Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

The psychological health of patients diagnosed with cancer in Iraq during the COVID-19 pandemic: A single center study

Alrubai, Tahseen ; Khalil, Arwa Mohsun ; Zaki, Rasha ; Sinno, Loubna ; AL Tabbah, Samaa

Objective : The objective of this study was to assess the psychological health status of patients diagnosed with cancer in Iraq during the COVID-19 pandemic. The study aim was to measure the prevalence of depression, anxiety, and stress among patients diagnosed with cancer. Secondary aims were to assess the association between depression, anxiety, and stress with sociodemographic characteristics, cancer-specific characteristics, patients' experience in healthcare visit, risk perception towards [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Unemployment and cancer screening: Baseline estimates to inform health care delivery in the context of COVID-19 economic distress

Fedewa, Stacey A. ; Yabroff, K. Robin ; Bandi, Priti ; Smith, Robert A. ; Nargis, Nigar ; Zheng, Zhiyuan ; Drope, Jeffrey ; Jemal, Ahmedin

Background: During the coronavirus disease 2019 pandemic, US unemployment rates rose to historic highs, and they remain nearly double those of prepandemic levels. Employers are the most common source of health insurance among nonelderly adults. Thus, job loss may lead to a loss of health insurance and reduce access to cancer screening. This study examined associations between unemployment, health insurance, and cancer screening to inform the pandemic's potential impacts on early cancer [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Efficacy of SARS-CoV-2 vaccine in thoracic cancer patients: a prospective study supporting a third dose in patients with minimal serologic response after two vaccine doses

Gounant, Valérie ; Ferré, Valentine Marie ; Soussi, Ghassen ; Charpentier, Charlotte ; Flament, Héloïse ; Fidouh, Nadhira ; Collin, Gilles ; Namour, Céline ; Assoun, Sandra ; Bizot, Alexandra ; Brouk, Zohra ; Vicaut, eric ; Teixeira, Luis ; Descamps, Diane ; Zalcman, Gerard

Hypothesis: Coronavirus disease 2019 (COVID-19) resulted in a 30% mortality rate in thoracic cancer patients. Given that cancer patients were excluded from serum anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccine registration trials, it is still unknown whether they would develop a protective anti-spike antibody response following vaccination. This prospective vaccine monitoring study primarily aimed to assess humoral responses to SARS-CoV2 vaccine in thoracic cancer [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Resilient health care in global pediatric oncology during the COVID-19 pandemic

Graetz, Dylan E. ; Sniderman, Elizabeth ; Villegas, Cesar A. ; Kaye, Erica C. ; Ragab, Iman ; Laptsevich, Aliaksandra ; Maliti, Biemba ; Naidu, Gita ; Huang, Haiying ; Gassant, Pascale Y. ; Nunes Silva, Luciana ; Arce, Daniela ; Montoya Vasquez, Jacqueline ; Arora, Ramandeep Singh ; Alcasabas, Ana Patricia ; Rusmawatiningtyas, Desy ; Raza, Muhammad Rafie ; Velasco, Pablo ; Kambugu, Joyce ; Vinitsky, Anna ; Rodriguez-Galindo, Carlos ; Agulnik, Asya ; Moreira, Daniel C. ; for the COVIMPACT Study Group

Background : In the face of unprecedented challenges because of coronavirus disease 2019, interdisciplinary pediatric oncology teams have developed strategies to continue providing high-quality cancer care. This study explored factors contributing to health care resilience as perceived by childhood cancer providers in all resource level settings. Methods : This qualitative study consisted of 19 focus groups conducted in 16 countries in 8 languages. Seven factors have been previously defined as [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer: The CANVAX Cohort Study

Vivek Naranbhai ; Claire A. Pernat ; Alexander Gavralidis ; Kerri J. St Denis ; Evan C. Lam ; Laura M. Spring ; Steven J. Isakoff ; Jocelyn R. Farmer ; Leyre Zubiri ; Gabriela S. Hobbs ; Joan How ; Andrew M. Brunner ; Amir T. Fathi ; Jennifer L. Peterson ; Mustafa Sakhi ; Grace Hambelton ; Elyssa N. Denault ; Lindsey J. Mortensen ; Lailoo A. Perriello ; Marissa N. Bruno ; Brittany Y. Bertaux ; Aleigha R. Lawless ; Monica A. Jackson ; Elizabeth Niehoff ; Caroline Barabell ; Christian N. Nambu ; Erika Nakajima ; Trenton Reinicke ; Cynthia Bowes ; Cristhian J. Berrios-Mairena ; Onosereme Ofoman ; Grace E. Kirkpatrick ; Julia C. Thierauf ; Kerry Reynolds ; Henning Willers ; Wilfredo-Garcia Beltran ; Anand S. Dighe ; Rebecca Saff ; Kimberly Blumenthal ; Ryan J. Sullivan ; Yi-Bin Chen ; Arthur Kim ; Aditya Bardia ; Alejandro B. Balazs ; A. John Iafrate ; Justin F. Gainor

