Menée à l'aide de données portant sur une cohorte australienne de 267 357 participants (durée médiane de suivi : 5,4 ans), cette étude analyse l'association entre une consommation d'alcool et le risque de cancer du rein (497 cas), en fonction du statut socioéconomique

Alcohol consumption and socioeconomic status associated with the risk of kidney cancer in a large Australian cohort study

Kim, Lawrence H. ; Bang, Albert ; Sarich, Peter ; Nair-Shalliker, Visalini ; Patel, Manish I. ; Smith, David P.

Purpose: Studies have shown an inverse association between alcohol consumption and kidney cancer risk. We postulate that this inverse association may be further influenced by other risk factors. Methods: We used an Australian cohort, the 45 and Up Study recruited between 2005-2009 to investigate the association between alcohol consumption, and other potential risk factors and kidney cancer incidence. The median follow up was 5.4 years. Results: Of the 267 357 participants aged ≥45 years living [...]

Menée en Suède auprès de 25 585 femmes ayant travaillé au moins un an en tant qu'infirmière ou aide-soignante sur la période 2008-2016, cette étude analyse l'association entre un travail de nuit et le risque de cancer du sein (299 cas)

Night work and breast cancer risk in a cohort of female healthcare employees in Stockholm, Sweden

Per Gustavsson ; Carolina Bigert ; Tomas Andersson ; Manzur Kader ; Mikko Härmä ; Jenny Selander ; Theo Bodin ; Maria Albin

Objectives: Night work has been classified as probably carcinogenic to humans by the International Agency for Research on Cancer, but epidemiological evidence was considered limited due to variability in findings and potential bias. This study aimed to investigate the risk of breast cancer in a cohort with detailed and registry-based data on night work. Methods: The cohort comprised 25 585 women (nurses and nursing assistants) employed 1 year or more between 2008 and 2016 in the healthcare [...]

Mené en Italie auprès de 1 349 témoins et 767 patients atteints d'un cancer du sein et non porteurs d'une mutation de BRCA1/2, cette étude identifie des variants pathogènes différents de ceux de BRCA et associés au risque de développer la maladie chez l'homme

Male breast cancer risk associated with pathogenic variants in genes other than BRCA1/2 : an Italian case-control study

Bucalo, Agostino ; Conti, Giulia ; Valentini, Virginia ; Capalbo, Carlo ; Bruselles, Alessandro ; Tartaglia, Marco ; Bonanni, Bernardo ; Calistri, Daniele ; Coppa, Anna ; Cortesi, Laura ; Giannini, Giuseppe ; Gismondi, Viviana ; Manoukian, Siranoush ; Manzella, Livia ; Montagna, Marco ; Peterlongo, Paolo ; Radice, Paolo ; Russo, Antonio ; Tibiletti, Maria Grazia ; Turchetti, Daniela ; Viel, Alessandra ; Zanna, Ines ; Palli, Domenico ; Silvestri, Valentina ; Ottini, Laura

Background: Germline pathogenic variants (PVs) in BRCA1/2 genes are associated with breast cancer (BC) risk in both women and men. Multigene panel testing is being increasingly used for BC risk assessment, allowing the identification of PVs in genes other than BRCA1/2. While data on actionable PVs in other cancer susceptibility genes are now available in female BC, reliable data are still lacking in male BC (MBC). This study aimed to provide the patterns, prevalence and risk estimates [...]