Interaction of Postmastectomy Radiation Treatment With Breast Reconstruction: Many Questions, Emerging Data

Menée auprès de 2 247 patientes atteintes d'un cancer du sein diagnostiqué entre 2012 et 2015 et traité par mastectomie, cette étude multicentrique évalue l'effet d'une radiothérapie adjuvante sur les complications liées à une reconstruction mammaire par implant ou par greffe autologue et analyse le niveau de satisfaction auto-rapporté des patientes en fonction du type de reconstruction mammaire

Résumé en anglais

PMRT is indicated for a number of clinical settings, for example, pathologically positive axillary lymph nodes, inadequate margins of resection, or locally advanced or inflammatory breast cancer. For patients with four or more positive lymph nodes, adding PMRT has generally been accepted. For patients with one to three positive lymph nodes, adding PMRT has been the subject of considerable debate, although national guidelines allow for or even recommend strong consideration of adding PMRT (1–3). In the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) meta-analysis of the randomized trials of radiotherapy after mastectomy, adding radiotherapy improved the 10-year risk of local-regional recurrence and 20-year breast cancer mortality rate in the setting of both one to three positive lymph nodes and four or more positive lymph nodes (all Ps ≤ .04) (4).