Menée en Suède à partir de données portant sur 68 patients pédiatriques ayant reçu une greffe allogénique de cellules souches hématopoïétiques (âge médian : 11,1 ans), cette étude prospective multicentrique analyse l'incidence et la sévérité de complications buccales et dentaires, notamment une mucite

Incidence, severity, and temporal development of oral complications in pediatric allogeneic hematopoietic stem cell transplant patients – a multicenter study

Agholme, Monica Barr ; Dahllöf, Göran ; Törlén, Johan Karlsson ; Majorana, Alessandra ; Brennan, Michael T. ; von Bültzingslöwen, Inger ; Tan, Poh Lin ; Hu, Shijia ; Sim, Yu Fan ; Hong, Catherine

Purpose: Oral mucositis is a common complication for patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) and causes pain and difficulties in functions like eating and swallowing, resulting in lower quality of life and greater need of treatment with opioids and parenteral nutrition. This prospective multicenter study focused on pediatric recipients of HSCT in the neutropenic phase concerning oral complications, timing, severity, and patient experience. Methods: The [...]

Mené sur 610 patients atteints d'un cancer et traités par chimiothérapie à l'extérieur de l'hôpital (âge : 19-65 ans), cette étude analyse l'association entre le sentiment de solitude, la capacité de résilience, le statut nutritionnel, l'altération du goût et la qualité de vie

The relationship between loneliness, psychological resilience, quality of life and taste change in cancer patients receiving chemotherapy

Ejder, Zeynep Bengisu ; Sanlier, Nevin

Purpose: This study aimed to determine the correlation between taste change, nutritional intake and quality of life in cancer patients receiving chemotherapy. A total of 610 (F = 314, M = 296) volunteers aged 19 and 65 who received outpatient chemotherapy treatment participated in the study. Methods: Individuals' general information was obtained, anthropometric measurements were carried out, malnutrition status (Patient-Generated Subjective Global Assessment PG-SGA), loneliness (Cancer [...]

Mené aux Pays-Bas sur 94 patients pédiatriques atteints d'un cancer (âge moyen : 7,5 ans), cet essai randomisé évalue l'intérêt d'une application de prise en charge de la douleur au domicile pour réduire la sévérité et la durée de la douleur et améliorer le bien-être psychique des parents

Pain monitoring app leads to less pain in children with cancer at home: Results of a randomized controlled trial

Simon, Julia D. H. P. ; Schepers, Sasja A. ; van Gorp, Marloes ; Michiels, Erna M. C. ; Fiocco, Marta ; Grootenhuis, Martha A. ; Tissing, Wim J. E.

Background: The authors developed a pain monitoring app offering educational information, and real-time health care professional feedback on clinically significant pain (>4 numeric rating scale [NRS]-11) for children with cancer to reduce pain at home. Methods: This monocenter, nonblinded randomized controlled trial enrolled Dutch children (0–18 years old) receiving cancer treatment (≥3 months after diagnosis, ≥2 months treatment remaining). Children were randomly assigned to use the app or [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2023 (17 études), cette méta-analyse évalue la prévalence des symptômes, pendant les traitements, des enfants atteints d'une leucémie lymphoblastique aiguë

Prevalence of symptoms in children with acute lymphoblastic leukaemia: a systematic review and meta-analysis

Lan, Xiaoyan ; Wu, Junjun ; Liao, Zhenling ; Wu, Yong ; Hu, Rong

Background: Children with acute lymphoblastic leukaemia (ALL) experience multiple symptoms that occur in complicated patterns and negatively affect patient outcomes. To date, no systematic review has been performed on the prevalence of symptoms in children with ALL. Objective: The study aimed to report and analyse the prevalence of symptoms in children with ALL during treatment. Methods: A systematic search was conducted in eight databases (PubMed, Ovid Embase, Web of Science, CINAHL, PsycINFO, [...]

