Ce dossier présente les enjeux liés à la prise en charge de l'"après-cancer" et les besoins en soins des patients ayant survécu à un cancer pédiatrique

Management of common clinical problems experienced by survivors of cancer

Emery, Jon ; Butow, Phyllis ; Lai-Kwon, Julia ; Nekhlyudov, Larissa ; Rynderman, Meg ; Jefford, Michael

Improvements in early detection and treatment have led to a growing prevalence of survivors of cancer worldwide. Models of care fail to address adequately the breadth of physical, psychosocial, and supportive care needs of those who survive cancer. In this Series paper, we summarise the evidence around the management of common clinical problems experienced by survivors of adult cancers and how to cover these issues in a consultation. Reviewing the patient's history of cancer and treatments [...]

Ce dossier présente les enjeux liés à la prise en charge de l'"après-cancer" et les besoins en soins des patients ayant survécu à un cancer pédiatrique

Improved models of care for cancer survivors

Jefford, Michael ; Howell, Doris ; Li, Qiuping ; Lisy, Karolina ; Maher, Jane ; Alfano, Catherine M. ; Rynderman, Meg ; Emery, Jon

The number of survivors of cancer is increasing substantially. Current models of care are unsustainable and fail to address the many unmet needs of survivors of cancer. Numerous trials have investigated alternate models of care, including models led by primary-care providers, care shared between oncology specialists and primary-care providers, and care led by oncology nurses. These alternate models appear to be at least as effective as specialist-led care and are applicable to many survivors of [...]

Ce dossier présente les enjeux liés à la prise en charge de l'"après-cancer" et les besoins en soins des patients ayant survécu à un cancer pédiatrique

Long-term care for people treated for cancer during childhood and adolescence

Tonorezos, Emily S. ; Cohn, Richard J. ; Glaser, Adam W. ; Lewin, Jeremy ; Poon, Eileen ; Wakefield, Claire E. ; Oeffinger, Kevin C.

Worldwide advances in treatment and supportive care for children and adolescents with cancer have resulted in a increasing population of survivors growing into adulthood. Yet, this population is at very high risk of late occurring health problems, including significant morbidity and early mortality. Unique barriers to high-quality care for this group include knowledge gaps among both providers and survivors as well as fragmented health-care delivery during the transition from paediatric to [...]

Ce dossier présente les enjeux liés à la prise en charge de l'"après-cancer" et les besoins en soins des patients ayant survécu à un cancer pédiatrique

Cancer care: beyond survival

The, Lancet

Ringing the bell at the end of cancer treatment. Being given the “all clear” at the final clinic visit. This idea—of a clear endpoint to cancer treatment, after which normality resumes—is prevalent in our assumptions about what successful cancer treatment is, and can be a powerful motivation for people undergoing treatment, as well as those delivering and researching it. But for most people who survive cancer, the reality is not as straightforward. At least two-thirds of cancer survivors—either [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Investigation of coronavirus anxiety and caregiving burden among the parents of children with cancer during the COVID-19 outbreak: A descriptive and cross-sectional study

Bekar, Pınar ; Erkul, Münevver ; Efe, Emine

Objective: This study aimed to investigate the coronavirus anxiety and caregiving burden of parents of children with cancer during the COVID-19 outbreak. Methods: This descriptive and cross-sectional study, including 136 parents of children with cancer, was administered through an online survey at a university hospital from 1 to 31 January 2021. Participants completed a questionnaire form, the Zarit Caregiver Burden Scale and the Coronavirus Anxiety Scale. Results: This study identified a [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Milano Policlinico ONCOVID modified Score for risk evaluation in oncology during the COVID-19 pandemic: a prospective monocentric study

Ben Kridis, Wala ; Lajnef, Maissa ; Khmeri, Souhir ; Khanfir, Afef

Purpose : Due to their immunosuppressed status, patients with cancer have been reported to be at increased risk of COVID-19 infection. We aimed to assess the prevalence of COVID-19 in patients with cancer and to identify its risk factors. Methods : A prospective study was conducted at the Department of Medical oncology of Sfax from November 2020 to February 2021. We analyzed data of 226 patients treated for solid cancer. We used the Milano Policlinico ONCOVID modified Score to quantify the risk [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Humoral Responses Against SARS-CoV-2 and Variants of Concern After mRNA Vaccines in Patients With Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia

