Menée à partir des données de l'étude française NutriNet-Santé portant sur 101 279 participants (78,7 % de femmes ; âge moyen : 42,2 ans ; durée médiane de suivi : 5,9 ans), cette étude analyse l'association entre la consommation de produits laitiers (au total et par sous-type) et le risque de cancer (2 503 cas)

Dairy product consumption and risk of cancer: a short report from the NutriNet-Santé prospective cohort study

Deschasaux-Tanguy, Mélanie ; Barrubés Piñol, Laura ; Sellem, Laury ; Debras, Charlotte ; Srour, Bernard ; Chazelas, Eloi ; Wendeu-Foyet, Gaëlle ; Hercberg, Serge ; Galan, Pilar ; Kesse-Guyot, Emmanuelle ; Julia, Chantal ; Babio Sánchez, Nancy Elvira ; Salas Salvadó, Jordi ; Touvier, Mathilde

The impact of dairy product consumption for long-term health remains unclear, in particular regarding their involvement in cancer etiology for frequent locations like breast or prostate. Besides, little is known about potentially different effects of dairy producto subtypes. Our objective was therefore to evaluate the associations between dairy product consumption (total and subtypes) and cancer risk. A total of 101,279 participants from the French NutriNet-Santé cohort study were included [...]

Menée à partir des données 2011-2017 d'une étude multicentrique italienne portant sur 774 témoins et 867 patients atteints d'un lymphome, cette étude analyse l'association entre le travail posté de nuit et le risque de développer la maladie, par sous-type

Night shift work and lymphoma: results from an Italian multicentre case–control study

Cocco, Pierluigi ; Piro, Sara ; Meloni, Federico ; Montagna, Andrea ; Pani, Michele ; Pilia, Ilaria ; Padoan, Marina ; Miligi, Lucia ; Magnani, Corrado ; Gambelunghe, Angela ; Muzi, Giacomo ; Ferri, Giovanni Maria ; Vimercati, Luigi ; Zanotti, Roberta ; Scarpa, Aldo ; Zucca, Mariagrazia ; Latte, Gian Carlo ; Angelucci, Emanuele ; De Matteis, Sara ; Puligheddu, Monica

Background: Night shift work can disrupt circadian rhythm and cause chronic sleep deprivation, which might increase the risk of lymphoma through immunosuppression and oxidative stress. Material and methods: We investigated the association between night shift work and risk of lymphoma subtypes in 867 incident cases and 774 controls, who participated in a multicentre Italian study between 2011 and 2017. Based on questionnaire information, occupational experts assessed the lifetime probability of [...]

Menée au Canada à l'aide d'une matrice emplois-expositions et menée auprès de 147 patients atteints d'un cancer du poumon et 1 032 témoins, cette étude analyse l'association entre une exposition professionnelle à 27 agents et le risque de développer la maladie

Occupational Exposures and Lung Cancer Risk – An Analysis of the CARTaGENE Study

Moayedi-Nia, Saeedeh ; Pasquet, Romain ; Siemiatycki, Jack ; Koushik, Anita ; Ho, Vikki

Objective: To the determine associations between prevalent occupational agents and lung cancer risk. Methods: A case-cohort design (ncases=147; nsub-cohort=1,032) was nested within the CARTaGENE prospective cohort study. The Canadian Job Exposure Matrix was used to determine the probability of exposure to 27 agents in participants’ longest-held jobs. Multivariable logistic regression with robust variance estimators was used to determine the associations between each agent and lung cancer risk [...]

