Menée par enquête auprès de 69 adolescents et jeunes adultes ayant survécu 5 ans ou plus à une tumeur cérébrale diagnostiquée pendant l'enfance (âge lors de l'enquête : 13-30 ans) et menée auprès de 43 aidants, cette étude analyse leurs besoins en soins de support et leur qualité de vie à long terme

Long-term unmet supportive care needs of teenage and young adult (TYA) childhood brain tumour survivors and their caregivers: a cross-sectional survey

Nicklin, Emma ; Velikova, Galina ; Glaser, Adam ; Kwok-Williams, Michelle ; Debono, Miguel ; Sarwar, Naseem ; Boele, Florien

Introduction : The supportive care needs of long-term childhood brain tumour survivors, now teenagers and young adults (TYAs), and their caregivers are largely unknown. We aimed to describe their supportive care needs and explore associations between needs and quality of life (QoL). Methods : Participants were recruited from long-term follow-up clinics (in three NHS Trusts in England) and online. Participants included childhood brain tumour survivors, ≥ 5 years from diagnosis, currently aged [...]

Menée à partir de données portant sur 1 387 patients âgés ayant survécu à un cancer, cette étude analyse l'association entre une séropositivité au cytomégalovirus, des marqueurs d'une inflammation et des déficiences cognitives

Cross sectional association between cytomegalovirus seropositivity, inflammation and cognitive impairment in elderly cancer survivors

Vivek, Sithara ; Nelson, Heather Hammond ; Prizment, Anna E. ; Faul, Jessica ; Crimmins, Eileen M. ; Thyagarajan, Bharat

Purpose : The higher prevalence of cognitive impairment/ dementia among cancer survivors is likely multifactorial. Since both exposures to cytomegalovirus (CMV) and inflammation are common among elderly cancer survivors, we evaluated their contribution towards dementia. Methods : Data from 1387 cancer survivors and 7004 participants without cancer in the 2016 wave of the Health and Retirement Study (HRS) was used in this study. Two inflammatory biomarkers, C-reactive protein (CRP) and [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2021 (41 articles, 1 197 564 participants), cette méta-analyse évalue l'association entre une consommation d'acide alpha linolénique d'origine alimentaire et la mortalité toutes causes confondues et par cancer

Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies

Naghshi, Sina ; Aune, Dagfinn ; Beyene, Joseph ; Mobarak, Sara ; Asadi, Masoomeh ; Sadeghi, Omid

Objective : To examine the associations between dietary intake and tissue biomarkers of alpha linolenic acid (ALA) and risk of mortality from all causes, cardiovascular disease (CVD), and cancer. Design: Systematic review and meta-analysis of prospective cohort studies. Data sources : PubMed, Scopus, ISI Web of Science, and Google Scholar to 30 April 2021. Study selection : Prospective cohort studies that reported the risk estimates for death from all causes, CVD, and cancer. Data synthesis : [...]

Menée en Chine à partir de données portant sur 1 744 patients atteints d'un cancer, cette étude de cohorte rétrospective analyse l'association entre l'indice de masse maigre et la mortalité

The association of fat-free mass index with mortality in cancer patients: a multicenter observational study

Zhang, Xi ; Li, Xiang-Rui ; Shi, Hong-yun ; Zhang, Kang-Ping ; Zhang, Qi ; Tang, Meng ; Li, Wei ; Zhou, Fu-xiang ; Liu, Ming ; Cong, Ming-Hua ; Shi, Han-Ping

Background : Low fat-free mass index (FFMI) has been related to higher mortality in community populations. However, the information on the relationship between FFMI and mortality is lacking for cancer patients. The objective of this study was to examine the association of FFMI with all-cause mortality in cancer patients. Methods : This retrospective analysis included 1,744 cancer patients from a multicenter cohort study. The restricted cubic splines were used to flexibly model the association [...]

Menée en Angleterre à partir de données portant sur 167 606 patients atteints d'un cancer du côlon ou du rectum, cette étude de cohorte analyse la survie globale à 5 ans, selon la localisation (côté droit ou gauche) de la tumeur

Survival outcomes for right-versus left-sided colon cancer and rectal cancer in England: A propensity-score matched population-based cohort study

Hodges, Nicola ; Mackenzie, Hugh ; D'Souza, Nigel ; Brown, Gina ; Miskovic, Danilo

Introduction : The aim of this study was to evaluate 5-year overall survival (OS) in patients operated on for potentially curable right versus left-sided colon cancer and rectal cancer in England. Materials and methods : A retrospective propensity-score matched population-based cohort study was performed using data from English Hospital Episode Statistics, Office for National Statistics and National Bowel Cancer Audit dataset. Patients ≥18 who underwent elective resection for right-colon, [...]