Andres Chang ; Akil Akhtar ; Susanne L. Linderman ; Lilin Lai ; Victor M. Orellana-Noia ; Rajesh Valanparambil ; Hasan Ahmed ; Veronika I. Zarnitsyna ; Ashley A. McCook-Veal ; Jeffrey M. Switchenko ; Jean L. Koff ; Kristie A. Blum ; Amy A. Ayers ; Colin B. O'Leary ; Michael C. Churnetski ; Shahana Sulaiman ; Melissa Kives ; Preston Sheng ; Carl W. Davis ; Ajay K. Nooka ; Rustom Antia ; Madhav V. Dhodapkar ; Mehul S. Suthar ; Jonathon B. Cohen ; Rafi Ahmed

PURPOSE : Patients with non-Hodgkin lymphoma including chronic lymphocytic leukemia (NHL/CLL) are at higher risk of severe SARS-CoV-2 infection. We investigated vaccine-induced antibody responses in patients with NHL/CLL against the original SARS-CoV-2 strain and variants of concern including B.1.167.2 (Delta) and B.1.1.529 (Omicron). MATERIALS AND METHODS : Blood from 121 patients with NHL/CLL receiving two doses of vaccine were collected longitudinally. Antibody binding against the [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

COVID-19 Sequelae and the Host Pro-Inflammatory Response: An Analysis From the OnCovid Registry

Cortellini, Alessio ; Gennari, Alessandra ; Pommeret, Fanny ; Patel, Grisma ; Newsom-Davis, Thomas ; Bertuzzi, Alexia ; Viladot, Margarita ; Aguilar-Company, Juan ; Mirallas, Orial ; Felip, Eudald ; Lee, Alvin J X ; Pria, Alessia Dalla ; Sharkey, Rachel ; Brunet, Joan ; Garcia, MCarmen Carmona ; Chester, John ; Mukherjee, Uma ; Scotti, Lorenza ; Dolly, Saoirse ; Sita-Lumsden, Ailsa ; Ferrante, Daniela ; Van Hemelrijck, Mieke ; Moss, Charlotte ; Russell, Beth ; Seguí, Elia ; Biello, Federica ; Krengli, Marco ; Marco-Hernández, Javier ; Gaidano, Gianluca ; Patriarca, Andrea ; Bruna, Riccardo ; Roldán, Elisa ; Fox, Laura ; Pous, Anna ; Griscelli, Franck ; Salazar, Ramon ; Martinez-Vila, Clara ; Sureda, Anna ; Loizidou, Angela ; Maluquer, Clara ; Stoclin, Annabelle ; Iglesias, Maria ; Pedrazzoli, Paolo ; Rizzo, Gianpiero ; Santoro, Armando ; Rimassa, Lorenza ; Rossi, Sabrina ; Harbeck, Nadia ; de Torre, Ana Sanchez ; Vincenzi, Bruno ; Libertini, Michela ; Provenzano, Salvatore ; Generali, Daniele ; Grisanti, Salvatore ; Berardi, Rossana ; Tucci, Marco ; Mazzoni, Francesca ; Lambertini, Matteo ; Tagliamento, Marco ; Parisi, Alessandro ; Zoratto, Federica ; Queirolo, Paola ; Giusti, Raffaele ; Guida, Annalisa ; Zambelli, Alberto ; Tondini, Carlo ; Maconi, Antonio ; Betti, Marta ; Colomba, Emeline ; Diamantis, Nikolaos ; Sinclair, Alasdair ; Bower, Mark ; Ruiz-Camps, Isabel ; Pinato, David J ; the OnCovid study group

Background : 15% of patients with cancer experience symptomatic sequelae, which impair post COVID-19 outcomes. In this study we investigated whether a pro-inflammatory status is associated with the development of COVID-19 sequelae. Methods : OnCovid recruited 2795 consecutive patients, diagnosed with SARS-CoV-2 infection between 27/02/2020-14/02/2021. This analysis focused on COVID-19 survivors who underwent a clinical re-assessment after the exclusion of patients with haematological [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Risk perceptions and health care use in the era of the COVID-19 pandemic in adults treated for childhood cancer

Janah, Asmaa ; Demoor-Goldschmidt, Charlotte ; de Vathaire, Florent ; Bougas, Nicolas ; Clavel, Jacqueline ; Poulalhon, Claire ; Lacour, Brigitte ; Souchard, Vincent ; Jackson, Angela ; Casagranda, Leonie ; Berger, Claire ; Allodji, Rodrigue ; Haddy, Nadia ; El Fayech, Chiraz ; Fresneau, Brice ; Dumas, Agnès

