Cell plasticity in epithelial homeostasis and tumorigenesis

Cet article passe en revue les travaux récents sur les mécanismes par lesquels la plasticité cellulaire favorise le développement et la progression d'une tumeur

Résumé en anglais

The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and the epithelial-mesenchymal transition - two distinct, yet closely related, forms of plasticity with fundamental roles in homeostasis and cancer.