A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2019 (14 études), cette méta-analyse évalue l'association entre l'apport en protéines et le risque de cancer du pancréas

The Association between Dietary Protein Intake and the Risk of Pancreatic Cancer: Evidence from 14 Publications

Zhang, Tao ; Wu, Shusheng ; Xu, Feiyang ; Chang, Junpeng ; Guo, Yaxun ; Zhou, Zhengtong ; Xu, Rongwei ; Wang, Tiancheng ; Wang, Xianming ; Wang, Minghai ; Qin, Shiyong ; Zhang, Shuguang ; Li, Jie

Many studies have been published to assess the association about dietary protein intake on the risk of pancreatic cancer, but with inconsistent result. This meta-analysis aimed to evaluate whether protein intake could affect the risk of pancreatic cancer. A systematic literature search was performed in PubMed, EMBASE and Web of Science up to October 1, 2019. Pooled relative risks (RR) and 95% confidence intervals (CI) were calculated using a random-effect model. A total of 14 studies (12 [...]

Menée à l'aide de données d'études menées entre 1985 et 2010 en Europe et au Canada et portant sur 20 965 témoins et 16 901 patients atteints d'un cancer du poumon, cette étude analyse l'association entre une exposition professionnelle aux hydrocarbures aromatiques polycycliques et le risque de développer la maladie, en fonction du statut tabagique

Occupational exposure to polycyclic aromatic hydrocarbons and lung cancer risk: results from a pooled analysis of case-control studies (SYNERGY)

Olsson, Ann ; Guha, Neela ; Bouaoun, Liacine ; Kromhout, Hans ; Peters, Susan ; Siemiatycki, Jack ; Ho, Vikki ; Gustavsson, Per ; Boffetta, Paolo ; Vermeulen, Roel ; Behrens, Thomas ; Brüning, Thomas ; Kendzia, Benjamin ; Guénel, Pascal ; Luce, Danièle ; Karrasch, Stefan ; Wichmann, Heinz-Erich ; Consonni, Dario ; Landi, Maria Teresa ; Caporaso, Neil E. ; Merletti, Franco ; Mirabelli, Dario ; Richiardi, Lorenzo ; Jöckel, Karl-Heinz ; Ahrens, Wolfgang ; Pohlabeln, Hermann ; Tardon, Adonina ; Zaridze, David ; Field, John K. ; Lissowska, Jolanta ; Swiatkowska, Beata ; McLaughlin, John R. ; Demers, Paul A. ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Pándics, Tamás ; Fabianova, Eleonora ; Mates, Dana ; Forastiere, Francesco ; Bueno-de-Mesquita, Bas ; Schüz, Joachim ; Straif, Kurt

Background: Exposure to polycyclic aromatic hydrocarbons (PAH) occurs widely in occupational settings. We investigated the association between occupational exposure to PAH and lung cancer risk and joint effects with smoking within the SYNERGY project. Methods: We pooled 14 case-control studies with information on lifetime occupational and smoking histories conducted between 1985 and 2010 in Europe and Canada. Exposure to benzo[a]pyrene (BaP) was used as a proxy of PAH and estimated from a [...]

Menée à partir de données 1953-2019 de la base "NORDCAN" (Danemark, Finlande, Norvège et Suède), cette étude analyse l'association entre une exposition au thorotrast (produit de contraste radiographique utilisé dans les années 30-40) et l'incidence du cancer du foie (y compris le carcinome hépatocellulaire et le cholangiocarcinome intrahépatique)

Long-term incidence in hepatocellular carcinoma and intrahepatic bile duct cancer in Denmark, Finland, Norway and Sweden, role of Thorotrast?

Hemminki, Kari ; Tichanek, Filip ; Försti, Asta ; Hemminki, Otto ; Liska, Vaclav ; Hemminki, Akseli

We analyzed long-term incidence trends in liver cancer (including hepatocellular carcinoma and intrahepatic cholangiocarcinoma) with an aim to interpret the changes in terms of known risk factors and hypothesize that historical exposure to Thorotrast, a radiographic contrast medium emitting alpha particles, has changed population rates. The NORDCAN database was used to collect cancer registry data from Denmark (DK), Finland (FI), Norway (NO) and Sweden (SE), which we used from 1953 (DK, FI, NO) [...]

