Which bisphosphonate to treat bone metastases?

Mené sur 705 patientes atteintes d'un cancer métastatique du sein, cet essai britannique de phase III compare l'efficacité et la toxicité de l'acide ibandronique par voie orale avec celles de l'acide zolédronique par voie intraveineuse pour le traitement des métastases osseuses

Résumé en anglais

Bisphosphonates were the first bone-targeted drugs proven to be effective in patients with bone metastases. With these agents, we learned that using a host-directed therapy was worthwhile for patients with bone metastases: they had fewer bone complications (reported as skeletal-related events) and less pain over the time. Several treatment options are available for patients with breast cancer with bone metastases: clodronate, ibandronic acid, pamidronic acid, and zoledronic acid (only the last t ...