Menée à partir de données portant sur 179 patients atteints d'un cancer colorectal de stade I à IV, cette étude internationale prospective analyse l'association entre la pratique d'une activité physique et la diversité du microbiote intestinal

Association of physical exercise and a healthy gut microbiome in colorectal cancer

Nierengarten, Mary Beth

Investigators report that regular physical activity may help patients with colorectal cancer by maintaining a healthy gut microbiome, according to the first study to look at the effects of physical activity on the gut microbiome in people with colorectal cancer. The study builds on prior evidence showing that a healthy gut microbiome is an important factor in preventing the development of colorectal cancer and that the presence of certain bacteria in the gut (e.g., Fusobacterium nucleatum) [...]

Menée aux Etats-Unis à partir de données portant sur des enfants atteints d'un cancer diagnostiqué entre 2011 et 2018 (âge : inférieur ou égal à 14 ans), cette étude analyse l'impact de l'extension de la couverture sociale Medicaid sur la survie globale

The association of Medicaid expansion and pediatric cancer overall survival

Barnes, Justin M ; Neff, Corey ; Han, Xuesong ; Kruchko, Carol ; Barnholtz-Sloan, Jill S ; Ostrom, Quinn T ; Johnson, Kimberly J

Medicaid eligibility expansion, though not directly applicable to children, has been associated with improved access to care in children with cancer, but associations with overall survival are unknown. Data for children ages 0 to 14 years diagnosed with cancer from 2011 to 2018 were queried from central cancer registries data covering cancer diagnoses from 40 states as part of the Centers for Disease Control’s National Program of Cancer Registries. Difference-in-differences analyses were [...]

Menée en France à partir de données portant sur 5 498 patients ayant survécu à un cancer pédiatrique (durée de suivi : 42 118 personnes-années), cette étude de cohorte analyse le risque d'hospitalisation liée à des maladies rénales et urinaires induites par les traitements anticancéreux

Risk of Renal or Urinary Related Hospitalization in Survivors of Childhood Cancer: Results from the French Childhood Cancer Survivor Study

Mansouri, Imene ; Schwartz, Boris ; Vu-Bezin, Giao ; Bejarano-Quisoboni, Daniel ; Fresneau, Brice ; El-Fayech, Chiraz ; Dufour, Christelle ; Bolle, Stéphanie ; Surun, Aurore ; Orbach, Daniel ; Allodji, Rodrigue S. ; Diallo, Ibrahima ; Demoor-Goldschmidt, Charlotte ; de Vathaire, Florent ; Haddy, Nadia

Background: Hospitalization rates can be used as an indirect indicator of the burden and severity of adverse health outcomes in childhood cancer survivors (CCS). We aimed to determine the long-term risks of hospitalization related to renal and urinary diseases among 5-year CCS. Methods: The French Childhood Cancer Survivor Study cohort was linked with data from the French National Healthcare System database, which enabled the identification of hospitalizations related to renal or urinary [...]

Menée au Japon par questionnaire auprès de 171 mères d'enfants ayant survécu à un cancer, cette étude transversale identifie les facteurs associés à leur situation professionnelle

Factors associated with employment status among mothers of survivors of childhood cancer: a cross-sectional study

Okada, Hiromi ; Irie, Wataru ; Sugahara, Akiko ; Nagoya, Yuko ; Saito, Masayo ; Sasahara, Yoji ; Yoshimoto, Yasuko ; Iwasaki, Fuminori ; Inoue, Masami ; Sato, Maho ; Ozawa, Miwa ; Kusuki, Shigenori ; Kamizono, Junji ; Ishida, Yasushi ; Suzuki, Ryoko ; Nakajima-Yamaguchi, Ryoko ; Shiwaku, Hitoshi

Purpose: To identify the factors associated with employment status among mothers of childhood cancer survivors (CCSs). Methods: We conducted a questionnaire survey on mothers of survivors of childhood cancer to clarify practical factors such as care demands, psychological factors such as motivation to work, and support. After calculating descriptive statistics for all variables, binary logistic regression analysis was performed. Results: Of 171 mothers, 129 (75.4%) were employed. The most [...]

