A partir d'une revue de la littérature, cette étude analyse les enjeux liés à la préservation de la fertilité chez les adolescents et jeunes adultes atteints d'un cancer

Fertility Preservation in Adolescents and Young Adults With Cancer: A Case-Based Review

Karen Burns ; Alison W. Loren

Adolescent and young adult (AYA) oncology patients are unique in many aspects of their care; fertility preservation (FP) is one of the most complex to address. In addition to the newly diagnosed AYA patient, there are growing numbers of AYA survivors of childhood cancer who present with concerns about their fertility. Emerging independence, emotional and intellectual growth, and development of an adult mindset are hallmarks of the AYA population; these transitions heighten the intrinsic [...]

Menée à partir de données des registres américains des cancers et de la base Medicare portant sur 15 002 patients ayant survécu à un cancer diagnostiqué entre 2010 et 2017, cette étude analyse l'association entre une diminution de l'utilisation d'opioïdes et la survenue d'événemenents indésirables, notamment de nature psychiatrique ou des hospitalisations liées à des overdoses médicamenteuses

Opioid Tapering in Older Cancer Survivors Does Not Increase Psychiatric or Drug Hospitalization Rates

Riviere, Paul ; Morgan, Kylie M ; Deshler, Leah N ; Huang, Xinyi ; Marienfeld, Carla ; Coyne, Christopher J ; Rose, Brent S ; Murphy, James D

Background: Opioid tapering in the general population is linked to increases in hospitalizations or emergency department visits related to psychiatric or drug-related diagnoses. Cancer survivors represent a unique population with different opioid indications, prescription patterns, and more frequent follow-up care. This study sought to describe patterns of opioid tapering among older cancer survivors, and to test the hypothesis of whether older cancer survivors face increased risks of adverse [...]

Mené sur 30 patients recevant une greffe de cellules souches hématopoïétiques, cet essai randomisé de phase II évalue l'intérêt de l'Hangeshashinto, une médecine traditionnelle japonaise à base d'extraits de plantes, pour prévenir une mucite

Hangeshashinto for prevention of oral mucositis in patients undergoing hematopoietic stem cell transplantation: a randomized phase II study

Yoshimatsu, Masako ; Kawashita, Yumiko ; Soutome, Sakiko ; Murata, Maho ; Sawayama, Yasushi ; Kurogi, Tadafumi ; Nakao, Noriko ; Miyazaki, Yasushi ; Umeda, Masahiro ; Ukai, Takashi

Purpose: Oral mucositis (OM) is a side effect associated with cancer treatment. Hangeshashinto (HST), a Kampo medicine, was originally prescribed to treat diarrhea, gastritis, and stomatitis. Several reports have described the effects of HST for OM induced by chemotherapy in patients with gastric or colorectal cancer. In this study, the effects of HST for prevention of OM were investigated in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods: Thirty patients scheduled [...]

Menée à partir de données portant sur 159 patients atteints d'un cancer gastro-intestinal de stade avancé, cette étude de cohorte analyse l'association entre des changements dans les symtômes déclarés par les patients au bout d'un mois de chimiothérapie, des marqueurs tumoraux (antigène carcino-embryonnaire et antigène carbohydrate CA19-9) et la réponse au traitement ainsi que la survie

Patient-Reported Outcomes, Tumor Markers, and Survival Outcomes in Advanced GI Cancer

Jarnagin, Joy X. ; Saraf, Anurag ; Baiev, Islam ; Chi, Gary ; Van Seventer, Emily E. ; Mojtahed, Amirkasra ; Allen, Jill N. ; Clark, Jeffrey W. ; Blaszkowsky, Lawrence ; Giantonio, Bruce J. ; Weekes, Colin D. ; Klempner, Samuel J. ; Franses, Joseph W. ; Roeland, Eric J. ; Goyal, Lipika ; Siravegna, Giulia ; Horick, Nora ; Corcoran, Ryan B. ; Nipp, Ryan D. ; Parikh, Aparna R.