PURPOSE : The immunogenicity and reactogenicity of SARS-CoV-2 vaccines in patients with cancer are poorly understood. METHODS : We performed a prospective cohort study of adults with solid-organ or hematologic cancers to evaluate anti–SARS-CoV-2 immunoglobulin A/M/G spike antibodies, neutralization, and reactogenicity ≥ 7 days following two doses of mRNA-1273, BNT162b2, or one dose of Ad26.COV2.S. We analyzed responses by multivariate regression and included data from 1,638 healthy controls, [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

mRNA-1273 COVID-19 vaccination in patients receiving chemotherapy, immunotherapy, or chemoimmunotherapy for solid tumours: a prospective, multicentre, non-inferiority trial

Oosting, Sjoukje F. ; van der Veldt, Astrid A. M. ; GeurtsvanKessel, Corine H. ; Fehrmann, Rudolf S. N. ; van Binnendijk, Rob S. ; Dingemans, Anne-Marie C. ; Smit, Egbert F. ; Hiltermann, T. Jeroen N. ; den Hartog, Gerco ; Jalving, Mathilda ; Westphal, Tatjana T. ; Bhattacharya, Arkajyoti ; van der Heiden, Marieke ; Rimmelzwaan, Guus F. ; Kvistborg, Pia ; Blank, Christian U. ; Koopmans, Marion P. G. ; Huckriede, Anke L. W. ; van Els, Cecile A. C. M. ; Rots, Nynke Y. ; van Baarle, Debbie ; Haanen, John B. A. G. ; de Vries, Elisabeth G. E.

Background : Patients with cancer have an increased risk of complications from SARS-CoV-2 infection. Vaccination to prevent COVID-19 is recommended, but data on the immunogenicity and safety of COVID-19 vaccines for patients with solid tumours receiving systemic cancer treatment are scarce. Therefore, we aimed to assess the impact of immunotherapy, chemotherapy, and chemoimmunotherapy on the immunogenicity and safety of the mRNA-1273 (Moderna Biotech, Madrid, Spain) COVID-19 vaccine as part of [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Lung Cancer and SARS-CoV-2 infection: Identifying important knowledge gaps for investigation

Rolfo, Christian ; Meshulami, Noy ; Russo, Alessandro ; Krammer, Florian ; Garcia-Sastre, Adolfo ; Mack, Philip C. ; Gomez, Jorge E. ; Bhardwaj, Nina ; Benyounes, Amin ; Sirera, Rafael ; Moore, Amy ; Rohs, Nicholas ; Henschke, Claudia I. ; Yankelevitz, David ; King, Jennifer ; Shyr, Yu ; Bunn, Paul A., Jr. ; Minna, John D. ; Hirsch, Fred R.

Patients with lung cancer are especially vulnerable to COVID-19 with a >7-fold higher rate of becoming infected with SARS-CoV-2 COVID-19, a >3-fold higher hospitalization rate with high complication rates, and an estimated case fatality rate of over 30%. The reasons for the increased vulnerability are not known. In addition, beyond the pandemic?s direct impact on morbidity and mortality among patients with lung cancer, COVID-19, with its disruption of patient care, has also resulted in [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Association Between Androgen Deprivation Therapy and Mortality Among Patients With Prostate Cancer and COVID-19

Schmidt, Andrew L. ; Tucker, Matthew D. ; Bakouny, Ziad ; Labaki, Chris ; Hsu, Chih-Yuan ; Shyr, Yu ; Armstrong, Andrew J. ; Beer, Tomasz M. ; Bijjula, Ragneel R. ; Bilen, Mehmet A. ; Connell, Cindy F. ; Dawsey, Scott Joseph ; Faller, Bryan ; Gao, Xin ; Gartrell, Benjamin A. ; Gill, David ; Gulati, Shuchi ; Halabi, Susan ; Hwang, Clara ; Joshi, Monika ; Khaki, Ali Raza ; Menon, Harry ; Morris, Michael J. ; Puc, Matthew ; Russell, Karen B. ; Shah, Neil J. ; Sharifi, Nima ; Shaya, Justin ; Schweizer, Michael T. ; Steinharter, John ; Wulff-Burchfield, Elizabeth M. ; Xu, Wenxin ; Zhu, Jay ; Mishra, Sanjay ; Grivas, Petros ; Rini, Brian I. ; Warner, Jeremy Lyle ; Zhang, Tian ; Choueiri, Toni K. ; Gupta, Shilpa ; McKay, Rana R.

