Menée en France auprès de 304 patients atteints d'une tumeur germinale du testicule et de 274 témoins (âge : 18-45 ans), cette étude multicentrique analyse l'association entre une exposition domestique précoce aux pesticides (entre 1 an avant le début de la grossesse de la mère et 1 an après la naissance de l'enfant) et le risque de développer la maladie à l'âge adulte

Domestic use of pesticides during early periods of development and risk of testicular germ cell tumors in adulthood: a French nationwide case-control study

Danjou, Aurélie M. N. ; Pérol, Olivia ; Coste, Astrid ; Faure, Elodie ; Béranger, Rémi ; Boyle, Helen ; Belladame, Elodie ; Grassot, Lény ; Dubuis, Matthieu ; Spinosi, Johan ; Bouaoun, Liacine ; Fléchon, Aude ; Bujan, Louis ; Drouineaud, Véronique ; Eustache, Florence ; Berthaut, Isabelle ; Perrin, Jeanne ; Brugnon, Florence ; Charbotel, Barbara ; Schüz, Joachim ; Fervers, Beatrice ; For the, Testis study group

Background: Testicular germ cell tumours (TGCT) are the most frequent cancers in young men in developed countries and their incidence rate has doubled worldwide over the past 40 years. Early life exposures to pesticides are suspected to increase TGCT risk. Our research aimed at estimating adult TGCT risk associated with parental domestic use of pesticides during early periods of child development. Methods: We conducted a case-control study of 304 TGCT cases, aged 18–45 years old, recruited in [...]

Menée à l'aide d'échantillons oraux prélevés chez 90 témoins et 90 patients atteints d'un carcinome hépatocellulaire diagnostiqué entre 2011 et 2016 (âge : 35-84 ans), cette étude analyse l'association entre la présence de cyanobactéries dans la cavité buccale et le risque de développer la maladie

Oral Cyanobacteria and hepatocellular carcinoma

Hernandez, Brenda Y ; Zhu, Xuemei ; Risch, Harvey A ; Lu, Lingeng ; Ma, Xiaomei ; Irwin, Melinda L ; Lim, Joseph K. ; Taddei, Tamar H ; Pawlish, Karen S ; Stroup, Antoinette M ; Brown, Robert ; Wang, Zhanwei ; Wong, Linda L ; Yu, Herbert

Background: Gut microbial alterations have been linked to chronic liver disease and hepatocellular carcinoma (HCC). The role of the oral microbiome in liver cancer development has not been widely investigated. Methods: Bacterial 16S rRNA sequences were evaluated in oral samples from 90 HCC cases and 90 controls who were a part of a larger U.S. case-control study of HCC among patients diagnosed from 2011-2016. Results: The oral microbiome of HCC cases showed significantly reduced alpha diversity [...]

Menée au Danemark auprès de 75 983 personnes âgées d'au moins 50 ans, cette étude multicentrique analyse l'association entre une rétention urinaire aiguë et le risque de cancers urogénitaux, colorectaux et neurologiques

Acute urinary retention and risk of cancer: population based Danish cohort study

Bengtsen, Maria Bisgaard ; Farkas, Dóra Körmendiné ; Borre, Michael ; Sørensen, Henrik Toft ; Nørgaard, Mette

Objective: To examine the risk of urogenital, colorectal, and neurological cancers after a first diagnosis of acute urinary retention. Design: Nationwide population based cohort study. Setting: All hospitals in Denmark. Participants: 75 983 patients aged 50 years or older with a first hospital admission for acute urinary retention during 1995-2017. Main outcome measures: Absolute risk of urogenital, colorectal, and neurological cancer and excess risk of these cancers among patients with acute [...]

Menée au Royaume-Uni sur la période 2007-2010 auprès de 445 555 participants (âge moyen : 56,3 ans ; durée médiane de suivi : 8,8 ans ; 54 % de femmes), cette étude analyse l'association entre la force de préhension, exprimée en fonction de l'indice de masse corporelle, et le risque de cancer (15 localisations, 37 291 cas), ainsi que la mortalité associée (11 363 décès)

Associations Between Relative Grip Strength and the Risk of 15 Cancer Sites

Parra-Soto, Solange ; Tumblety, Craig ; Ho, Frederick K. ; Pell, Jill P. ; Celis-Morales, Carlos

Introduction: Grip strength is the most commonly used muscle strength proxy in clinical research. However, evidence regarding the associations of grip strength with cancer has been mainly restricted to overall cancer risk. Therefore, this study aims to evaluate the associations between grip strength relative to BMI and 15 cancer sites as well as with all-cause cancer mortality. Methods: A total of 445,555 participants (53.8% women, mean age=56.3 years) were recruited across the United Kingdom. [...]

Menée à partir de données de la cohorte "the Health Professionals Follow-Up Study" portant sur 35 662 hommes (durée médiane de suivi : 19 ans), cette étude analyse l'association entre la couleur des yeux et le risque de cancer de la peau (445 mélanomes, 1 123 carcinomes épidermoïdes et 7 198 carcinomes basocellulaires)

Eye color and the risk of skin cancer

Li, Yueyao ; Li, Wen-Qing ; Li, Tricia ; Qureshi, Abrar A. ; Cho, Eunyoung

Melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common skin cancers. The incidence rates of all three types of skin cancers have increased in the past three decades. Light pigmentary traits have been recognized as one of the host risk factors for skin cancer, but findings on associations between eye colors and risk of skin cancers have been inconsistent. We performed a prospective analysis to examine the association between eye colors and risk of skin cancers [...]

Menée à partir de données d'analyses sanguine et urinaire portant sur 581 témoins et 687 patientes atteintes d'un cancer du sein, cette étude analyse l'effet de la longueur des télomères des leucocytes sur l'association entre une exposition environnementale aux phtalates ou aux phénols et le risque de développer la maladie

Phthalates and Phenols, Leukocyte Telomere Length, and Breast Cancer Risk and Mortality in the Long Island Breast Cancer Study Project

Zhang, Xueying ; Wolff, Mary S ; Shen, Jing ; Parada, Humberto ; Santella, Regina M ; Neugut, Alfred I ; Chen, Jia ; Teitelbaum, Susan L

Background: Phthalates and phenols from the environment have been inconsistently associated with breast cancer risk or mortality. Studies on the potential modifying role of leukocyte telomere length (LTL), a biomarker of biological aging, on these associations are lacking. Methods: We included 1268 women from the Long Island Breast Cancer Study Project with available data on phthalate and phenol analytes and LTL measurements. Twenty-two phthalate and phenol analytes were measured in spot urines [...]