RNA modifications in cancer

Cet article décrit 6 modifications de l'ARN messager impliquées dans la régulation de l'expression génique (N1-méthyladénosine, 5-méthylcytidine, N7-méthylguanosine, 2′-O-méthylation, pseudouridine et adénosine en inosine) puis examine le rôle de ces modifications dans les cancers

Résumé en anglais

Currently, more than 170 modifications have been identified on RNA. Among these RNA modifications, various methylations account for two-thirds of total cases and exist on almost all RNAs. Roles of RNA modifications in cancer are garnering increasing interest. The research on m6A RNA methylation in cancer is in full swing at present. However, there are still many other popular RNA modifications involved in the regulation of gene expression post-transcriptionally besides m6A RNA methylation. In this review, we focus on several important RNA modifications including m1A, m5C, m7G, 2′-O-Me, Ψ and A-to-I editing in cancer, which will provide a new perspective on tumourigenesis by peeking into the complex regulatory network of epigenetic RNA modifications, transcript processing, and protein translation.