Obesity-dependent selection of driver mutations in cancer

Menée à partir de l'analyse génomique de 34 274 échantillons tumoraux couvrant 102 types de cancer, cette étude examine la relation entre l'obésité et le génotype tumoral

Résumé en anglais

Obesity is a risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. We examined the relationship between obesity and tumor genotype in two clinicogenomic corpora. Obesity was associated with specific driver mutations in lung adenocarcinoma, endometrial carcinoma and cancers of unknown primaries, independent of clinical covariates, demographic factors and genetic ancestry. Obesity is therefore a driver of etiological heterogeneity in some cancers.