Menée à partir de données de la "UK Biobank" portant sur 133 416 hommes, cette étude analyse l'association entre le travail posté de nuit, le variant rs10830963 du gène MTNR1B (codant pour le récepteur de la mélatonine) et le risque de cancer de la prostate

Night shift work, MTNR1B rs10830963 polymorphism and prostate cancer risk: Findings from a prospective, population-based study

Yang, Lulu ; Chen, Jie ; Feng, Hongliang ; Ai, Sizhi ; Liu, Yue ; Chen, Xinru ; Lei, Binbin ; Chan, Joey WY ; Chau, Steven Wai Ho ; Tse, Lap Ah ; Ho, Amy Wing-Yin ; Ho, Chung Shun ; Wing, Yun Kwok ; Zhang, Jihui

Background: The association between night shift work and prostate cancer is controversial. Evidence shows that genetic and environmental factors both contribute to the development of prostate cancer. It is well-known that melatonin plays a protective role in prostate cancer. MTNR1B rs10830963 influences the dynamics of melatonin secretion, and night shift work, which disrupts our internal circadian rhythms, also dysregulates the production of melatonin. Therefore, we aimed to examine the [...]

Menée à partir de données 1998-2016 des cohortes "the Nurses’ Health Studies" et "the Health Professionals Follow-Up Study" (durée de suivi : 2 745 862 personnes-années), cette étude analyse l'association entre des résidus de pesticides provenant de la consommation de fruits et de légumes et le risque de gliome (275 cas)

Pesticide residue intake from fruit and vegetable consumption and risk of glioma

Cote, David J ; Bever, Alaina M ; Chiu, Yu-Han ; Sandoval-Insausti, Helena ; Smith-Warner, Stephanie A ; Chavarro, Jorge E ; Stampfer, Meir J

Several studies have identified positive associations between pesticides and glioma. We aimed to determine whether intake of pesticide residues from fruits and vegetables (FV) was associated with glioma. Within three prospective cohorts from 1998-2016—the Nurses’ Health Study (NHS), Nurses’ Health Study II (NHSII), and Health Professionals Follow-Up Study (HPFS)—we computed multivariable-adjusted (MV) hazard ratios (HR) and 95% confidence intervals (CI) for glioma by quintiles of intake of low [...]

A partir d'une revue systématique de la littérature publiée jusqu'en août 2020 (58 méta-analyses), cette étude évalue l'association entre une utilisation de contraceptifs hormonaux et les risques pour la santé dont le risque de cancer

Association of Hormonal Contraceptive Use With Adverse Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials and Cohort Studies

Brabaharan, Sharmila ; Veettil, Sajesh K. ; Kaiser, Jennifer E. ; Raja Rao, Vrosha Rau ; Wattanayingcharoenchai, Rujira ; Maharajan, Marikannan ; Insin, Putsarat ; Talungchit, Pattarawalai ; Anothaisintawee, Thunyarat ; Thakkinstian, Ammarin ; Chaiyakunapruk, Nathorn

Meta-analyses have reported conflicting data on the safety of hormonal contraception, but the quality of evidence for the associations between hormonal contraceptive use and adverse health outcomes has not been quantified in aggregate.To grade the evidence from meta-analyses of randomized clinical trials (RCTs) and cohort studies that assessed the associations between hormonal contraceptive use and adverse health outcomes among women.MEDLINE, Embase, and the Cochrane Database of Systematic [...]

Menée à l'aide de données 2006-2018 des registres américains des cancers et menée auprès de 5 773 personnes infectées par le virus de l'hépatite B, cette étude analyse l'association entre cette infection et le risque de cancer autre que le carcinome hépatocellulaire

Incidence of malignancies among patients with chronic hepatitis B in US health care organizations, 2006–2018

Spradling, Philip R ; Xing, Jian ; Zhong, Y ; Rupp, Loralee B ; Moorman, Anne C ; Lu, Mei ; Teshale, Eyasu H ; Schmidt, Mark A ; Daida, Yihe G ; Boscarino, Joseph A ; Gordon, Stuart C ; for the Chronic Hepatitis Cohort Study Investigators

Hepatitis B virus (HBV) infection causes hepatocellular carcinoma but its association with other cancers is not well established. We compared age-adjusted incidence of primary cancers among 5,773 HBV-infected persons with US cancer registries during 2006–2018. Compared with the US population, substantially higher incidence among HBV-infected persons was observed for hepatocellular carcinoma (Standardized rate ratio [SRR] 30.79), gastric (SRR 7.95), neuroendocrine (SRR 5.88), cholangiocarcinoma [...]

