Another step towards improving oncofertility counselling of young women with Hodgkin's lymphoma

Menée à partir des données portant sur 67 patientes atteintes d'un lymphome hodgkinen de stade avancé, incluses dans un essai de phase III et âgées entre 18 et 45 ans, cette étude de cohorte prospective compare la fonction ovarienne chez les patientes selon la chimiothérapie reçue (de type ABVD, de type AVD ou de type BEACOPP) et évalue le risque d'insuffisance ovarienne précoce afin de proposer des conseils adaptés en oncofertilité

Résumé en anglais

Possible chemotherapy-induced premature ovarian in-sufficiency is of great concern for female premenopausal patients with cancer. Therefore, appropriate counselling on the risk of premature ovarian insufficiency is now mandatory in all countries.Oncofertility counselling is of particular importance for women who have Hodgkin's lymphoma, who are often diagnosed at a young age. However, the counselling of these women can be quite complex because of the paucity of accurate data to estimate the effect of different chemotherapy regimens on their gonadal function. Previous studies in this setting were mostly retrospective or relied only on menstrual function after treatment to define premature ovarian insufficiency, a measure that is not an optimal surrogate for assessing gonadal damage associated with treatment.