Menée aux Etats-Unis à partir de données portant sur 358 patients ayant survécu à un cancer du testicule (âge médian : 46 ans), cette étude analyse l'effet de la douleur liée aux traitements sur leur santé physique et psychique à long terme

Impact of Pain and Adverse Health Outcomes on Long-term U.S. Testicular Cancer Survivors

Dinh, Paul C ; Monahan, Patrick O ; Fosså, Sophie D ; Sesso, Howard D ; Feldman, Darren R ; Dolan, M Eileen ; Nevel, Kathryn ; Kincaid, John ; Vaughn, David J ; Martin, Neil E ; Sanchez, Victoria A ; Einhorn, Lawrence H ; Frisina, Robert ; Fung, Chunkit ; Kroenke, Kurt ; Travis, Lois B

PURPOSE: No study has quantified the impact of pain and other adverse health outcomes (AHOs) on global physical/mental health in long-term U.S. testicular cancer survivors (TCS) or evaluated patient-reported functional impairment due to pain. METHODS: TCS given cisplatin-based chemotherapy completed validated surveys, including PROMIS-v1.2 Global-Physical-and-Mental-Health, PROMIS pain questionnaires, and others. Multivariable linear regression examined relationships between 25 AHOs with [...]

Menée aux Etats-Unis à partir de données portant sur 624 témoins et 4 115 patients ayant survécu 5 ans ou plus à un cancer pédiatrique (âge moyen : 35,2 ans), cette étude analyse la prévalence d'une dyslipidémie et le risque associé de maladie cardiovasculaire

Dyslipidemia and Cardiovascular Disease Among Childhood Cancer Survivors: A St. Jude Lifetime Cohort Report

Goldberg, Jason F ; Hyun, Geehong ; Ness, Kirsten K ; Dixon, Stephanie B ; Towbin, Jeffrey A ; Rhea, Isaac B ; Ehrhardt, Matthew J ; Srivastava, Deo Kumar ; Mulrooney, Daniel A ; Hudson, Melissa M ; Robison, Leslie L ; Jefferies, John L ; Rohatgi, Anand ; Armstrong, Gregory T

Purpose: Childhood cancer survivors have increased risk of dyslipidemia and atherosclerotic cardiovascular disease (ASCVD). The aim of this study was to evaluate the prevalence and associated cardiovascular risks of specific lipid abnormalities among childhood cancer survivors. Patients and Methods: Comprehensive lipid panel measurements were obtained from 4,115 5-year survivors, with 3,406 (mean age at evaluation 35.2 ± 10.4 years) not having previous dyslipidemia diagnosis, as well as 624 [...]

Menée à partir de données de la "Multiethnic Cohort Study" incluant 211 414 participants, cette étude estime l'incidence d'un second cancer primitif du poumon chez des patients ayant survécu à un cancer du poumon en fonction de leur statut tabagique (fumeurs ou n'ayant jamais fumé)

Second Primary Lung Cancer Among Lung Cancer Survivors Who Never Smoked

Choi, Eunji ; Su, Chloe C. ; Wu, Julie T. ; Aredo, Jacqueline V. ; Neal, Joel W. ; Leung, Ann N. ; Backhus, Leah M. ; Lui, Natalie S. ; Le Marchand, Loic ; Stram, Daniel O. ; Liang, Su-Ying ; Cheng, Iona ; Wakelee, Heather A. ; Han, Summer S.

Importance : Lung cancer among never-smokers accounts for 25% of all lung cancers in the US; recent therapeutic advances have improved survival among patients with initial primary lung cancer (IPLC), who are now at high risk of developing second primary lung cancer (SPLC). As smoking rates continue to decline in the US, it is critical to examine more closely the epidemiology of lung cancer among patients who never smoked, including their risk for SPLC. Objective : To estimate and compare the [...]

Menée aux Etats-Unis sur la période 2006-2020 à partir de données portant sur 175 545 patients atteints d'un cancer du rectum (âge moyen : 63 ans), cette étude rétrospective analyse l'évolution des stratégies thérapeutiques néoadjuvantes ou adjuvantes avec préservation d'organe

Practice Patterns for Organ Preservation in US Patients With Rectal Cancer, 2006-2020

Loria, Anthony ; Tejani, Mohamedtaki A. ; Temple, Larissa K. ; Justiniano, Carla F. ; Melucci, Alexa D. ; Becerra, Adan Z. ; Monson, John R. T. ; Aquina, Christopher T. ; Fleming, Fergal J.

