A partir d'une revue de la littérature (27 articles), cette étude analyse les effets sur la santé, notamment le risque de cancer, d'une consommation d'huiles tropicales comme l'huile de palme ou de coco

Tropical oils consumption and health: a scoping review to inform the development of guidelines in tropical regions

Hormenu, Thomas ; Salifu, Iddrisu ; Paku, Juliet Elikem ; Kordowu, Peace Yaa ; Abdul-Karim, Adams ; Gyan, Thomas Boateng ; Asiedu, Immanuel ; Abdul-Ganiyu, Osman ; Amoadu, Mustapha

Background: Tropical oils such as palm and coconut oils are renowned for their high saturated fat content and culinary versatility. However, their consumption has sparked debate regarding their health benefits and production concerns. The purpose of this review was to map existing evidence on the health benefits and challenges associated with the consumption of tropical oils. Method: The recommendations for conducting a scoping review by Arksey and O’Malley were followed. PubMed, Dimensions AI, [...]

Menée à l'aide d'une matrice emploi-exposition et de données portant sur 61 377 hommes (âge : 40-74 ans ; durée de suivi : 15 ans), cette étude analyse l'association entre une exposition professionnelle au benzène et le risque de leucémie, de lymphome, de myélome et de cancer du poumon, de l'estomac, du foie et du rein (2 759 cas)

Occupational Benzene Exposure and Cancer Risk among Chinese Men: A Report from the Shanghai Men’s Health Study

DeMoulin, Douglas ; Cai, Hui ; Vermeulen, Roel ; Zheng, Wei ; Lipworth, Loren ; Shu, Xiao-Ou

Benzene exposure has been associated with increased risk of leukemia and other cancers; however, epidemiologic evidence is inconsistent for the latter, and confounding from smoking and alcohol was rarely adjusted.We investigated associations between occupational benzene exposure and risk of leukemia, lymphoma, myeloma, and lung, stomach, liver, and kidney cancers in a population-based cohort of 61,377 men, ages 40 to 74 years. A job-exposure matrix, constructed by industrial hygienists [...]

Menée à l'aide de données 2002-2021 de l'Assurance maladie coréenne portant sur 37 011 personnes, cette étude analyse le risque de cancer chez les employés du transport aérien

Cancer risk among air transportation industry workers in Korea: a national health registry-based study

Park, Soojin ; Lee, Ga Bin ; Lee, Dalnim ; Cha, Eun-Shil ; Han, Kyunghee ; Cho, Minsu ; Seo, Songwon

Background: Flight attendants face various risk factors in their working environments, particularly occupational exposure to cosmic radiation. This study aimed to assess cancer risk among air transportation industry workers, including flight attendants, in Korea by constructing a cohort using national health registry-based data and analyzing cancer incidence risk. Methods: We used the Korea National Health Insurance Service database from 2002 to 2021 to construct a cohort of 37,011 workers in [...]

Menée à partir de données portant sur 5 059 témoins et 5 058 patientes atteintes d'un cancer du sein, cette étude identifie des trajectoires d'exposition aux polluants atmosphériques polychlorobiphényles et benzo[a]pyrène puis analyse l'association entre ces polluants et le risque de développer la maladie

Trajectories of long-term exposure to PCB153 and Benzo[a]pyrene (BaP) air pollution and risk of breast cancer

Desnavailles, Pauline ; Praud, Delphine ; Le Provost, Blandine ; Kobayashi, Hidetaka ; Deygas, Floriane ; Amadou, Amina ; Coudon, Thomas ; Grassot, Lény ; Faure, Elodie ; Couvidat, Florian ; Severi, Gianluca ; Mancini, Francesca Romana ; Fervers, Beatrice ; Proust-Lima, Cecile ; Leffondre, Karen

Background: While genetic, hormonal, and lifestyle factors partially elucidate the incidence of breast cancer, emerging research has underscored the potential contribution of air pollution. Polychlorinated biphenyls (PCBs) and benzo[a]pyrene (BaP) are of particular concern due to endocrine-disrupting properties and their carcinogenetic effect. Objective: To identify distinct long term trajectories of exposure to PCB153 and BaP, and estimate their associations with breast cancer risk. Methods: [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 182 625 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre une infection par le virus d'Epstein-Barr et le risque de développer un cancer de la prostate

Unveiling the Impact of Epstein-Barr Virus on the Risk of Prostate Cancer: A Mendelian Randomization Study

Liao, Haihong ; Wang, Zhihan ; Qian, Yuhang ; Chen, Haojie ; Shi, Yuntian ; Huang, Jiacheng ; Guo, Xiuchen ; Yu, Mingming ; Yu, Yongjiang

Given the consistent detection of Epstein-Barr virus (EBV) in prostate tissues and the clinical evidence suggesting its involvement in prostate cancer (PCa), the potential association between EBV infection and PCa warrants further investigation. This study aimed to assess the causal relationship between EBV infection and PCa using Mendelian randomization (MR). We utilized data from a publicly available genome-wide association study (GWAS) on PCa, alongside data on five serum anti-EBV [...]

