Dietary acrylamide is not associated with renal cell cancer risk in the CPS-II Nutrition Cohort

Menée aux Etats-Unis à partir des données portant sur 102 154 participants, cette étude met en évidence une absence d'association entre une ingestion d'acrylamide d'origine alimentaire et le risque de carcinome à cellules rénales (période de suivi : 1 137 441 personnes-années ; 412 cas)

Résumé en anglais

Background: Acrylamide, an industrial chemical and probable human carcinogen, can be formed in primarily carbohydrate-containing foods during high heat cooking or processing. Most epidemiological studies show no associations of dietary acrylamide intake with most cancer outcomes, but limited prospective evidence suggests a positive association with renal cell carcinoma (RCC).

Methods: In 1999, 102,154 men and women from the Cancer Prevention Study-II Nutrition Cohort completed a questionnaire on diet, lifestyle and cancer risk factors and were followed through June 30, 2013. Cox proportional hazards regression was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for the association between estimated dietary acrylamide intake and risk of RCC.

Results: After 1,137,441 person-years of follow-up, 412 cases of invasive RCC occurred. In multivariable adjusted models, there was no association between acrylamide intake and risk of RCC (HR=1.09, 95% CI 0.82-1.43) for the highest vs. lowest quartile of intake. Associations were not modified by sex or smoking history.

Conclusions: We found no associations between dietary acrylamide exposure and risk of invasive RCC.

Impact: Findings from this large, prospective analysis do not support a positive association between higher dietary acrylamide intake and RCC risk.