Importance : In March 2023, the National Comprehensive Cancer Network endorsed watch and wait for those with complete clinical response to total neoadjuvant therapy. Neoadjuvant therapy is highly efficacious, so this recommendation may have broad implications, but the current trends in organ preservation in the US are unknown. Objective : To describe organ preservation trends among patients with rectal cancer in the US from 2006 to 2020. Design, Setting, and Participants : This retrospective, [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2020 (2,4 millions de patientes atteintes d'un cancer du sein), cette méta-analyse examine la distribution des stades au diagnostic de la maladie par pays, période, âge et statut socio-économique

Global Stage Distribution of Breast Cancer at Diagnosis: A Systematic Review and Meta-Analysis

Benitez Fuentes, Javier David ; Morgan, Eileen ; de Luna Aguilar, Alicia ; Mafra, Allini ; Shah, Richa ; Giusti, Francesco ; Vignat, Jérôme ; Znaor, Ariana ; Musetti, Carina ; Yip, Cheng-Har ; van Eycken, Liesbet ; Jedy-Agba, Elima ; Piñeros, Marion ; Soerjomataram, Isabelle

Importance : Stage at diagnosis is a key prognostic factor for cancer survival. Objective :To assess the global distribution of breast cancer stage by country, age group, calendar period, and socioeconomic status using population-based data. Data Sources : A systematic search of MEDLINE and Web of Science databases and registry websites and gray literature was conducted for articles or reports published between January 1, 2000, and June 20, 2022. Study Selection : Reports on stage at diagnosis [...]

Cette étude passe en revue les données portant sur la santé psychologique, le fonctionnement social et les déficiences cognitives des adolescents et jeunes adultes ayant survécu à un cancer

Psychological Outcomes in Adolescent and Young Adult Cancer Survivors

Meghan E. McGrady ; Victoria W. Willard ; Annalynn M. Williams ; Tara M. Brinkman

The diagnosis of cancer during adolescent and young adulthood (AYA) may alter the development and psychological trajectory of survivors across their lifespan. The current review focuses broadly on emotional health, social functioning, health behaviors, and cancer-related cognitive impairment (CRCI) among AYA survivors. Overall, AYA survivors appear to be at elevated risk of emotional distress symptoms, mood and anxiety disorders, suicide, and mental health care service utilization compared with [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2022 (37 essais cliniques), cette méta-analyse identifie les interventions psychosociales destinées à faciliter la croissance post-traumatique chez des patients atteints d'un cancer

Psychosocial interventions on the posttraumatic growth of adults with cancer: A systematic review and meta-analysis of clinical trials

Vrontaras, Nikolaos ; Koulierakis, Georgios ; Ntourou, Iliana ; Karakatsoulis, Georgios ; Sergentanis, Theodoros Ν. ; Kyrou, Dimitrios ; Kapetanakis, Anargyros ; Karademas, Evangelos ; Karamanidou, Christina

Background: It has been increasingly recognized that some people experience post-traumatic growth (PTG) as a result of struggling with cancer. Objective: This systematic review aims to identify psychosocial interventions that might facilitate PTG in adults with cancer. Methods: A search was conducted in PsycINFO, PubMed, Scopus, the Cochrane Library, and ProQuest up to 16 September 2022. The PRISMA guidelines were followed; all included interventional studies had to comprise 30 or more adults [...]

Menée à partir de données portant sur 88 patients atteints d'un mélanome de stade IIIB-D et inclus dans un essai de phase II, cette étude analyse l'association entre une détresse psychologique avant le début du traitement néoadjuvant par inhibiteurs de point de contrôle immunitaire et la réponse thérapeutique

Association between pretreatment emotional distress and neoadjuvant immune checkpoint blockade response in melanoma

Fraterman, Itske ; Reijers, Irene L. M. ; Dimitriadis, Petros ; Broeks, Annegien ; Gonzalez, M. ; Menzies, A. M. M. ; Lopez-Yurda, Marta ; Kapiteijn, Ellen ; van der Veldt, Astrid A. M. ; Suijkerbuijk, Karijn P. M. ; Hospers, Geke A. P. ; Long, Georgina V. ; Blank, Christian U. ; van de Poll-Franse, Lonneke V.

Neoadjuvant immune checkpoint blockade (ICB) outperforms adjuvant ICB for treatment of stage IIIB–D melanoma, but potential biomarkers of response, such as interferon-gamma (IFNγ) signature and tumor mutational burden (TMB), are insufficient. Preclinical studies suggest that emotional distress (ED) can negatively affect antitumor immune responses via β-adrenergic or glucocorticoid signaling. We performed a post hoc analysis evaluating the association between pretreatment ED and clinical [...]

Menée aux Pays-Bas à partir de données portant sur 610 patients atteints d'un cancer de la tête et du cou, cette étude analyse leur utilisation de soins de santé psychique et les facteurs associés

Mental healthcare utilization among head and neck cancer patients: A longitudinal cohort study

Jansen, Femke ; Lissenberg-Witte, Birgit I. ; Hardillo, José A. ; Takes, Robert P. ; de Bree, Remco ; Lamers, Femke ; Langendijk, Johannes A. ; Leemans, C. René ; Verdonck-de Leeuw, Irma M.

