A Molecular Voyage: Multiomics Insights into Circulating Tumor Cells

Cet article passe en revue les connaissances concernant la biologie des cellules tumorales circulantes, analyse le rôle des technologies omiques dans la compréhension de la propagation des cellules cancéreuses puis examine le potentiel des cellules tumorales circulantes pour le diagnostic et le traitement des cancers

Résumé en anglais

Circulating tumor cells (CTCs) play a pivotal role in metastasis, the leading cause of cancer-associated death. Recent improvements of CTC isolation tools, coupled with a steady development of multiomics technologies at single-cell resolution, have enabled an extensive exploration of CTC biology, unlocking insights into their molecular profiles. A detailed molecular portrait requires CTC interrogation across various levels encompassing genomic, epigenetic, transcriptomic, proteomic and metabolic features. Here, we review how state-of-the-art multiomics applied to CTCs are shedding light on how cancer spreads. Further, we highlight the potential implications of CTC profiling for clinical applications aimed at enhancing cancer diagnosis and treatment.Exploring the complexity of cancer progression through cutting-edge multiomics studies holds the promise of uncovering novel aspects of cancer biology and identifying therapeutic vulnerabilities to suppress metastasis.