Menée à l'aide de données d'une enquête réalisée sur la période 1976-2018 et des registres américains des cancers, cette étude analyse l'association entre le taux de tabagisme et l'incidence du cancer du poumon en fonction du sexe puis estime, par modélisation, le délai nécessaire pour que l'incidence soit modifiée par un changement de comportement tabagique

Gender-specific trends in cigarette smoking and lung cancer incidence: A two-stage age-stratified Bayesian joinpoint model

Kafle, Ram C. ; Kim, Doo Young ; Holt, Melinda M.

Background: Previous studies have explored population-level smoking trends and the incidence of lung cancer, but none has jointly modeled them. This study modeled the relationship between smoking rate and incidence of lung cancer, by gender, in the U.S. adult population and estimated the lag time between changes in smoking trend and changes in incidence trends. Methods: The annual total numbers of smokers, by gender, were obtained from the database of the National Health Interview Survey (NHIS) [...]

Menée à l'aide de données d'une étude portant sur 159 401 femmes ménopausées dont 302 sont atteintes d'un cancer de l'estomac et 183 d'un cancer de l'oesophage (âge : 50-79 ans ; durée de suivi : 19 ans), cette étude analyse l'association entre une supplémentation en vitamines B et le risque de développer ces maladies

Supplemental B-Vitamins and Risk of Upper Gastrointestinal Cancers in the Women’s Health Initiative

Brasky, Theodore M. ; Ray, Roberta M. ; Newton, Alison M. ; Navarro, Sandi L. ; Schenk, Jeannette M. ; Loomans-Kropp, Holli A. ; Arthur, Rhonda S. ; Snetselaar, Linda G. ; Hays, John ; Neuhouser, Marian L.

B-vitamins contribute to DNA synthesis, maintenance, and regulation. Few studies have examined associations of supplemental sources of B-vitamins with the incidence of upper gastrointestinal (GI) cancers [including gastric (GCA) and esophageal (ECA) cancers]; the only prior study to comprehensively examine such intakes reported potential elevated risks of ECA. We examined 159,401 postmenopausal women, ages 50?79?years at baseline, including 302 incident GCA and 183 incident ECA cases, over [...]

Menée à partir de données portant sur 5 353 témoins et 6 434 patients atteints d'un cancer colorectal (âge médian : 69 ans ; 60,3 % d'hommes), cette étude analyse l'association entre un surpoids, une obésité ou une perte de poids récente et le risque développer la maladie

Association of Overweight, Obesity, and Recent Weight Loss With Colorectal Cancer Risk

Mandic, Marko ; Safizadeh, Fatemeh ; Niedermaier, Tobias ; Hoffmeister, Michael ; Brenner, Hermann

Overweight and obesity, conditions with rising prevalence in many countries, are associated with increased colorectal cancer (CRC) risk. However, many patients with CRC lose weight before diagnosis, which may lead the association to be underestimated.To evaluate the association of body mass index (BMI) and weight change with CRC risk when considering BMI at different time frames, with the intention to account for prediagnostic weight loss.This population-based case-control study was conducted [...]

A partir d'une revue systématique de la littérature (17 articles), cette étude évalue l'association entre un emploi dans l'industrie du pneu en caoutchouc et le risque de cancer

Occupational exposures in the rubber tire industry and risk of cancer: a systematic review

Chamot, Sylvain ; Delzard, Marion ; Leroy, Lea ; Marhic, Gwen ; Ganry, Olivier

Objective: This study aimed at investigate the association between cancer and the rubber tire industry using indicators used to estimate exposure, such as duration or historical time period of exposure. Methods: A systematic review using MEDLINE was carried out. The Preferred Reporting Items for Systematic Reviews (PRISMA) statement guided the systematic review. The Risk of Bias in Non-Randomized Studies of Exposures (ROBINS-E) was used to analyze biases in the selected studies. Results: A [...]

