A partir d'une revue systématique de la littérature (15 études), cette méta-analyse évalue l'association entre une consommation de poisson, d'acides gras polyinsaturés et le risque de cancer du poumon

Fish Intake, Dietary Polyunsaturated Fatty Acids, and Lung Cancer: Systematic Review and Dose–Response Meta-Analysis of 1.7 Million Men and Women

Lv, Dan ; Wang, Ran ; Chen, Meiping ; Li, Yiting ; Cao, Chao

To determine the association between fish intake and dietary polyunsaturated fatty acids (PUFA) and incidence of lung cancer. We systematically reviewed and meta-analyzed all available studies to quantify the associations of fish and PUFA consumption with risk of lung cancer. Relative risk (RR) with 95% confidence interval (CI) was calculated. 13 population-based prospective cohort studies involving 1,785,000 participants and two randomized control trials were included. Our study demonstrated [...]

A partir d'une revue systématique de la littérature publiée entre janvier 1970 et octobre 2019 (37 études, 43 429 patients, 67 396 témoins), cette méta-analyse évalue l'association entre un apport alimentaire en calcium ou en vitamine D et le risque de cancer colorectal

The role of calcium and vitamin D dietary intake on risk of colorectal cancer: systematic review and meta-analysis of case–control studies

Lopez-Caleya, Juan Francisco ; Ortega-Valín, Luis ; Fernandez-Villa, Tania ; Delgado-Rodriguez, Miguel ; Martín-Sánchez, Vicente ; Molina, Antonio José

Purpose: The aim of this study is to analyze the current evidence about the relationships between calcium/vitamin D and CRC based on case–control studies according to sex, tumor location and continental region to complement the information obtained in meta-analyses of other designs. Methods: The articles were located in three databases (PUBMED, EMBASE and SCOPUS), they should be written in English language, with a case and control design and published between 1 January 1970 and 31 October 2019. [...]

A partir d'une revue systématique de la littérature publiée jusqu'en février 2021 (10 études), cette méta-analyse évalue l'association entre une consommation de café et le risque de cancer du rein

Coffee consumption and risk of renal cancer: a meta-analysis of cohort evidence

Rhee, Jongeun ; Lim, Rachel K. ; Purdue, Mark P.

Purpose: There is increasing evidence that coffee consumption is related to reduced risks for some cancers, but the evidence for renal cancer is inconclusive. Therefore, we conducted a meta-analysis to summarize the cohort evidence of this relationship. Methods: A literature search was performed in PubMed and Embase through February 2021. Meta-analyses using a random effects model were conducted for reported relative risk estimates (RRs) relating coffee intake and renal cancer incidence or [...]

Menée en Suède entre 2005 et 2018 auprès de 296 964 femmes et de témoins (âge : au moins 45 ans ; durée médiane de suivi : 9,7 ans), cette étude analyse l'association entre un traitement hormonal substitutif et le risque d'adénocarcinome de l'oesophage

Menopausal hormone therapy and risk of oesophageal adenocarcinoma in a population-based cohort study

Xie, Shao-Hua ; Santoni, Giola ; Lagergren, Jesper

Background: Oesophageal adenocarcinoma is characterised by a strong male predominance. We aimed to test the hypothesis that menopausal hormonal therapy decreases the risk of oesophageal adenocarcinoma. Methods: This population-based cohort study included all women who used systemic menopausal hormonal therapy (exposed) in Sweden between 2005 and 2018. For each exposed participant, five randomly selected female age-matched non-users of menopausal hormonal therapy (unexposed) were included. Cox [...]

Menée aux Pays-Bas à l'aide de données de 2 registres portant sur 94 753 témoins et sur 69 272 utilisateurs de statines, cette étude analyse l'association entre cette utilisation et le risque de cancer colorectal, par sous-type moléculaire

Statin use is associated with a reduced incidence of colorectal cancer expressing SMAD4

Ouahoud, Sarah ; Jacobs, Rutger J. ; Kodach, Ludmilla L. ; Voorneveld, Philip W. ; Hawinkels, Lukas J. A. C. ; Weil, Nikki L. ; van Vliet, Britt ; Herings, Ron M. ; van der Burg, Lennart R. A. ; van Wezel, Tom ; Morreau, Hans ; Slingerland, Marije ; Bastiaannet, Esther ; Putter, Hein ; Hardwick, James C. H.

Background: Long-term use of statins is associated with a small reduced risk of colorectal cancer but their mechanism of action is not well understood. While they are generally believed to act on KRAS, we have previously proposed that they act via influencing the BMP pathway. The objective of this study was to look for associations between statin use and the risk of developing colorectal cancer of a particular molecular subtype. Methods: By linking two registries unique to the Netherlands, [...]

Menée à l'aide d'un modèle murin de tumorigenèse mammaire, cette étude analyse le rôle chimiopréventif du vénétoclax, utilisé comme inhibiteur de la protéine anti-apoptotique BCL-2

Targeting the Pro-Survival Protein BCL-2 to Prevent Breast Cancer

Young, Adelaide I J ; Bu, Wen ; Jiang, Weiyu ; Ku, Amy T ; Kapali, Jyoti ; Dhamne, Sagar ; Qin, Lan ; Hilsenbeck, Susan G ; Du, Yi-Chieh Nancy ; Li, Yi

Current chemopreventive strategies require 3-5 years of continuous treatment and have the concerns of significant side effects; therefore, new chemopreventive agents that require shorter and safer treatments are urgently needed. In this study, we developed a new murine model of breast cancer that mimics human breast cancer initiation and is ideal for testing the efficacy of chemopreventive therapeutics. In this model, introduction of lentivirus carrying a PIK3CA gene mutant commonly found in [...]

Menée à partir de données des registres d'immunisation et des cancers de l'Etat du Michigan portant sur 773 193 femmes, cette étude évalue l'efficacité du vaccin anti papillomavirus humain contre les lésions cervicales intraépithéliales de haut grade (CIN3+) en fonction du nombre de doses de vaccin reçues et selon l'âge au moment de la vaccination

An Evaluation of Dose-related HPV Vaccine Effectiveness Using Central Registries in Michigan

Gargano, Julia W ; You, Mei ; Potter, Rachel ; Alverson, Georgetta ; Swanson, Robert ; Saraiya, Mona ; Markowitz, Lauri E ; Copeland, Glenn

Background: Human papillomavirus (HPV) vaccine effectiveness (VE) evaluations provide important information for vaccination programs. We established a linkage between statewide central registries in Michigan to estimate HPV VE against in situ and invasive cervical lesions (CIN3+). Methods: We linked females in Michigan's immunization and cancer registries using birth records to establish a cohort of 773,193 women with known vaccination history, of whom 3,838 were diagnosed with CIN3+. [...]