Long term outcomes for women treated for cervical precancer

A partir des données du registre suédois des cancers et celui des décès portant sur 150 883 femmes atteintes d'une néoplasie cervicale intraépithéliale de grade 3 et ayant été traitées, cette étude de cohorte en population analyse les facteurs associés à un risque à long terme de cancer du col de l'utérus ou du vagin, ainsi qu'avec la mortalité par cancer

Résumé en anglais

Although the risk of cervical cancer after treatment for screen detected cervical precancer is low compared with non-treated women, the incidence of invasive cervical cancer is still significantly higher than in the general population.1 These findings are confirmed by Strander and colleagues (doi:10.1136/bmj.f7361) in a trend analysis that linked data from pathology, cancer, and cause of death registries that have covered the whole Swedish population for more than half a century.2 The authors report that the risk of developing or dying from cervical or vaginal cancer in women with a history of treatment for CIN3 (cervical intraepithelial neoplasia grade 3) is two to three times higher than in the general population. Furthermore the increase in risk among women treated for CIN3 rises significantly with older age and more recent year of treatment.