Radiation-Associated Secondary Cancer in Patients With Breast Cancer Harboring TP53 Germline Variants

Cette étude analyse le risque de sarcome associé à une radiothérapie chez des patientes atteintes d'un cancer du sein et porteuses de variants constitutionnels du gène TP53

Résumé en anglais

Patients with breast cancer who carry TP53 germline variants may be at increased risk of radiation (RT)-associated secondary cancers, yet risk estimates are not well established. We conducted a multi-institutional cohort study to evaluate the risk of sarcoma following RT among patients with breast cancer who carry germline TP53 variants.