Menée au Danemark à partir de données portant sur 1 281 334 individus nés entre 1980 et 2001, cette étude analyse le risque de cancer chez des adolescents et jeunes adultes ayant connu des difficultés pendant l'enfance (privations matérielles, perte d'un parent, dynamique familiale dysfonctionnelle ; 8 229 cas de cancer, 662 décès par cancer)

Cancer burden among adolescents and young adults in relation to childhood adversity: a nationwide life-course cohort study of 1.2 million individuals

Rod, Naja Hulvej ; Bengtsson, Jessica ; Elsenburg, Leonie K. ; Davies, Megan ; Taylor-Robinson, David ; Bhatt, Samir ; Rieckmann, Andreas

Background: Childhood adversity such as poverty, loss of a parent, and dysfunctional family dynamics may be associated with exposure to environmental and behavioral hazards, interfere with normal biological functions, and affect cancer care and outcomes. To explore this hypothesis, we assessed the cancer burden among young men and women exposed to adversity during childhood. Methods: We undertook a population-based study using Danish nationwide register data on childhood adversity and cancer [...]

Menée en Islande, cette étude analyse la prévalence et les caractéristiques du myélome multiple indolent (un précurseur asymptomatique du myélome multiple) à partir de données issues d'un programme de dépistage national (75 422 participants, 193 cas, âge médian : 70 ans)

Prevalence of smoldering multiple myeloma based on nationwide screening

Thorsteinsdóttir, Sigrún ; Gíslason, Gauti K. ; Aspelund, Thor ; Rögnvaldsson, Sæmundur ; Óskarsson, Jón Þórir ; Sigurðardóttir, Guðrún Á ; Þórðardóttir, Ásdís R. ; Viðarsson, Brynjar ; Önundarson, Páll T. ; Agnarsson, Bjarni A. ; Sigurðardóttir, Margrét ; Þorsteinsdóttir, Ingunn ; Ólafsson, Ísleifur ; Eyþórsson, Elías ; Jónsson, Ásbjörn ; Berlanga, Oscar ; Hulcrantz, Malin ; Durie, Brian G. M. ; Löve, Thorvardur J. ; Harding, Stephen ; Landgren, Ola ; Kristinsson, Sigurður Y.

Smoldering multiple myeloma (SMM) is an asymptomatic precursor to multiple myeloma. Here we define the epidemiological characteristics of SMM in the general population in Iceland. The iStopMM study (ClinicalTrials.gov ID: NCT03327597) is a nationwide screening study for multiple myeloma precursors where all residents in Iceland 40 years or older were invited to participate. SMM was defined as 10–60% bone marrow plasma cells and/or monoclonal (M) protein concentration ≥3 g dl−1, in the absence [...]

Menée à partir des données des registres américains des cancers portant sur 60 137 patientes atteintes d'un cancer du sein ER+ de stade précoce diagnostiqué entre 2004 et 2015, cette étude rétrospective analyse l'association entre des caractéristiques biologiques de la tumeur, des déterminants socioéconomiques (couverture médicale, statut du voisinage, etc.) et les disparités ethniques dans le risque de décès lié à la maladie

Association of Social Determinants and Tumor Biology With Racial Disparity in Survival From Early-Stage, Hormone-Dependent Breast Cancer

Hoskins, Kent F. ; Calip, Gregory S. ; Huang, Hsiao-Ching ; Ibraheem, Abiola ; Danciu, Oana C. ; Rauscher, Garth H.

Importance : Black women with hormone receptor–positive breast cancer experience the greatest racial disparity in survival of all breast cancer subtypes. The relative contributions of social determinants of health and tumor biology to this disparity are uncertain. Objective : To determine the proportion of the Black-White disparity in breast cancer survival from estrogen receptor (ER)-positive, axillary node-negative breast cancer that is associated with adverse social determinants and [...]

Menée à partir de données portant sur 2 607 patientes atteintes d'un cancer de l'utérus et bénéficiaires du régime Médicaid, cette étude analyse les disparités ethniques dans la qualité du diagnostic après une consultation pour des saignements utérins anormaux

Racial Disparities in Diagnostic Evaluation of Uterine Cancer among Medicaid Beneficiaries

Xu, Xiao ; Chen, Ling ; Nunez-Smith, Marcella ; Clark, Mitchell ; Wright, Jason D

Background: To inform reasons contributing to Black-White disparity in early diagnosis of uterine cancer, we compared the quality of diagnostic evaluation received by Black versus White patients with abnormal uterine bleeding (AUB) ultimately diagnosed with uterine cancer. Methods: Using 2008-2019 MarketScan Multi-State Medicaid Database, we identified Black (n = 858) and White (n = 1,749) patients with uterine cancer presenting with AUB. Quality of diagnostic evaluation was measured by delayed [...]