Menée à partir de données portant sur 2 326 patients atteints d'un cancer colorectal de stade métastatique inclus dans un essai multicentrique randomisé, cette étude analyse l'association entre l'âge des patients et la survie

Survival in Young-Onset Metastatic Colorectal Cancer: Findings from Cancer and Leukemia Group B (Alliance)/SWOG 80405

Lipsyc-Sharf, Marla ; Zhang, Sui ; Ou, Fang-Shu ; Ma, Chao ; McCleary, Nadine Jackson ; Niedzwiecki, Donna ; Chang, I-Wen ; Lenz, Heinz-Josef ; Blanke, Charles D ; Piawah, Sorbarikor ; Van Loon, Katherine ; Bainter, Tiffany M ; Venook, Alan P ; Mayer, Robert J ; Fuchs, Charles S ; Innocenti, Federico ; Nixon, Andrew B ; Goldberg, Richard ; O’Reilly, Eileen M ; Meyerhardt, Jeffrey A ; Ng, Kimmie

Background : The incidence of young-onset colorectal cancer (yoCRC) is increasing. It is unknown if there are survival differences between young and older patients with metastatic colorectal cancer (mCRC). Methods : We studied the association of age with survival in 2326 mCRC patients enrolled in the CALGB/SWOG 80405 trial, a multi-center, randomized trial of first-line chemotherapy plus biologics. The primary and secondary outcomes of this study were overall survival (OS) and progression-free [...]

A partir d'une revue systématique de la littérature (28 études), cette méta-synthèse examine les expériences professionnelles de patientes au moment du diagnostic d'un cancer du sein et lors de la reprise du travail

Experiences of women with breast cancer while working or returning to work: a qualitative systematic review and meta-synthesis

Tan, Faustine Sze Ing ; Shorey, Shefaly

Purpose : This systematic review aims to consolidate the available qualitative evidence regarding the experiences of women with breast cancer while working or returning to work. Methods : Six electronic databases were searched until December 2020 for qualitative English-language articles examining the experiences of adult females with reproductive cancers while working or returning to work. The Critical Appraisal Skills Program checklist was used to assess the quality of included studies while [...]

Cette étude internationale analyse les disparités géographiques dans l'évolution, sur la période 1990-2017, de l'incidence du cancer du larynx et de la mortalité associée

Temporal trends in incidence and mortality rates of laryngeal cancer at the global, regional and national levels, 1990–2017

Wang, Jing-Yuan ; Zhang, Qiang-Wei ; Wen, Kaixue ; Wang, Chen ; Ji, Xiaolin ; Zhang, Lixia

Objectives : Laryngeal cancer is the most prevalent entity of head and neck cancer. Knowing the trends of incidence and mortality of laryngeal cancer is important for the reduction in related disease burden. Design : Population-based observational study. Main outcomes and measures : The incidence and mortality data of laryngeal cancer were retrieved from the Global Burden of Disease study 2017 online database. The estimated average percentage change was used to quantify the trends of laryngeal [...]

Mené sur 120 aidants familiaux de patients atteints d'un cancer, cet essai randomisé évalue l'efficacité d'une intervention en ligne dirigée par des infirmières et dispensée pendant 8 semaines avec ou sans psychothérapie comportementale, pour soulager les symptômes d'anxiété et de dépression

The effects of SmartCare© on neuro-oncology family caregivers’ distress: a randomized controlled trial

Boele, Florien W. ; Weimer, Jason M. ; Proudfoot, Judith ; Marsland, Anna L. ; Armstrong, Terri S. ; Given, Charles W. ; Drappatz, Jan ; Donovan, Heidi S. ; Sherwood, Paula R.

Purpose : Patients with primary malignant brain tumors have high symptom burden and commonly rely on family caregivers for practical and emotional support. This can lead to negative mental and physical consequences for caregivers. We investigated effectiveness of an 8-week nurse-led online needs-based support program (SmartCare©) with and without online self-guided cognitive behavioral therapy (CBT) for depression compared to enhanced care as usual (ECAU) on depressive symptoms, [...]

Mené en Italie sur 762 patients atteints d'un cancer, cet essai randomisé évalue l'intérêt, du point de vue de l'amélioration des fonctions sociales et émotionnelles des patients et de leur qualité de vie pendant les traitements, d'une intervention de soins psychosociaux

Effectiveness of a Psychosocial Care Quality Improvement Strategy to Address Quality of Life in Patients With Cancer: The HuCare2 Stepped-Wedge Cluster Randomized Trial

