Association Between Vitamin B6 and the Risk of Colorectal Cancer: A Meta-analysis of Observational Studies

A partir d'une revue systématique de la littérature publiée jusqu'en août 2022 (28 études), cette méta-analyse évalue l'association entre l'apport en vitamine B6, les taux sériques de phosphate de pyridoxal (PLP) et le risque de cancer colorectal

Résumé en anglais

Objective: This meta-analysis aimed to assess the association between vitamin B6 intake, blood PLP levels, and the risk of colorectal cancer.

Methods: The databases PubMed, Cochrane Library and Embase databases were comprehensively searched for cohort studies or case-control studies. The odds ratio (OR) and 95% confidence interval (CI) were extracted from each eligible study, and the statistical software Stata was used to perform statistical merging.

Results: Twenty-eight studies (20 cohort studies, 8 case-control studies) were included in our meta-analysis. The combined OR for the association between colorectal cancer risk and vitamin B6 intake was 0.80 (95% CI: 0.68?0.94), while the combined OR between blood PLP levels and colorectal cancer risk was 0.54 (95% CI: 0.35?0.84). In addition, the subgroup analysis revealed that vitamin B6 could reduce the risk of colorectal cancer in women [vitamin B6 intake OR?=?0.79, 95% CI (0.65?0.96); blood PLP levels OR?=?0.41, 95% CI (0.30?0.57)] and also reduce the risk of colon cancer in men and women [vitamin B6 intake OR?=?0.76, 95% CI (0.64?0.91); blood PLP levels OR?=?0.56, 95% CI (0.42?0.73)].

Conclusion: In this meta-analysis, vitamin B6 intake and blood PLP levels were inversely associated with colorectal cancer risk.