised and coordinated decision and information support, exercise and nutrition management, specialised [...]

Menée à partir de données portant sur 23 296 patients atteints d'un cancer et inclus dans des essais cliniques, cette étude analyse le risque d'événements indésirables liés aux différents traitements anticancéreux systémiques (chimiothérapie, immunothérapie, thérapie ciblée), en fonction du sexe

Sex Differences in Risk of Severe Adverse Events in Patients Receiving Immunotherapy, Targeted Therapy, or Chemotherapy in Cancer Clinical Trials

Joseph M. Unger ; Riha Vaidya ; Kathy S. Albain ; Michael LeBlanc ; Lori M. Minasian ; Carolyn C. Gotay ; N. Lynn Henry ; Michael J. Fisch ; Shing M. Lee ; Charles D. Blanke ; Dawn L. Hershman

PURPOSE : Women have more adverse events (AEs) from chemotherapy than men, but few studies have investigated sex differences in immune or targeted therapies. We examined AEs by sex across different treatment domains. METHODS : We analyzed treatment-related AEs by sex in SWOG phase II and III clinical trials conducted between 1980 and 2019, excluding sex-specific cancers. AE codes and grade were categorized using the Common Terminology Criteria for Adverse Events. Symptomatic AEs were defined as [...]

Cette étude présente une projection de la mortalité par cancer dans les pays de l'Union européenne pour l'année 2022, en mettant en avant la mortalité par cancer de l'ovaire

European cancer mortality predictions for the year 2022 with focus on ovarian cancer

Dalmartello, M. ; La Vecchia, C. ; Bertuccio, P. ; Boffetta, P. ; Levi, F. ; Negri, E. ; Malvezzi, M.

Background : Cancer mortality rates, though not absolute numbers of deaths, have been decreasing over the last three decades in Europe. Materials and methods : We estimated projections and the number of avoided deaths for total cancer mortality and 10 major cancer sites, between 1989 and 2022, for the European Union (EU), the UK, France, Germany, Italy, Poland and Spain using cancer death certification and population data since 1970 from the World Health Organization and Eurostat. Results : In [...]

Menée en Italie à partir de données portant sur 8 158 patients atteints d'un cancer du pancréas entre 2003 et 2011, cette étude analyse l'association entre une utilisation d'inhibiteurs de l'enzyme de conversion de l'angiotensine après le diagnostic et la survie ainsi que le risque de décès

Angiotensin blockade therapy and survival in pancreatic cancer: a population study

Keith, Scott W. ; Maio, Vittorio ; Arafat, Hwyda A. ; Alcusky, Matthew ; Karagiannis, Thomas ; Rabinowitz, Carol ; Lavu, Harish ; Louis, Daniel Z.

Background : Pancreatic cancer (PC) is one of the most aggressive and challenging cancer types to effectively treat, ranking as the fourth-leading cause of cancer death in the United States. We investigated if exposures to angiotensin II receptor blockers (ARBs) or angiotensin I converting enzyme (ACE) inhibitors after PC diagnosis are associated with survival. Methods : PC patients were identified by ICD-9 diagnosis and procedure codes among the 3.7 million adults living in the Emilia-Romagna [...]

Menée aux Etats-Unis auprès de 76 couples dont l'un des partenaires est atteint d'un cancer de stade avancé (cancer du poumon de stade III/V ou tumeur cérébrale de grade III/IV), cette étude analyse la présence de difficultés financières et évalue l'impact de ces difficultés sur les symptômes et la qualité de vie

Financial distress and its associated burden in couples coping with an advanced cancer

Kroll, Juliet L. ; Kim, Seokhun ; Cho, Dalnim ; Weathers, Shiao-Pei ; Chen, Aileen B. ; Smith, Grace ; Bruera, Eduardo ; Milbury, Kathrin

Purpose : In efforts to understand financial distress (FD) associated with advanced cancer care from the perspective of both patients with incurable disease and their spousal caregivers, we assessed FD in both members of the couple, identified symptom and quality of life (QOL) correlates, and examined the potential role of illness communication. Methods : Patients undergoing treatment for stage III/IV lung cancer or a grade III/IV primary brain tumor and their spousal caregivers (n = 76 dyads) [...]

Menée auprès de 430 patients atteints d'un cancer et ayant reçu une greffe de cellules souches hématopoïétiques, cette étude identifie les facteurs associés à la croissance posttraumatique

Predictors of Posttraumatic Growth Among Hematopoietic Cell Transplant Recipients

Schwartz, Jessica R. ; Thomas, Emily B. K. ; Juckett, Mark B. ; Costanzo, Erin S.

Objective : Prior research has shown that cancer survivors often report positive psychological changes from the experience of cancer, or posttraumatic growth (PTG). However, few studies have focused on PTG in cancer patients recovering from hematopoietic cell transplantation (HCT). The present study measured PTG at specific milestones during the year following HCT and investigated psychosocial and treatment-related factors that may hinder or facilitate PTG. Methods : Participants (N = 430) [...]