Importance: Androgen deprivation therapy (ADT) has been theorized to decrease the severity of SARS-CoV-2 infection in patients with prostate cancer owing to a potential decrease in the tissue-based expression of the SARS-CoV-2 coreceptor transmembrane protease, serine 2 (TMPRSS2). Objective : To examine whether ADT is associated with a decreased rate of 30-day mortality from SARS-CoV-2 infection among patients with prostate cancer. Design, Setting, and Participants : This cohort study analyzed [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer

Shapiro, Lauren C. ; Thakkar, Astha ; Campbell, Sean T. ; Forest, Stefanie K. ; Pradhan, Kith ; Gonzalez-Lugo, Jesus D. ; Quinn, Ryann ; Bhagat, Tushar D. ; Choudhary, Gaurav S. ; McCort, Margaret ; Sica, R. Alejandro ; Goldfinger, Mendel ; Goel, Swati ; Anampa, Jesus D. ; Levitz, David ; Fromowitz, Ariel ; Shah, Akash Pradip ; Sklow, Charlotte ; Alfieri, Gregory ; Racine, Andrew ; Wolgast, Lucia ; Greenberger, Lee ; Verma, Amit ; Halmos, Balazs

Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vaccination. Prior anti-CD20/BTK inhibitor therapy was associated with reduced vaccine efficacy.

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

How can we create resilient research systems in a pandemic?

Wolfson, Julie A. ; Dye, Candice C. ; Levine, Jennifer M

Graetz et al provide a qualitative examination of diverse global pediatric oncology health care systems and the features that have helped them effectively face challenges in the face of COVID-19. With research systems serving as a hallmark of pediatric oncology, the resiliency of the research-focused systems (and individuals) also require consideration as outlined here.

Menée au Danemark à partir de données portant sur 36 924 femmes atteintes d'un cancer du sein diagnostiqué entre 1987 et 2004, cette étude analyse les facteurs associés au risque de récidive (10 à 32 ans après le diagnostic initial)

The Incidence of Breast Cancer Recurrence 10-32 Years after Primary Diagnosis

Pedersen, Rikke Nørgaard ; Esen, Buket Öztürk ; Mellemkjær, Lene ; Christiansen, Peer ; Ejlertsen, Bent ; Lash, Timothy Lee ; Nørgaard, Mette ; Cronin-Fenton, Deirdre

Extended, more effective breast cancer (BC) treatments have increased the prevalence of long term survivors. We investigated the risk of late breast cancer recurrence (BCR), 10 years or more after primary diagnosis, and associations between patient and tumor characteristics at primary diagnosis and late BCR up to 32 years after primary BC diagnosis.Using the Danish Breast Cancer Group clinical database, we identified all women with an incident early BC diagnosed during 1987–2004. We restricted [...]

Menée au Danemark à partir de données portant sur 36 924 femmes atteintes d'un cancer du sein diagnostiqué entre 1987 et 2004, cette étude analyse les facteurs associés au risque de récidive (10 à 32 ans après le diagnostic initial)

Prevention of Late Recurrence: An Increasingly Important Target for Breast Cancer Research and Control

Negoita, Serban ; Ramirez-Pena, Esmeralda

Breast cancer recurrence has become an increasingly important aspect of cancer control as the number of breast cancer survivors continues to increase.1-3 It was previously thought that the risk of recurrence decreases five years after diagnosis, however an increasing body of literature has sustained a considerable risk of “late recurrence” beyond the canonical time frame.4-5 Further characterizing the risk of recurrence thus remains of key importance both in guiding clinical management and [...]

Menée aux Etats-Unis auprès de 541 patients âgés de plus de 70 ans, atteints d'un cancer de stade avancé et inclus dans un essai clinique, cette étude analyse l'association entre des degrés de fragilité et la communication entre le patient et son médecin sur les problèmes liés à l'âge

Evaluating the association of frailty with communication about aging-related concerns between older patients with advanced cancer and their oncologists

Gilmore, Nikesha ; Xu, Huiwen ; Kehoe, Lee ; Kleckner, Amber S. ; Moorthi, Kiran ; Lei, Lianlian ; Mohamed, Mostafa R. S. ; Loh, Kah Poh ; Culakova, Eva ; Flannery, Marie ; Ramsdale, Erika ; Duberstein, Paul R. ; Canin, Beverly ; Kamen, Charles ; Giri, Gilbert ; Watson, Erin ; Patil, Amita ; Onitilo, Adedayo A. ; Burnette, Brian ; Janelsins, Michelle ; Mohile, Supriya G.

Background : A geriatric assessment (GA) intervention improves communication about aging-related concerns, but its effect on communication in patients with various levels of frailty is unknown. Methods : This was a secondary analysis of a nationwide trial of patients aged ≥70 years with incurable cancer and impairment on 1 or more GA domains (ClinicalTrials.gov Identifier NCT02107443; principal investigator Supriya G. Mohile). Practice sites were randomized to either the GA-intervention or [...]

Menée aux Etats-Unis auprès de 541 patients âgés de plus de 70 ans, atteints d'un cancer de stade avancé et inclus dans un essai clinique, cette étude analyse l'association entre des degrés de fragilité et la communication entre le patient et son médecin sur les problèmes liés à l'âge

Multidimensional impact of the geriatric assessment in the cancer care of older adults

Subbiah, Ishwaria M. ; Tejero, Isabel ; Alibhai, Shabbir M. H.

Frailty is common in older adults with cancer. This editorial explores the significance of frailty to patient-clinician communication in an article by Gilmore et al.