Menée à l'aide de données 1975-2017 des registres américains des cancers portant sur 59 221 patients ayant survécu à un cancer différencié de la thyroïde non métastatique (durée médiane de suivi : 15 ans), cette étude analyse l'association entre un traitement à l'iode radioactif et le risque de second cancer

Association Between Radioactive Iodine Treatment for Pediatric and Young Adulthood Differentiated Thyroid Cancer and Risk of Second Primary Malignancies

Elisa Pasqual ; Sara Schonfeld ; Lindsay M. Morton ; Daphnée Villoing ; Choonsik Lee ; Amy Berrington de Gonzalez ; Cari M. Kitahara

PURPOSE: Since the 1980s, both the incidence of differentiated thyroid cancer (DTC) and use of radioactive iodine (RAI) treatment increased markedly. RAI has been associated with an increased risk of leukemia, but risks of second solid malignancies remain unclear. We aimed to quantify risks of second malignancies associated with RAI treatment for DTC in children and young adults, who are more susceptible than older adults to the late effects of radiation. METHODS: Using nine US SEER cancer [...]

Menée aux Etats-Unis auprès de 929 patientes atteintes d'un carcinome canalaire in situ, cette étude analyse l'association entre une utilisation d'antidépresseurs et le risque de développer un second cancer du sein (337 cas)

Association between antidepressant use and second breast cancer event after ductal carcinoma in situ diagnosis: a nested case–control study

Mansi, Elizabeth T. ; Malone, Kathleen E. ; Tang, Mei-Tzu ; Loroña, Nicole C. ; Li, Christopher I.

Purpose: Controversy exists regarding the potential relationship between antidepressant use and risk of breast cancer. No previous studies have evaluated the relationship between antidepressant use after diagnosis of ductal carcinoma in situ (DCIS) and risk of a subsequent breast cancer restricted to women with a history of DCIS. Methods: We conducted a population-based, nested case–control study in western Washington State. Cases included 337 women diagnosed with DCIS and a subsequent breast [...]

Menée en Espagne sur la période 2011-2019 auprès de 631 témoins et 457 patients non-fumeurs atteints d'un cancer du poumon (72,8 % de femmes), cette étude multicentrique analyse l'association entre la présence d'un génotype associé à un déficit en alpha-1 antitrypsine et le risque de développer la maladie

Alpha-1 antitrypsin deficiency and risk of lung cancer in never-smokers: a multicentre case–control study

Tubío-Pérez, Ramón Antonio ; Torres-Durán, María ; García-Rodríguez, María Esmeralda ; Candal-Pedreira, Cristina ; Rey-Brandariz, Julia ; Perez-Rios, Monica ; Barros-Dios, Juan ; Fernández-Villar, Alberto ; Ruano-Ravina, Alberto

Background: Lung cancer (LC) is the most commonly diagnosed cancer and the leading cause of cancer-related death in both sexes worldwide. Although the principal risk factor in the western world is tobacco smoking, genetic factors, including alpha-1 antitrypsin deficiency (AATD), have been associated with increased risk. This study is the continuation of an earlier one published by the same group in 2015, aimed at analysing risk of LC in never-smokers, associated with carriers of the AATD [...]

Menée à l'aide des données d'une enquête portant sur 1 374 hommes, cette étude analyse l'association entre le niveau sérique des hormones sexuelles ou des facteurs de croissance analogues à l'insuline et le risque de cancer de la prostate, en fonction du statut diabétique

Hormonal patterns in men with prediabetes and diabetes in NHANES III: possible links with prostate cancer

Beckmann, Kerri ; Crawley, Danielle ; Nelson, William G. ; Platz, Elizabeth A. ; Selvin, Elizabeth ; Van Hemelrijck, Mieke ; Rohrmann, Sabine