Caminiti, Caterina ; Annunziata, Maria Antonietta ; Verusio, Claudio ; Pinto, Carmine ; Airoldi, Mario ; Aragona, Marcello ; Caputo, Francesca ; Cinieri, Saverio ; Giordani, Paolo ; Gori, Stefania ; Mattioli, Rodolfo ; Novello, Silvia ; Pazzola, Antonio ; Procopio, Giuseppe ; Russo, Antonio ; Sarobba, Giuseppina ; Zerilli, Filippo ; Diodati, Francesca ; Iezzi, Elisa ; Maglietta, Giuseppe ; Passalacqua, Rodolfo

Importance : Many patients with cancer who would benefit from psychosocial care do not receive it. Implementation strategies may favor the integration of psychosocial care into practice and improve patient outcomes. Objective : To evaluate the effectiveness of the Humanization in Cancer Care (HuCare) Quality Improvement Strategy vs standard care as improvement of at least 1 of 2 domains (emotional or social function) of patient health-related quality of life at baseline and 3 months. A key [...]

A partir d'une revue de la littérature, cette étude souligne la nécessité de prendre en compte la toxicité cognitive des traitements évalués dans des essais de phase I incluant des patients atteints d'un cancer

Assessing cognitive toxicity in early Phase Trials - What are we missing?

Stapleton, Sarah. E. ; Darlington, Anne-Sophie ; Minchom, Anna ; Pal, Abhijit ; Raynaud, Florence ; Wiseman, Theresa

Objectives : Novel therapies, such as, small protein molecule inhibitors and immunotherapies are first tested clinically in Phase I trials. Moving on to later phase trials and ultimately standard practice. A key aim of these early clinical trials is to define a toxicity profile; however, the emphasis is often on safety. The concern is cognitive toxicity is poorly studied in this context and may be under-reported. The aim of this review is to map evidence of cognitive assessment, toxicity, and [...]

Cet article analyse les facteurs associés au risque de déficiences cognitives liées aux traitements anticancéreux chez des patientes atteintes d'un cancer du sein, identifie les mécanismes de ces déficiences puis passe en revue les outils d'évaluation ainsi que les stratégies thérapeutiques

Cancer-Related Cognitive Impairment in Patients With a History of Breast Cancer

Van Dyk, Kathleen ; Ganz, Patricia A.

Clinical reports of cognitive difficulties in patients with breast cancer began to appear in the literature in the 1990s, coincident with the increasing use of postoperative adjuvant chemotherapy. Symptoms were more frequently reported in women who received very high-dose chemotherapy, raising concerns that cognitive impairment might become a dose-limiting treatment toxicity. However, this has not occurred, in that over the past 2 decades there has been a deescalation of both the intensity and [...]

Menée par questionnaire auprès de 200 patients ayant survécu à un cancer de la tête et du cou, cette étude analyse les facteurs associés à l'évolution de leur croissance post-traumatique

A Longitudinal Investigation of Posttraumatic Growth and Its Associated Factors among Head and Neck Cancer Survivors

Hamdan, Nur Amirah ; Hamid, Norhaliza Abd ; Iman Leong Bin Abdullah, Mohammad Farris

Objectives : Posttraumatic growth (PTG) may improve among cancer survivors, but a longitudinal study addressing head and neck cancer (HNC) is lacking. This longitudinal study examined PTG trends and determined the associations of physical symptoms and complications, as well as sociodemographic and tumor characteristics on PTG over time among HNC survivors. Methods : Participants completed the European Organization of Research and Treatment of Cancer’s “Quality of Life Questionnaire—Head and [...]

Menée aux Etats-Unis à partir des données d'une enquête nationale menée entre 2013 et 2016, de données des registres américains des cancers et de la base Medicare sur la période 2007-2013, cette étude estime, pour une période de 5 ans, les coûts associés à l'incidence des cancers liés à l'alimentation

Estimated economic burden of cancer associated with suboptimal diet in the United States

Khushalani, Jaya S. ; Cudhea, Frederick P. ; Ekwueme, Donatus U. ; Ruan, Mengyuan ; Shan, Zhilei ; Harris, Diane M. ; Mozaffarian, Dariush ; Zhang, Fang Fang

Purpose : Suboptimal diet is a preventable cause of cancer. We aimed to estimate the economic burden of diet-associated cancer among US adults. Methods : We used a Comparative Risk Assessment model to quantify the number of new cancer cases attributable to seven dietary factors among US adults ages 20 + years. A Markov cohort model estimated the 5-year medical costs for 15 diet-associated cancers diagnosed in 2015. We obtained dietary intake from 2013 to 2016 National Health and Nutrition [...]