Menée à partir de données de registres danois portant sur 302 789 personnes ayant travaillé dans les secteurs du transport, du sauvetage et de la sécurité entre 2001 et 2015 (durée moyenne de suivi : 13,4 ans), cette étude analyse la part des cancers attribuable à des facteurs de risque modifiables (22 116 cas)

The role of modifiable risk factors in incident cancer in transport, rescue, and security industries

Herttua, Kimmo ; Thapa, Subash ; Ahrenfeldt, Linda Juel ; Paljarvi, Tapio

Purpose: Examine the risk for site-specific incident cancer across representative transport, rescue, and security industries. Methods: We conducted a nationwide study using Danish registers including all 302,789 workers from transport, rescue and security industries from 2001 through 2015 and 2,230,877 individuals aged 18-64 years from a total sample of the economically active population for comparison. Cox models were used to estimate the hazard ratios (HRs) of incident cancers. We categorized [...]

Menée en Suède auprès de 2 180 témoins et 564 patients atteints d'un cancer colorectal précoce diagnostiqué entre 1991 et 2017, cette étude analyse l'association entre une naissance par césarienne et la survenue précoce de la maladie (18-49 ans)

Evaluation of Birth by Cesarean Delivery and Development of Early-Onset Colorectal Cancer

Cao, Yin ; Nguyen, Long H. ; Tica, Stefani ; Otegbeye, Ebunoluwa ; Zong, Xiaoyu ; Roelstraete, Bjorn ; Chan, Andrew T. ; Warner, Barbara B. ; Stephansson, Olof ; Ludvigsson, Jonas F.

The incidence of early-onset colorectal cancer (CRC), diagnosed younger than 50 years of age, has increased worldwide. Gut dysbiosis throughout the life course is hypothesized as a leading mechanism, yet epidemiologic data are limited.To prospectively examine the association between birth by cesarean delivery and early-onset CRC among offspring.In this population-based, nationwide case-control study in Sweden, adults diagnosed with CRC between 18 and 49 years of age from 1991 to 2017 were [...]

Menée à partir de données 2008-2015 portant sur 1 200 témoins et 600 patients atteints d'un cancer colorectal de survenue précoce (âge moyen : 45,2 ans) et à l'aide de 1 200 coloscopies témoins, cette étude identifie les facteurs de risque de la maladie

Risk Factors for Early Onset Sporadic Colorectal Cancer in Male Veterans

Imperiale, Thomas F. ; Myers, Laura J. ; Barker, Barry C. ; Larson, Jason ; Stump, Timothy E. ; Daggy, Joanne K.

Identifying risk factors for early onset colorectal cancer (EOCRC) could help reverse its rising incidence through risk factor reduction and/or early screening. We sought to identify EOCRC risk factors that could be used for decisions about early screening. Using electronic databases and medical record review, we compared male veterans aged 35-49 years diagnosed with sporadic EOCRC (2008-2015) matched 1:4 to clinic and colonoscopy controls without CRC, excluding those with established [...]

Menée en Thaïlande sur la période 2004-2018 auprès de 29 314 patients atteints de diabète, cette étude analyse l'association entre un diabète et le risque de cancer (1 113 cas)

Diabetes Mellitus as Cancer Risk: A 14-year, Cross-Sectional Analysis

Saewai, Chutchawan ; Fumaneeshoat, Orapan ; Thongsuksai, Paramee ; Ingviya, Thammasin

Diabetes mellitus is widely thought to be a risk factors of cancers, but evidence of the association remains inconclusive, especially in Asian countries where few relevant studies have been conducted. Our study aimed to estimate overall and specific types of cancer risks among diabetes patients in Southern Thailand. Patients diagnosed with diabetes who visited the outpatient clinic of Songklanagarind Hospital during 2004 to 2018 were included. Newly diagnosed cancer patients were identified [...]