Importance : Patient-reported outcomes (PROs), such as quality of life (QOL) and symptoms, are often associated with clinical outcomes in patients with cancer. In practice, oncologists use serum tumor markers (TMs) (ie, carcinoembryonic antigen [CEA] and carbohydrate antigen 19-9 [CA 19-9]) and imaging to monitor clinical outcomes in patients with gastrointestinal cancer. Objective : To examine associations of 1-month changes in PROs and TMs with treatment response and survival among patients [...]

Menée en Chine à partir de données portant sur 512 724 adultes (âge : 30-79 ans ; durée de suivi : 12 ans), cette étude de cohorte prospective analyse l'association entre une consommation d'alcool et la mortalité, notamment par cancer

Alcohol intake and cause-specific mortality: conventional and genetic evidence in a prospective cohort study of 512000 adults in China

Millwood, Iona Y. ; Im, Pek Kei ; Bennett, Derrick ; Hariri, Parisa ; Yang, Ling ; Du, Huaidong ; Kartsonaki, Christiana ; Lin, Kuang ; Yu, Canqing ; Chen, Yiping ; Sun, Dianjianyi ; Zhang, Ningmei ; Avery, Daniel ; Schmidt, Dan ; Pei, Pei ; Chen, Junshi ; Clarke, Robert ; Lv, Jun ; Peto, Richard ; Walters, Robin G. ; Li, Liming ; Chen, Zhengming

Background: Genetic variants that affect alcohol use in East Asian populations could help assess the causal effects of alcohol consumption on cause-specific mortality. We aimed to investigate the associations between alcohol intake and cause-specific mortality using conventional and genetic epidemiological methods among more than 512 000 adults in China. Methods: The prospective China Kadoorie Biobank cohort study enrolled 512 724 adults (210 205 men and 302 519 women) aged 30–79 years, during [...]

Cette étude passe en revue les données portant sur les morbidités et la mortalité chez les adolescents et jeunes adultes ayant survécu à un cancer

Burden of Morbidity and Mortality in Adolescent and Young Adult Cancer Survivors

Saro H. Armenian ; Chun Chao

There are an estimated 650,00 survivors of adolescent and young adult (AYA) cancers in the United States, a number that is expected to markedly increase in the coming decades. The recognition of the potential for some cancer treatments to affect the health of patients for many years after the initial diagnosis has prompted investigators to examine the evolving burden of late morbidity and mortality in AYAs with cancer after treatment completion. Studies in large international cohorts of AYA [...]

Menée en Suède à partir de données portant sur 1 530 patients atteints d'un mélanome de l'uvée diagnostiqué après 1960, cette étude de cohorte identifie les causes de décès

Comprehensive Causes of Death in Uveal Melanoma: Mortality in 1530 Consecutively Diagnosed Patients Followed Until Death

Stålhammar, Gustav

Background: Uveal melanoma has a high propensity for metastatic spread. Yet, the comprehensive causes of death in a large consecutive cohort followed from diagnosis to death remain unknown. Methods: All Swedish patients diagnosed with melanoma involving the iris, choroid, and/or ciliary body after January 1st, 1960, were assessed for this study. Sequential inclusion was halted upon encountering the first surviving patient during data collection. Causes of death were collected from the National [...]

Menée au Canada à partir de données portant sur 400 patients atteints d'un carcinome à cellules de Merkel situé sur les zones de la tête et du cou et diagnostiqué entre 2000 et 2018 (âge moyen au diagnostic : 78,4 ans), cette étude de cohorte rétrospective identifie les facteurs associés à la survie globale à 5 ans

Survival of Patients With Head and Neck Merkel Cell Cancer: Findings From the Pan-Canadian Merkel Cell Cancer Collaborative