Menée à partir de données portant sur 2,3 millions de personnes nées entre 1987 et 2013 en Suède, cette étude analyse l'association entre des troubles du spectre autistique et le risque de cancer

Cancer risk in individuals with autism spectrum disorder

Liu, Q. ; Yin, W. ; Meijsen, J. J. ; Reichenberg, A. ; Gådin, J. R. ; Schork, A. J. ; Adami, H. O. ; Kolevzon, A. ; Sandin, S. ; Fang, F.

Background: Whether individuals with autism spectrum disorders (ASD) have a higher-than-expected risk of cancer remains unknown. Patients and methods: We performed a population-based cohort study including 2.3 million individuals live-born to mothers from Nordic countries during 1987-2013 in Sweden with follow-up through 2016 (up to age 30). Individuals with ASD were ascertained through the Swedish National Patient Register. We estimated the relative risk of cancer in relation to ASD by odds [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de la "UK Biobank" et de la cohorte européenne "EPIC" portant au total sur 638 530 personnes, cette étude analyse l'association entre l'indice de masse corporelle à différents âges (10, 18-20 et 40-69 ans) et le risque de cancer lié à l'obésité (côlon-rectum, rein, pancréas, poumon, ovaire et endomètre)

Body size at different ages and risk of six cancers: a Mendelian randomization and prospective cohort study

Mariosa, Daniela ; Smith-Byrne, Karl ; Richardson, Tom G ; Ferrari, Pietro ; Gunter, Marc J ; Papadimitriou, Nikos ; Murphy, Neil ; Christakoudi, Sofia ; Tsilidis, Konstantinos K ; Riboli, Elio ; Muller, David ; Purdue, Mark P ; Chanock, Stephen J ; Hung, Rayjean J ; Amos, Christopher I ; O'Mara, Tracy A ; Amiano, Pilar ; Pasanisi, Fabrizio ; Rodriguez-Barranco, Miguel ; Krogh, Vittorio ; Tjønneland, Anne ; Halkjær, Jytte ; Perez-Cornago, Aurora ; Chirlaque, María-Dolores ; Skeie, Guri ; Rylander, Charlotta ; Borch, Kristin Benjaminsen ; Aune, Dagfinn ; Heath, Alicia K ; Ward, Heather A ; Schulze, Matthias ; Bonet, Catalina ; Weiderpass, Elisabete ; Smith, George Davey ; Brennan, Paul ; Johansson, Mattias

It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23–2.11) and kidney cancer [...]

Menée à partir de données 2003-2018 de la "Biobank Japan" portant sur 37 086 témoins et 63 828 patients atteints d'un cancer (14 localisations), cette étude identifie les types de cancer et les caractéristiques cliniques associés aux variants pathogènes de BRCA1 et BRCA2

Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants

Momozawa, Yukihide ; Sasai, Rumi ; Usui, Yoshiaki ; Shiraishi, Kouya ; Iwasaki, Yusuke ; Taniyama, Yukari ; Parsons, Michael T. ; Mizukami, Keijiro ; Sekine, Yuya ; Hirata, Makoto ; Kamatani, Yoichiro ; Endo, Mikiko ; Inai, Chihiro ; Takata, Sadaaki ; Ito, Hidemi ; Kohno, Takashi ; Matsuda, Koichi ; Nakamura, Seigo ; Sugano, Kokichi ; Yoshida, Teruhiko ; Nakagawa, Hidewaki ; Matsuo, Keitaro ; Murakami, Yoshinori ; Spurdle, Amanda B. ; Kubo, Michiaki

The clinical importance of genetic testing of BRCA1 and BRCA2 in breast, ovarian, prostate, and pancreatic cancers is widely recognized. However, there is insufficient evidence to include other cancer types that are potentially associated with BRCA1 and BRCA2 in clinical management guidelines.To evaluate the association of BRCA1 and BRCA2 pathogenic variants with additional cancer types and their clinical characteristics in 100 914 individuals across 14 cancer types.This case-control analysis [...]

Menée à partir de données 2003-2017 de registres médicaux danois portant sur 461 646 femmes (âge : moins de 49 ans), cette étude analyse l'association entre un indice de masse corporelle supérieur à 18,5kg/m2 à l'âge adulte et l'incidence du cancer de l'ovaire (102 cas) ou du sein (3 032 cas) avant la ménopause

Early adulthood overweight and obesity and risk of premenopausal ovarian cancer, and premenopausal breast cancer including receptor status: prospective cohort study of nearly 500,000 Danish women

Urbute, Aivara ; Frederiksen, Kirsten ; Kjaer, Susanne K.