Purpose : During the COVID-19 pandemic, childhood cancer survivors (CCS) may have felt more at risk of having severe consequences of COVID-19 and therefore may have been more likely to defer their health care use. We aimed to assess the risk perceptions of CCS related to COVID-19 (perceived infection risk, perceived risk of experiencing a severe illness in the event of infection), and their forgoing of health care during the year 2020. Methods : In December 2020, we interviewed through an [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

The impact of the COVID-19 pandemic on cancer diagnosis based on pathology notifications: A comparison across the Nordic countries during 2020

Johansson, Anna LV ; Larønningen, Siri ; Skovlund, Charlotte Wessel ; Kristiansen, Marnar Fríðheim ; Mørch, Lina Steinrud ; Friis, Søren ; Johannesen, Tom Børge ; Myklebust, Tor Åge ; Skog, Anna ; Pettersson, David ; Birgisson, Helgi ; Virtanen, Anni ; Malila, Nea ; Pitkäniemi, Janne ; Tanskanen, Tomas ; Tryggvadottir, Laufey ; Ursin, Giske ; Lambe, Mats

The severity of the COVID-19 pandemic and subsequent mitigation strategies have varied across the Nordic countries. In a joint Nordic population-based effort, we compared patterns of new cancer cases and notifications between the Nordic countries during 2020. We used pathology notifications to cancer registries in Denmark, the Faroe Islands, Finland, Iceland, Norway and Sweden to determine monthly numbers of pathology notifications of malignant and in-situ tumors from January to December 2020 [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Evaluation of the Durability of the Immune Humoral Response to COVID-19 Vaccines in Patients With Cancer Undergoing Treatment or Who Received a Stem Cell Transplant

Khan, Qamar J. ; Bivona, Cory R. ; Martin, Grace A. ; Zhang, Jun ; Liu, Ben ; He, Jianghua ; Li, Kevin H. ; Nelson, Maggie ; Williamson, Stephen ; Doolittle, Gary C. ; Sun, Weijing ; Mudaranthakam, Dinesh Pal ; Streeter, Natalie R. ; McGuirk, Joseph P. ; Al-Rajabi, Raed ; Hoffmann, Marc ; Kasi, Anup ; Parikh, Rahul A. ; Zhong, Cuncong ; Mitchell, Laura ; Pessetto, Ziyan Y. ; Pathak, Harsh ; Arnab, Ghosh ; LaFaver, Stephanie ; Sharma, Priyanka ; Godwin, Andrew K.

Importance : The durability of the antibody response to COVID-19 vaccines in patients with cancer undergoing treatment or who received a stem cell transplant is unknown and may be associated with infection outcomes. Objective : To evaluate anti–SARS-CoV-2 spike protein receptor binding domain (anti-RBD) and neutralizing antibody (nAb) responses to COVID-19 vaccines longitudinally over 6 months in patients with cancer undergoing treatment or who received a stem cell transplant (SCT). Design, [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Cancer Prevention in a Postpandemic World: A One-Stop-Shop Approach

Miller, Sarah J. ; Sly, Jamilia R. ; Jandorf, Lina ; Minardi, Francesca ; Beyrouty, Matthew W. ; Taioli, Emanuela ; Calman, Neil S.

Cancer is currently the second leading cause of death in the U.S. and is expected to claim approximately 600,000 lives in 2021. In an effort to promote the early detection and prevention of cancer, the U.S. Preventive Services Task Force recommends regular screening for many cancers, including breast, cervical, lung, and colorectal cancers.

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Cancer and Covid-19: a preliminary study on the trauma aspects of Coronavirus in cancer patients

Mirandola, Mara ; Andreis, Federica ; Abdel Kader, Sonia ; Bianchetti, Margherita ; Runcan, Mariana ; Malighetti, Clelia ; Meriggi, Fausto ; Zaniboni, Alberto

Objective : Because of Covid 19, it has become necessary to revise the treatment of cancer patients (“how” and “when”). That has had important psychological repercussions. The purpose of this study is the evaluation of the impact of Covid19 in terms of Post-Traumatic Stress Disorder and Depression and the potential association with coping strategies. Methods : We conducted an exploratory study with 106 patients undergoing treatment, using following questionnaires: Screening Questionnaire for [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Immunogenicity and early clinical outcome after two or three doses of SARS-CoV-2 mRNA-BNT162b2 vaccine in actively treated cancer patients: results from the prospective observational Vax-On-Third study

Nelli, F. ; Giannarelli, D. ; Fabbri, A. ; Silvestri, M. A. ; Giron Berrios, J. R. ; Virtuoso, A. ; Marrucci, E. ; Schirripa, M. ; Mazzotta, M. ; Onorato, A. ; Panichi, V. ; Topini, G. ; Pessina, G. ; Natoni, F. ; Signorelli, C. ; Chilelli, M. G. ; Primi, F. ; Ruggeri, E. M.

