Intratumoral delivery of an adenoviral vector carrying the SOCS-1 gene enhances T cell-mediated anti-tumor immunity by suppressing PD-L1
Menée in vitro et à l'aide d'un modèle murin de cancer de l'ovaire, cette étude montre que l'administration intratumorale d'un adénovirus transportant le gène SOCS-1 améliore, en supprimant l'expression de PD-L1, l'immunité antitumorale induite par les lymphocytes T
Molecular Cancer Therapeutics, sous presse, 2018, résumé
Résumé en anglais
Ovarian cancer (OvCa) is the leading cause of gynecological cancer-related deaths and novel therapeutic strategies are required. Programmed cell death 1 and programmed cell death ligand 1 (PD-L1), which are key mediators of host immune tolerance, are associated with OvCa progression. Recent evidence indicates the importance of IFN-
