Concurrent and Concordant Oral and Genital High-Risk Human Papillomavirus in the U.S.: Results from the National Health and Nutrition Examination Survey

Menée aux Etats-Unis entre 2009 et 2016 par enquête auprès de 3 241 hommes et 7 093 femmes, cette étude analyse la prévalence d'une infection orale et génitale par le papillomavirus humain et les facteurs associés, en fonction du sexe

Résumé en anglais

Oropharyngeal cancers associated with high-risk human papillomavirus (HR-HPV) infection are increasing in the U.S., especially among men. We evaluated prevalence and predictors of concurrent (genital and oral) and concordant (same-type) HR-HPV infections in U.S.We used National Health and Nutrition Examination Survey from 2009-2016. Predictors were assessed via multivariable logistic regression.Among 10,334 respondents, 172 (2.1%) had concurrent infections [109 (3.5%) men and 63 (0.76%) women]. Ninety-three (1.0%) had concordant infections [54 (1.6%) men and 39 (0.5%) women]. Predictors of concurrence in men were: no longer married vs. married [2.3 (OR); 1.3-4.9 (95% CI)], living with a partner vs. married [3.0; 1.2-7.5], and having 2-5 lifetime oral sex partners [3.0; 1.2-7.5]. In women they were: no longer married vs. married [3.6; 1.3-10.3], ≥2 recent sex partners [4.6; 1.4-15.6 for 2-5 partners and 3.9; 1.1-14.3 for 6+ partners], and marijuana use [2.2; 1.0-4.5]. The predictor of concordance in men and women was no longer married vs. married [3.5; 1.2-9.9 in men and 3.2; 1.1-9.4 in women].Concurrent and concordant HR-HPV infections occur at a high rate, especially among men, and are associated with behavioral factors. This underscores the importance of HPV vaccination, screening, and education in men.