Menée au Japon auprès de 885 patients atteints d'un cancer de stade avancé et traités dans des unités de soins palliatifs, cette étude de cohorte prospective analyse l'effet du cathétérisme urinaire sur la "qualité du décès"

Does Urinary Catheterization Affect the Quality of Death in Patients with Advanced Cancer? A Secondary Analysis of Multicenter Prospective Cohort Study

Higashibata, Takahiro ; Hamano, Jun ; Hisanaga, Takayuki ; Hagiwara, Shingo ; Shimokawa, Miho ; Yabuki, Ritsuko ; Yokomichi, Naosuke ; Shimoinaba, Junichi ; Kamura, Rena ; Baba, Mika ; Funaki, Hiromi ; Mori, Masanori ; Morita, Tatsuya ; Tsuneto, Satoru ; Kizawa, Yoshiyuki ; Inoue, Satoshi ; Imai, Kengo ; Tsukuura, Hiroaki ; Yamauchi, Toshihiro ; Naito, Akemi Shirado ; Maeda, Isseki ; Uneno, Yu ; Yoshioka, Akira ; Hiramoto, Shuji ; Kikuchi, Ayako ; Hori, Tetsuo ; Matsuda, Yosuke ; Kohara, Hiroyuki ; Tanaka, Keiko ; Suzuki, Kozue ; Kamei, Tina ; Azuma, Yukari ; Amano, Koji ; Uno, Teruaki ; Miyamoto, Jiro ; Katayama, Hirofumi ; Kashiwagi, Hideyuki ; Matsumoto, Eri ; Oya, Kiyofumi ; Yamaguchi, Takeya ; Okamura, Tomonao ; Hashimoto, Hoshu ; Kosugi, Shunsuke ; Ikuta, Nao ; Matsumoto, Yaichiro ; Ohmori, Takashi ; Nakai, Takehiro ; Ikee, Takashi ; Unoki, Yuto ; Kitade, Kazuki ; Koito, Shu ; Ishibashi, Nanao ; Ehara, Masaya ; Kuwahara, Kosuke ; Ueno, Shohei ; Nakashima, Shunsuke ; Ishiyama, Yuta ; Sakashita, Akihiro ; Matsunuma, Ryo ; Takatsu, Hana ; Yamaguchi, Takashi ; Ito, Satoko ; Terabayashi, Toru ; Nakagawa, Jun ; Yamagiwa, Tetsuya ; Inoue, Akira ; Yamaguchi, Takuhiro ; Miyashita, Mitsunori ; Yoshida, Saran ; Hiratsuka, Yusuke ; Tagami, Keita ; Watanabe, Hiroaki ; Odagiri, Takuya ; Ito, Tetsuya ; Ikenaga, Masayuki ; Shimizu, Keiji ; Hayakawa, Akira ; Nishi, Tomohiro ; Shibata, Yasuhiro ; Miyake, Satoshi ; Nozato, Junko ; Ishiki, Hiroto ; Iriyama, Tetsuji ; Kaneishi, Keisuke ; Miura, Tomofumi ; Matsumoto, Yoshihisa ; Kosugi, Kazuhiro ; Okizaki, Ayumi ; Watanabe, Yuki Sumazaki ; Uehara, Yuko ; Satomi, Eriko ; Nishijima, Kaoru ; Nakahori, Ryoichi ; Hirohashi, Takeshi ; Kawashima, Natsuki ; Kawaguchi, Takashi ; Uchida, Megumi ; Sato, Ko ; Matsuda, Yoichi ; Hatano, Yutaka ; Maeda, Sayaka ; Otani, Hiroyuki

Background: Patients with life-limiting illnesses frequently experience urinary difficulties, and urinary catheterization is one of the interventions for managing them. However, evidence supporting the effects of urinary catheters on the quality of death (QoD) is lacking in this population. Objectives: To investigate whether urinary catheterization affects QoD in patients with advanced cancer in palliative care units. Design: A secondary analysis of a multicenter, prospective cohort study. [...]

Menée en Italie par enquête auprès de 283 patients atteints d'un cancer de stade avancé et suivis à domicile, cette étude analyse leur utilisation de médecines complémentaires et alternatives

The use of complementary alternative medicines in advanced cancer patients followed at home

Mercadante, Sebastiano ; Bellavia, Giuseppe ; Cascio, Alessio Lo ; Dabbene, Marcella ; di Silvestre, Grazia ; Casuccio, Alessandra ; Orlando, Bruno ; Favara, Tommaso ; Scibilia, Carla ; Gueci, Marina ; Adamoli, Lucia ; Mauceri, Marco ; de Lisi, Alessandro ; Mauro, Mario Lo ; Pirajno, Giuseppe ; the Regional home care program in Sicily, Samot

Objectives : To assess the use of complementary alternative medicines (CAM) in advanced cancer patients followed at home. Methods : A consecutive sample of advanced cancer patients admitted to a home palliative care program was invited to participate in the study in a period of two months. Demographic characteristics, religious belief, education level, diagnosis, and socio-economic condition were recorded. Patients were asked about the use of CAM, considered to be a health-related treatment [...]