Purpose: Pathways involving sex hormones and insulin-like growth factors (IGFs) have been proposed to explain, in part, the lower risk of prostate cancer among men with diabetes. To gain insights into potential biological mechanisms we explored differences in serum concentrations of sex hormones and IGFs across the trajectory from normoglycemia to prediabetes to poorly controlled diabetes. Methods: Using cross-sectional data from the National Health and Nutrition Examination Survey III we [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 48 214 patients atteints d'un cancer colorectal et 64 159 témoins, cette étude analyse l'association entre l'insuline à jeun, la glycémie 2 heures après ingestion de glucose, la glycémie à jeun, l'hémoglobine glyquée ou le diabète de type 2 et le risque de développer la maladie

Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis

Murphy, Neil ; Song, Mingyang ; Papadimitriou, Nikos ; Carreras-Torres, Robert ; Langenberg, Claudia ; Martin, Richard M ; Tsilidis, Konstantinos K ; Barroso, Inês ; Chen, Ji ; Frayling, Tim ; Bull, Caroline J ; Vincent, Emma E ; Cotterchio, Michelle ; Gruber, Stephen B ; Pai, Rish K ; Newcomb, Polly A ; Perez-Cornago, Aurora ; van Duijnhoven, Franzel J B ; Van Guelpen, Bethany ; Vodicka, Pavel ; Wolk, Alicja ; Wu, Anna H ; Peters, Ulrike ; Chan, Andrew T ; Gunter, Marc J

Glycemic traits—such as hyperinsulinemia, hyperglycemia, and type-2 diabetes—have been associated with higher colorectal cancer risk in observational studies; however, causality of these associations is uncertain. We used Mendelian randomization (MR) to estimate the causal effects of fasting insulin, 2-hour glucose, fasting glucose, glycated hemoglobin (HbA1c), and type-2 diabetes with colorectal cancer.Genome-wide association study summary data were used to identify genetic variants associated [...]

Menée en Chine sur la période 1998-2018 auprès de 1 385 patients hospitalisés pour une maladie inflammatoire chronique de l'intestin (durée de suivi : 5-7 ans), cette étude analyse l'incidence du cancer (53 cas) ainsi que les facteurs de risque associés

Risk of malignancy in patients with inflammatory bowel disease: a population-based cohort study from China

Zhang, Huimin ; Zhang, MengMeng ; Chen, Xuanfu ; Guo, Mingyue ; Zhou, Runing ; Lv, Hong ; Li, Yue ; Tan, Bei ; Li, Ji ; Xu, Hui ; Zheng, Weiyang ; Yang, Hong ; Qian, Jiaming

Carcinogenesis is one of major complications for patients with inflammatory bowel disease (IBD) and causes poor prognosis. We aimed to describe cancer incidence in Chinese IBD cohort compared with general population-based cancer registration data and further explore associated risk factors for cancer occurrence in IBD patients. IBD inpatients from January 1998 to January 2018 were included in this study. Patients were followed up from date of IBD diagnosis until either the date of first cancer [...]

Menée à partir des données d'une étude internationale portant sur 8 948 témoins et 4 327 patients atteints d'un cancer de la vessie (âge moyen : 61 ans), cette étude analyse l'association entre des antécédents familiaux de cancer et le risque de développer la maladie

Family history and risk of bladder cancer: an analysis accounting for first- and second-degree relatives

Yu, Evan Yi-Wen ; Stern, Mariana C ; Jiang, Xuejuan ; Tang, Li ; van den Brandt, Piet A ; Lu, Chih-Ming ; Karagas, Margaret R. ; La Vecchia, Carlo ; Bosetti, Cristina ; Polesel, Jerry ; Golka, Klaus ; Zhang, Zuo-Feng ; Villeneuve, Paul ; Zeegers, Maurice P ; Wesselius, Anke

Although evidence suggests that a positive family history of bladder cancer in first-degree relatives is an important risk factor for bladder cancer occurrence, results remain unclear. The influence of family history of non-bladder cancers and more distant relatives on bladder cancer risk is inconsistent. This research therefore, aims to increase the understanding of the association between family history and bladder cancer risk based on worldwide case-control studies. In total 4,327 cases and [...]