LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

Menée à l'aide de modèles murins, cette étude évalue l'activité antitumorale de la phenformine, un analogue de la metformine, dans les cancers du poumon non à petites cellules présentant une mutation inactivant le gène suppresseur de tumeurs LKB1

Résumé en anglais

The LKB1 (also called STK11) tumor suppressor is mutationally inactivated in <20% of non-small cell lung cancers (NSCLC). LKB1 is the major upstream kinase activating the energy-sensing kinase AMPK, making LKB1-deficient cells unable to appropriately sense metabolic stress. We tested the therapeutic potential of metabolic drugs in NSCLC and identified phenformin, a mitochondrial inhibitor and analog of the diabetes therapeutic metformin, as selectively inducing apoptosis in LKB1-deficient NSCLC cells. Therapeutic trials in Kras-dependent mouse models of NSCLC revealed that tumors with Kras and Lkb1 mutations, but not those with Kras and p53 mutations, showed selective response to phenformin as a single agent, resulting in prolonged survival. This study suggests phenformin as a cancer metabolism-based therapeutic to selectively target LKB1-deficient tumors.

º Phenformin is a mitochondrial inhibitor that selectively kills LKB1 / NSCLC cells
º LKB1 / NSCLC cells exhibit defective mitochondria and ROS following phenformin
º Phenformin improves tumors and survival in KrasG12DLkb1 / , not KrasG12Dp53 / mice
º eIF2