Body Mass Index Trajectories Across the Adult Life Course and Pancreatic Cancer Risk
Menée à l'aide des données d'une étude portant sur 269 480 personnes (durée de suivi : jusqu'à 15,2 ans), cette étude analyse l'association entre l'indice de masse corporelle, sa trajectoire à l'âge adulte et le risque d'adénocarcinome canalaire du pancréas en fonction du sexe
Résumé en anglais
Body mass index (BMI) during adulthood has been associated with pancreatic ductal adenocarcinoma (PDAC), however patterns of body size across the adult life course have not been studied extensively. We comprehensively evaluated the association between adiposity across adulthood and PDAC.We conducted a prospective analysis of 269,480 (162,735 males, 106,745 females) NIH-AARP Diet and Health Study participants, aged 50-71years (1995-1996) who self-reported height and weight history. Participants were followed through December 31, 2011. We examined associations between BMI (kg/m2) at ages 18, 35, 50, and 50-71 (baseline) years, their trajectories determined from latent-class trajectory modeling, and incident PDAC. Cox proportional hazard models were used to calculate multivariable adjusted hazards ratios (HR) and 95% confidence intervals (CI).During up to 15.2 years of follow-up, 3,092 (2,020 males, 1,072 females) incident PDAC cases were identified. BMI at all four ages were significantly associated with increased PDAC (per 5-unit increase, HRs = 1.09 to 1.13) with higher magnitude associations in males than females at ages ≥ 35 (P-interaction < 0.05). Four BMI trajectories were created. Compared to normal-weight-maintainers, normal-to-overweight, normal-to-obese class I, and overweight-to-severely obese trajectories had HRs (95% CI) of 1.15 (1.06-1.25), 1.39 (1.25-1.54), and 1.48 (1.18-1.87), respectively (P-interaction by sex = 0.07).High BMI and BMI trajectories that result in overweight or obesity during adulthood were positively associated with PDAC, with stronger associations among those with early onset adiposity and male sex. Avoidance of excess body weight throughout the life course may prevent PDAC.