Purpose: To assess the association between higher than normal BMI and incidence of premenopausal ovarian and breast cancers. Methods: This prospective cohort study included 461,646 women registered in the Danish Medical Birth Registry with self-reported early adulthood BMI ≥18.5 kg/m2, without a history of cancer. We used Cox proportional hazards regression models to estimate the hazard ratios (HRs) with 95% confidence intervals (95% CIs) of premenopausal epithelial ovarian cancer, breast [...]

Menée à partir de données 2005-2017 de l'Assurance maladie coréenne portant sur 22 543 patients atteints d'un cancer du pancréas (durée de suivi : 11,5 ans), cette étude analyse l'association entre le statut tabagique, l'indice de masse corporelle ou la présence d'un diabète et le risque de développer la maladie

Lifestyle, body mass index, diabetes, and the risk of pancreatic cancer in a nationwide population-based cohort study with 7.4 million Korean subjects

Park, Byung Kyu ; Seo, Jeong Hun ; Chung, Jae Bock ; Choi, Jung Kyu

Background: Large-scale epidemiological studies on pancreatic cancer in non-Western populations are insufficient. We investigated the risk factors for pancreatic cancer. Methods: Using the Korean National Health Insurance database, subjects who participated in the health examination program between 2005 and 2006 were identified and followed up until 2017. Adjusted hazard ratios (HRs) for pancreatic cancer risk were estimated using a Cox proportional hazards model. Results: During 11.5 years [...]

Menée à partir de données de la "UK Biobank" portant sur 231 203 femmes (âge moyen : 56,2 ans ; durée médiane de suivi : 11,3 ans), cette étude analyse l'association entre la vitamine D sérique et le risque de carcinome canalaire in situ (1 340 cas)

Association of prediagnostic serum levels of vitamin D with risk of ductal carcinoma in situ of the breast in the UK biobank cohort study

Peila, Rita ; Rohan, Thomas E.

Background: Higher circulating levels of vitamin D (25(OH)D) have been associated with reduced risk of developing invasive breast cancer. However, their association with risk of ductal carcinoma in situ (DCIS) of the breast has received little attention. Methods: We examined the association of serum vitamin D with risk of DCIS in 231,203 women, aged 40-69 years at enrollment in the UK Biobank cohort study. Multivariable Cox proportional hazards models were used to estimate hazard ratios and 95% [...]

Menée en Pologne à l'aide du génotypage de l'ADN de 1 028 patients atteints d'un cancer de la vessie, 688 patients atteints d'un cancer du rein et 4 000 témoins, cette étude analyse le rôle de mutations spécifiques des gènes BRCA1 et BRCA2 dans la tumorigenèse vésicale et rénale

Germline BRCA1 and BRCA2 mutations and the risk of bladder or kidney cancer in Poland

Złowocka-Perłowska, Elżbieta ; Tołoczko-Grabarek, Aleksandra ; Narod, Steven A. ; Lubinski, Jan

Introduction: The role of the BRCA1 and BRCA2 genes in bladder and renal tumorigenesis is unclear. Our goal was to determine the prevalence of specific founder mutations genes BRCA1 (5328 insC, C61G and 4153 delA) and BRCA2 (C5972T) mutations in bladder and kidney cancer patients from Poland. Materials and methods: We genotyped 1028 patients with bladder cancer and 688 cases with kidney cancer and two control groups. Results: A BRCA1 mutation (all variants combined) was detected in peripheral [...]

Menée aux Etats-Unis auprès de 451 témoins et 451 patients atteints d'un cancer différencié de la thyroïde (âge médian : 36 ans ; 61,4 % d'hommes), cette étude analyse l'association entre une auto-immunité thyroïdienne et le risque de développer la maladie

Pre-existing Thyroid Autoimmunity and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study of US Active-Duty Personnel

Donald S.A. McLeod ; Sheryl A. Bedno ; David S. Cooper ; Susan M. Hutfless ; Silvia Ippolito ; Susan J. Jordan ; Peter G. Matos ; Rachel E. Neale ; Elena Sabini ; David C. Whiteman ; Paul W. Ladenson ; Patrizio Caturegli

PURPOSE: Thyroid autoimmunity has been associated with differentiated thyroid cancer although multiple potential biases might have influenced the results of previous studies. METHODS: We conducted a case-control study nested within the cohort of US active-duty personnel 1996-2014 to assess the association between thyroid autoimmunity, defined by serology, and thyroid cancer diagnosis. The primary exposure was thyroid peroxidase (TPO) antibody status 7-10 years before the thyroid cancer index [...]