The SARS-CoV-2 variants of concern (VOC) widespread and breakthrough infections prompted additional preventive measures in fully-vaccinated immunocompromised recipients, including actively treated cancer patients1. Regulatory agencies recommended a third homologous (booster) dose of an mRNA-based vaccine for this condition based on evidence from immunosuppressed organ transplant recipients2. This study aimed to evaluate the safety, immunogenicity, and clinical outcome of two or three doses of [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Effect of Androgen Suppression on Clinical Outcomes in Hospitalized Men With COVID-19: The HITCH Randomized Clinical Trial

Nickols, Nicholas G. ; Mi, Zhibao ; DeMatt, Ellen ; Biswas, Kousick ; Clise, Christina E. ; Huggins, John T. ; Maraka, Spyridoula ; Ambrogini, Elena ; Mirsaeidi, Mehdi S. ; Levin, Ellis R. ; Becker, Daniel J. ; Makarov, Danil V. ; Adorno Febles, Victor ; Belligund, Pooja M. ; Al-Ajam, Mohammad ; Muthiah, Muthiah P. ; Montgomery, Robert B. ; Robinson, Kyle W. ; Wong, Yu-Ning ; Bedimo, Roger J. ; Villareal, Reina C. ; Aguayo, Samuel M. ; Schoen, Martin W. ; Goetz, Matthew B. ; Graber, Christopher J. ; Bhattacharya, Debika ; Soo Hoo, Guy ; Orshansky, Greg ; Norman, Leslie E. ; Tran, Samantha ; Ghayouri, Leila ; Tsai, Sonny ; Geelhoed, Michelle ; Rettig, Mathew B.

SARS-CoV-2 entry requires the TMPRSS2 cell surface protease. Antiandrogen therapies reduce expression of TMPRSS2.To determine if temporary androgen suppression induced by degarelix improves clinical outcomes of inpatients hospitalized with COVID-19.The Hormonal Intervention for the Treatment in Veterans With COVID-19 Requiring Hospitalization (HITCH) phase 2, placebo-controlled, double-blind, randomized clinical trial compared efficacy of degarelix plus standard care vs placebo plus standard [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

The National COVID-19 Vaccination Campaign Targeting the Extremely Vulnerable: the Florence Medical Oncology Unit Experience in Patients with Cancer

Pino, Maria Simona ; Cheli, Simone ; Perna, Marco ; Fabbroni, Valentina ; Giordano, Clara ; Martella, Francesca ; Lanini, Fabio ; Ribecco, Angela Stefania ; Scoccianti, Silvia ; Bacci, Carlotta ; Baldazzi, Valentina ; Bertolini, Ilaria ; Di Leonardo, Greta ; Fulignati, Chiara ; Grifoni, Raffaella ; Molinara, Elena ; Rangan, Sheila ; Tassi, Renato ; Furlan, Federica ; Goldzweig, Gil ; Bassetti, Andrea ; Fioretto, Luisa

Background : International and national oncology societies had released recommendations in favor of COVID-19 vaccination in cancer patients. In the context of the national vaccination campaign targeting the so called extremely vulnerable, we aimed to assess the safety and efficacy of the mRNA vaccines in a cohort of 623 patients. Methods : Between March 26th, and April 04th, 2021, the Pfizer and BioNTech BNT162b2 mRNA and the Moderna mRNA-1273 vaccines were given as a two-dose prime-boost [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Survey on the effectiveness of telephone-based communication with relatives of hospitalized cancer patients in COVID-19 era in Italy

Riccò, Beatrice ; Fiorani, Claudia ; Ferrara, Leonardo ; Potenza, Leonardo ; Saviola, Alessia ; Malavasi, Norma ; Acquaviva, Gloria ; Carboni, Chiara ; Scarabelli, Laura ; Dominici, Massimo ; Luppi, Mario ; Longo, Giuseppe

Objective : No-visitor policies adopted to prevent coronavirus disease-19 (COVID-19) spread in hospital wards have deeply impacted communication with patients and their relatives. Whereas in pre-COVID-19 era family-clinician meetings were held in person, during the pandemic interactions often took place over the phone, frequently causing feelings of uncertainty and distress to the close ones at home. The goal of this study was to assess and improve the effectiveness of structured [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Outcomes of COVID-19 and risk factors in patients with cancer