Menée à partir des données 2006-2017 des registres américains des cancers portant sur 76 095 patients atteints d'un cancer de la tête et du cou, cette étude analyse les disparités ethniques dans la survie en fonction du niveau socioéconomique du lieu de résidence

The Intersectionality Between Race, Ethnicity, and Residential-level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER study

Karanth, Shama D. ; Akinyemiju, Tomi ; Walker, Courtney J. ; Yang, Danting ; Migliorati, Cesar A. ; Yoon, Hyung-Suk ; Hong, Young-Rock ; Washington, Caretia J. ; Lattimore, Chayil ; Fredenburg, Kristianna M. ; Braithwaite, Dejana

Background : Head and Neck cancer (HNC) mortality differs by race, ethnicity, and socioeconomic status (SES). However, it is unclear whether the relationship between race/ethnicity and HNC-specific mortality varies according to the residence-level SES. Methods: Data from the Surveillance, Epidemiology, and End Results database included participants with primary HNC between 2006-2017 (followed through 2018) to assess the joint association of race/ethnicity and census-tract level SES Yost-index [...]

Menée en Grèce auprès de 150 patients atteints d'un cancer (âge moyen : 62 ans), cette étude prospective transversale identifie les facteurs associés à leurs symptômes d'anxiété et de dépression

Factors associated with anxiety and depression in cancer patients: Demographic factors and the role of demoralization and satisfaction with care

Arvaniti, Eleni ; Nikoloudi, Maria ; Tsoukalas, Nikolaos ; Parpa, Efi ; Mystakidou, Kyriaki

Objective : Anxiety and depression are common in cancer patients and seem to affect quality of life, treatment compliance and even survival. Defining factors related to anxiety and depression and exploring the role of demoralization and satisfaction with care, could contribute to the improvement of patients’ quality of life and quality of health services as well. Methods: A convenience sample of 150 cancer inpatients and outpatients from two oncology centers, with various types of solid tumors, [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2021 (7 articles), cette méta-synthèse analyse la communication entre les femmes atteintes d'un cancer du sein et leur enfant mineur au sujet de la maladie

Communication between mothers with breast cancer and minor children: a qualitative systematic review and meta-synthesis

Yu, Junwen ; Huang, Xiaoyan ; Qiu, Jiajia ; Zhang, Mingdi

Purpose: Both women with breast cancer and their minor children were affected by a breast cancer diagnosis. The purpose of this review was to synthesize the evidence from qualitative studies on illness-related communication between mothers with breast cancer and their minor children from mothers’ perspectives. Methods: A thorough systematic review and meta-synthesis of qualitative studies was conducted. English articles published prior to 6 November 2021 were searched from five databases, [...]

Cette étude présente une mise à jour des recommandations concernant la surveillance du risque de cardiomyopathie chez des enfants, adolescents et jeunes adultes ayant survécu à un cancer pédiatrique

Systematic review and updated recommendations for cardiomyopathy surveillance for survivors of childhood, adolescent, and young adult cancer from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Ehrhardt, Matthew J. ; Leerink, Jan M. ; Mulder, Renée L. ; Mavinkurve-Groothuis, Annelies ; Kok, Wouter ; Nohria, Anju ; Nathan, Paul C. ; Merkx, Remy ; de Baat, Esmée ; Asogwa, Ogechukwu A. ; Skinner, Roderick ; Wallace, Hamish ; Lieke Feijen, E. A. M. ; de Ville de Goyet, Maëlle ; Prasad, Maya ; Bárdi, Edit ; Pavasovic, Vesna ; van der Pal, Helena ; Fresneau, Brice ; Demoor-Goldschmidt, Charlotte ; Hennewig, Ulrike ; Steinberger, Julia ; Plummer, Chris ; Chen, Ming Hui ; Teske, Arco J. ; Haddy, Nadia ; van Dalen, Elvira C. ; Constine, Louis S. ; Chow, Eric J. ; Levitt, Gill ; Hudson, Melissa M. ; Kremer, Leontien C. M. ; Armenian, Saro H.

Survivors of childhood, adolescent, and young adult cancer, previously treated with anthracycline chemotherapy (including mitoxantrone) or radiotherapy in which the heart was exposed, are at increased risk of cardiomyopathy. Symptomatic cardiomyopathy is typically preceded by a series of gradually progressive, asymptomatic changes in structure and function of the heart that can be ameliorated with treatment, prompting specialist organisations to endorse guidelines on cardiac surveillance in [...]