Menée auprès de 304 témoins et 136 patients atteints d'un carcinome à cellules rénales (100 % d'hommes fumeurs ; durée moyenne de suivi : 16,3 ans), cette étude analyse l'effet d'une consommation de café sur l'association entre la concentration sanguine en plomb ou d'autres métaux lourds et le risque de développer la maladie

Coffee intake and trace element blood concentrations in association with renal cell cancer among smokers

Wu, Hongke ; Weinstein, Stephanie ; Moore, Lee E. ; Albanes, Demetrius ; Wilson, Robin Taylor

To determine whether higher coffee intake may reduce the risk of renal cell cancer (RCC) associated with lead (Pb) and other heavy metals with known renal toxicity. Methods: We conducted a nested case–control study of male smokers (136 RCC cases and 304 controls) within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Cases diagnosed with RCC at 5 or more years following cohort enrollment were matched to controls on age (± 7 years) and whole blood draw date (± 30 days). Conditional [...]

Menée au Danemark auprès de 31 393 personnes ayant reçu au moins 2 prescriptions de ranitidine entre 1996 et 2008, cette étude analyse l'association entre l'utilisation de cet antagoniste des récepteurs H2 et le risque de cancer de la vessie ou du rein

Ranitidine and risk of bladder and kidney cancer: a population based cohort study

Nørgaard, Mette ; Andersen, Ina Trolle ; Heide-Jørgensen, Uffe ; Erichsen, Rune ; Rees, Judy R ; Karagas, Margaret R ; Sorensen, Henrik Toft

Background: In 2019, ranitidine was withdrawn due to high levels of N-nitrosodimethylamine, a probable human carcinogen. The risk of bladder and kidney cancer in ranitidine users, however, remains unclear. Methods: In a Danish nationwide cohort study, we included adults (18 years or older) without previous cancer, who between 1996 and 2008 redeemed at least two prescriptions for ranitidine and, as two separate comparison cohorts patients with at least two prescriptions for other H2-receptor [...]

Menée entre 2017 et 2021 auprès de 283 patientes atteintes d'un cancer du sein lobulaire héréditaire, cette étude analyse l'association entre la présence de variants pathogènes de CDH1 et le risque de cancer gastrique

Association Between Hereditary Lobular Breast Cancer Due to CDH1 Variants and Gastric Cancer Risk

Gamble, Lauren A. ; Rossi, Alexander ; Fasaye, Grace-Ann ; Kesserwan, Chimene ; Hernandez, Jonathan M. ; Blakely, Andrew M. ; Davis, Jeremy L.

Hereditary cancer risk is informed by the presence of a germline gene variant more so than by family history of cancer.To assess gastric cancer risk among patients who received a diagnosis of hereditary lobular breast cancer (HLBC) owing to a germline loss-of-function variant in CDH1 by establishing prevalence of signet ring cell carcinomas among asymptomatic patients.A prospective cohort study of patients with germline CDH1 pathogenic or likely pathogenic (P/LP) variants at a quaternary [...]

Menée en Islande depuis 1967 auprès de 2 037 personnes (durée moyenne de suivi : 64-66 ans), cette étude analyse l'association entre la croissance (hauteur) entre 8 et 13 ans (enfance) ou après 13 ans (adolescence) et le risque de cancer du sein (117 cas) ou de la prostate (118 cas)

Growth Rate in Childhood and Adolescence and Risk of Breast and Prostate Cancer: A Population-Based Study

Haraldsdottir, Alfheidur ; Steingrimsdottir, Laufey ; Maskarinec, Gertraud ; Adami, Hans-Olov ; Aspelund, Thor ; Valdimarsdottir, Unnur A ; Bjarnason, Ragnar ; Thorsdottir, Inga ; Halldorsson, Thorhallur I ; Gunnarsdottir, Ingibjorg ; Tryggvadottir, Laufey ; Gudnason, Vilmundur ; Birgisdottir, Bryndis E ; Torfadottir, Johanna E

Growth rate is regulated by hormonal pathways that might affect early cancer development. We explored the association between rate of growth in height from age 8 to 13 (childhood) years and from age 13 to height at study entry (adolescence), and risk of breast and prostate cancer. Participants were 2,037 Icelanders born 1915 – 1935, who took part in the Reykjavik Study established 1967. Height measures were obtained from school records and at study entry. We used multivariable Cox regression [...]

Menée à l'aide de données 1968-2006 du registre danois des cancers portant sur 31 970 témoins et sur 2 974 patientes atteintes d'un cancer entre 15 et 44 ans, cette étude analyse le risque de second cancer chez les patientes ayant eu une grossesse moins de 6 mois après le diagnostic de cancer

Pregnancy-associated cancer and the risk of second primary cancer

Mellemkjær, Lene ; Eibye, Simone ; Albieri, Vanna ; Kjær, Susanne K. ; Boice, John D.

Purpose: Hormonal changes related to pregnancy and lactation among women treated for cancer might influence the risk of second primary cancer. We investigated whether pregnancy near the time of breast cancer, Hodgkin lymphoma or other cancer diagnoses is associated with increased risk of developing a new primary cancer. Methods: Women born after 1 April 1935 diagnosed with cancer at ages 15–44 years during 1968–2006 were identified in the Danish Cancer Registry. Information about pregnancies [...]

Menée en Pologne auprès de 103 témoins et 103 patients atteints d'une leucémie myéloïde aiguë (âge médian au diagnostic : 56 ans), cette étude identifie, sur 3 gènes (CEBPA, ETV6 et IDH2), 8 mutations constitutionnelles associées au développement de la maladie

Germline mutations among Polish patients with acute myeloid leukemia

Bąk, Aneta ; Skonieczka, Katarzyna ; Jaśkowiec, Anna ; Junkiert-Czarnecka, Anna ; Heise, Marta ; Pilarska-Deltow, Maria ; Potoczek, Stanisław ; Czyżewska, Maria ; Haus, Olga

Background: A small but important proportion of patients (4–10 %) with AML have germline mutations. They can cause the development of AML at an earlier age, confer a higher risk of relapse or predispose to secondary leukemias, including therapy-related leukemias. The analysis of germline mutations in a patient and his/her family is also critical for the selection of suitable family donors if the patient is a candidate for hematopoietic stem cell transplantation (HSCT). Methods: 103 unrelated [...]