Sengar, Manju ; Chinnaswamy, Girish ; Ranganathan, Priya ; Ashok, Apurva ; Bhosale, Shilpushp ; Biswas, Sanjay ; Chaturvedi, Pankaj ; Dhamne, Chetan ; Divatia, Jigeeshu ; D’Sa, Karishma ; Jain, Hasmukh ; Laskar, Sarbani ; Moulik, Nirmalya Roy ; Mummudi, Naveen ; Nair, Sindhu ; Nayak, Lingaraj ; Nayak, Prakash ; Patkar, Shraddha ; Pawaskar, Preeti ; Ramaswamy, Anant ; Shetty, Omshree ; Singh, Arjun ; Sridhar, Epari ; Thorat, Jayashree ; Badwe, Rajendra ; Pramesh, C. S. ; Bakshi, Ganesh ; Chatterjee, Abhishek ; Chaudhari, Vikram ; Chopade, Sunil ; Doctor, Jeson ; Goel, Nishu Singh ; Gollamudi, Venkata Rama Mohan ; Khobrekar, Sarita ; Mishra, Gauravi ; Narula, Gaurav ; Niyogi, Devayani ; Parambil, Badira Cheriyalinkal ; Parab, Swapnil ; Patankar, Sumedha ; Prakash, Gagan ; Rajput, Pankaj ; Rath, Sushmita ; Samant, Vinit ; Sawakare, Sandeep ; Sinha, Shwetabh ; Srinivas, Sujay ; Srinivasan, Shyam ; Tandon, Sandeep ; Thakkar, Purvi ; Thiagarajan, Shivakumar ; Tiwari, Virendra ; on behalf of the, T. M. H. Covid-action group

Patients with cancer are at higher risk for adverse coronavirus disease 2019 (COVID-19) outcomes. Here, we studied 1,253 patients with cancer, who were diagnosed with severe acute respiratory syndrome coronavirus 2 at a tertiary referral cancer center in India. Most patients had mild disease; in our settings, recent cancer therapies did not impact COVID-19 outcomes. Advancing age, smoking history, concurrent comorbidities and palliative intent of treatment were independently associated with [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Low rates of HPV vaccination and cervical cancer screening: Challenges and opportunities in the context of the COVID-19 pandemic

Smith, Debi ; Perkins, Rebecca B.

This invited commentary discusses the article by Richards et al. describing differences in rates of on-time HPV vaccination and cervical cancer screening in 2018 among enrollees in different insurance plans. The commentary focuses on the larger problem of low vaccination HPV rates and decreasing cervical cancer screening rates seen across all sectors. We outline challenges posed by the COVID-19 pandemic on HPV vaccination and cervical cancer screening, and discuss opportunities to improve [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Stagnant US Mammography Rates and the Influence of COVID-19

Suran, Melissa

Mammography rates had stagnated over recent years in the US, and then came COVID-19. The pandemic put life on hold for many people, including their receipt of preventive care such as mammography screenings.The aftermath of the pandemic on mammography rates isn’t clear yet because, as the American Cancer Society (ACS) notes in its recent 2022 cancer projections report, quantifying “secondary consequences of the pandemic at the population level will take several years because of the lag in [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Long-term Immunogenicity of BNT162b2 Vaccine in Patients With Solid Tumors

Waldhorn, Ithai ; Holland, Roy ; Goshen-Lago, Tal ; Benguigui, Madeleine ; Halberthal, Michael ; Shaked, Yuval ; Ben-Aharon, Irit

In a previous cohort study, administration of the BNT162b2 vaccine in patients with solid tumors demonstrated a favorable safety and efficacy profile following the second vaccination, although gradual immunogenicity was observed compared with the general population. We had previously demonstrated at 6 months postvaccination a steady decline in antibody titers and seropositivity rates among patients with solid tumors treated at a center in Haifa, Israel, that were comparable with the general [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Breakthrough SARS-CoV-2 Infections, Hospitalizations, and Mortality in Vaccinated Patients With Cancer in the US Between December 2020 and November 2021

Wang, William ; Kaelber, David C. ; Xu, Rong ; Berger, Nathan A.

Importance : Limited data have been presented to examine breakthrough SARS-CoV-2 infections, hospitalizations, and mortality in vaccinated patients with cancer in the US. Objectives : To examine the risk of breakthrough SARS-CoV-2 infection, hospitalizations, and mortality in vaccinated patients with cancer between December 2020 and November 2021. Design, Setting, and Participants : Retrospective cohort study of electronic health records (EHRs) of vaccinated patients from a multicenter and [...]