Menée à l'aide de données de la cohorte européenne "EPIC" portant sur 817 témoins et 817 patientes atteintes d'un cancer de l'endomètre, cette étude analyse l'association entre la santé métabolique (évaluée par le taux sérique de peptide C), l'indice de masse corporelle et le risque de développer la maladie

Metabolically-Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Kliemann, Nathalie ; Ould Ammar, Romain ; Biessy, Carine ; Gicquiau, Audrey ; Katzke, Verena ; Kaaks, Rudolf ; Tjoenneland, Anne ; Olsen, Anja ; Sánchez, María-José ; Crous-Bou, Marta ; Pasanisi, Fabrizio ; Tin Tin, Sandar ; Perez-Cornago, Aurora ; Aune, Dagfinn ; Christakoudi, Sofia ; Heath, Alicia K. ; Colorado-Yohar, Sandra M. ; Grioni, Sara ; Skeie, Guri ; Sartor, Hanna ; Idahl, Annika ; Rylander, Charlotta ; M. May, Anne ; Weiderpass, Elisabete ; Freisling, Heinz ; Playdon, Mary C. ; Rinaldi, Sabina ; Murphy, Neil ; Huybrechts, Inge ; Dossus, Laure ; Gunter, Marc J.

Background: Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known. Methods: The association of metabolically-defined body size phenotypes with endometrial cancer risk was investigated in a nested case-control study (817 cases/ 817 controls) within the European Prospective Investigation into Cancer and Nutrition (EPIC). Concentrations of C-peptide were used to define metabolically healthy (MH; [...]

Menée à partir des données de 2 études américaines d'association à l'échelle du génome entier portant sur 4 493 témoins et 2 171 patients atteints d'un cancer de la tête et du cou, puis répliquée à l'aide de données européennes portant sur 6 034 patients et 6 585 témoins, cette étude identifie des polymorphismes à simple nucléotide de gènes impliqués dans le métabolisme des hydrocarbures aromatiques polycycliques et des nitrosamines spécifiques du tabac et associés au risque de développer la maladie

Genetic variants in CYP2B6 and HSD17B12 associated with the risk of squamous cell carcinoma of the head and neck

Liu, Hongliang ; Li, GuoJun ; Sturgis, Erich M. ; Shete, Sanjay ; Dahlstrom, Kristina R. ; Du, Mulong ; Amos, Christopher I. ; Christiani, David C. ; Lazarus, Philip ; Wei, Qingyi

Polycyclic aromatic hydrocarbons (PAHs) and tobacco-specific nitrosamines (TSNA) metabolism-related genes play important role in the development of cancers. We assessed the associations of genetic variants in genes involved in the metabolism of PAHs and TSNA, and the risk of squamous cell carcinoma of the head and neck (SCCHN) in European populations using two published genome-wide association study datasets. In the single-locus analysis, we identified two SNPs (rs145533669 and rs35246205) in [...]

Menée sur la période 2013-2020 auprès de 676 667 personnes ayant réalisé un test multigénique, cette étude identifie 6 variants de gènes couramment inclus dans les tests génétiques et associés au risque d'adénocarcinome canalaire du pancréas (2 445 cas)

Pancreatic Ductal Carcinoma Risk Associated with Hereditary Cancer-Risk Genes

Gardiner, Anna ; Kidd, John ; Elias, Maria C ; Young, Kayla  ; Mabey, Brent ; Taherian, Nassim ; Cummings, Shelly ; Malafa, Mokenge ; Rosenthal, Eric ; Permuth, Jennifer B

Although several hereditary cancer predisposition genes have been implicated in pancreatic ductal adenocarcinoma (PDAC) susceptibility, gene-specific risks are not well defined, and are potentially biased due to the design of previous studies. More precise and unbiased risk estimates can result in screening and prevention better tailored to genetic findings.This is a retrospective analysis of 676,667 individuals, 2,445 of whom had a personal diagnosis of PDAC, who received multigene panel [...]