Nayak, Ameeta Lubina ; Pickett, Arthur Travis ; Delisle, Megan ; Dingley, Brittany ; Mallick, Ranjeeta ; Hamilton, Trevor ; Stuart, Heather ; Talbot, Martha ; McKinnon, Gregory ; Jost, Evan ; Thiboutot, Eva ; Francescutti, Valerie ; Samman, Sal ; Easson, Alexandra ; Schellenberg, Angela ; Merchant, Shaila ; La, Julie ; Vanderbeck, Kaitlin ; Wright, Frances ; Berger-Richardson, David ; Hebbard, Pamela ; Hershorn, Olivia ; Younan, Rami ; Patocskai, Erica ; Rodriguez-Qizilbash, Samuel ; Meguerditichian, Ari ; Tchuente, Vanina ; Kazandjian, Suzanne ; Mathieson, Alex ; Hossain, Farisa ; Hetu, Jessika ; Corsten, Martin ; Tohmé, Angelina ; Nessim, Carolyn ; Johnson-Obaseki, Stephanie

Importance : Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. Due to its relatively low incidence and limited prospective trials, current recommendations are guided by historical single-institution retrospective studies. Objective : To evaluate the overall survival (OS) of patients in Canada with head and neck MCC (HNMCC) according to American Joint Committee on Cancer 8th edition staging and treatment modalities. Design, Setting, and Participants : A [...]

Menée en Norvège par questionnaire auprès de 358 551 participants à un programme de dépistage des maladies cardiovasculaires (âge : 40-43 ans), cette étude prospective analyse l'association entre les pratiques tabagiques (nombre d'années de tabagisme, nombre de cigarettes consommées par jour), un sevrage tabagique avant l'âge de 43 ans et la mortalité par cancer du poumon

Smoking history and all-cause, ischaemic heart disease and lung cancer mortality: follow-up study of 358 551 men and women aged 40–43 years

Aage Tverdal ; Randi Selmer ; Dag S Thelle

Aims: We studied the health consequences of quitting smoking before age 43 by time since quitting, number of years smoked and cigarettes smoked per day. The outcomes were all-cause, ischaemic heart disease and lung cancer mortality. Design: Prospective study. Setting: Norwegian counties. Participants: Men and women aged 40–43 years who participated in a national cardiovascular screening programme and who were followed from 1985 to 2018. Measurements: Self-reports from questionnaire on time [...]

Menée à partir de données portant sur 298 patientes atteintes d'une hyperplasie atypique du sein ou d'un carcinome lobulaire in situ (âge moyen : 58,2 ans), cette étude de cohorte rétrospective compare l'utilisation chimiopréventive de statines et de modulateurs sélectifs des récepteurs des oestrogènes ou d'inhibiteurs de l'aromatase, ainsi que le risque de développer un cancer du sein ou une maladie cardiovasculaire en lien avec ces agents

Comparing Breast Cancer and Cardiovascular Disease Risk and Use of Chemoprevention and Statins among Women with High-risk Breast Lesions

Crew, Katherine D. ; Kukafka, Rita ; Amenta, Jacquelyn ; McGuinness, Julia E. ; Lawal, Kehinde O. ; Nilan, Luisa

Breast cancer chemoprevention with selective estrogen receptor modulators (SERM) or aromatase inhibitors (AI) remains underutilized among high-risk women. A potential barrier to chemoprevention is competing comorbidities such as atherosclerotic cardiovascular disease (ASCVD), due to concern for additional medication side effects. We conducted a retrospective cohort study among women with atypical hyperplasia (AH) or lobular carcinoma in situ (LCIS), an important target population for [...]

Menée aux Etats-Unis par questionnaire auprès de 29 793 témoins et de 369 adolescents et jeunes adultes ayant survécu à un cancer (âge moyen : 20,5 ans), cette étude analyse leur santé mentale et leur utilisation de soins psychiques (psychothérapie, médicaments)

Mental Health and Care Utilization in Survivors of Adolescent and Young Adult Cancer

Baclig, Nikita V ; Comulada, Warren Scott ; Ganz, Patricia A

Background: Adolescent and Young Adult (AYA) cancer survivors experience mental health challenges, yet little is known about the evolution of these difficulties. This study explored mental health symptoms and utilization among long-term AYA cancer survivors. Methods: Using 30,432 respondents from the 2019 National Health Interview Survey (NHIS), this study compared adults with a history of AYA cancer (diagnosed between 15-39) to adults without AYA cancer. Mental health symptom severity was [...]

