A partir d'une revue systématique de la littérature publiée entre 2007 et 2021 (233 articles), cette étude analyse les connaissances actuelles et les perspectives concernant les risques pour la santé liés à une exposition aux pesticides en Amérique Latine et aux Caraïbes

Health Effects of Pesticide Exposure in Latin American and the Caribbean Populations: A Scoping Review

Liliana A. Zúñiga-Venegas ; Carly Hyland ; María Teresa Muñoz-Quezada ; Lesliam Quirós-Alcalá ; Mariana Butinof ; Rafael Buralli ; Andres Cardenas ; Ricardo A. Fernandez ; Claudia Foerster ; Nelson Gouveia ; Juan P. Gutiérrez Jara ; Boris A. Lucero ; María Pía Muñoz ; Muriel Ramírez-Santana ; Anna R. Smith ; Noemi Tirado ; Berna van Wendel de Joode ; Gloria M. Calaf ; Alexis J. Handal ; Agnes Soares da Silva ; Sandra Cortés ; Ana M. Mora

Background: Multiple epidemiological studies have shown that exposure to pesticides is associated with adverse health outcomes. However, the literature on pesticide-related health effects in the Latin American and the Caribbean (LAC) region, an area of intensive agricultural and residential pesticide use, is sparse. We conducted a scoping review to describe the current state of research on the health effects of pesticide exposure in LAC populations with the goal of identifying knowledge gaps [...]

Menée en Suède à l'aide de données de plusieurs registres portant sur 5 889 441 personnes (durée médiane de suivi : 7,2 ans), cette étude analyse l'association entre une mauvaise santé dentaire et le risque de cancer du pancréas (10 081 cas)

Poor dental health and risk of pancreatic cancer: a nationwide registry-based cohort study in Sweden, 2009–2016

Yu, Jingru ; Ploner, Alexander ; Chen, Margaret Sällberg ; Zhang, Ji ; Sandborgh-Englund, Gunilla ; Ye, Weimin

Background: Previous studies have reported inconsistent results regarding the association between poor dental health and pancreatic cancer risk. This study aimed to assess this association using a well-functioning nationwide dental health registry in Sweden. Methods: Information of exposures (dental caries, root canal infection, mild inflammation, and periodontitis; the number of teeth) was ascertained from the Swedish Dental Health Register, and occurrence of pancreatic cancer was identified [...]

Menée à partir de données portant sur 385 porteurs de variants pathogènes constitutionnels du gène CDKN2A, cette étude analyse l'association entre des altérations au niveau des transcrits p16 et p14ARF et le risque de cancer

Impact of Transcript (p16/p14ARF) Alteration on Cancer Risk in CDKN2A Germline Pathogenic Variant Carriers

Sargen, Michael R ; Helgadottir, Hildur ; Yang, Xiaohong R ; Harland, Mark ; Hatton, Jessica N ; Jones, Kristine ; Hicks, Belynda D ; Hutchinson, Amy ; Curry, Michael ; Tucker, Margaret A ; Goldstein, Alisa M ; Pfeiffer, Ruth M

Few studies have evaluated the relationship between CDKN2A germline pathogenic variants (GPV), transcript (p16, p14ARF) alteration, and cancer risk.Standardized incidence ratios (SIRs) comparing cancer risk to the general population were calculated for 385 CDKN2A GPV carriers from two large cohorts (259 United States and 126 Swedish individuals) using Poisson regression; statistical significance was defined as P<.002 (Bonferroni correction). Cumulative incidence is reported for melanoma and [...]

Menée à l'aide des données d'une étude portant sur 269 480 personnes (durée de suivi : jusqu'à 15,2 ans), cette étude analyse l'association entre l'indice de masse corporelle, sa trajectoire à l'âge adulte et le risque d'adénocarcinome canalaire du pancréas en fonction du sexe

Body Mass Index Trajectories Across the Adult Life Course and Pancreatic Cancer Risk

Arjani, Simran ; Saint-Maurice, Pedro F ; Julián-Serrano, Sachelly ; Eibl, Guido ; Stolzenberg-Solomon, Rachael

Body mass index (BMI) during adulthood has been associated with pancreatic ductal adenocarcinoma (PDAC), however patterns of body size across the adult life course have not been studied extensively. We comprehensively evaluated the association between adiposity across adulthood and PDAC.We conducted a prospective analysis of 269,480 (162,735 males, 106,745 females) NIH-AARP Diet and Health Study participants, aged 50-71years (1995-1996) who self-reported height and weight history. Participants [...]

Menée au Japon à l'aide d'une méthode de randomisation mendélienne et de données portant sur 38 042 témoins et 7 936 patients atteints d'un cancer colorectal, cette étude analyse l'association entre les lipides circulants (cholestérols et triglycérides) et le risque de développer la maladie

Blood Lipids and the Risk of Colorectal Cancer: Mendelian Randomization Analyses in the Japanese Consortium of Genetic Epidemiology Studies

Iwagami, Masao ; Goto, Atsushi ; Katagiri, Ryoko ; Sutoh, Yoichi ; Koyanagi, Yuriko N. ; Nakatochi, Masahiro ; Nakano, Shiori ; Hanyuda, Akiko ; Narita, Akira ; Shimizu, Atsushi ; Tanno, Kozo ; Hozawa, Atsushi ; Kinoshita, Kengo ; Oze, Isao ; Ito, Hidemi ; Yamaji, Taiki ; Sawada, Norie ; Nakamura, Yohko ; Nakamura, Sho ; Kuriki, Kiyonori ; Suzuki, Sadao ; Hishida, Asahi ; Kasugai, Yumiko ; Imoto, Issei ; Suzuki, Midori ; Momozawa, Yukihide ; Takeuchi, Kenji ; Yamamoto, Masayuki ; Sasaki, Makoto ; Matsuo, Keitaro ; Tsugane, Shoichiro ; Wakai, Kenji ; Iwasaki, Motoki

The associations between blood lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides, and low-density lipoprotein cholesterol (LDL-C), and colorectal cancer risk are controversial. We evaluated potential causal relationships between blood lipids and colorectal cancer risk. Using the baseline data from the Japanese Consortium of Genetic Epidemiology studies, we estimated the single-nucleotide polymorphism (SNP)–exposure associations (n = 34,546 for [...]