A partir d'une revue systématique de la littérature (25 études), cette méta-analyse évalue le risque de second cancer primitif associé à un traitement par immunothérapie à base de lymphocytes CAR-T pour un lymphome ou un myélome

Second primary malignancies after CAR T-cell therapy: A systematic review and meta-analysis of 5,517 lymphoma and myeloma patients

Tix, Tobias ; Alhomoud, Mohammad ; Shouval, Roni ; Cliff, Edward R. Scheffer. ; Perales, Miguel-Angel ; Cordas dos Santos, David M. ; Rejeski, Kai

Purpose: CAR T-cell therapy is a potent immunotherapy for hematologic malignancies, but patients can develop long-term adverse events including second primary malignancies (SPMs) that impact morbidity and mortality. To delineate the frequency and subtypes of SPMs following CAR-T in lymphoma and myeloma, we performed a systematic review and meta-analysis. Design: A literature search was conducted in the MEDLINE, Embase, and CENTRAL (Cochrane) databases. Following extraction of SPM cases and [...]

Cette étude analyse le risque de sarcome associé à une radiothérapie chez des patientes atteintes d'un cancer du sein et porteuses de variants constitutionnels du gène TP53

Radiation-Associated Secondary Cancer in Patients With Breast Cancer Harboring TP53 Germline Variants

Cederquist, Gustav Y. ; Boe, Lillian A. ; Walsh, Michael ; Freedman, Gary M. ; Maxwell, Kara N. ; Taunk, Neil ; Braunstein, Lior Z.

Patients with breast cancer who carry TP53 germline variants may be at increased risk of radiation (RT)-associated secondary cancers, yet risk estimates are not well established. We conducted a multi-institutional cohort study to evaluate the risk of sarcoma following RT among patients with breast cancer who carry germline TP53 variants.

Menée à partir de données de la "UK Biobank" portant sur 106 973 femmes, cette étude pangénomique analyse l'association entre des variants rares codant pour des protéines impliquées dans le vieillissement ovarien et le risque de cancer

Genetic links between ovarian ageing, cancer risk and de novo mutation rates

Stankovic, Stasa ; Shekari, Saleh ; Huang, Qin Qin ; Gardner, Eugene J. ; Ivarsdottir, Erna V. ; Owens, Nick D. L. ; Mavaddat, Nasim ; Azad, Ajuna ; Hawkes, Gareth ; Kentistou, Katherine A. ; Beaumont, Robin N. ; Day, Felix R. ; Zhao, Yajie ; Jonsson, Hakon ; Rafnar, Thorunn ; Tragante, Vinicius ; Sveinbjornsson, Gardar ; Oddsson, Asmundur ; Styrkarsdottir, Unnur ; Gudmundsson, Julius ; Stacey, Simon N. ; Gudbjartsson, Daniel F. ; Kennedy, Kitale ; Wood, Andrew R. ; Weedon, Michael N. ; Ong, Ken K. ; Wright, Caroline F. ; Hoffmann, Eva R. ; Sulem, Patrick ; Hurles, Matthew E. ; Ruth, Katherine S. ; Martin, Hilary C. ; Stefansson, Kari ; Perry, John R. B. ; Murray, Anna ; Breast Cancer Association, Consortium

Human genetic studies of common variants have provided substantial insight into the biological mechanisms that govern ovarian ageing1. Here we report analyses of rare protein-coding variants in 106,973 women from the UK Biobank study, implicating genes with effects around five times larger than previously found for common variants (ETAA1, ZNF518A, PNPLA8, PALB2 and SAMHD1). The SAMHD1 association reinforces the link between ovarian ageing and cancer susceptibility1, with damaging germline [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2023 (29 études, 6 265 patients), cette méta-analyse évalue l'association entre les polymorphismes TNF-alpha -308G>A ou -238G>A et le risque de cancer du poumon

Correlation of TNF-α polymorphisms with susceptibility to lung cancer: evidence from a meta-analysis based on 29 studies

HaghighiKian, Seyed Masoud ; Shirinzadeh-Dastgiri, Ahmad ; Ershadi, Reza ; Vakili-Ojarood, Mohammad ; Barahman, Maedeh ; Dastgheib, Seyed Alireza ; Asadian, Fatemeh ; Shiri, Amirmasoud ; Aghasipour, Maryam ; Rahmani, Amirhossein ; Aghili, Kazem ; Neamatzadeh, Hossein

Objective: This meta-analysis aims to clarify the association between the TNF-