Sporadic colorectal cancer : microbial contributors to disease prevention, development and therapy

Cet article passe en revue les études récentes concernant le rôle du microbiote intestinal dans le développement, la prévention et le traitement d'un cancer colorectal

Résumé en anglais

The gut microbiota has been hailed as an accessory organ, with functions critical to the host including dietary metabolic activities and assistance in the development of a proper functioning immune system. However, an aberrant microbiota (dysbiosis) may influence disease processes such as colorectal cancer. In this review, we discuss recent advances in our understanding of the contributions of the microbiota to prevention, initiation/progression, and treatment of colorectal cancer, with a major focus on biofilms and the antimicrobial and antitumoural immune response.