Menée à partir de données portant sur 519 patientes atteintes d'un cancer du sein et sur 338 témoins, cette étude analyse l'association entre la présence d'une inflammation et des difficultés dans l'attention et la rapidité de traitement des informations, avant et après la chimiothérapie

Inflammation, Attention, and Processing Speed in Patients with Breast Cancer before and after Chemotherapy

Belcher, Elizabeth K ; Culakova, Eva ; Gilmore, Nikesha J ; Hardy, Sara J ; Kleckner, Amber S ; Kleckner, Ian R ; Lei, Lianlian ; Heckler, Charles ; Sohn, Michael B ; Thompson, Bryan D ; Lotta, Louis T, Jr ; Werner, Zachary A ; Geer, Jodi ; Hopkins, Judith O ; Corso, Steven W ; Rich, David Q ; van Wijngaarden, Edwin ; Janelsins, Michelle C

Background : Inflammation may contribute to cognitive difficulties in patients with breast cancer. We tested two hypotheses: inflammation is elevated in patients versus control subjects, and inflammation is associated with worse attention and processing speed over the course of chemotherapy. Methods : Serum cytokines (IL-4, 6, 8, 10; TNF-  [...]

Menée aux Etats-Unis par questionnaire auprès de 1 576 patients atteints d'un cancer, cette étude prospective analyse l'association entre une hospitalisation non programmée, la durée du séjour, les symptômes et la satisfaction vis-à-vis de la qualité et de la coordination des soins reçus

Associations of patient-reported care satisfaction with symptom burden and healthcare use in hospitalized patients with cancer

Qian, Carolyn L. ; Kaslow-Zieve, Emilia R. ; Azoba, Chinenye C. ; Horick, Nora ; Wang, Irene ; Van Seventer, Emily ; Newcomb, Richard ; Cashavelly, Barbara J. ; Jackson, Vicki A. ; Ryan, David P. ; Greer, Joseph A. ; El-Jawahri, Areej ; Temel, Jennifer S. ; Nipp, Ryan D.

Background : Hospitalized patients with cancer often experience a high symptom burden, which may impact care satisfaction and healthcare utilization. Methods : We prospectively enrolled patients with cancer and unplanned hospitalizations from September 2014 to April 2017. Upon admission, we assessed patients’ care satisfaction (FAMCARE items: satisfaction with care coordination and speed with which symptoms are treated) and physical (Edmonton Symptom Assessment System [ESAS]) and psychological [...]

Menée dans un contexte américain, cette étude compare le rapport coût-efficacité de deux stratégies thérapeutiques pour les patients atteints d'un cancer du rectum de stade localement avancé et résécable, l'une comportant une radiothérapie de courte durée et une thérapie néoadjuvante totale (traitement de type SCRT-TNT) suivie d'une excision mésorectale totale, et l'autre comportant une chimioradiothérapie conventionnelle de longue durée (traitement de type LCCRT) suivie d'une excision mésorectale totale et d'une chimiothérapie adjuvante

Cost-effectiveness of Total Neoadjuvant Therapy With Short-Course Radiotherapy for Resectable Locally Advanced Rectal Cancer

Chin, Re-I ; Otegbeye, Ebunoluwa E. ; Kang, Kylie H. ; Chang, Su-Hsin ; McHenry, Scott ; Roy, Amit ; Chapman, William C., Jr ; Henke, Lauren E. ; Badiyan, Shahed N. ; Pedersen, Katrina ; Tan, Benjamin R. ; Glasgow, Sean C. ; Mutch, Matthew G. ; Samson, Pamela P. ; Kim, Hyun

Importance : Short-course radiotherapy and total neoadjuvant therapy (SCRT-TNT) followed by total mesorectal excision (TME) has emerged as a new treatment paradigm for patients with locally advanced rectal adenocarcinoma. However, the economic implication of this treatment strategy has not been compared with that of conventional long-course chemoradiotherapy (LCCRT) followed by TME with adjuvant chemotherapy. Objective : To perform a cost-effectiveness analysis of SCRT-TNT vs LCCRT in [...]

Menée en Asie (Japon, Corée, Taïwan) à partir de données portant sur 1 530 patients atteints d'un cancer en phase terminale, cette étude analyse l'association entre le niveau d'hydratation artificielle et la qualité du décès

Association between the amount of artificial hydration and quality of dying among terminally ill patients with cancer: The East Asian Collaborative Cross-Cultural Study to Elucidate the Dying Process

Wu, Chien-Yi ; Chen, Ping-Jen ; Cheng, Shao-Yi ; Suh, Sang-Yeon ; Huang, Hsien-Liang ; Lin, Wen-Yuan ; Hiratsuka, Yusuke ; Kim, Sun-Hyun ; Yamaguchi, Takashi ; Morita, Tatsuya ; Tsuneto, Satoru ; Mori, Masanori ; EASED Investigators

Background : Artificial hydration (AH) is a challenging issue in terminally ill patients with cancer, because it influences patients' symptoms control, quality of life, and quality of dying (QOD). To date, it is not clear how much AH supply is proper for imminently dying patients. This study aimed to investigate the association between the amount of AH and QOD. Methods : This study is part of the East Asian Collaborative Cross-Cultural Study to Elucidate the Dying Process (EASED) conducted in [...]