Menée sur la période 2005-2022 auprès de 7 302 patients atteints du syndrome tumoral hamartomateux (durée médiane de suivi : 4 ans ; âge médian : 38 ans ; 59 % de femmes), cette étude analyse le risque de cancer chez les enfants et adultes porteurs de mutations constitutionnelles de PTEN

Longitudinal Analysis of Cancer Risk in Children and Adults With Germline PTEN Variants

Yehia, Lamis ; Plitt, Gilman ; Tushar, Ann M. ; Joo, Julia ; Burke, Carol A. ; Campbell, Steven C. ; Heiden, Katherine ; Jin, Judy ; Macaron, Carole ; Michener, Chad M. ; Pederson, Holly J. ; Radhakrishnan, Kadakkal ; Shin, Joyce ; Tamburro, Joan ; Patil, Sujata ; Eng, Charis

Identifying hereditary cancer predisposition facilitates high-risk organ-specific cancer surveillance and prevention. In PTEN hamartoma tumor syndrome (PHTS), longitudinal studies remain lacking, and there are insufficient data on cancers in children and young adults, as well as individuals with neurodevelopmental disorders (NDD).To evaluate lifetime cancer risks, including second malignant neoplasms (SMN), among patients with PHTS.Prospective longitudinal cohort study (September 1, 2005, [...]

Menée entre 2008 et 2020 auprès de 10 481 femmes ayant bénéficié d'un dépistage du cancer du sein sur une période allant jusqu'à 10 ans, cette étude analyse l'association entre une évolution de la densité mammographique de chaque sein et le risque de cancer du sein

Longitudinal Analysis of Change in Mammographic Density in Each Breast and Its Association With Breast Cancer Risk

Jiang, Shu ; Bennett, Debbie L. ; Rosner, Bernard A. ; Colditz, Graham A.

Although breast density is an established risk factor for breast cancer, longitudinal changes in breast density have not been extensively studied to determine whether this factor is associated with breast cancer risk.To prospectively evaluate the association between change in mammographic density in each breast over time and risk of subsequent breast cancer.This nested case-control cohort study was sampled from the Joanne Knight Breast Health Cohort of 10 481 women free from cancer at entry and [...]

Menée auprès de 61 660 témoins et 6 166 patients présentant une tumeur germinale du testicule diagnostiquée entre 1992 et 2014, cette étude analyse l'association entre des antécédents de troubles psychiatriques ou neurodéveloppementaux et le risque de développer la maladie, ainsi que la mortalité spécifique et toutes causes confondues

Risk and mortality of testicular cancer in patients with neurodevelopmental or other psychiatric disorders

Jansson, Anna K. ; Söderling, Jonas ; Reutfors, Johan ; Thor, Anna ; Sköld, Camilla ; Cohn-Cedermark, Gabriella ; Stahl, Olof ; Smedby, Karin E. ; Pettersson, Andreas ; Glimelius, Ingrid

Background: Both testicular germ cell tumours (TGCT) and neurodevelopmental disorders are associated with urogenital malformations. Few studies have investigated the association between psychiatric disorders and TGCT. We investigated whether history of any psychiatric or neurodevelopmental disorder is associated with increased risk or mortality of TGCT. Method: This is a nested case–control study including 6166 TGCT patients diagnosed during 1992–2014, individually matched for age and calendar [...]

Menée auprès de 3 058 témoins et 751 patients atteints d'un cancer colorectal, cette étude analyse l'association entre une alimentation riche en acides gras saturés, une prédisposition génétique et le risque de développer la maladie

Saturated fatty acid intake, genetic risk and colorectal cancer incidence: A large-scale prospective cohort study

Fan, Linyun ; Cai, Yimin ; Wang, Haoxue ; Zhang, Heng ; Chen, Can ; Zhang, Ming ; Lu, Zequn ; Li, Yanmin ; Zhang, Fuwei ; Ning, Caibo ; Wang, Wenzhuo ; Liu, Yizhuo ; Li, Hanting ; Li, Gaoyuan ; Peng, Jingyi ; Hu, Kexin ; Li, Bin ; Huang, Chaoqun ; Yang, Xiaojun ; Wei, Yongchang ; Zhu, Ying ; Jin, Meng ; Miao, Xiaoping ; Tian, Jianbo

Previous investigations mainly focused on the associations of dietary fatty acids with colorectal cancer (CRC) risk, which ignored gene-environment interaction and mechanisms interpretation. We conducted a case-control study (751 cases and 3058 controls) and a prospective cohort study (125 021 participants) to explore the associations between dietary fatty acids, genetic risks, and CRC. Results showed that high intake of saturated fatty acid (SFA) was associated with a higher risk of CRC than [...]