Hepatitis B virus reactivation in patients with solid tumors receiving systemic anticancer treatment
A partir d'une revue systématique de la littérature publiée entre 1990 et 2016, cette étude évalue l'association entre une chimiothérapie et le risque de réactivation du virus de l'hépatite B chez les patients atteints de tumeurs solides
Résumé en anglais
Background : Hepatitis B virus (HBV) reactivation is a well-known risk during chemotherapy for hematological malignancies with reported rates ranging between 14% and 72%. However, there is a paucity of data regarding HBV infection management and reactivation risk in patients receiving systemic treatments for solid tumors.
Design : We conducted a PubMed search for publications from January 1990 until May 2016 related to HBV reactivation. The search terms were ‘hepatitis B reactivation’, cross-referenced with ‘chemotherapy’, then ‘hepatitis B’ cross-referenced with International Non-proprietary Name of each of the most used chemotherapy drugs in solid tumors.
Results : From these data, a grading of HBV reactivation risk and recommendations for management are given for most frequently used anticancer drugs in solid tumors.
Conclusion : Most drugs used for the treatment of solid tumors can induce hepatitis B reactivation in HBs antigen-positive patients. HBV screening can be recommended before systemic treatment initiation. Pre-emptive antiviral treatment can reduce the risk of HBV reactivation and prevent chemotherapy disruption.
