The Association between Leisure Time Physical Activity and Pancreatic Cancer Risk in Adults: A Systematic Review and Meta-Analysis

A partir d'une revue systématique de la littérature publiée jusqu'en février 2015 (26 études), cette méta-analyse évalue l'association entre l'activité physique durant le temps de loisir et le risque de cancer du pancréas chez l'adulte

Résumé en anglais

We conducted a meta-analysis of the association between leisure time physical activity (LTPA) and risk of pancreatic cancer to update previous analyses to examine subgroups of interest and potential sources of heterogeneity. We searched PubMed and MEDLINE databases for studies to February, 2015. Study information was collected using a standardized form to abstract relevant data on participant and study characteristics, assessment of LTPA and pancreatic cancer. We used random-effects models to pool estimates from included studies of lowest versus highest comparison of LTPA. The search identified 26 studies eligible for inclusion into the meta-analysis. The combined summary risk estimate was (RR, 0.89; 95% CI, 0.82-0.96). There was, evidence of heterogeneity across studies (I2=22.1%, P-heterogeneity=0.130). Some of the heterogeneity could be explained by study design, with stronger protective effects among case-control studies compared to cohort studies. Across study designs, age of population was a source of heterogeneity, with stronger effects observed among younger (<50 years of age) populations. The present meta-analysis supports a slightly protective association between LTPA and pancreatic cancer with an 11% risk reduction observed. LTPA appears to have the strongest effect among young populations and therefore investigations are needed to encourage increases in LTPA.