A partir d'une revue systématique de la littérature (31 études), cette méta-analyse évalue la détresse psychologique chez les aidants familiaux de patients atteints d'un cancer de stade avancé

Existential distress among family caregivers of patients with advanced cancer: A systematic review and meta-analysis

Walbaum, Charlotte ; Philipp, Rebecca ; Oechsle, Karin ; Ullrich, Anneke ; Vehling, Sigrun

Objective: Caregiving for a loved one is challenging and requires significant resources. Existential distress in family caregivers may include hopelessness, demoralization, fear of death, pre-loss grief, or a sense of not being emotionally prepared. The aim of this systematic review is to synthesize the quantitative literature on existential distress among family caregivers of patients with advanced cancer, focusing on its prevalence, association with mental disorders, as well as with [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2023 (32 articles), cette étude analyse l'effet, sur la santé psychosociale, de certains facteurs liés aux programmes de dépistage du cancer du poumon

Lung cancer screening program factors that influence psychosocial outcomes: A systematic review

McFadden, Kathleen ; Rankin, Nicole M. ; Nickel, Brooke ; Li, Tong ; Jennett, Chloe J. ; Sharman, Ashleigh R. ; Quaife, Samantha L. ; Dodd, Rachael H. ; Houssami, Nehmat

Objectives: Lung cancer screening (LCS) programs are being designed and implemented globally. Early data suggests that the psychosocial impacts of LCS are influenced by program factors, but evidence synthesis is needed. This systematic review aimed to elucidate the impact of service-level factors on psychosocial outcomes to inform optimal LCS program design and future implementation. Methods: Four databases were searched from inception to July 2023. Inclusion criteria were full-text articles [...]

Menée aux Pays-Bas, cette étude analyse l'effet, sur la réduction des déchets et sur les économies monétaires réalisées, d'une redistribution de médicaments anticancéreux oraux inutilisés par les patients

Cost Savings and Waste Reduction Through Redispensing Unused Oral Anticancer Drugs: The ROAD Study

Smale, Elisabeth M. ; van den Bemt, Bart J. F. ; Heerdink, Eibert R. ; Desar, Ingrid M. E. ; Egberts, Toine C. G. ; Bekker, Charlotte L. ; ROAD Study Group

Importance : New strategies targeting waste are required to improve financial and ecologic sustainability of expensive therapies, such as oral anticancer drugs, that frequently remain unused by patients. Redispensing unused oral anticancer drugs seems to be a promising strategy when drug quality is guaranteed. Objectives : To determine the waste reduction and net cost savings attained by redispensing oral anticancer drugs that go unused by patients compared with the standard practice of [...]

Menée à l'aide de données portant sur 271 jeunes utilisateurs de cigarettes électroniques (âge : 15-24 ans), cette étude analyse leurs connaissances concernant la présence, la forme et le type de nicotine contenue dans leur e-cigarette habituelle

What do young people know about the nicotine in their e-cigarettes?

Grace Balzer ; Anthony Landrus ; Ilona Ovestrud ; Jill M Singer ; Bo Lu ; Dylan D Wagner ; Elizabeth G Klein ; Loren E Wold ; Clark Wilson ; Alayna P Tackett ; Megan E Roberts

Introduction: In recent years, the nicotine in e-cigarettes has been available in either a ‘free-base’ (unprotonated) or ‘nicotine salt’ (protonated) form. Additionally, e-cigarette nicotine can be either ‘synthetic’ or ‘tobacco-derived’. These dimensions of nicotine have implications for nicotine absorption, bioavailability and sensory experiences. However, it is unclear if the young people using e-cigarettes are aware of these nicotine dimensions. Methods: Data came from a cohort of Ohio [...]