Objective: To investigate utilization of mental healthcare among head and neck cancer (HNC) patients from diagnosis to 2 years after treatment, in relation to psychological symptoms, mental disorders, need for mental healthcare, and sociodemographic, clinical and personal factors. Methods: Netherlands Quality of life and Biomedical Cohort study data as measured before treatment, at 3 and 6 months, and at 1 and 2 years after treatment was used (n = 610). Data on mental healthcare utilization [...]

A partir d'une revue systématique de la littérature publiée entre 2008 et 2023 (50 études), cette méta-analyse évalue les difficultés financières des patientes atteintes d'un cancer du sein et identifie les facteurs associés

Evaluation of financial toxicity and associated factors in female patients with breast cancer: a systematic review and meta-analysis

Çeli̇k, Yusuf ; Çeli̇k, Sevilay Şenol ; Sarıköse, Seda ; Arslan, Hande Nur

Purpose: These systematic review and meta-analysis were conducted to discuss the financial toxicity (FT) level among breast cancer (BC) patients and the associated demographic and economic factors. Methods: A systematic review and meta-analysis of single means were used by following the Joanna Briggs Institute guidelines and PRISMA guidance. Untransformed means (MRAW) were used to estimate the confidence interval for individual studies, while I2 and tau2 statistics were used to examine [...]

Menée en Australie à partir de données portant sur 82 patients atteints d'une tumeur cérébrale primitive, cette étude analyse le rapport coût-efficacité d'une intervention de télémédecine proposant un soutien psychologique

Cost-utility analysis of a telehealth psychological support intervention for people with primary brain tumor: Telehealth Making Sense of brain tumor

Gordon, Louisa G. ; Jones, Stephanie ; Parker, Giverny ; Chambers, Suzanne ; Aitken, Joanne F. ; Foote, Matthew ; Shum, David H. K. ; Robertson, Julia ; Conlon, Elizabeth ; Pinkham, Mark B. ; Ownsworth, Tamara

Objective: To undertake an economic evaluation of a telehealth psychological support intervention for patients with primary brain tumor (PBT). Methods: A within-trial cost-utility analysis over 6 months was performed comparing a tailored telehealth-psychological support intervention with standard care (SC) in a randomized control trial. Data were sourced from the Telehealth Making Sense of Brain Tumor (Tele-MAST) trial survey data, project records, and administrative healthcare claims. [...]

A partir d'une revue systématique de la littérature (47 études), cette étude analyse l'avis des patients atteints d'un cancer et de leurs aidants familiaux concernant la manière de communiquer des médecins et les informations transmises susceptibles d'être préjudiciables

Harmful communication behaviors in cancer care: A systematic review of patients and family caregivers perspectives

Westendorp, Janine ; Geerse, Olaf P. ; van der Lee, Marije L. ; Schoones, Jan W. ; van Vliet, Milon H. M. ; Wit, Tamara ; Evers, Andrea W. M. ; van Vliet, Liesbeth M.

Objective: Issues regarding clinician communication remain an important source of complaints within healthcare. This systematic review aims to determine cancer patients' and their family caregivers' views on which clinicians' communication behaviors can harm (i.e. eliciting negative feelings/consequences for patients/family caregivers). Methods: We searched for all types of peer-reviewed studies that determined adult (≥18 years) cancer patients' and/or family caregivers' perspectives on which [...]

Cette étude analyse les facteurs facilitant ou entravant la mise en place et l'utilisation d'interventions de prise en charge des symptômes basées sur les données du dossier médical électronique et les symptômes déclarés par les patients

Implementing cancer symptom management interventions utilizing patient-reported outcomes: a pre-implementation evaluation of barriers and facilitators

Minteer, Sarah A. ; Cheville, Andrea ; Tesch, Nathan ; Griffin, Joan M. ; Austin, Jessica D. ; Mitchell, Sandra ; Leppin, Aaron L. ; Ridgeway, Jennifer L.

Purpose: Symptoms can negatively impact quality of life for patients with a history of cancer. Digital, electronic health record (EHR)-integrated approaches to routine symptom monitoring accompanied by evidence-based interventions for symptom management have been explored as a scalable way to improve symptom management, particularly between clinic visits. However, little research has evaluated barriers and facilitators to implementing these approaches in real-world settings, particularly during [...]